Frontiers in Immunology | Viral Immunology

Original Research

Published on 25 Nov 2025

A comprehensive longitudinal analysis of the cellular immune response specific to the spike protein in healthcare workers vaccinated against SARS-CoV-2– ORCHESTRA Project

in Viral Immunology

Stefano Ugel
Akshita Gupta
Gianluca Spiteri
Pierpaolo Marchetti
Francesco De Sanctis
Shari Wouters
Angelina Konnova
Maria Grazia Lourdes Monaco
Angela Carta
Maria Diletta Pezzani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707449

1,127 views

Original Research

Published on 25 Nov 2025

TCR repertoire of human cytotoxic CD4 T cells responding to betaherpesviruses HHV-6B and HCMV

in Viral Immunology

Aniuska Becerra-Artiles
Grant C. Weaver
Peter O. Oluoch
Lawrence J. Stern

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631558

1,287 views

Original Research

Published on 21 Nov 2025

Coordinated kinetics of humoral, T-cell, and cytokine responses to SARS-COV-2 in West African healthcare workers: a multicenter longitudinal study in university hospitals of Abidjan, Côte d’Ivoire

in Viral Immunology

Amah Patricia Victorine Goran-Kouacou
Oppong Richard Yéboah
Yida Jocelyne Séri
Aya Ursule Aniela Assi
Adjoumanvoulé Honoré Adou
Salimata Moussa
Brou Doris Oura
Koffi N’Guessan
Kouabla Liliane Siransy
Séry Romuald Dassé

Frontiers in Immunology

doi 10.3389/fimmu.2025.1669517

754 views

Review

Published on 20 Nov 2025

Exosomes at the crossroads of HIV-1 pathogenesis and therapeutics

in Viral Immunology

Pengpeng Lu
Xu Lin
Wenyi Yang
Junhao Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634726

1,055 views

Original Research

Accepted on 19 Nov 2025

Deficiency of IL-20 receptor subunit A decreases enterovirus A71 lethality of mice with increases of M1 macrophage polarization and cytokine

in Viral Immunology

SHUN-HUA CHEN
Cheng-Huei Hung
Yi-Ling Hsiao
Yi-Ping Tsai
Ming-Shi Chang
Ching-Chuan Liu
Li-Chiu Wang

Frontiers in Immunology

331 views

Original Research

Published on 19 Nov 2025

Analysis of blood proteome in influenza-infected patients reveals new insights into the host response signatures distinguishing mild severe infections

in Viral Immunology

Klaus Schughart
Stephen C. Threlkeld
Subhashini A. Sellers
Willam A. Fischer
Jens Schreiber
Eva Lücke
Mark Heise
Amber M Smith

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693728

1,078 views

Original Research

Published on 19 Nov 2025

Transplacental transferred anti-SARS-CoV-2 neutralizing antibodies in unvaccinated pregnant women in Cameroon occurred during the COVID-19 pandemic, but not in the pre-pandemic period

in Viral Immunology

Reine Medouen Ndeumou Seumko’o
Thandeka Moyo-Gwete
Tandile Hermanus
Sosthene Hillary Matabou Tene
Romeo Brice Dieffouo Djounda
Chris Marco Mbianda Nana
Bernard Marie Zambo Bitye
Tekougang Berenice Kenfack Zangue
Bodin Darcisse Kwanou Tchakounte
Eitel Mpoudi Ngolle

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628102

1,034 views

Original Research

Published on 19 Nov 2025

Comparing human pediatric immune responses to primary infection with dengue, chikungunya and Zika viruses

in Viral Immunology

Lewis E Tomalin
Sandra Bos
Rafael Fenutria
Yitong Chen
Seunghee Kim-Schulze
Adeeb H Rahman
Angel Balmaseda
Ana Fernandez-Sesma
Eva Harris
Mayte Suaréz-Fariñas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679566

1,258 views

Original Research

Published on 18 Nov 2025

Methionine enkephalin upregulates toll-like receptors in macrophages to suppress severe fever with thrombocytopenia syndrome virus infection

in Viral Immunology

Jing Tian
Zhuping Ma
Xiaomeng Wang
Yonggang Li
Yulian Mu
Xiaoli Tao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700988

