Frontiers in Immunology | Vaccines and Molecular Therapeutics

Original Research

Published on 10 Nov 2025

Assessment of immune responses to Brucella abortus S19 vaccination in cattle and buffaloes

in Vaccines and Molecular Therapeutics

Rajeswari Shome
Prabhakar Yallanur Konda
Somy Skariah
Gandu Shanmugam
Praveen Kumar Attiganahalli Muninarayanaswamy
Pavan Kalyan Nagaraja
Kirti Megha
Nanditha Thimmappa Rajeshwari
Nagalingam Mohandoss

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663259

1,916 views

Original Research

Published on 07 Nov 2025

Impact of immunodeficiencies on immunity induced by SARS-CoV-2 infection, mRNA BNT162b2 vaccination, and their combination in children and young adults

in Vaccines and Molecular Therapeutics

Lubica Fialova
Birivan Macek-Nabova
Monika Zilkova
Natalia Turic-Csokova
Denisa Palova
Stanislav Katina
Gabriela Paulikova-Rolkova
Peter Ciznar
Julia Horakova
Lubica Wojciakova

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661282

1,990 views

Original Research

Published on 04 Nov 2025

Gram-positive enhancer matrix delivering FVpE via M cell targeting elicit protective mucosal and adaptive immune responses against Helicobacter pylori infection

in Vaccines and Molecular Therapeutics

Furui Zhang
Yaqin He
Hongpeng Liu
Jing Wu
Xin Li
Jiale Chen
Linhan Ni
Zhen Zhang
Juan Chen
Kunmei Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697591

1,522 views

Brief Research Report

Published on 03 Nov 2025

Towards new approach methodologies for biological therapeutics: a novel model-informed metric to assess immunogenicity risk

in Vaccines and Molecular Therapeutics

Rachel H. Rose
Aban Shuaib
Manon Wigbers
Maryam Khalifa
Andrzej M. Kierzek
Piet H. van der Graaf

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677925

2,319 views

Original Research

Published on 03 Nov 2025

Synergistic nano-vaccine strategy for comprehensive activation of adaptive and innate immunity against Staphylococcus aureus infection

in Vaccines and Molecular Therapeutics

Jiayue Xi
Minxuan Cui
Zhuoyue Shi
Zhuo Wan
Yufei Hou
Nan Sun
Muqiong Li
Zhengjun Ma
Yupu Zhu
Xin He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665710

1,541 views

Original Research

Published on 03 Nov 2025

An mRNA-based FimH nanoparticle vaccine against uropathogenic Escherichia coli is highly immunogenic in rodents

in Vaccines and Molecular Therapeutics

Sandro Roier
Roberto Adamo
Roberto Rosini
Alfredo Pezzicoli
Maria Scarselli
Benjamin Petsch
Edith Jasny
Susanne Rauch

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668937

3,864 views

Original Research

Published on 30 Oct 2025

Identification of immunogenic KIF5B-RET fusion neopeptides driving immune stimulation in tumor specific CD8+ T cells

in Vaccines and Molecular Therapeutics

Micah B. Castillo
Sakuni Rankothgedera
Shiyanth Thevasagayampillai
Aaranyah Kandasamy
Jaila Lewis
Cole Woody
Martiela Vaz de Freitas
Dinler Amaral Antunes
Randa El-Zein
Preethi H. Gunaratne

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635810

2,420 views

Original Research

Published on 30 Oct 2025

Minimal association between Th1-specific responses to COVID-19 vaccines and SARS-CoV-2 breakthrough infections in multiple sclerosis patients receiving disease-modifying therapies

in Vaccines and Molecular Therapeutics

Alessandra Aiello
Assunta Navarra
Shalom Haggiag
Serena Ruggieri
Gilda Cuzzi
Valentina Vanini
Andrea Salmi
Stefania Notari
Anna Maria Gerarda Altera
Silvia Meschi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682049

1,785 views

Systematic Review

Published on 29 Oct 2025

CKD-related impairment in humoral and cellular immune response and potential correlation with long COVID-19: a systematic review

in Vaccines and Molecular Therapeutics

Dali Wang
Fenghua Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690298

1,401 views

Review

Published on 29 Oct 2025

Research progress in vaccination during pregnancy

in Vaccines and Molecular Therapeutics

Jiao Zhang
Zhimin Li
Shiran Li
Pengfei Li
Jingxian Xie
Yong Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1687362

