Frontiers in Immunology | Vaccines and Molecular Therapeutics

General Commentary

Published on 12 Aug 2025

Commentary: Expression of salivary hepcidin and its inducer, interleukin 6 as well as type I interferons are significantly elevated in infants with poor oral rotavirus vaccine take in South Africa

in Vaccines and Molecular Therapeutics

Artur Słomka

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651751

1,285 views

Original Research

Published on 08 Aug 2025

Epitope mapping using immunopeptidomics reveals novel immunodominant CD8 T cell epitopes of the AAV9 capsid

in Vaccines and Molecular Therapeutics

Akhila Balasubramanian
Marek Prachar
Birgit Klaproth
Victoria Copeland
Sune Justesen
Yi Wen
Robert W. Siegel
Laurent P. Malherbe

Frontiers in Immunology

doi 10.3389/fimmu.2025.1641289

3,162 views

Original Research

Published on 08 Aug 2025

Study of the influence of population immunity to tick-borne encephalitis virus on the characteristics of the epidemic process in Russia

in Vaccines and Molecular Therapeutics

Temur K. Muminov
Vladimir A. Gushchin
Denis A. Kleymenov
Artem P. Tkachuk
Viktor A. Manuylov
Andrei E. Siniavin
Daria A. Ogarkova
Nadezhda A. Kuznetsova
Vladimir I. Zlobin
Alexander L. Gintsburg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1525388

1,600 views

Original Research

Published on 07 Aug 2025

Distinct humoral responses induced by heterologous versus homologous prime–boost immunization strategies in early life

in Vaccines and Molecular Therapeutics

Poorya Foroutan Pajoohian
Audur Anna Aradottir Pind
Jenny Lorena Molina Estupiñan
Dennis Christensen
Gabriel Kristian Pedersen
Thorunn A. Olafsdottir
Ingileif Jonsdottir
Stefania P. Bjarnarson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563345

2,202 views

Original Research

Published on 06 Aug 2025

Recombinant SADS-CoV as a vector for porcine epidemic diarrhea vaccine development

in Vaccines and Molecular Therapeutics

Xiaoling Yan
Xiaoli Zhang
Xiaocheng Lyu
Yaoyao Zheng
Qianniu Li
Xiaoya Zhao
Jun Fu
Jingyun Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633661

2,799 views

Review

Published on 06 Aug 2025

Immune organoids: emerging platforms for modeling and analyzing human adaptive immunity

in Vaccines and Molecular Therapeutics

Tianlong Li
Dingkun Peng
Meng Yao
Meilin Li
Yijing Wang
Su Li
Ding Zhang
Bo Yang
Hua-Ji Qiu
Lian-Feng Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1632117

5,334 views

Original Research

Published on 04 Aug 2025

Neutralizing antibody response to different COVID-19 vaccines in Brazil: the impact of previous infection and booster doses

in Vaccines and Molecular Therapeutics

Beatriz L. L. Caetano
Paolla B. A. Pinto
Agatha R. Pacheco
Agnes R. Lage
Aline S. G. Pereira
Amanda V. P. Nascimento
Thiago R. Machado
Anderson Paulino
Thiago L. Medeiros
Lorena O. Fernandes-Siqueira

Frontiers in Immunology

doi 10.3389/fimmu.2025.1603612

2,628 views

Original Research

Published on 01 Aug 2025

Evaluation of the viability and functionality of human peripheral blood mononuclear cells cryopreserved up to 2 years in animal-protein-free freezing media compared to the FBS-supplemented reference medium

in Vaccines and Molecular Therapeutics

Frédérique Jantet-Blaudez
Joseline Ruiz
Sylviane Gautheron
Anke Pagnon

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627973

3,609 views
1 citation

Original Research

Published on 01 Aug 2025

Autovaccine immunoprophylaxis in patients with neurogenic bladder experiencing recurrent urinary tract infections

in Vaccines and Molecular Therapeutics

Miguel Ángel Bonillo-García
Domingo Guzmán Ordaz-Jurado
Juan Ortiz-Salvador
Josep Oriol Colet-Guitert
Eduardo Morán-Pascual
Esther Martínez-Cuenca
Salvador Arlandis-Guzmán

Frontiers in Immunology

doi 10.3389/fimmu.2025.1626422

1,862 views

Original Research

Published on 01 Aug 2025

The immunogenicity and safety of an inactivated quadrivalent influenza vaccine and a 23-valent pneumococcal polysaccharide vaccine in individuals with chronic diseases

in Vaccines and Molecular Therapeutics

Wanqin Tang
Xi Lu
Zhongkui Zhu
Dan Yu
Huaxian Liu
Yufei Song
Lu Shen
Yang Yu
Yanwei Zhao
Yan Xie

