Frontiers in Immunology | Vaccines and Molecular Therapeutics

Original Research

Published on 01 Sep 2025

Rational design of an epitope-centric vaccine against Pseudomonas aeruginosa using pangenomic insights and immunoinformatics approach

in Vaccines and Molecular Therapeutics

Santhosh Mudipalli Elavarasu
Sasikumar K

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617251

3,270 views
1 citation

Original Research

Published on 27 Aug 2025

Effect of co-vaccination of cattle with RB51 and BCG on vaccine-specific CD4+ T cell responses

in Vaccines and Molecular Therapeutics

Haley M. Sterle
Ellie J. Putz
Mitchell V. Palmer
Steven C. Olsen
Paola M. Boggiatto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664398

1,974 views
1 citation

Review

Published on 27 Aug 2025

Personalized immunization to optimize vaccine immunogenicity: exploring the multidimensional effects of host intrinsic factors, external intervention strategies, and the external environment

in Vaccines and Molecular Therapeutics

Keda Chen
Siyi Gu
Jiaxuan Li
Yutong Xu
Zhiyi Wang
Yanjun Zhang
Jianhua Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655819

2,506 views
2 citations

Original Research

Published on 25 Aug 2025

Risk of developing juvenile idiopathic arthritis after quadrivalent HPV vaccination: a retrospective cohort study using the TriNetX U.S. Network

in Vaccines and Molecular Therapeutics

Wen-Yu Wu
Hsin-Hua Chen
Ming-Chin Tsai
Yung-Chieh Huang
Jun-Peng Chen
Lin-Shien Fu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621939

2,989 views

Correction

Published on 25 Aug 2025

Correction: BCG and beyond: unlocking new frontiers in TB vaccine development

in Vaccines and Molecular Therapeutics

Aishwarya Shaji
Akanksha Verma
Ashima Bhaskar
Ved Prakash Dwivedi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677868

1,480 views
1 citation

Study Protocol

Published on 21 Aug 2025

A phase II randomized trial of individualized neoantigen peptide vaccine combined with unusual radiotherapy (iNATURE) in advanced solid tumors-GCOG0028

in Vaccines and Molecular Therapeutics

Yan Zhang
Ye-Fan Hu
Lingyu Ma
Yifei Wu
Dandan Chao
Xian Chen
Zhiyuan Xu
Xiaoping Su
Wei Dai
Jiandong Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1538032

5,435 views
3 citations

Methods

Published on 20 Aug 2025

CoreTIA: a modular, statistically robust transduction inhibition assay for AAV neutralization

in Vaccines and Molecular Therapeutics

Beatrix Kovács
Fanni Somogyi
Viktória Szabó
Zoltán Zsolt Nagy
István Hernádi
Ferenc Mátyás
Wim Vanduffel
Zsuzsanna Szemlaky
Balázs Rózsa
István Ulbert

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623848

2,303 views
2 citations

Correction

Published on 20 Aug 2025

Correction: The immunogenicity and safety of an inactivated quadrivalent influenza vaccine and a 23-valent pneumococcal polysaccharide vaccine in individuals with chronic diseases

in Vaccines and Molecular Therapeutics

Frontiers Production Office

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682368

1,107 views

Review

Published on 19 Aug 2025

Molecular ingredients of an immunogen for long-lasting IgG

in Vaccines and Molecular Therapeutics

Sneh Lata Gupta
Alexander R. Meyer
Erika Kay-Tsumagari
Wei Cheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639371

2,332 views

Systematic Review

Published on 18 Aug 2025

Evaluating the efficacy, safety, and immunogenicity of FDA-approved RSV vaccines: a systematic review of Arexvy, Abrysvo, and mResvia

in Vaccines and Molecular Therapeutics

Thamir A. Alandijany
Fadi S. Qashqari

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624007

13,121 views
3 citations

Original Research

Published on 18 Aug 2025

A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers

in Vaccines and Molecular Therapeutics

Antonio José Cabrera-Serrano
Lucía Ruiz-Durán
Juan Francisco Gutiérrez-Bautista
María Carretero-Fernández
Rob ter Horst
Yang Li
Fernando Jesús Reyes-Zurita
Francisco José García-Verdejo
Mihai G. Netea
Pedro Sánchez-Rovira

