Frontiers in Immunology | Viral Immunology

Original Research

Accepted on 16 Dec 2025

The Impact of Metabolic Dysfunction-Associated Steatotic Liver Disease on the Efficacy of Pegylated Interferon-Based Therapy in Patients with Chronic Hepatitis B

in Viral Immunology

Jiaxin Han
Lianxin Xu
Yuqin Li
Ziling Wang
Minghui Zeng
Jieru Gao
Yuqiang Mi
Wentao Kuai
Huiling Xiang
Xu Liang

Frontiers in Immunology

142 views

Review

Accepted on 15 Dec 2025

Viral Glycoprotein-Mediated Entry and Antibody-Mediated Immunity in HIV-1 and SARS-CoV-2 Infection

in Viral Immunology

Michael W. Grunst
Wenwei Li
Walther Mothes

Frontiers in Immunology

226 views

Review

Accepted on 12 Dec 2025

Mitochondrial DNA Damage in HIV Infection: A Mechanistic Driver of Immunometabolic Dysfunction and Chronic Inflammation

in Viral Immunology

Xiaolei Wang
Li Ma
HUANBIN XU

Frontiers in Immunology

186 views

Mini Review

Published on 12 Dec 2025

Multimodal cell death drives the immunopathogenesis of RSV infection

in Viral Immunology

Tianxiang Yang
Zhizhong Mi
Zhaolong Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1740904

838 views

Mini Review

Published on 11 Dec 2025

Intrathecal rituximab for the treatment of Epstein–Barr virus-associated encephalitis

in Viral Immunology

Aude G. Chapuis
Johnnie J. Orozco
Filippo Milano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1736017

644 views

Original Research

Published on 11 Dec 2025

Computational characterization of peptide binding stability to HLA-C allotypes and its association with HIV-1 infection progression and HIV-1 related neurocognitive impairment

in Viral Immunology

Mauro Voi
Antonella Sangalli
Erica Ginevra Milano
Carola De Martinis
Elisa Orlandi
Stefano Tamburin
Elisa Mantovani
Angela Federico
Massimiliano Lanzafame
Emanuela Lattuada

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703026

856 views

Original Research

Accepted on 10 Dec 2025

Contrasting Immune Responses in COVID-19: Insights from Healthcare Workers and Infected Patients on Plasmablast, pDC, and NK Cell Dynamics

in Viral Immunology

Laura Martín-Pedraza
Eulalia Rodríguez-Martín
Erick De La Torre Tarazona
Elena Moreno
Roberto Pariente Rodríguez
Paulette Esperanza Walo-Delgado
Javier García-Pérez
JORGE DIAZ ALVAREZ
Laura Luna
Mario Rodriguez Dominguez

Frontiers in Immunology

287 views

Review

Accepted on 10 Dec 2025

Double, Double Toil and Trouble: Transforming Growth Factor Beta (TGF-β) in HIV Infection

in Viral Immunology

Jakob Harrison-Gleason
Kayla Lacin Yerlioglu
Ariel Wolfgang Halle
Judd Hultquist
Elena Martinelli

Frontiers in Immunology

186 views

Original Research

Accepted on 09 Dec 2025

Acetylsalicylic acid disrupts SARS-CoV-2 spike protein glycosylation and selectively impairs binding to ACE2

in Viral Immunology

Luca Perico
Alessandra Bovio
Susanna Tomasoni
Piera Trionfini
Domenico Cerullo
Daniela Corna
Anna Pezzotta
Monica Locatelli
Marta Alberti
Ariela Benigni

Frontiers in Immunology

12,349 views

Original Research

Published on 09 Dec 2025

Acid ceramidase regulates CD8+ T-cell exhaustion via type I interferon-mediated upregulation of PD-L1

in Viral Immunology

Zhongwen Hu
Hossam Abdelrahman
Abdelrahman Elwy
Fei Kuang
Swati Dhiman
Shafaqat Ali
Marcel Marson
Lisa Holnsteiner
Thamer A. Hamdan
Justa Friebus-Kardash