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624095

2,913 views

Original Research

Published on 31 Jul 2025

Dose-sparing effects of novel adjuvants and aluminum hydroxide on two different vaccines in a neonatal mouse model

in Vaccines and Molecular Therapeutics

Jenny Lorena Molina Estupiñan
Poorya Foroutan Pajoohian
Gabriel Kristian Pedersen
Dennis Christensen
Serena Marchi
Emanuele Montomoli
Stefanía P. Bjarnarson
Ingileif Jonsdottir
Audur Anna Aradottir Pind

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646677

3,252 views

Original Research

Published on 31 Jul 2025

Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa

in Vaccines and Molecular Therapeutics

Jillian Eisenhauer
Spencer Dublin
Jihae Choi
Abigail R. Trachtman
Jacqueline D. Chu
David Custodio-Zegarra
Suman Bharti
Bhavya Bhardwaj
Shuangyi Bai
William T. Witt

Frontiers in Immunology

doi 10.3389/fimmu.2025.1618297

3,615 views

Original Research

Published on 31 Jul 2025

MDSC depletion during immunization with heat-killed Mycobacterium tuberculosis increases protection against BCG infection

in Vaccines and Molecular Therapeutics

Arpa Aintablian
Anna M. Arold
Haisam Alattar
Laura Cyran
Christoph Schoen
Nelita Du Plessis
Gerhard Walzl
Ulrich Schaible
Andreas Beilhack
Natalie E. Nieuwenhuizen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646526

3,160 views
1 citation

Review

Published on 30 Jul 2025

BCG and beyond: unlocking new frontiers in TB vaccine development

in Vaccines and Molecular Therapeutics

Aishwarya Shaji
Akanksha Verma
Ashima Bhaskar
Ved Prakash Dwivedi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608104

3,942 views
1 citation

Brief Research Report

Published on 28 Jul 2025

Hypertension attenuates COVID-19 vaccine protection in elderly patients: a retrospective cohort study

in Vaccines and Molecular Therapeutics

Zhen Yuan
Iong Fong Wong
Ren-He Xu
Xiao Zhan Zhang
Chon Lok Lei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1612205

2,385 views

Original Research

Published on 28 Jul 2025

Mixed lipopeptide-based mucosal vaccine elicits a long-term bone marrow memory response that is potentially cross-reactive against a broad-spectrum of coronaviruses in mice

in Vaccines and Molecular Therapeutics

Raj S. Patel
Babita Agrawal

Frontiers in Immunology

doi 10.3389/fimmu.2025.1619882

2,872 views

Original Research

Published on 25 Jul 2025

Integrating bioinformatics to explore HPV-31 and HPV-52 E6/E7 proteins: from structural analysis to antigenic epitope prediction

in Vaccines and Molecular Therapeutics

Qixue Cai
Yifan Feng
Wenbo Dong
Yanling Meng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1561572

2,184 views

Original Research

Published on 24 Jul 2025

AS04 drives superior cross-protective antibody response by increased NOTCH signaling of dendritic cells and proliferation of memory B cells

in Vaccines and Molecular Therapeutics

Valentino D’Onofrio
Ana Carolina Santana
Marthe Pauwels
Gwenn Waerlop
Anthony Willems
Fien De Boever
Martin Müller
Peter Sehr
Tim Waterboer
Isabel Leroux-Roels

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623405

3,129 views

Original Research

Published on 22 Jul 2025

Development and characterization of the genotype F attenuated mumps candidate strains

in Vaccines and Molecular Therapeutics

Hongtao Liu
Na Liu
Yueqiu Sun
Shuang Li
Hang Li
Menghan Wang
Hui Shuang
Yan Cai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629585

1,945 views

Original Research

Published on 22 Jul 2025

Non-cognate ligands of hepatitis C virus envelope broadly neutralizing antibodies induce virus-neutralizing sera in mice

in Vaccines and Molecular Therapeutics

Stephen Ian Walimbwa
Shiv Bharadwaj
Petr Kosztyu
Lucie Vankova
Milan Kuchar
Eliska Kopecna
Roman Effenberg
Lukas Drasar
Leona Raskova Kafkova
Petr Maly

