Frontiers in Immunology | Vaccines and Molecular Therapeutics

Review

Published on 03 Feb 2026

Revisiting the streptococcal M protein: modern perspectives on antibody function, host interactions, and therapeutic targeting

in Vaccines and Molecular Therapeutics

Sebastian Wrighton
Pontus Nordenfelt

Frontiers in Immunology

doi 10.3389/fimmu.2026.1771053

741 views

Brief Research Report

Accepted on 02 Feb 2026

Experimental Validation and Immunogenic Insights of Multiepitope Vaccine design against Streptococcus pneumoniae

in Vaccines and Molecular Therapeutics

Yogeshwar Devarakonda
MVN Janardhan Reddy
Arunima Binu
KIRTIMAAN SYAL

Frontiers in Immunology

134 views

Original Research

Accepted on 02 Feb 2026

Immunopeptidomics of cutaneous leishmaniasis patients reveals the natural antigenic landscape

in Vaccines and Molecular Therapeutics

Nicky De Vrij
Elise Pepermans
Louise Laurijssen
Thao-Thy Pham
Lauren Thijs
Kurt Boonen
Kadrie Ramadan
Ilse Maes
Yetemwork Aleka
Mekibib Kassa

Frontiers in Immunology

113 views

Review

Published on 02 Feb 2026

VNAR: shark single-domain antibodies for the new era of medical biotechnology

in Vaccines and Molecular Therapeutics

Richard A. Olivares-Olivares
Angélica R. Bravo
Carlos Garrido-Soto
Jonatan J. Carvajal
Augusto Manubens
Mariella Rivas
Carlos Bustamente
Angello Retamal-Díaz
Alexis M. Kalergis
Margarita K. Lay

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716916

815 views

Review

Published on 02 Feb 2026

Harnessing pro-inflammatory and immunopathologic immune responses in urinary tract infections for vaccine development: it’s all about a balance

in Vaccines and Molecular Therapeutics

Sivakumar Periasamy
Joyce Lübbers
Susan King
Elise S. Hovingh
Leslie van der Fits
Germie P. J. M. van den Dobbelsteen

Frontiers in Immunology

doi 10.3389/fimmu.2026.1753331

628 views

Original Research

Accepted on 31 Jan 2026

B and T cell responses to pre-erythrocytic R21/Matrix-M and blood-stage RH5.1/Matrix-M malaria vaccines in endemic settings

in Vaccines and Molecular Therapeutics

Caroline Bundi
Olivia Muñoz
Elizabeth Kibwana
Duncan Bellamy
Lisa Stockdale
Jordan R Barrett
Kirsty McHugh
Ivanny Mtaka
WILMINA KALINGA
Domtila KIMANI

Frontiers in Immunology

168 views

Original Research

Published on 30 Jan 2026

Enhanced immunogenicity of the Brucella A19 ΔbtpB mutant leads to accelerated clearance in the host

in Vaccines and Molecular Therapeutics

Ye Yuan
Xuan Bu
Yunyi Zhai
Gaowa WuDong
Qing Lu
Ting Tang
Dong Zhou
Wei Liu
Yaping Jin
Aihua Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1747903

748 views

Case Report

Published on 30 Jan 2026

Case Report: Extracorporeal photopheresis for cutaneous lupus erythematosus induces putatively atheroprotective B and T cell responses

in Vaccines and Molecular Therapeutics

Marcella Visentini
Maria Ozsvar-Kozma
Ilenia Pacella
Alessandra Pinzon Grimaldos
Federica Falco
Mahnaz Shafii-Bafti
Ilenia Minicocci
Francesca La Gualana
Maurizio Carlesimo
Milvia Casato

Frontiers in Immunology

doi 10.3389/fimmu.2026.1741656

895 views

Review

Published on 29 Jan 2026

Circular nucleic acids at the host-virus interface: from immune modulation to therapeutic innovation

in Vaccines and Molecular Therapeutics

Jiacheng Lou
Jing Liu
Danlu Zhang
Yuchao Hao

Frontiers in Immunology

doi 10.3389/fimmu.2026.1751068

789 views

Original Research

Published on 29 Jan 2026

Long-term cellular and humoral responses to SARS-CoV-2 vaccinations in patients with solid malignancies undergoing chemotherapy

in Vaccines and Molecular Therapeutics

Andrew Liu
Brian Necela
Zhuo Li
Davitte Cogen
Mikolaj A. Wieczorek
Ashita Mummareddy
Marites Acampora
Gina A. Reynolds
Pooja P. Advani
Alvaro Moreno-Aspitia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690495

815 views

Hypothesis and Theory

Published on 28 Jan 2026

Could artificial intelligence gradually replace classical adjuvants?

