Frontiers in Immunology | Vaccines and Molecular Therapeutics

Original Research

Accepted on 19 Jan 2026

mRNA-based SARS-CoV-2 vaccines: Intracellular processing and aggregation of the encoded spike protein as a mechanistic contributor to cardiac cellular stress

in Vaccines and Molecular Therapeutics

Rolf Schreckenberg
Nadine Woitasky
Nadja Itani
Laureen Czech
Anita Cornelia Windhorst
Malte Juchem
Christian Bär
Thomas Thum
Péter Ferdinandy
Rainer Schulz

Frontiers in Immunology

19,250 views

Review

Published on 16 Jan 2026

Flavin and deazaflavin biosynthesis in mycobacteria: relevance to physiology, implications for drug discovery, MR-1 antigenicity, and vaccine development

in Vaccines and Molecular Therapeutics

Nurudeen Oketade
Melissa D. Chengalroyen
Dylan Kain
David M. Lewinsohn
Karen M. Dobos

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656167

1,467 views

Original Research

Published on 16 Jan 2026

Intranasal vaccines adjuvanted with Nexavant demonstrate robust protective efficacy by inducing both mucosal and systemic immunity in a murine model

in Vaccines and Molecular Therapeutics

Kwang Hyun Ko
Hyun Shik Bae
So Min Lee
Somin Park
Seung Hyun Han
Jun Heo
Jinil Kim
Yerim Cho
Dong-Ho Kim
Seung Bin Cha

Frontiers in Immunology

doi 10.3389/fimmu.2025.1745319

1,013 views

Original Research

Published on 16 Jan 2026

Harnessing mRNA for the expression of monoclonal IgG and IgA in non-human primates

in Vaccines and Molecular Therapeutics

Romy Rouzeau
Hayden R. Schmidt
Cailin E. Deal
Joel D. Allen
Dawn M. Dudley
Iszac Burton
Eva G. Rakasz
Obadiah Plante
Max Crispin
Andrea Carfi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700041

1,260 views

Editorial

Published on 15 Jan 2026

Editorial: Data-driven vaccine design for microbial-associated diseases

in Vaccines and Molecular Therapeutics

Gurudeeban Selvaraj
Satyavani Kaliamurthi
Dongqing Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1749184

954 views

Original Research

Published on 14 Jan 2026

A shikonin-based hydrogel dressing exhibiting synergistic anti-inflammatory, anti-angiogenic, and anti-fibrotic effects for the prevention of hypertrophic scars

in Vaccines and Molecular Therapeutics

Ziyu Wang
Yujie Zhao
Zhoujiang Qu
Hui Wang
Yuling Zhang
Yufang Liu
Chengde Li
Kun Wang
Guoqi Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1736748

866 views

Review

Published on 14 Jan 2026

Understanding the performance of HIV-1 viral vector vaccines: adenovirus and poxvirus case studies

in Vaccines and Molecular Therapeutics

Mahdiyeh M. Manafi
Touraj Farzani
Nallely Espinoza
Al Ozonoff
Pardis C. Sabeti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720342

1,272 views

Original Research

Published on 13 Jan 2026

Antibody levels to variant and conserved Plasmodium falciparum antigens predict reduction in parasite burden in Malian children

in Vaccines and Molecular Therapeutics

Delesa Damena
Lauren Dang
Amadou Barry
Jonathan P. Renn
Santara Gaoussou
Almahamoudou Mahamar
Oumar Attaher
Djibrilla Issiaka
Robert D. Morrison
Santosh A. Misal

Frontiers in Immunology

doi 10.3389/fimmu.2025.1745097

891 views

Systematic Review

Published on 13 Jan 2026

Comprehensive evaluation of prophylactic HPV vaccines: a systematic review and meta-analysis of efficacy, safety, and immunogenicity in males and females

in Vaccines and Molecular Therapeutics

Zhiliang Wang
Hui Zhang
Yuhang Zhu
Yuanli Jiang
Danhe Yang
Xiaofeng Zou
Yi Fang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1747082

1,537 views

Editorial

Published on 13 Jan 2026

Editorial: Community series in research advances of tuberculosis vaccine and its implication on COVID-19, volume III

in Vaccines and Molecular Therapeutics

Wenping Gong
Ashok Aspatwar
Jianping Xie
Hao Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1757051

