Frontiers in Immunology | Vaccines and Molecular Therapeutics

Original Research

Published on 23 Sep 2025

Comparative analysis of neutralization assays performed using live SARS-CoV-2 virus and pseudovirus to assess immunogenicity of a bivalent SARS-CoV-2 protein vaccine in humans

in Vaccines and Molecular Therapeutics

Cuige Gao
Jiang Yi
Adam Baidoo
Dongfang Liu
Jing Li
Dongyang Li
Jian Li
Qiang Zhou
Liangzhi Xie

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650083

2,121 views

Original Research

Published on 22 Sep 2025

Humoral response induced after intranasal vaccination with heat inactivated Acinetobacter baumannii protects immunodeficient mice against hypervirulent LAC-4 strain

in Vaccines and Molecular Therapeutics

Thomas Rouma
Emeline Barbieux
Lorenzo Bossi
Katy Poncin
Sébastien Denanglaire
Yohannes Tafesse
David Vermijlen
Sandrine Delbauve
Véronique Flamand
Juliette Van Buylaere

Frontiers in Immunology

doi 10.3389/fimmu.2025.1641997

2,262 views

Original Research

Published on 22 Sep 2025

Preclinical in vivo evaluation of a gonococcal multivalent vaccine containing antigens identified by CASS

in Vaccines and Molecular Therapeutics

Shea K. Roe
Bo Zheng
Sunita Gulati
Caroline Genco
Sanjay Ram
Paola Massari

Frontiers in Immunology

doi 10.3389/fimmu.2025.1688536

2,131 views
1 citation

Original Research

Published on 19 Sep 2025

A nanodiamond-formulated plant protein induces robust immunity against porcine epidemic diarrhea virus in piglets

in Vaccines and Molecular Therapeutics

Thuong Thi Ho
Hoai Thu Tran
Phuong Minh Thi Nguyen
Huyen Thi Bui
Hien Thu Thi Nguyen
Thao Bich Thi Le
Minh Dinh Pham
Wesley Wei-Wen Hsiao
Dai Huu Nguyen
Ha Hoang Chu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674222

2,107 views

Review

Published on 19 Sep 2025

Decadal advances and future prospects in subunit vaccine development against Streptococcus suis infection

in Vaccines and Molecular Therapeutics

Lihua Fang
Jie Ning

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680732

2,688 views
1 citation

Original Research

Published on 19 Sep 2025

Heterologous prime-pull mucosal vaccination with an adjuvanted RBD vaccine elicits robust IgA production and protects against SARS-CoV-2

in Vaccines and Molecular Therapeutics

Allyson H. Hirsch
Calder R. Ellsworth
William A. Lewis
Ryan Craig
Amy E. Meyer
Jonatan Maldonado
Frania Ramirez Lopez
Syamala Rani Thimmiraju
James B. McLachlan
Xuebin Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673460

4,425 views

Correction

Published on 19 Sep 2025

Correction: Immune response dynamics of SARS-CoV-2 vaccination in chronic lymphocytic leukemia individuals: a descriptive analysis

in Vaccines and Molecular Therapeutics

Clara Sánchez-Menéndez
Alejandro Zurdo
Magdalena Corona
Elena Mateos de la Morenas
Sara Rodríguez-Mora
Guiomar Casado
Javier García-Pérez
Mayte Pérez-Olmeda
Susana Domínguez
María Aránzazu Murciano-Antón

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706723

1,341 views

Original Research

Published on 18 Sep 2025

Heterologous prime-boost vaccination with VLA2001 and an ORFV-based vector enhances spike- and nucleocapsid-specific immunity in mice

in Vaccines and Molecular Therapeutics

Alena Reguzova
Verena Haug
Carina Metz
Melanie Müller
Madeleine Fandrich
Alex Dulovic
Ralf Amann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675859

2,080 views
1 citation

Review

Published on 18 Sep 2025

Controlled human malaria infection studies: insights into recent advances and key immunological and ethical implementation lessons

in Vaccines and Molecular Therapeutics

Rodney Ogwang
Mohamed Adan
Philip Bejon
Melissa C. Kapulu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672945

3,155 views

Review

Published on 16 Sep 2025

Review of advanced research on swine Actinobacillus pleuropneumoniae vaccine development strategy

in Vaccines and Molecular Therapeutics

Adehanom Baraki Tesfaye
Rui Han
Zhengyu Tao
Liuchao You
Jiayao Zhu
Pengcheng Gao
Lei Fu
Yuefeng Chu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645610

3,035 views
1 citation

Clinical Trial

Published on 16 Sep 2025

No evidence of MMR induced trained immunity to prevent SARS COV2: results from a multi-centre RCT

in Vaccines and Molecular Therapeutics

Sinead Delany-Moretlwe
Hakim-Moulay Dehbi
Izukanji Sikazwe
George Kyei
Kwadwo Koram
Erik Dubberke
Noluthando Mwelase
Dominic Hague
Linda-Gail Bekker
Linda Yun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1588190

2,721 views

Original Research

Published on 15 Sep 2025

Comparative single-cell immune responses in peripheral blood and lymph node of immunized SARS-CoV-2 challenged infant rhesus macaques

in Vaccines and Molecular Therapeutics

Sasha Anronikov
Cameron Meikle
Emma C. Milligan
Han Chen
Nilanjan Mukherjee
Zach Bjornson
Brice Gaudillière
Sizun Jiang
Sallie R. Permar
Koen K. A. Van Rompay

