Frontiers in Immunology | Viral Immunology

Original Research

Published on 01 Sep 2025

Mechanisms underlying the mitigating action of Maxing Shigan Decoction in acute lung injury caused by influenza virus based on UPLC-HRMS analysis and network pharmacology

in Viral Immunology

Jue Hu
Xiangming Ma
Yufeng Xiao
Chunjing Chen
Chang Liu
Jun Lu
Xiaoqi Wang
Fangguo Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634442

2,869 views

Original Research

Published on 29 Aug 2025

c-Met inhibitor NVP-BVU972 induces antiviral protection and suppresses NF-κB-mediated inflammation

in Viral Immunology

Yunfei Xie
Yang Zhao
Xingyu Chen
Hongli Jia
Xiao Wang
Tianyi Liu
Haocheng Wang
Yang Li
Xuefei Guo
Fuping You

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651730

2,234 views

Original Research

Published on 27 Aug 2025

IFIT3 activation significantly contributes to HIV-1-associated neurodegenerative disorder-mediated neuroinflammation

in Viral Immunology

Ranjit Kumar Das
Nirakar Sahoo
Deepa Roy
Chun Xu
Jose Galarza
Maria Camila Mejia Garza
Hansapani Rodrigo
Asim K. Duttaroy
Upal Roy

Frontiers in Immunology

doi 10.3389/fimmu.2025.1532318

2,607 views

Mini Review

Published on 27 Aug 2025

The role of Tat in HIV latency and reactivation

in Viral Immunology

David M. Margolis
Edward P. Browne

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650385

3,436 views
1 citation

Original Research

Published on 21 Aug 2025

Integrative scRNA-seq and transcriptomic analysis initially reveals monocyte/macrophage activation drives EV-A71-induced immune dysregulation and neural injury in severe HFMD

in Viral Immunology

Muqi Wang
Meng Zhang
Huiling Deng
Yufeng Zhang
Chenrui Liu
Yuan Chen
Chuting Zhang
Wen Zhang
Xiaoli Jia
Shuangsuo Dang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620633

2,575 views
2 citations

Original Research

Published on 21 Aug 2025

Attenuation of IFITM proteins’ antiviral activity through sequestration into intraluminal vesicles of late endosomes

in Viral Immunology

David Prikryl
You Zhang
Smita Verma
Gregory B. Melikyan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1647166

2,027 views

Original Research

Published on 20 Aug 2025

The role of the 3′-UTR of the chemokine receptor CCR2 and hnRNPA0 in regulating mRNA stability and subcellular distribution in human CD4+ T cells

in Viral Immunology

Yunus Yukselten
Hanan Wishah
Lingyun Wang
Richard E. Sutton

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655273

2,785 views
1 citation

Correction

Published on 19 Aug 2025

Correction: High-dimensional single-cell phenotyping unveils persistent differences in immune cell profiles between severe and moderate seasonal influenza

in Viral Immunology

Frontiers Production Office

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685215

766 views

Original Research

Published on 18 Aug 2025

Immune counter-evolution: immortalized B cell clones can undergo ex vivo directed evolution to counteract viral escape

in Viral Immunology

Casper Marsman
Jurgen Heinen
Vanessa Clerico Mosina
Kelly Maijoor
Arjen Q. Bakker
Michael Koslowski
Alessandra Villa
Stefano Gullà

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648717

2,960 views

Original Research

Published on 15 Aug 2025

Ouabain alleviates Mycobacterium abscessus-triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization

in Viral Immunology

Nan Li
Songqiang Huang
Xing Shi
Kuo Lu
Xiu Yu
Chen Qiu
Rongchang Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633882

2,562 views

Original Research

Published on 15 Aug 2025

A fusion ORF3a-E subgenomic RNA involved in SARS-CoV-2 infection efficacy by influencing cellular protein synthesis

in Viral Immunology

Yifan Zhang
Jing Li
Xinglong Zhang
Xin Zhang
Jiali Li
Heng Li
Xin Zhao
Zihan Zhang
Yingyan Li
Keqi Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1619538