2,147 views

Original Research

Published on 28 Oct 2025

An oral M-cell targeted Lactococcus lactis vaccine against Echinococcus multilocularis infection

in Vaccines and Molecular Therapeutics

Yang Xiao
Zhao-Hui Luo
Shun-Juan Wang
Yao Dai
Jia-Yu Chen
Jia-Yong Cui
Run-Le Li
Feng Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683003

1,450 views

Original Research

Published on 27 Oct 2025

Construction of a prognostic model based on palmitoylation-related lncRNAs for assessing drug benefits in breast cancer

in Vaccines and Molecular Therapeutics

Yan Wang
Mengsi Zhang
Yuqin Zhou
Zaozhuo Li
Xinglin Yi
Lin Ren
Yi Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656593

1,723 views

Clinical Trial

Published on 24 Oct 2025

Safety, tolerability, and immunogenicity of INO-4500, a synthetic DNA-based vaccine against Lassa virus, in a phase 1b clinical trial in healthy Ghanaian adults

in Vaccines and Molecular Therapeutics

Kwadwo Ansah Koram
Kathleen A. Walker
Bonaventure Orizu
Idania Marrero
Jean Boyer
ShuPing Yang
Kate E. Broderick
Kwadwo Asamoah Kusi
Eric Kyei-Baafour
Ebenezer Addo Ofori

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658549

2,939 views

Original Research

Published on 24 Oct 2025

Exogenous melatonin boosts vaccine-induced immunity in individuals with high pre-existing influenza immunity

in Vaccines and Molecular Therapeutics

Kyosuke Oda
Janine Danko
Eileen Villasante
Elke Bergmann-Leitner
Rachel Lee
Wathsala Wijayalath

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663763

2,646 views

Original Research

Published on 24 Oct 2025

rBCG-LTAK63 enhances protection against tuberculosis by inducing autophagy and circadian gene regulation

in Vaccines and Molecular Therapeutics

Lázaro M. Marques-Neto
Monalisa M. Trentini
Ana Carolina R. Moreno
Silas F. Eto
Ana Carolina O. Carvalho
Almiro P.S. Neto
Murilo S. Amaral
André G. C. Martins
André N. A. Gonçalves
Ana Marisa Chudzinski-Tavassi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1695560

2,071 views

Original Research

Published on 22 Oct 2025

Exploring ceRNA mechanisms in COVID-19 mRNA vaccine-induced myocarditis: implications for future vaccine design

in Vaccines and Molecular Therapeutics

Jing Wang
Xin-Yi Sun
Qian Gao
Min Fu
Mian Xiao
Ning Du
Xi-Yuan Ge

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674049

4,430 views

Review

Published on 22 Oct 2025

Different antibody isotypes against tuberculosis: what we know and what we need to know

in Vaccines and Molecular Therapeutics

Huoming Li
Hao Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682934

3,111 views
1 citation

Review

Published on 21 Oct 2025

Harnessing cytokines: innovative adjuvants for improved veterinary vaccine efficacy

in Vaccines and Molecular Therapeutics

Shihong Yan
Huimin Chen
Qiao Liu
Xinyu Zhang
Qiulu Wei
Chenqi Hu
Dianfeng Chu
Hongxiu Diao
Shasha Liu
Ji-Long Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643855

2,153 views
1 citation

Original Research

Published on 21 Oct 2025

Insufficient immune protection in preterm infants due to delayed or incomplete hexavalent vaccination

in Vaccines and Molecular Therapeutics

Elisabeth Kaiser
Regine Weber
Michelle Bous
Ingmar Fortmann
Marie-Theres Dammann
Janina Marißen
Dorothee Viemann
Christoph Derouet
Steve Hein
Nasenien Nourkami-Tutdibi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1626057

2,284 views

Original Research

Published on 20 Oct 2025

Integrated immunodominant epitope discovery for dual-purpose rapid and economical diagnostic and immunoprotective applications against MRSA

in Vaccines and Molecular Therapeutics

Longlong Chen
Pengju Yan
LianLi Duan
Guangyang Ming
Xiaoqiong Wang
Jinyong Zhang
Zhifu Chen
Qiang Gou
Yue Yuan
Haiming Jing