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599408

3,218 views

Original Research

Published on 15 Sep 2025

Modified recombinant collagen-peptide/gallic acid grafted chitosan composites with antibacterial and antioxidant property for wound dressing: a preliminary study

in Vaccines and Molecular Therapeutics

Yu Chen
Wenjie Wen
Jie Wang
Shiting Huang
Qianqian Ren
Jiayao Cai
Songlin Zhou
Rui Li
Dandan Ren
Liaotian Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675212

1,755 views

Original Research

Published on 12 Sep 2025

Virus-like particles containing the extracellular domain of G protein in combination with a CTL peptide of M2 elicit protection against respiratory syncytial virus infection without pulmonary disease

in Vaccines and Molecular Therapeutics

Huan Qin
Jin Luo
Zishu Pan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1625670

2,348 views

Original Research

Published on 12 Sep 2025

Immunization route-mediated differences in long-term maturation of humoral immune response induced by adenovirus vector-based COVID-19 vaccine Sputnik V in nonhuman primates

in Vaccines and Molecular Therapeutics

Amir I. Tukhvatulin
Ilya V. Gordeychuk
Alina S. Dzharullaeva
Inna V. Dolzhikova
Ekaterina O. Bayurova
Fatima M. Izhaeva
Anna V. Kovyrshina
Alla S. Zhitkevich
Daria V. Avdoshina
Stanislav A. Gulyaev

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634187

2,648 views

Correction

Published on 12 Sep 2025

Correction: Protection against N. gonorrhoeae induced by OMV-based meningococcal vaccines are associated with cross-species directed humoral and cellular immune responses

in Vaccines and Molecular Therapeutics

Weiyan Zhu
Andreea Waltmann
Marguerite B. Little
Kristie L. Connolly
Kathryn A. Matthias
Keena S. Thomas
Mary C. Gray
Aleksandra E. Sikora
Alison K. Criss
Margaret C. Bash

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697855

1,385 views

Original Research

Published on 11 Sep 2025

Elevating MHC I expression on tumor cells by nanovesicles loading tyrosine kinase inhibitors can improve the efficacy of cancer vaccines

in Vaccines and Molecular Therapeutics

Huimin Xie
Lin Ma
Xiaoli He
Songsong Zhao
Jin Wang
Ao Zhu
Changming Liu
Olga Piskareva
Chao Deng
Fenghua Meng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653533

2,447 views

Editorial

Published on 11 Sep 2025

Editorial: Community series in development and harmonization of assays and models to assess immunogenicity and correlates of protection of vaccines against pathogens causing respiratory infections, volume 2

in Vaccines and Molecular Therapeutics

Geert Leroux-Roels
Donata Medaglini

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670957

1,814 views

Original Research

Published on 10 Sep 2025

Mature dengue virus particles inactivated by a non-ionic detergent retain quaternary neutralizing epitopes and induce potent neutralizing antibodies

in Vaccines and Molecular Therapeutics

Wen-Yang Tsai
Theodore C. Pierson
Jens Wrammert
Wanwisa Dejnirattisai
Amonrat Jumnainsong
Juthathip Mongkolsapaya
Gavin Screaton
James E. Crowe
Wei-Kung Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1626823

1,889 views

Original Research

Published on 05 Sep 2025

Reduced spike specific T-cell responses in COVID-19 vaccinated subjects undergoing SARS-CoV-2 breakthrough infection

in Vaccines and Molecular Therapeutics

Stefania Varchetta
Federica Sole Golfetto
Patrizia Bono
Annapaola Callegaro
Tanya Fabbris
Andrea Favalli
Mariacristina Crosti
Tullia Maria De Feo
Nathalie Iannotti
Giorgio Bozzi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657082

3,350 views

Review

Published on 05 Sep 2025

Antigen-presenting cell internalization is key for understanding and evaluating therapeutic antibodies’ immunogenicity

in Vaccines and Molecular Therapeutics

Maria Lteif
Marc Pallardy
Isabelle Turbica

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617395

2,765 views

Clinical Trial

Published on 05 Sep 2025

Preliminarily evaluation the safety and immunogenicity of tetanus, reduced diphtheria and acellular pertussis (five components) combined vaccine, adsorbed (Tdcp) in participants aged 6 years and above: a blinded and randomised, and controlled phase I clinical trial

in Vaccines and Molecular Therapeutics

Xiaoyu Liu
Chen Wei
Haitao Huang
Jingxuan Wan
Yajun Li
Feiyu Wang
Siwen Li
Ying Wang
Xuewen Wang
Xue Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1616574

2,622 views

Original Research

Published on 04 Sep 2025

Antibodies elicited by altSonflex1-2-3 GMMA vaccine are bactericidal against a panel of drug-resistant Shigella clinical isolates

in Vaccines and Molecular Therapeutics

Elena Boero
Roberta Di Benedetto
Giacomo Vezzani
Renzo Alfini
Pieter-Jan Ceyssens
Giannoula S. Tansarli
Ferric C. Fang
Carla Fontana
Alberto Rossi
Stefania Carrara

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652460

1,866 views

Clinical Trial

Published on 03 Sep 2025

Immunogenicity and safety of co-administration with the Sabin-strain-based inactivated poliovirus vaccine (vero cell) and the diphtheria-tetanus-acellular pertussis vaccine in eligible children in China: a randomized, controlled, multicenter, non-inferiority trial

in Vaccines and Molecular Therapeutics

Xiaoyu Liu
Shasha Han
Xiao Chen
Li Sun
Ruize Wang
Xuanwen Shi
Yu Guo
Hui Wang
Haiping Chen
Shaoying Chang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633170

2,092 views
1 citation