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638403

1,576 views

Original Research

Published on 09 Dec 2025

Modulation of TLR7, TYK2 and OAS1 expression during SARS-CoV-2 infection

in Viral Immunology

Estíbaliz Alegría-Carrasco
Marta Jaén-Castaño
Pablo Delgado-Wicke
Nelly D. Zurita-Cruz
Nuria Montes
Emilia Roy-Vallejo
Sara Fernández de Córdoba-Oñate
Ana Nicolao-Gómez
Rosa Carracedo-Rodríguez
Ana Marcos-Jiménez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713928

784 views

Original Research

Published on 08 Dec 2025

The local cellular response to Human Papillomavirus focuses on basal layer restoration as visualized in situ by specific cellular neighborhoods near infected cells

in Viral Immunology

Roderick C. Slieker
Ziena Abdulrahman
Saskia Santegoets
Mariette I. E. van Poelgeest
Marij J. P. Welters
Sjoerd H. van der Burg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1728629

996 views

Review

Published on 05 Dec 2025

Viral manipulation of the HLA class I antigen processing and presentation pathway

in Viral Immunology

Dominic S Nolan
Arwen F Altenburg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694498

1,068 views

Original Research

Published on 05 Dec 2025

Transcriptome analysis of differences in the infection of African swine fever virus (SY-1 strain) in iPAMs and PAMs

in Viral Immunology

Haiying Mao
Chuxing Cheng
Yong Wang
Wenhui Zhou
Ke Zhang
Yongqi Wang
Lihao Wang
Zhenrui Song
Xiaomei Sun
Yuanfeng Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692373

935 views

Original Research

Accepted on 03 Dec 2025

Study on Spatiotemporal Regulation of Interferon-Stimulated Genes during Zika Virus Infection

in Viral Immunology

Xiao Zhong Chen
Yuan Xin Gong
Hong Xia Guo
Jiu Xiang He
TongYan Yang
Jintao Li

Frontiers in Immunology

327 views

Brief Research Report

Published on 02 Dec 2025

Latent reservoirs in memory T cell subsets are linked to poor immune recovery in people living with HIV

in Viral Immunology

Selwyn Selva Kumar
John Paul Demosthenes
Madheswaran A.
Milton P.
Inbanathan A.
Nagaraj V.
Abi Manesh
Saravanabhavan Thangavel
Luke Elizabeth Hanna
Rajesh Kannangai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684924

1,156 views

Systematic Review

Published on 02 Dec 2025

High prevalence of baseline Non-R5 viral tropism in PLWH is associated with immune damage: a systematic review and meta-analysis

in Viral Immunology

Yangyang Liu
Defu Yuan
Yueqi Yin
Qian He
Meng Zhao
Hongfei Ma
Pingmin Wei
You Ge

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701028

609 views

Original Research

Accepted on 01 Dec 2025

Pilot Proteomic Analysis of Immune Dysregulation in Dengue with Prior SARS-CoV-2 Infection

in Viral Immunology

Elizabeth Cruz-Altamirano
Miguel-Angel Mayoral
Luis Román Ramírez-Palacios
Luz Maria Quirino-Vela
Diego Sait Cruz-Hernández
Sergio Aguilar
Juan Alpuche

Frontiers in Immunology

212 views

Review

Published on 28 Nov 2025

Hidden players of COVID-19: the evolving roles of SARS-CoV-2 accessory proteins

in Viral Immunology

Miguel Padilla-Blanco
Tránsito García-García
Juozas Grigas
Blanca D. López-Ayllón
Juan J. Garrido
María A. Oliva
María Montoya

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726698

2,028 views

Mini Review

Published on 28 Nov 2025

Dysregulated TFEB–autophagy-lysosome pathway links acute COVID-19 immunopathology to Long COVID sequelae

in Viral Immunology

Magdalena Gabig-Cimińska

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708364

1,185 views

Original Research

Published on 28 Nov 2025

Single‐cell transcriptomics reveals pathogen interactions and T cell reprogramming in HIV and Mycobacterium tuberculosis co‐infection

in Viral Immunology

Zihui Zhao
Suyue Huang
Wei Huang
Wei Song
Li Liu
Jun Chen
Renfang Zhang
Yinzhong Shen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680538