773 views

Original Research

Published on 18 Nov 2025

Development of nanobody-based DAS-ELISA and Au nanoparticle-based immunochromatographic test strip for highly sensitive detection of Chikungunya virus

in Viral Immunology

Mengmeng Guo
Liyuan Song
Jingliang Liu
Yating Hu
Yihui Chen
Guangcheng Fu
Hongyu Yuan
Jianmin Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707358

1,389 views

Review

Published on 17 Nov 2025

HBc: the multifunctional architect of HBV replication, immune evasion, and therapeutic innovation

in Viral Immunology

Yujia Zhu
Hongxiao Song
Fengchao Xu
Mian Huang
Guangyun Tan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657920

1,173 views

Original Research

Published on 14 Nov 2025

Inflammatory and redox reprogramming of macrophages by HIV cell-to-cell transmission inhibits bone resorption capacity

in Viral Immunology

Franco A. Sviercz
Patricio Jarmoluk
Constanza Russo
Cynthia Alicia López
Nicole Freiberger
Cintia Cevallos
M. Victoria Delpino
Jorge Quarleri

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694065

1,726 views

Correction

Published on 14 Nov 2025

Correction: Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile

in Viral Immunology

Rocío Rubio
Ruth Aguilar
Mariona Bustamante
Erica Muñoz
Miquel Vázquez-Santiago
Rebeca Santano
Marta Vidal
Natalia Rodrigo Melero
Daniel Parras
Pau Serra

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672095

1,226 views

Mini Review

Published on 11 Nov 2025

Chikungunya fever: pathogenesis and mechanisms underlying pain symptoms

in Viral Immunology

Wuping Sun
Shuqi Shi
Shengyun Liao
Mingzhu Zhai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679385

2,452 views
1 citation

Original Research

Published on 07 Nov 2025

Transcriptome analysis of classical blood cells reveals downregulation of pro-inflammatory genes in the classical monocytes of long COVID patients

in Viral Immunology

Florian Fricke
Franz Mai
Christine Wossidlo
Felix Steinbeck
Wendy Bergmann-Ewert
Marcel Kordt
Karin Kraft
Britta Müller
Emil C. Reisinger
Brigitte Müller-Hilke

Frontiers in Immunology

doi 10.3389/fimmu.2025.1710783

2,222 views

Original Research

Published on 07 Nov 2025

A contemporary strain of RSV activates primary human monocytes after abortive infection

in Viral Immunology

Ayse Agac
Martin Ludlow
Marie-Christin Knittler
Chittappen Kandiyil Prajeeth
Giulietta Saletti
Albert D. M. E. Osterhaus
Robert Meineke
Guus F. Rimmelzwaan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699818

1,474 views

Editorial

Published on 06 Nov 2025

Editorial: Immunological and virological aspects of the pathogenesis of type 1 diabetes

in Viral Immunology

Didier Hober

Frontiers in Immunology

doi 10.3389/fimmu.2025.1688257

693 views

Original Research

Published on 06 Nov 2025

Impaired and restored CD8+ T cell responses to a sequentially mutated spike epitope in Omicron variants

in Viral Immunology

Eun Joo Chung
Soyoung Park
Su-Hwan Kim
Ju-yeon Choi
Hye-Sook Jeong
Jae-Hoon Ko
Joon Young Song
Young Jae Lee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684193

1,572 views

Original Research

Published on 05 Nov 2025

Serum proteomics and machine learning identify PSMD11 as a prognostic biomarker in severe fever with thrombocytopenia syndrome

in Viral Immunology

Chenxi Zhao
Ziruo Ge
Ranran Wang
Yanli Xu
Tingyu Zhang
Zhouling Jiang
Lu Liu
Ling Lin
Zhihai Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693946

1,532 views

Review

Published on 29 Oct 2025

T-cell exhaustion in COVID-19: what do we know?