1,931 views

Original Research

Published on 14 Aug 2025

From immune evasion to broad in silico binding: computational optimization of SARS-CoV-2 RBD-targeting nanobody

in Viral Immunology

Shuyuan Cao
Bo Sun
Feng Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637955

2,519 views
1 citation

Correction

Published on 12 Aug 2025

Correction: Proteome-wide characterization of PTMs reveals host cell responses to viral infection and identifies putative antiviral drug targets

in Viral Immunology

Xiaolu Li
Adam Kabza
Ashley N. Ives
Julianne Thiel
Katrina M. Waters
Wei-Jun Qian
Amy C. Sims
Tong Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672766

934 views

Review

Published on 08 Aug 2025

HIV cure research contributions from Africa in the last three decades

in Viral Immunology

Damalie Nakanjako
Edward N. Kankaka
Cynthia Lungu
Ronald M. Galiwango
Steven J. Reynolds
Tokameh Mahmoudi
Thumbi Ndung’u

Frontiers in Immunology

doi 10.3389/fimmu.2025.1576667

4,138 views

Review

Published on 07 Aug 2025

HIV-Tat and vascular endothelium: implications in the HIV associated brain, heart, and lung complications

in Viral Immunology

Sivasankar Chandran
Morgan Adler
Ling Chen
Sandeep Kaur
Navneet K. Dhillon

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621338

2,509 views
5 citations

Original Research

Published on 06 Aug 2025

The impact of intravenous immunoglobulin therapy on resource utilization associated with viral respiratory tract infections

in Viral Immunology

Antoine Azar
M. Chris Runken
Eric Moughames
Reuben Howden
Joshua Oh
Christopher M. Blanchette

Frontiers in Immunology

doi 10.3389/fimmu.2025.1513712

2,185 views

Brief Research Report

Published on 06 Aug 2025

Antiphospholipid antibodies during acute COVID-19 are not associated with long COVID: findings from a retrospective cohort study

in Viral Immunology

Robin Arcani
Alexandre Brodovitch
Xavier Heim
Jean-Louis Mège
Nathalie Bardin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634663

1,692 views

Correction

Published on 06 Aug 2025

Correction: Pre-activation of toll-like receptor 2 enhances CD8+ T-cell responses and accelerates hepatitis B virus clearance in the mouse models

in Viral Immunology

Yong Lin
Xuan Huang
Jun Wu
Jia Liu
Mingfa Chen
Zhiyong Ma
Ejuan Zhang
Yan Liu
Shunmei Huang
Qian Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650574

869 views

Review

Published on 01 Aug 2025

COVID-19: a vascular nightmare unfolding

in Viral Immunology

Qinan Yin
Youjin Huang
Hulin Wang
Yin Wang
Xuefei Huang
Yujie Song
Yueyuan Wang
Lizhu Han
Bian Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593885

5,987 views

Original Research

Published on 01 Aug 2025

Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections

in Viral Immunology

José De Jesus Bravo-Silva
Ricardo Jimenez-Camacho
Magda Lizbeth Benítez-Vega
Jonathan Hernández-Castillo
Carlos Daniel Cordero-Rivera
Carlos Noe Farfan-Morales
Marcos Pérez-García
Raymundo Cruz
Rosa María del Ángel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630116

3,374 views

Original Research

Published on 31 Jul 2025

The dialog between mother and newborn: insights from immune mediator crosstalk elicited by antenatal SARS-COV-2 exposure

in Viral Immunology

Maria Eduarda Canellas-de-Castro
Lizandra Moura Paravidine Sasaki
Geraldo Magela Fernandes
Felipe Motta
David Alves de Araújo Júnior
Heidi Luise Schulte
Ângelo Pereira da Silva
Caroline de Oliveira Alves
Rosana Maria Tristão
José Alfredo Lacerda de Jesus

