Frontiers in Immunology | Vaccines and Molecular Therapeutics

Review

Published on 21 Oct 2025

Harnessing cytokines: innovative adjuvants for improved veterinary vaccine efficacy

in Vaccines and Molecular Therapeutics

Shihong Yan
Huimin Chen
Qiao Liu
Xinyu Zhang
Qiulu Wei
Chenqi Hu
Dianfeng Chu
Hongxiu Diao
Shasha Liu
Ji-Long Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643855

1,729 views
1 citation

Original Research

Published on 20 Oct 2025

Integrated immunodominant epitope discovery for dual-purpose rapid and economical diagnostic and immunoprotective applications against MRSA

in Vaccines and Molecular Therapeutics

Longlong Chen
Pengju Yan
LianLi Duan
Guangyang Ming
Xiaoqiong Wang
Jinyong Zhang
Zhifu Chen
Qiang Gou
Yue Yuan
Haiming Jing

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697829

1,837 views

Original Research

Published on 16 Oct 2025

Development and protective efficacy of multi-epitope vaccine FL46 against cystic echinococcosis

in Vaccines and Molecular Therapeutics

Tingting Jiang
Maerdan Mahemuti
Weina Wang
Shuai Han
Xiaoying Wu
Hua Liu
Quan Chen
Xiaojin Mo
Xu Wang
Aerxin Kadiaili

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686959

2,008 views

Original Research

Published on 16 Oct 2025

A20 mRNA therapeutics ameliorate systemic sclerosis by suppressing TRAF-6/NF-KB signaling and DREAM expression and exerting antifibrotic effects

in Vaccines and Molecular Therapeutics

A Ram Lee
Su Been Jeon
Hye Won Kwak
Suh Won Yang
Yoo Jin Bang
Seon-Yeong Lee
So Won Lee
Jin Hyung Park
Se Gyeong Han
Jeong Won Choi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665998

2,083 views

Review

Published on 15 Oct 2025

Biomimetic strategies of cell membrane vesicles driven by pathogen-host interactions: novel insights into antimicrobial immunotherapy and infection prevention

in Vaccines and Molecular Therapeutics

Ximin Xia
Yu Fang
Jia Zhong
Fanzhu Li
Lai Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681889

1,465 views

Original Research

Published on 15 Oct 2025

The mRNA component of LNP-mRNA vaccines triggers IFNAR-dependent immune activation which attenuates the adaptive immune response

in Vaccines and Molecular Therapeutics

Liat Bar-On
Hila Cohen
Uri Elia
Lilach Cherry-Mimran
Ofer Cohen
Noam Erez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670350

3,268 views

Original Research

Published on 14 Oct 2025

Investigation on antigen-specific T-cell responses induced by outer membrane vesicles from Escherichia coli Δ60 strain

in Vaccines and Molecular Therapeutics

Michele Tomasi
Lorenzo Croia
Ilaria Zanella
Assunta Gagliardi
Giulia Boscato Sopetto
Mattia Benedet
Gabriele Di Lascio
Gaia Gambini
Alvise Berti
Riccardo Corbellari

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633961

1,709 views

Brief Research Report

Published on 13 Oct 2025

SARS-CoV-2 vaccines induce a diverse spike-specific CD4+ T cell receptor repertoire in people living with HIV with low CD4 nadirs

in Vaccines and Molecular Therapeutics

Alicia Mercado
Joel Sop
Steven Amanat
Li Zhang
Natasha M. Chida
Christie R. Basseth
Kelly A. Gebo
Annukka A. R. Antar
Kellie N. Smith
Zhen Zeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663819

1,989 views

Review

Published on 10 Oct 2025

Monoclonal antibodies against influenza viruses: a clinical trials review

in Vaccines and Molecular Therapeutics

Kenneth Gabriel Mota
Ana Maria Moro

Frontiers in Immunology

doi 10.3389/fimmu.2025.1669073

3,331 views

Original Research

Published on 10 Oct 2025

A biomimetic model composed of injectable 3D muscle-like tissue, stromal and immune cells for recapitulating the rapid immune signature predictive of mRNA vaccine immunogenicity

in Vaccines and Molecular Therapeutics

Marilena Paola Etna
Claudia Fuoco
Martina Severa
Daniela Ricci
Alessandro Sinigaglia
Camilla Lucca
Giada Cairo
Barbara Bottazzi
Cecilia Garlanda
Anna Teresa Palamara