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624299

2,399 views

Original Research

Published on 21 Jul 2025

MetE: a promising protective antigen for tuberculosis vaccine development

in Vaccines and Molecular Therapeutics

Salem Salman Almujri
Elena Stylianou
Annalisa Nicastri
Iman Satti
Marcellus Korompis
Shuailin Li
Christopher J. De Voss
Marco Polo Peralta Alvarez
Rachel Tanner
Paulo J. G. Bettencourt

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593263

3,469 views
2 citations

Original Research

Published on 17 Jul 2025

Immune memory reactivation and T cell dynamics following 12-month homologous CoronaVac booster: a longitudinal cohort study

in Vaccines and Molecular Therapeutics

Xinran Song
Weixin Chen
Shuang Bai
Min Lv
Jian Wang
Ao Zhang
Jiang Wu
Wei Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636629

2,747 views

Original Research

Published on 17 Jul 2025

Adjuvant combination and antigen multimerization shape neutralizing antibody and T cell responses to a SARS-CoV-2 RBD subunit vaccine

in Vaccines and Molecular Therapeutics

João Pedro da Silva Nunes
Mariângela de Oliveira Silva
Juliana de Souza Apostolico
Isabela Pazotti Daher
Rodolfo Ferreira Marques
Marcio Massao Yamamoto
Alexia Adrianne Venceslau Brito Carvalho
Maria Fernanda de Castro-Amarante
Edison Luiz Durigon
Carsten Wrenger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610422

3,035 views

Clinical Trial

Published on 17 Jul 2025

Immunogenicity and safety study of 23-valent pneumococcal polysaccharide vaccine revaccination among elderly individuals aged 60–70 years in Shanghai, China

in Vaccines and Molecular Therapeutics

Jing Qiu
Zhi Li
Fang Huang
Zhuoying Huang
Xiufang Liang
Juan Li
Yuting Liao
Xiang Guo
Xiaodong Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623611

2,764 views

3,150 articles

articles

Commentary: Expression of salivary hepcidin and its inducer, interleukin 6 as well as type I interferons are significantly elevated in infants with poor oral rotavirus vaccine take in South Africa

Epitope mapping using immunopeptidomics reveals novel immunodominant CD8 T cell epitopes of the AAV9 capsid

Study of the influence of population immunity to tick-borne encephalitis virus on the characteristics of the epidemic process in Russia

Distinct humoral responses induced by heterologous versus homologous prime–boost immunization strategies in early life

Recombinant SADS-CoV as a vector for porcine epidemic diarrhea vaccine development

Immune organoids: emerging platforms for modeling and analyzing human adaptive immunity

Neutralizing antibody response to different COVID-19 vaccines in Brazil: the impact of previous infection and booster doses

Evaluation of the viability and functionality of human peripheral blood mononuclear cells cryopreserved up to 2 years in animal-protein-free freezing media compared to the FBS-supplemented reference medium

Autovaccine immunoprophylaxis in patients with neurogenic bladder experiencing recurrent urinary tract infections

The immunogenicity and safety of an inactivated quadrivalent influenza vaccine and a 23-valent pneumococcal polysaccharide vaccine in individuals with chronic diseases

Dose-sparing effects of novel adjuvants and aluminum hydroxide on two different vaccines in a neonatal mouse model

Fc-modification of anti-PcrV gene-encoded antibodies modulates complement-mediated killing of Pseudomonas aeruginosa

MDSC depletion during immunization with heat-killed Mycobacterium tuberculosis increases protection against BCG infection

BCG and beyond: unlocking new frontiers in TB vaccine development

Hypertension attenuates COVID-19 vaccine protection in elderly patients: a retrospective cohort study

Mixed lipopeptide-based mucosal vaccine elicits a long-term bone marrow memory response that is potentially cross-reactive against a broad-spectrum of coronaviruses in mice

Integrating bioinformatics to explore HPV-31 and HPV-52 E6/E7 proteins: from structural analysis to antigenic epitope prediction

AS04 drives superior cross-protective antibody response by increased NOTCH signaling of dendritic cells and proliferation of memory B cells

Development and characterization of the genotype F attenuated mumps candidate strains

Non-cognate ligands of hepatitis C virus envelope broadly neutralizing antibodies induce virus-neutralizing sera in mice

MetE: a promising protective antigen for tuberculosis vaccine development

Immune memory reactivation and T cell dynamics following 12-month homologous CoronaVac booster: a longitudinal cohort study

Adjuvant combination and antigen multimerization shape neutralizing antibody and T cell responses to a SARS-CoV-2 RBD subunit vaccine

Immunogenicity and safety study of 23-valent pneumococcal polysaccharide vaccine revaccination among elderly individuals aged 60–70 years in Shanghai, China