776 views

Original Research

Published on 13 Jan 2026

A rapid method to reduce drug interferences for antibody measurements in pegunigalsidase alfa-treated patients with Fabry disease

in Vaccines and Molecular Therapeutics

Malte Lenders
Elisa Rudolph
Michael Rudnicki
Markus Cybulla
Eva Brand

Frontiers in Immunology

doi 10.3389/fimmu.2025.1724835

1,271 views

Review

Published on 12 Jan 2026

T cell assays for non-clinical immunogenicity risk assessment: best practices recommended by the European Immunogenicity Platform

in Vaccines and Molecular Therapeutics

Sophie Tourdot
Anette Christine Karle
Marc Rosenbaum
Chloé Ackaert
Pauline Le Vu
Michael Gutknecht
Maryam Ahmadi
Annelies W. Turksma
Timothy P. Hickling

Frontiers in Immunology

doi 10.3389/fimmu.2025.1723110

1,612 views

Original Research

Published on 12 Jan 2026

An antibody uniquely binding short 2′-O-methyl RNA oligonucleotide duplexes: formation and recognition of target duplexes on cell surfaces

in Vaccines and Molecular Therapeutics

Ian S. Dunn
Matthew M. Lawler
Leah Fagundes
Milto Simoes Junior
April Mangold
Domenic Rinaldi
Lenora B. Rose
James T. Kurnick

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699400

906 views

Original Research

Published on 12 Jan 2026

Susceptibility of broad reactivity nanobodies to resistance mutations in the S2 domain of SARS-CoV-2 predicted by yeast display deep mutational scanning

in Vaccines and Molecular Therapeutics

Christina R. Ball
Walter Ramage
Ryan Mate
Simon E. Hufton

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726449

898 views

Original Research

Published on 09 Jan 2026

Different Fc scaffolds enhance the breadth of in vitro neutralization of the same Fab against different Rotavirus strains

in Vaccines and Molecular Therapeutics

Mabel Rocio Miranda-Echagüe
Giacomo Vezzani
Elena Morandi
Melania Della Peruta
Mirko Scordio
Teresa Anne Clarisse Reyes
Davide Oldrini
Miren Iturriza-Gómara
Rebecca Jo Loomis
Omar Rossi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709107

1,088 views

Original Research

Published on 08 Jan 2026

Antigen binding triggers long-range conformational changes in monoclonal antibodies

in Vaccines and Molecular Therapeutics

Davide Bianchi
Simona Saporiti
Wolf Palinsky
Omar Ben Mariem
Mara Rossi
Ivano Eberini
Fabio Centola

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680199

1,202 views

Review

Published on 07 Jan 2026

Glycan masking in immunogen design: computational and experimental methods

in Vaccines and Molecular Therapeutics

Gustavo Araiza
Josuel Morel
Minh H. Tran
Shan Jiang
Sean Murray
Emika Miyamoto
Hannah Vogts
Kyle L. Brown
Jens Meiler
Cristina E. Martina

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726810

1,149 views

Review

Published on 07 Jan 2026

Therapeutic antibody delivery: vector tools to boost efficacy and affordability

in Vaccines and Molecular Therapeutics

Abhishek Chiyyeadu
Bushra Khan
Katrin Ehrhardt
Hildegard Büning
Michael Morgan
Axel Schambach

Frontiers in Immunology

doi 10.3389/fimmu.2025.1714390

1,674 views

Review

Published on 06 Jan 2026

PCV20 in pediatric pneumococcal prevention: expanded coverage, remaining challenges

in Vaccines and Molecular Therapeutics

Nicola Principi
Alberto Argentiero
Beatrice Campana
Susanna Esposito

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707345

1,368 views

Original Research

Published on 05 Jan 2026

Site- and structure-specific characterization of glycoproteins of H11: potent vaccine candidates against parasitic worm Haemonchus

in Vaccines and Molecular Therapeutics

Xin Liu
Feng Liu
Hui Liu
Lisha Ye
Yao Zhang
Wenjie Peng
Nishith Gupta
Min Hu
Chunqun Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1669536

1,165 views

Brief Research Report

Published on 05 Jan 2026

Robust neutralization of emerging JN.1 subvariants by the updated JN.1 vaccine: rationale for catch-up booster recommendations in high-risk individuals

in Vaccines and Molecular Therapeutics

Ju-yeon Choi
Su-Hwan Kim
Soyoung Park
Hye Min Jang
Young Jae Lee
Hye-Jin Kim
Dokeun Kim
Jae-Hoon Ko
Hye-Sook Jeong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1696676