Frontiers in Immunology

doi 10.3389/fimmu.2025.1606582

1,473 views

Brief Research Report

Published on 31 Jul 2025

Case Report: Inherited chromosomally integrated HHV-6B in a pediatric medulloblastoma patient with encephalitis

in Viral Immunology

Scott Sun
Konstance Knox
Alexander Romashko
Madhu Kundu
Haiying Zhu
Meei-Li Huang
Denise M. Malicki
John R. Crawford

Frontiers in Immunology

doi 10.3389/fimmu.2025.1615359

2,289 views

Brief Research Report

Published on 31 Jul 2025

Correlation between SARS-CoV-2-specific antibody titers and the hormones DHEA, cortisol, testosterone, and progesterone

in Viral Immunology

Tanja Karl
Anja Schuster
Janne Cadamuro
Gertie Janneke Oostingh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560623

1,658 views

Original Research

Published on 28 Jul 2025

No associations between HIV reservoir and inflammation in long-term virally suppressed dolutegravir-based ART-treated individuals

in Viral Immunology

Céline Fombellida-Lopez
Diego Aguilar Ortmans
Michel Moutschen
Alexander O. Pasternak
Gilles Darcis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628086

2,769 views
1 citation

2,717 articles

articles

Mechanisms underlying the mitigating action of Maxing Shigan Decoction in acute lung injury caused by influenza virus based on UPLC-HRMS analysis and network pharmacology

c-Met inhibitor NVP-BVU972 induces antiviral protection and suppresses NF-κB-mediated inflammation

IFIT3 activation significantly contributes to HIV-1-associated neurodegenerative disorder-mediated neuroinflammation

The role of Tat in HIV latency and reactivation

Integrative scRNA-seq and transcriptomic analysis initially reveals monocyte/macrophage activation drives EV-A71-induced immune dysregulation and neural injury in severe HFMD

Attenuation of IFITM proteins’ antiviral activity through sequestration into intraluminal vesicles of late endosomes

The role of the 3′-UTR of the chemokine receptor CCR2 and hnRNPA0 in regulating mRNA stability and subcellular distribution in human CD4+ T cells

Correction: High-dimensional single-cell phenotyping unveils persistent differences in immune cell profiles between severe and moderate seasonal influenza

Immune counter-evolution: immortalized B cell clones can undergo ex vivo directed evolution to counteract viral escape

Ouabain alleviates Mycobacterium abscessus-triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization

A fusion ORF3a-E subgenomic RNA involved in SARS-CoV-2 infection efficacy by influencing cellular protein synthesis

From immune evasion to broad in silico binding: computational optimization of SARS-CoV-2 RBD-targeting nanobody

Correction: Proteome-wide characterization of PTMs reveals host cell responses to viral infection and identifies putative antiviral drug targets

HIV cure research contributions from Africa in the last three decades

HIV-Tat and vascular endothelium: implications in the HIV associated brain, heart, and lung complications

The impact of intravenous immunoglobulin therapy on resource utilization associated with viral respiratory tract infections

Antiphospholipid antibodies during acute COVID-19 are not associated with long COVID: findings from a retrospective cohort study

Correction: Pre-activation of toll-like receptor 2 enhances CD8+ T-cell responses and accelerates hepatitis B virus clearance in the mouse models

COVID-19: a vascular nightmare unfolding

Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections

The dialog between mother and newborn: insights from immune mediator crosstalk elicited by antenatal SARS-COV-2 exposure

Case Report: Inherited chromosomally integrated HHV-6B in a pediatric medulloblastoma patient with encephalitis

Correlation between SARS-CoV-2-specific antibody titers and the hormones DHEA, cortisol, testosterone, and progesterone

No associations between HIV reservoir and inflammation in long-term virally suppressed dolutegravir-based ART-treated individuals