Frontiers in Immunology | Vaccines and Molecular Therapeutics

Original Research

Published on 03 Sep 2025

The impact of mycobacteria-induced trained immunity on SARS-CoV-2 vaccine responses

in Vaccines and Molecular Therapeutics

Lidia Sánchez-Morales
Néstor Porras
Andrea Pérez-Domingo
Marta Pérez-Sancho
Teresa García-Seco
Marta Diaz-Frutos
Aranzazu Buendia
Inmaculada Moreno
Leydis Zamora
Ana Balseiro

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633977

2,485 views
1 citation

Review

Published on 03 Sep 2025

MS2 virus-like particles as a versatile platform for multi-disease vaccines: a review

in Vaccines and Molecular Therapeutics

Guodong Zhou
Zhili Luo
Zhihui Zhang
Shengliang Cao
Yubao Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651594

3,258 views
2 citations

Original Research

Published on 02 Sep 2025

Harnessing outer membrane vesicles derived from Bordetella pertussis to overcome key limitations of acellular pertussis vaccines

in Vaccines and Molecular Therapeutics

Lucía Locati
Daniela Bottero
Francisco Carriquiriborde
Oriana López
Bernarda Pschunder
Eugenia Zurita
Pablo Martin Aispuro
Maria Emilia Gaillard
Daniela Hozbor

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655910

2,295 views

Original Research

Published on 02 Sep 2025

Upper respiratory tract immunization with Pam2Cys-adjuvanted spike protein vaccine achieves sterilizing protection against SARS-CoV-2

in Vaccines and Molecular Therapeutics

Erica L. Stewart
Skye Stockdale
Matt D. Johansen
Lachlan Smith
Sibel Alca
Joshua W. C. Maxwell
Duc H. Nguyen
Stefan Miemczyk
Guanshu Zhao
Stuart Turville

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654126

5,637 views

Mini Review

Published on 01 Sep 2025

Immunomodulatory biomaterials in HIV-1 infection prevention, control and treatment

in Vaccines and Molecular Therapeutics

Jiaying Li
Huan Tang
Xiaoyi Zhou
Zijun Ni
Yuxin Liang
Xinyue Sun
Xun Zhuang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670423

2,097 views
1 citation

Original Research

Published on 01 Sep 2025

Evaluation of a multi-epitope vaccine PME for Pasteurella multocida in mouse model

in Vaccines and Molecular Therapeutics

Rui Zhang
Lu Dai
Yizhen Jia
Haoran Qi
Junfeng He
Jiaxin Cheng
Xuejun Gao
Liancheng Lei
Feng Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652907

2,710 views
1 citation

Original Research

Published on 01 Sep 2025

Rational design of an epitope-centric vaccine against Pseudomonas aeruginosa using pangenomic insights and immunoinformatics approach

in Vaccines and Molecular Therapeutics

Santhosh Mudipalli Elavarasu
Sasikumar K

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617251

2,746 views

Original Research

Published on 27 Aug 2025

Effect of co-vaccination of cattle with RB51 and BCG on vaccine-specific CD4+ T cell responses

in Vaccines and Molecular Therapeutics

Haley M. Sterle
Ellie J. Putz
Mitchell V. Palmer
Steven C. Olsen
Paola M. Boggiatto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664398

1,645 views
1 citation

Review

Published on 27 Aug 2025

Personalized immunization to optimize vaccine immunogenicity: exploring the multidimensional effects of host intrinsic factors, external intervention strategies, and the external environment

in Vaccines and Molecular Therapeutics

Keda Chen
Siyi Gu
Jiaxuan Li
Yutong Xu
Zhiyi Wang
Yanjun Zhang
Jianhua Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655819

2,019 views
1 citation

Original Research

Published on 25 Aug 2025

Risk of developing juvenile idiopathic arthritis after quadrivalent HPV vaccination: a retrospective cohort study using the TriNetX U.S. Network

in Vaccines and Molecular Therapeutics

Wen-Yu Wu
Hsin-Hua Chen
Ming-Chin Tsai
Yung-Chieh Huang
Jun-Peng Chen
Lin-Shien Fu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621939

2,555 views

Correction

Published on 25 Aug 2025

Correction: BCG and beyond: unlocking new frontiers in TB vaccine development

in Vaccines and Molecular Therapeutics

Aishwarya Shaji
Akanksha Verma
Ashima Bhaskar
Ved Prakash Dwivedi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677868

1,243 views

Study Protocol

Published on 21 Aug 2025

A phase II randomized trial of individualized neoantigen peptide vaccine combined with unusual radiotherapy (iNATURE) in advanced solid tumors-GCOG0028

in Vaccines and Molecular Therapeutics

Yan Zhang
Ye-Fan Hu
Lingyu Ma
Yifei Wu
Dandan Chao
Xian Chen
Zhiyuan Xu
Xiaoping Su
Wei Dai
Jiandong Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1538032