1,095 views

Original Research

Published on 05 Jan 2026

An mRNA vaccine encoding the Ebola virus glycoprotein induces high neutralizing antibody titers and provides strong protection against lethal infections in mouse models

in Vaccines and Molecular Therapeutics

Zachary R. Stromberg
Elvia E. Silva
Sara C. Johnston
Dylan M. Johnson
Dominique Hall
Emmanuel F. Adjei
John A. Altin
Abisola Abisoye-Ogunniyan
Travis Gollott
Wei He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682418

1,878 views

Original Research

Published on 02 Jan 2026

Antibodies directed against extracellular loops of FadL orthologs disrupt outer membrane integrity and neutralize infectivity of Treponema pallidum, the syphilis spirochete

in Vaccines and Molecular Therapeutics

Kristina N. Delgado
Crystal F. Vicente
Carson J. La Vake
Everton Bettin
Melissa J. Caimano
Justin D. Radolf
Kelly L. Hawley

Frontiers in Immunology

doi 10.3389/fimmu.2025.1724458

1,275 views

Original Research

Published on 02 Jan 2026

Intranasal BCG vaccination induces systemic and pulmonary mucosal immune responses against tuberculosis in a goat model

in Vaccines and Molecular Therapeutics

Patricia Cuenca-Lara
Miriam Blay-Benach
Zoraida Cervera
Julia Moraleda
Iker A. Sevilla
Joseba M. Garrido
Mahavir Singh
Sergio López-Soria
Enric Vidal
Mariano Domingo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1740197

1,225 views
1 citation

3,191 articles

articles

mRNA-based SARS-CoV-2 vaccines: Intracellular processing and aggregation of the encoded spike protein as a mechanistic contributor to cardiac cellular stress

Flavin and deazaflavin biosynthesis in mycobacteria: relevance to physiology, implications for drug discovery, MR-1 antigenicity, and vaccine development

Intranasal vaccines adjuvanted with Nexavant demonstrate robust protective efficacy by inducing both mucosal and systemic immunity in a murine model

Harnessing mRNA for the expression of monoclonal IgG and IgA in non-human primates

Editorial: Data-driven vaccine design for microbial-associated diseases

A shikonin-based hydrogel dressing exhibiting synergistic anti-inflammatory, anti-angiogenic, and anti-fibrotic effects for the prevention of hypertrophic scars

Understanding the performance of HIV-1 viral vector vaccines: adenovirus and poxvirus case studies

Antibody levels to variant and conserved Plasmodium falciparum antigens predict reduction in parasite burden in Malian children

Comprehensive evaluation of prophylactic HPV vaccines: a systematic review and meta-analysis of efficacy, safety, and immunogenicity in males and females

Editorial: Community series in research advances of tuberculosis vaccine and its implication on COVID-19, volume III

A rapid method to reduce drug interferences for antibody measurements in pegunigalsidase alfa-treated patients with Fabry disease

T cell assays for non-clinical immunogenicity risk assessment: best practices recommended by the European Immunogenicity Platform

An antibody uniquely binding short 2′-O-methyl RNA oligonucleotide duplexes: formation and recognition of target duplexes on cell surfaces

Susceptibility of broad reactivity nanobodies to resistance mutations in the S2 domain of SARS-CoV-2 predicted by yeast display deep mutational scanning

Different Fc scaffolds enhance the breadth of in vitro neutralization of the same Fab against different Rotavirus strains

Antigen binding triggers long-range conformational changes in monoclonal antibodies

Glycan masking in immunogen design: computational and experimental methods

Therapeutic antibody delivery: vector tools to boost efficacy and affordability

PCV20 in pediatric pneumococcal prevention: expanded coverage, remaining challenges

Site- and structure-specific characterization of glycoproteins of H11: potent vaccine candidates against parasitic worm Haemonchus

Robust neutralization of emerging JN.1 subvariants by the updated JN.1 vaccine: rationale for catch-up booster recommendations in high-risk individuals

An mRNA vaccine encoding the Ebola virus glycoprotein induces high neutralizing antibody titers and provides strong protection against lethal infections in mouse models

Antibodies directed against extracellular loops of FadL orthologs disrupt outer membrane integrity and neutralize infectivity of Treponema pallidum, the syphilis spirochete

Intranasal BCG vaccination induces systemic and pulmonary mucosal immune responses against tuberculosis in a goat model