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639825

4,508 views

Brief Research Report

Published on 15 Aug 2025

Orally administered extracellular vesicles from Salmonella-infected macrophages confer protective immunity in vivo

in Vaccines and Molecular Therapeutics

Saloni Bhimani
Jorge J. Canas
Samantha M. Enslow
Ryan Mulcare
Mariola J. Ferraro

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628756

2,802 views

Original Research

Published on 14 Aug 2025

Impact of vaccination strategy adjustments on antibody levels against measles, rubella, mumps, and varicella in China: a single-center serological survey

in Vaccines and Molecular Therapeutics

Zhixin Geng
Wen Wang
Yuanyuan Zhu
Yan Xu
Qiang Chen
Lei Zhang
Jing Yu
Xiang Sun
Zhiguo Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630442

2,616 views
1 citation

Original Research

Published on 14 Aug 2025

Therapeutic vaccination with the Ag85B-Rv2660c-MPT70 fusion protein enhances Mycobacterium tuberculosis H37Ra clearance in post-exposure mice

in Vaccines and Molecular Therapeutics

Zhiming Hu
Shaohua Guo
Wenlong Chen
Jiangshan Ouyang
Chunxu Huang
Ting Cao
Jun Mou
Xinxia Gu
Jie Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624923

3,065 views
1 citation

Editorial

Published on 14 Aug 2025

Editorial: Basic and applied research toward the development of vaccines against African swine fever virus

in Vaccines and Molecular Therapeutics

Daniel Pérez-Núñez
Sandra Blome
Linda K. Dixon

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658984

2,272 views

Original Research

Published on 13 Aug 2025

BIDpred: unraveling B cell Immunodominance hierarchical pattern using statistical feature discovery and deep learning prediction

in Vaccines and Molecular Therapeutics

Sungjin Choi
Dongsup Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646946

2,358 views

Review

Published on 13 Aug 2025

Harnessing cellular immunity for next-generation vaccines against respiratory viruses: mechanisms, platforms, and optimization strategies

in Vaccines and Molecular Therapeutics

Keda Chen
Jutao Hu
Jiaxuan Li
Guangshang Wu
Xiaotian Tie
Hao Wu
Hongyu Li
Jianhua Li
Yanjun Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1618406

10,886 views
1 citation

Original Research

Published on 12 Aug 2025

Circulating SARS-CoV-2 spike IgG antibody responses in cancer patients following multiple COVID-19 vaccination boosters

in Vaccines and Molecular Therapeutics

Huijing Xue
Troy J. Kemp
Hayley North
Nancy V. Roche
Thomas E. Hickey
Ligia A. Pinto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629473

5,569 views
3 citations

General Commentary

Published on 12 Aug 2025

Commentary: Expression of salivary hepcidin and its inducer, interleukin 6 as well as type I interferons are significantly elevated in infants with poor oral rotavirus vaccine take in South Africa

in Vaccines and Molecular Therapeutics

Artur Słomka

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651751

1,410 views

Original Research

Published on 08 Aug 2025

Epitope mapping using immunopeptidomics reveals novel immunodominant CD8 T cell epitopes of the AAV9 capsid

in Vaccines and Molecular Therapeutics

Akhila Balasubramanian
Marek Prachar
Birgit Klaproth
Victoria Copeland
Sune Justesen
Yi Wen
Robert W. Siegel
Laurent P. Malherbe

Frontiers in Immunology

doi 10.3389/fimmu.2025.1641289

3,561 views

Original Research

Published on 08 Aug 2025

Study of the influence of population immunity to tick-borne encephalitis virus on the characteristics of the epidemic process in Russia

in Vaccines and Molecular Therapeutics

Temur K. Muminov
Vladimir A. Gushchin
Denis A. Kleymenov
Artem P. Tkachuk
Viktor A. Manuylov
Andrei E. Siniavin
Daria A. Ogarkova
Nadezhda A. Kuznetsova
Vladimir I. Zlobin
Alexander L. Gintsburg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1525388