4,673 views
1 citation

Methods

Published on 20 Aug 2025

CoreTIA: a modular, statistically robust transduction inhibition assay for AAV neutralization

in Vaccines and Molecular Therapeutics

Beatrix Kovács
Fanni Somogyi
Viktória Szabó
Zoltán Zsolt Nagy
István Hernádi
Ferenc Mátyás
Wim Vanduffel
Zsuzsanna Szemlaky
Balázs Rózsa
István Ulbert

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623848

2,007 views
1 citation

Correction

Published on 20 Aug 2025

Correction: The immunogenicity and safety of an inactivated quadrivalent influenza vaccine and a 23-valent pneumococcal polysaccharide vaccine in individuals with chronic diseases

in Vaccines and Molecular Therapeutics

Frontiers Production Office

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682368

1,024 views

Review

Published on 19 Aug 2025

Molecular ingredients of an immunogen for long-lasting IgG

in Vaccines and Molecular Therapeutics

Sneh Lata Gupta
Alexander R. Meyer
Erika Kay-Tsumagari
Wei Cheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639371

2,017 views

Systematic Review

Published on 18 Aug 2025

Evaluating the efficacy, safety, and immunogenicity of FDA-approved RSV vaccines: a systematic review of Arexvy, Abrysvo, and mResvia

in Vaccines and Molecular Therapeutics

Thamir A. Alandijany
Fadi S. Qashqari

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624007

11,134 views

Original Research

Published on 18 Aug 2025

A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers

in Vaccines and Molecular Therapeutics

Antonio José Cabrera-Serrano
Lucía Ruiz-Durán
Juan Francisco Gutiérrez-Bautista
María Carretero-Fernández
Rob ter Horst
Yang Li
Fernando Jesús Reyes-Zurita
Francisco José García-Verdejo
Mihai G. Netea
Pedro Sánchez-Rovira

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639825

3,810 views

Brief Research Report

Published on 15 Aug 2025

Orally administered extracellular vesicles from Salmonella-infected macrophages confer protective immunity in vivo

in Vaccines and Molecular Therapeutics

Saloni Bhimani
Jorge J. Canas
Samantha M. Enslow
Ryan Mulcare
Mariola J. Ferraro

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628756

2,446 views

Original Research

Published on 14 Aug 2025

Impact of vaccination strategy adjustments on antibody levels against measles, rubella, mumps, and varicella in China: a single-center serological survey

in Vaccines and Molecular Therapeutics

Zhixin Geng
Wen Wang
Yuanyuan Zhu
Yan Xu
Qiang Chen
Lei Zhang
Jing Yu
Xiang Sun
Zhiguo Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630442

2,301 views
1 citation

Original Research

Published on 14 Aug 2025

Therapeutic vaccination with the Ag85B-Rv2660c-MPT70 fusion protein enhances Mycobacterium tuberculosis H37Ra clearance in post-exposure mice

in Vaccines and Molecular Therapeutics

Zhiming Hu
Shaohua Guo
Wenlong Chen
Jiangshan Ouyang
Chunxu Huang
Ting Cao
Jun Mou
Xinxia Gu
Jie Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624923

2,764 views
1 citation

Editorial

Published on 14 Aug 2025

Editorial: Basic and applied research toward the development of vaccines against African swine fever virus

in Vaccines and Molecular Therapeutics

Daniel Pérez-Núñez
Sandra Blome
Linda K. Dixon

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658984

1,903 views

Original Research

Published on 13 Aug 2025

BIDpred: unraveling B cell Immunodominance hierarchical pattern using statistical feature discovery and deep learning prediction

in Vaccines and Molecular Therapeutics

Sungjin Choi
Dongsup Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646946

1,866 views

Review

Published on 13 Aug 2025

Harnessing cellular immunity for next-generation vaccines against respiratory viruses: mechanisms, platforms, and optimization strategies

in Vaccines and Molecular Therapeutics

Keda Chen
Jutao Hu
Jiaxuan Li
Guangshang Wu
Xiaotian Tie
Hao Wu
Hongyu Li
Jianhua Li
Yanjun Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1618406

8,506 views

Original Research

Published on 12 Aug 2025

Circulating SARS-CoV-2 spike IgG antibody responses in cancer patients following multiple COVID-19 vaccination boosters

in Vaccines and Molecular Therapeutics

Huijing Xue
Troy J. Kemp
Hayley North
Nancy V. Roche
Thomas E. Hickey
Ligia A. Pinto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629473

4,988 views
3 citations