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651095

1,951 views

Original Research

Published on 10 Oct 2025

Nasal vaccination against Trypanosoma cruzi: a dual approach for prevention and treatment of chronic Chagas cardiomyopathy

in Vaccines and Molecular Therapeutics

Paula Cacik
Maria Florencia Pacini
Camila Bulfoni Balbi
Brenda Dinatale
Genaro Diaz
Ulises Cha
Cecilia Farré
Mónica Gianeselli
Estefanía Prochetto
Ana Rosa Peréz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662036

1,814 views

Review

Published on 10 Oct 2025

MAPPs assays for non-clinical immunogenicity risk assessment: best practices recommended by the European immunogenicity platform

in Vaccines and Molecular Therapeutics

A.C. Karle
K. L. Kopp
R.J. Seward
S. Tourdot
C. Ackaert
M. Gutknecht
E. Cloake
N. Smith
A. Ducret

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690101

2,204 views
1 citation

Review

Published on 08 Oct 2025

Insights into tumor vaccines for elderly individuals in the context of immunosenescence

in Vaccines and Molecular Therapeutics

Chenglong Li
Zhujun Chen
Changyu Zhu
Min Chen
Jinqi Li
Lei Zhong
Yingying Hou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1660874

2,218 views

Original Research

Published on 08 Oct 2025

Immunoadjuvanted influenza vaccine immunogenicity in children with type 1 diabetes over two consecutive seasons

in Vaccines and Molecular Therapeutics

Mikhail Petrovich Kostinov
Maria Alexandrovna Kvasova
Alla Anatolievna Tarasova
Anna Vlasenko
Elena Vladimirovna Kolbasina
Darya Alexandrovna Bydanova
Aristitsa Kostinova
Valentina Polishchuk
Isabella Abramovna Khrapunova
Marina Loktionova

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597619

1,727 views

Original Research

Published on 07 Oct 2025

Subcutaneous administration of the malaria R21/Matrix M vaccine and immune complex formation with anti-circumsporozoite protein mAb 2A10 elicit protective efficacy in mice

in Vaccines and Molecular Therapeutics

Ekta Mukhopadhyay
César López Camacho
Adrian V. S. Hill
Ahmed M. Salman

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675780

2,000 views

Original Research

Published on 07 Oct 2025

Machine learning insights into vaccine adjuvants and immune outcomes

in Vaccines and Molecular Therapeutics

Yuhyun Ji
Kavitha Bekkari
Ruchin Patel
Mohammed Shardar
Geoffrey A. Walford
SamMoon Kim
Yaping Liu
Willis Read-Button
Kristina Tracy
Jennifer Kriss

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654060

2,943 views

Original Research

Published on 06 Oct 2025

Development of potent HLA-A02:01-restricted peptide-based cytotoxic T-cells against SARS-CoV-2 infections in patients awaiting a kidney transplant

in Vaccines and Molecular Therapeutics

Chih-Chao Chang
Ya Nan Liu
Zheng Xu
Elena-Rodica Vasilescu
Ping Li
Eric K. Ho
Muyang Li
Syed A. Husain
Govind Bhagat
Sumit Mohan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664371

1,984 views

Original Research

Published on 01 Oct 2025

Impact of an aerosolized or intramuscular adenovirus type 5-vectored COVID-19 vaccine on Fc-mediated immune effector functions in a hybrid immunity population

in Vaccines and Molecular Therapeutics

Mingzhi Gan
Weiwei Han
Chuang Li
Simin Li
Zhuangzhuang Huang
Lingjie Xu
Xiaoyu Xu
Xiangjun Zhai
Yuxin Chen
Jingxin Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657235

1,937 views

Original Research

Published on 30 Sep 2025

Personalized prediction of SARS-CoV-2 vaccine-induced immunity after boost: a longitudinal analysis using joint modeling

in Vaccines and Molecular Therapeutics

Iraklis Papadopoulos
Anh Nguyet Diep
Joey Schyns
Claire Gourzones
Frédéric Minner
Germain Bonhomme
M. Paridans
Nicolas Gillain
Eddy Husson
Mutien Garigliany

Frontiers in Immunology

doi 10.3389/fimmu.2025.1619631

1,888 views

Opinion

Published on 30 Sep 2025

One hundred years of BCG: the journey of tuberculosis vaccination in Brazil

in Vaccines and Molecular Therapeutics

Eloise Trostdorf Monteiro Filardi
Roberto Carlos Cruz Carbonell
Fernando Rogério Pavan
Felipe Augusto Cerni
Manuela Berto Pucca