1,895 views

Original Research

Published on 07 Aug 2025

Distinct humoral responses induced by heterologous versus homologous prime–boost immunization strategies in early life

in Vaccines and Molecular Therapeutics

Poorya Foroutan Pajoohian
Audur Anna Aradottir Pind
Jenny Lorena Molina Estupiñan
Dennis Christensen
Gabriel Kristian Pedersen
Thorunn A. Olafsdottir
Ingileif Jonsdottir
Stefania P. Bjarnarson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1563345

2,457 views

Original Research

Published on 06 Aug 2025

Recombinant SADS-CoV as a vector for porcine epidemic diarrhea vaccine development

in Vaccines and Molecular Therapeutics

Xiaoling Yan
Xiaoli Zhang
Xiaocheng Lyu
Yaoyao Zheng
Qianniu Li
Xiaoya Zhao
Jun Fu
Jingyun Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633661

3,191 views

Review

Published on 06 Aug 2025

Immune organoids: emerging platforms for modeling and analyzing human adaptive immunity

in Vaccines and Molecular Therapeutics

Tianlong Li
Dingkun Peng
Meng Yao
Meilin Li
Yijing Wang
Su Li
Ding Zhang
Bo Yang
Hua-Ji Qiu
Lian-Feng Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1632117

6,352 views
4 citations

3,192 articles

articles

Rational design of an epitope-centric vaccine against Pseudomonas aeruginosa using pangenomic insights and immunoinformatics approach

Effect of co-vaccination of cattle with RB51 and BCG on vaccine-specific CD4+ T cell responses

Personalized immunization to optimize vaccine immunogenicity: exploring the multidimensional effects of host intrinsic factors, external intervention strategies, and the external environment

Risk of developing juvenile idiopathic arthritis after quadrivalent HPV vaccination: a retrospective cohort study using the TriNetX U.S. Network

Correction: BCG and beyond: unlocking new frontiers in TB vaccine development

A phase II randomized trial of individualized neoantigen peptide vaccine combined with unusual radiotherapy (iNATURE) in advanced solid tumors-GCOG0028

CoreTIA: a modular, statistically robust transduction inhibition assay for AAV neutralization

Correction: The immunogenicity and safety of an inactivated quadrivalent influenza vaccine and a 23-valent pneumococcal polysaccharide vaccine in individuals with chronic diseases

Molecular ingredients of an immunogen for long-lasting IgG

Evaluating the efficacy, safety, and immunogenicity of FDA-approved RSV vaccines: a systematic review of Arexvy, Abrysvo, and mResvia

A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers

Orally administered extracellular vesicles from Salmonella-infected macrophages confer protective immunity in vivo

Impact of vaccination strategy adjustments on antibody levels against measles, rubella, mumps, and varicella in China: a single-center serological survey

Therapeutic vaccination with the Ag85B-Rv2660c-MPT70 fusion protein enhances Mycobacterium tuberculosis H37Ra clearance in post-exposure mice

Editorial: Basic and applied research toward the development of vaccines against African swine fever virus

BIDpred: unraveling B cell Immunodominance hierarchical pattern using statistical feature discovery and deep learning prediction

Harnessing cellular immunity for next-generation vaccines against respiratory viruses: mechanisms, platforms, and optimization strategies

Circulating SARS-CoV-2 spike IgG antibody responses in cancer patients following multiple COVID-19 vaccination boosters

Commentary: Expression of salivary hepcidin and its inducer, interleukin 6 as well as type I interferons are significantly elevated in infants with poor oral rotavirus vaccine take in South Africa

Epitope mapping using immunopeptidomics reveals novel immunodominant CD8 T cell epitopes of the AAV9 capsid

Study of the influence of population immunity to tick-borne encephalitis virus on the characteristics of the epidemic process in Russia

Distinct humoral responses induced by heterologous versus homologous prime–boost immunization strategies in early life

Recombinant SADS-CoV as a vector for porcine epidemic diarrhea vaccine development

Immune organoids: emerging platforms for modeling and analyzing human adaptive immunity