1,448 views

Original Research

Published on 28 Nov 2025

Convalescent plasma therapy for COVID-19 prophylaxis in adults early post-hematopoietic stem cell transplantation: one-year outcomes from a randomized controlled trial

in Viral Immunology

Yigeng Cao
Qiang Li
Wenwen Guo
Mingyue Xu
Kuo Fang
Fengjiao Wang
Rongli Zhang
Lin Li
Jialin Wei
Zhenyun Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1626775

830 views

Original Research

Published on 28 Nov 2025

Impact of HCV cure on systemic inflammation and bone density, quality, and turnover

in Viral Immunology

Christina K. Psomas
Elsa Lellouche-Slama
Susan Langan
Mark Sulkowski
Kendall F. Moseley
Jenny Pena-Dias
Smita Khati
Jing Sun
Alison G. Abraham
Todd T. Brown

Frontiers in Immunology

doi 10.3389/fimmu.2025.1626875

868 views

Case Report

Published on 28 Nov 2025

Human herpesvirus 6B infection in an adult with hemophagocytic lymphohistiocytosis carrying an UNC13D mutation: a case report and literature review

in Viral Immunology

Pingping Xiao
Qingqing Wang
Tingting Li
Zhigao Dong
Junnan Su
Yongquan Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679372

738 views

2,717 articles

articles

The Impact of Metabolic Dysfunction-Associated Steatotic Liver Disease on the Efficacy of Pegylated Interferon-Based Therapy in Patients with Chronic Hepatitis B

Viral Glycoprotein-Mediated Entry and Antibody-Mediated Immunity in HIV-1 and SARS-CoV-2 Infection

Mitochondrial DNA Damage in HIV Infection: A Mechanistic Driver of Immunometabolic Dysfunction and Chronic Inflammation

Multimodal cell death drives the immunopathogenesis of RSV infection

Intrathecal rituximab for the treatment of Epstein–Barr virus-associated encephalitis

Computational characterization of peptide binding stability to HLA-C allotypes and its association with HIV-1 infection progression and HIV-1 related neurocognitive impairment

Contrasting Immune Responses in COVID-19: Insights from Healthcare Workers and Infected Patients on Plasmablast, pDC, and NK Cell Dynamics

Double, Double Toil and Trouble: Transforming Growth Factor Beta (TGF-β) in HIV Infection

Acetylsalicylic acid disrupts SARS-CoV-2 spike protein glycosylation and selectively impairs binding to ACE2

Acid ceramidase regulates CD8+ T-cell exhaustion via type I interferon-mediated upregulation of PD-L1

Modulation of TLR7, TYK2 and OAS1 expression during SARS-CoV-2 infection

The local cellular response to Human Papillomavirus focuses on basal layer restoration as visualized in situ by specific cellular neighborhoods near infected cells

Viral manipulation of the HLA class I antigen processing and presentation pathway

Transcriptome analysis of differences in the infection of African swine fever virus (SY-1 strain) in iPAMs and PAMs

Study on Spatiotemporal Regulation of Interferon-Stimulated Genes during Zika Virus Infection

Latent reservoirs in memory T cell subsets are linked to poor immune recovery in people living with HIV

High prevalence of baseline Non-R5 viral tropism in PLWH is associated with immune damage: a systematic review and meta-analysis

Pilot Proteomic Analysis of Immune Dysregulation in Dengue with Prior SARS-CoV-2 Infection

Hidden players of COVID-19: the evolving roles of SARS-CoV-2 accessory proteins

Dysregulated TFEB–autophagy-lysosome pathway links acute COVID-19 immunopathology to Long COVID sequelae

Single‐cell transcriptomics reveals pathogen interactions and T cell reprogramming in HIV and Mycobacterium tuberculosis co‐infection

Convalescent plasma therapy for COVID-19 prophylaxis in adults early post-hematopoietic stem cell transplantation: one-year outcomes from a randomized controlled trial

Impact of HCV cure on systemic inflammation and bone density, quality, and turnover

Human herpesvirus 6B infection in an adult with hemophagocytic lymphohistiocytosis carrying an UNC13D mutation: a case report and literature review