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655969

1,752 views

Review

Published on 29 Sep 2025

Advances in molecular adjuvants for nucleic acid vaccines

in Vaccines and Molecular Therapeutics

Casey E. Hojecki
Nicholas J. Tursi
Cory Livingston
David B. Weiner
Ebony N. Gary

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646800

3,105 views
1 citation

Original Research

Published on 29 Sep 2025

Identification of novel genetic biomarkers for ChAdOx1 nCoV-19 mediated immunogenicity

in Vaccines and Molecular Therapeutics

Wan-Hsuan Chou
Che-Mai Chang
Jafit Ting
Min-Rou Lin
Hsin-Ni Liao
Yi-Chien Chou
Chun-Yu Wei
Hsin-Hui Chi
Szu-Ying Ho
Wei-Tzu Luo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1622122

1,681 views

Systematic Review

Published on 25 Sep 2025

Efficacy of different allergen-specific immunotherapies for the treatment of allergic rhinitis in children and adults: an umbrella review

in Vaccines and Molecular Therapeutics

Yu He
Xinghong Liu
Bin Zhou
Tianrong Dai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658826

3,716 views
1 citation

Original Research

Published on 23 Sep 2025

Effects of sex but not race and geographic origin on vaccine-induced HIV-specific antibody responses

in Vaccines and Molecular Therapeutics

Wilbert Mbuya
Augusta Horvath
Kathrin Held
Lucas Maganga
Michael Hoelscher
Linda-Gail Bekker
Ann Duerr
Zoe Moodie
Gavin Churchyard
Michael C. Keefer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601865

2,881 views

3,150 articles

articles

Harnessing cytokines: innovative adjuvants for improved veterinary vaccine efficacy

Integrated immunodominant epitope discovery for dual-purpose rapid and economical diagnostic and immunoprotective applications against MRSA

Development and protective efficacy of multi-epitope vaccine FL46 against cystic echinococcosis

A20 mRNA therapeutics ameliorate systemic sclerosis by suppressing TRAF-6/NF-KB signaling and DREAM expression and exerting antifibrotic effects

Biomimetic strategies of cell membrane vesicles driven by pathogen-host interactions: novel insights into antimicrobial immunotherapy and infection prevention

The mRNA component of LNP-mRNA vaccines triggers IFNAR-dependent immune activation which attenuates the adaptive immune response

Investigation on antigen-specific T-cell responses induced by outer membrane vesicles from Escherichia coli Δ60 strain

SARS-CoV-2 vaccines induce a diverse spike-specific CD4+ T cell receptor repertoire in people living with HIV with low CD4 nadirs

Monoclonal antibodies against influenza viruses: a clinical trials review

A biomimetic model composed of injectable 3D muscle-like tissue, stromal and immune cells for recapitulating the rapid immune signature predictive of mRNA vaccine immunogenicity

Nasal vaccination against Trypanosoma cruzi: a dual approach for prevention and treatment of chronic Chagas cardiomyopathy

MAPPs assays for non-clinical immunogenicity risk assessment: best practices recommended by the European immunogenicity platform

Insights into tumor vaccines for elderly individuals in the context of immunosenescence

Immunoadjuvanted influenza vaccine immunogenicity in children with type 1 diabetes over two consecutive seasons

Subcutaneous administration of the malaria R21/Matrix M vaccine and immune complex formation with anti-circumsporozoite protein mAb 2A10 elicit protective efficacy in mice

Machine learning insights into vaccine adjuvants and immune outcomes

Development of potent HLA-A02:01-restricted peptide-based cytotoxic T-cells against SARS-CoV-2 infections in patients awaiting a kidney transplant

Impact of an aerosolized or intramuscular adenovirus type 5-vectored COVID-19 vaccine on Fc-mediated immune effector functions in a hybrid immunity population

Personalized prediction of SARS-CoV-2 vaccine-induced immunity after boost: a longitudinal analysis using joint modeling

One hundred years of BCG: the journey of tuberculosis vaccination in Brazil

Advances in molecular adjuvants for nucleic acid vaccines

Identification of novel genetic biomarkers for ChAdOx1 nCoV-19 mediated immunogenicity

Efficacy of different allergen-specific immunotherapies for the treatment of allergic rhinitis in children and adults: an umbrella review

Effects of sex but not race and geographic origin on vaccine-induced HIV-specific antibody responses