in Viral Immunology

Roderick Chen-Camaño
Rodrigo DeAntonio
Sandra López-Vergès

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678149

8,087 views

Original Research

Published on 29 Oct 2025

A DNA vaccine based on hemagglutinin and conserved epitopes of influenza B virus provides cross-lineage protection in mice

in Viral Immunology

Xiangyu Zhu
Zhuo Ha
Siyang Liu
He Zhang
Wenxin Zhao
Xiangshu Qiu
Xinyu Cao
Wei Wang
Yubiao Xie
Ning Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645744

1,691 views

Editorial

Published on 29 Oct 2025

Editorial: Animal-borne viral disease: pathogenesis, innate immunity, acquired immunity, and novel vaccine development

in Viral Immunology

Lei Tan
Fulong Nan
Shen Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713564

1,085 views

Review

Published on 28 Oct 2025

Transfusion-transmitted occult hepatitis B virus infection: current understanding, challenges, and its implication in blood safety

in Viral Immunology

Linbin Huang
Baoren He
Qiuhong Mo
Bin Li
Xipeng Yan
Rongji Lai
Xinwei Wang
Jinlian Li
Mingshuang Lai
He Xie

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663306

1,815 views
1 citation

Review

Published on 28 Oct 2025

Epstein–Barr virus in thyroid disease: an integrated immunovirological perspective

in Viral Immunology

Zhengda Wang
Xiwen Chang
Xianbin Cheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1687214

2,470 views

2,717 articles

articles

A comprehensive longitudinal analysis of the cellular immune response specific to the spike protein in healthcare workers vaccinated against SARS-CoV-2– ORCHESTRA Project

TCR repertoire of human cytotoxic CD4 T cells responding to betaherpesviruses HHV-6B and HCMV

Coordinated kinetics of humoral, T-cell, and cytokine responses to SARS-COV-2 in West African healthcare workers: a multicenter longitudinal study in university hospitals of Abidjan, Côte d’Ivoire

Exosomes at the crossroads of HIV-1 pathogenesis and therapeutics

Deficiency of IL-20 receptor subunit A decreases enterovirus A71 lethality of mice with increases of M1 macrophage polarization and cytokine

Analysis of blood proteome in influenza-infected patients reveals new insights into the host response signatures distinguishing mild severe infections

Transplacental transferred anti-SARS-CoV-2 neutralizing antibodies in unvaccinated pregnant women in Cameroon occurred during the COVID-19 pandemic, but not in the pre-pandemic period

Comparing human pediatric immune responses to primary infection with dengue, chikungunya and Zika viruses

Methionine enkephalin upregulates toll-like receptors in macrophages to suppress severe fever with thrombocytopenia syndrome virus infection

Development of nanobody-based DAS-ELISA and Au nanoparticle-based immunochromatographic test strip for highly sensitive detection of Chikungunya virus

HBc: the multifunctional architect of HBV replication, immune evasion, and therapeutic innovation

Inflammatory and redox reprogramming of macrophages by HIV cell-to-cell transmission inhibits bone resorption capacity

Correction: Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile

Chikungunya fever: pathogenesis and mechanisms underlying pain symptoms

Transcriptome analysis of classical blood cells reveals downregulation of pro-inflammatory genes in the classical monocytes of long COVID patients

A contemporary strain of RSV activates primary human monocytes after abortive infection

Editorial: Immunological and virological aspects of the pathogenesis of type 1 diabetes

Impaired and restored CD8+ T cell responses to a sequentially mutated spike epitope in Omicron variants

Serum proteomics and machine learning identify PSMD11 as a prognostic biomarker in severe fever with thrombocytopenia syndrome

T-cell exhaustion in COVID-19: what do we know?

A DNA vaccine based on hemagglutinin and conserved epitopes of influenza B virus provides cross-lineage protection in mice

Editorial: Animal-borne viral disease: pathogenesis, innate immunity, acquired immunity, and novel vaccine development

Transfusion-transmitted occult hepatitis B virus infection: current understanding, challenges, and its implication in blood safety

Epstein–Barr virus in thyroid disease: an integrated immunovirological perspective