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697829

2,228 views

Original Research

Published on 16 Oct 2025

Development and protective efficacy of multi-epitope vaccine FL46 against cystic echinococcosis

in Vaccines and Molecular Therapeutics

Tingting Jiang
Maerdan Mahemuti
Weina Wang
Shuai Han
Xiaoying Wu
Hua Liu
Quan Chen
Xiaojin Mo
Xu Wang
Aerxin Kadiaili

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686959

2,340 views

Original Research

Published on 16 Oct 2025

A20 mRNA therapeutics ameliorate systemic sclerosis by suppressing TRAF-6/NF-KB signaling and DREAM expression and exerting antifibrotic effects

in Vaccines and Molecular Therapeutics

A Ram Lee
Su Been Jeon
Hye Won Kwak
Suh Won Yang
Yoo Jin Bang
Seon-Yeong Lee
So Won Lee
Jin Hyung Park
Se Gyeong Han
Jeong Won Choi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665998

2,677 views
1 citation

Review

Published on 15 Oct 2025

Biomimetic strategies of cell membrane vesicles driven by pathogen-host interactions: novel insights into antimicrobial immunotherapy and infection prevention

in Vaccines and Molecular Therapeutics

Ximin Xia
Yu Fang
Jia Zhong
Fanzhu Li
Lai Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681889

1,900 views

Original Research

Published on 15 Oct 2025

The mRNA component of LNP-mRNA vaccines triggers IFNAR-dependent immune activation which attenuates the adaptive immune response

in Vaccines and Molecular Therapeutics

Liat Bar-On
Hila Cohen
Uri Elia
Lilach Cherry-Mimran
Ofer Cohen
Noam Erez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670350

4,598 views
3 citations

3,192 articles

articles

Assessment of immune responses to Brucella abortus S19 vaccination in cattle and buffaloes

Impact of immunodeficiencies on immunity induced by SARS-CoV-2 infection, mRNA BNT162b2 vaccination, and their combination in children and young adults

Gram-positive enhancer matrix delivering FVpE via M cell targeting elicit protective mucosal and adaptive immune responses against Helicobacter pylori infection

Towards new approach methodologies for biological therapeutics: a novel model-informed metric to assess immunogenicity risk

Synergistic nano-vaccine strategy for comprehensive activation of adaptive and innate immunity against Staphylococcus aureus infection

An mRNA-based FimH nanoparticle vaccine against uropathogenic Escherichia coli is highly immunogenic in rodents

Identification of immunogenic KIF5B-RET fusion neopeptides driving immune stimulation in tumor specific CD8+ T cells

Minimal association between Th1-specific responses to COVID-19 vaccines and SARS-CoV-2 breakthrough infections in multiple sclerosis patients receiving disease-modifying therapies

CKD-related impairment in humoral and cellular immune response and potential correlation with long COVID-19: a systematic review

Research progress in vaccination during pregnancy

An oral M-cell targeted Lactococcus lactis vaccine against Echinococcus multilocularis infection

Construction of a prognostic model based on palmitoylation-related lncRNAs for assessing drug benefits in breast cancer

Safety, tolerability, and immunogenicity of INO-4500, a synthetic DNA-based vaccine against Lassa virus, in a phase 1b clinical trial in healthy Ghanaian adults

Exogenous melatonin boosts vaccine-induced immunity in individuals with high pre-existing influenza immunity

rBCG-LTAK63 enhances protection against tuberculosis by inducing autophagy and circadian gene regulation

Exploring ceRNA mechanisms in COVID-19 mRNA vaccine-induced myocarditis: implications for future vaccine design

Different antibody isotypes against tuberculosis: what we know and what we need to know

Harnessing cytokines: innovative adjuvants for improved veterinary vaccine efficacy

Insufficient immune protection in preterm infants due to delayed or incomplete hexavalent vaccination

Integrated immunodominant epitope discovery for dual-purpose rapid and economical diagnostic and immunoprotective applications against MRSA

Development and protective efficacy of multi-epitope vaccine FL46 against cystic echinococcosis

A20 mRNA therapeutics ameliorate systemic sclerosis by suppressing TRAF-6/NF-KB signaling and DREAM expression and exerting antifibrotic effects

Biomimetic strategies of cell membrane vesicles driven by pathogen-host interactions: novel insights into antimicrobial immunotherapy and infection prevention

The mRNA component of LNP-mRNA vaccines triggers IFNAR-dependent immune activation which attenuates the adaptive immune response