in Vaccines and Molecular Therapeutics

Jose G. Marchan-Alvarez

Frontiers in Immunology

doi 10.3389/fimmu.2026.1710109

862 views

Review

Published on 27 Jan 2026

Outer membrane vesicles as a versatile nanoplatform for advanced vaccine development and immunotherapy

in Vaccines and Molecular Therapeutics

Jiawen Zhang
Yuhang Zhi
Yu Lu
Fang Ma

Frontiers in Immunology

doi 10.3389/fimmu.2026.1707391

1,009 views

Brief Research Report

Published on 27 Jan 2026

Identification of a growth-inhibitory epitope in PfRipr5, a malaria vaccine candidate against Plasmodium falciparum

in Vaccines and Molecular Therapeutics

Hikaru Nagaoka
Akihisa Fukushima
Takafumi Tsuboi
Eizo Takashima

Frontiers in Immunology

doi 10.3389/fimmu.2026.1724796

893 views

Opinion

Accepted on 26 Jan 2026

Architects of folding, editors of immunity: the strategic use of N-glycans in vaccine design

in Vaccines and Molecular Therapeutics

Sofia Orioli
Tommy Idrovo-Hidalgo
Maria de los Angeles Martinez Saucedo
Cecilia D'Alessio

Frontiers in Immunology

252 views

Original Research

Published on 26 Jan 2026

Trivalent coronavirus vaccines elicit broad-spectrum immunity in mice and attenuate respiratory viral load in golden hamsters

in Vaccines and Molecular Therapeutics

Xiuli Shen
Jiangshan He
Maoshun Liu
Xinyu Zhang
Peijia Wang
Yiming Shao

Frontiers in Immunology

doi 10.3389/fimmu.2026.1734382

685 views

Original Research

Published on 23 Jan 2026

CMTM8 variants influence BNT162b2 COVID-19 vaccination response by regulating granulocytic/polymorphonuclear myeloid-derived suppressor cell activity

in Vaccines and Molecular Therapeutics

Alessandro Testori
Antonella Mulas
Mara Marongiu
Valeria Orrù
Monia Lobina
Maria Grazia Piras
Erika Lutzu
Nicolò Curreli
Cristina Politi
Marco Mobrici

Frontiers in Immunology

doi 10.3389/fimmu.2026.1717058

1,109 views

Original Research

Published on 22 Jan 2026

Structure-guided design of a bivalent SARS-CoV-2 mRNA vaccine with NTD stabilizing mutations enhances broad immunity

in Vaccines and Molecular Therapeutics

Jinah Yeo
Mi-ran Yun
Seo-Yeon Kim
Jong-Hyun Seok
Ji Hyang Jeon
Taeyoung Lee
Jeonghun Kim
Kisoon Kim
Man-Seong Park
Dokeun Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718740

1,388 views

Systematic Review

Published on 21 Jan 2026

Nanoparticles in influenza research: a bibliometric analysis of global trends (2005 - 2025)

in Vaccines and Molecular Therapeutics

Yezi Zhang
Xi Lin
Lingling Wen
Jiaona Zhang
Jian Lin
Xinghua Liu
Yuxiang Liu
Siyuan Xu
Xingdong Lin
Zhizhun Mo

Frontiers in Immunology

doi 10.3389/fimmu.2026.1715271

867 views

Review

Published on 21 Jan 2026

Metabolism of tumor infiltrating T cells

in Vaccines and Molecular Therapeutics

Hildegund CJ Ertl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711328

909 views

Original Research

Published on 21 Jan 2026

Immunogenicity and protection mediated by dmLT and alum adjuvants for an HIV-1 vaccine

in Vaccines and Molecular Therapeutics

Kasey Stokdyk
Anusmita Sahoo
Sailaja Gangadhara
LaTonya D. Williams
Tiffany M. Styles
Caleb A. Hellman
Lu Zhang
Ahmad J. Odeh
Shelby Flaherty
Xiaoying Shen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706958

1,002 views

Original Research

Published on 21 Jan 2026

Immunogenicity evaluation of altSonflex1-2–3 Shigella vaccine across mice, rats, and rabbits to inform human translational insights

in Vaccines and Molecular Therapeutics

Valentina Caradonna
Renzo Alfini
Marika Pinto
Roberta Di Benedetto
Carlo Giannelli
Donata Medaglini
Elena Pettini
Miren Iturriza
Omar Rossi
Francesca Micoli

Frontiers in Immunology

doi 10.3389/fimmu.2025.1740821

728 views

Review

Published on 21 Jan 2026

Advances in the application of tumor vaccines and combination strategies: new perspectives in lung cancer treatment

in Vaccines and Molecular Therapeutics

Lei Sun
Qi Zhao
Liyun Miao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707183

767 views

General Commentary

Published on 20 Jan 2026

Commentary: Immunogenicity of dupilumab in adult and pediatric patients with atopic dermatitis

in Vaccines and Molecular Therapeutics

Miao-Chun Tsai
Hao-Yun Chen
Jhe-Cyun Liao
Yan-Yu Liu
Xiao-Ling Liu
Su-Boon Yong
Chia-Jung Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1725709

1,592 views

Original Research

Accepted on 19 Jan 2026

mRNA-based SARS-CoV-2 vaccines: Intracellular processing and aggregation of the encoded spike protein as a mechanistic contributor to cardiac cellular stress

in Vaccines and Molecular Therapeutics

Rolf Schreckenberg
Nadine Woitasky
Nadja Itani
Laureen Czech
Anita Cornelia Windhorst
Malte Juchem
Christian Bär
Thomas Thum
Péter Ferdinandy
Rainer Schulz

Frontiers in Immunology

19,250 views