Frontiers in Medicine | Regulatory Science

Original Research

Accepted on 22 Dec 2025

Confronting Antimicrobial Resistance in Jordan: Regulatory, Economic, and Behavioural Determinants of Non-Prescription Antibiotic Dispensing in Community Pharmacies –A Mixed-Methods Study

in Regulatory Science

Anas Abed
Mohammad Abu Assab
Zekrayat J.H Merdas
Wael Abu Dayyih
Majd Nawras Maaita
Zainab Zakaray
Badriyah S Alotaibi
Nawal Alsubaie

Frontiers in Medicine

Original Research

Accepted on 12 Dec 2025

Disruption of Normal Saline Supply Chain due to a Disaster: an analysis of the impact of normal saline shortage on anesthesia practice in a large hospital system and models towards resiliency

in Regulatory Science

Rashid S. Hussain
Elizabeth Pickle
Taylor Lonjin
Janine Then
Ryan Rivosecchi
Jessica Cassavaugh
Mark Fichman
Ata Murat Kaynar

Frontiers in Medicine

106 views

Systematic Review

Published on 12 Dec 2025

Clinical pharmacist-led interventions and their impact on outcomes in patients with bipolar I disorder: a systematic review and meta-analysis

in Regulatory Science

Moteb Khobrani
Sultan M. Alshahrani

Frontiers in Medicine

doi 10.3389/fmed.2025.1725491

383 views

Original Research

Published on 12 Dec 2025

Global trends in e-labeling: a comprehensive geographical perspective

in Regulatory Science

Agnès Dangy-Caye
Valentin Lebreton
Rebecca Lumsden
Sabine Faber
Ana Cavalli
Maria Lucia De Lucia
Sima Desai

Frontiers in Medicine

doi 10.3389/fmed.2025.1662782

698 views

Mini Review

Accepted on 11 Dec 2025

Regulatory implementation of Optical Coherence Tomography as an analytical technique in pharmaceutical fillings

in Regulatory Science

Jesús Alberto Afonso Urich
Raymar Andreina Lara Garcia
Matthias Wolfgang
Johannes Khinast

Frontiers in Medicine

168 views

Review

Published on 11 Dec 2025

The evolution and application of the medical evidence chain

in Regulatory Science

Yanan Bai
Wanying Wang
Jiajia Duan
Xue Wang
Mingjing Jiang
Han Ni
Lu Sun
Chuanxin Liu
Ding Li

Frontiers in Medicine

doi 10.3389/fmed.2025.1690197

224 views

Original Research

Accepted on 10 Dec 2025

Deficiencies of the EU Medical Device Regulation when applying its own rules

in Regulatory Science

Martin Haimerl
Michael D'Agosto
Mike Fornefett
Massimo Kubon
Thomas Schiepp

Frontiers in Medicine

117 views

Perspective

Accepted on 09 Dec 2025

Strengthening translational preclinical research through confirmatory multi-laboratory studies

in Regulatory Science

Sophia C. Rotter
María Arroyo-Araujo
Natascha Ingrid Drude
Pasquale Pellegrini
Sebastian Kobold
Guenther H. S. Richter
Oliver J. Müller
Dunja Bruder
Lars B. Riecken
Björn Gerlach

Frontiers in Medicine

Review

Accepted on 08 Dec 2025

An exploration and analysis of the role positioning, duty comparison, and career development path of clinical research nurses in developed and developing countries

in Regulatory Science

Xiaotao Cao
Jiaxing Xu
Li Zheng

Frontiers in Medicine

Hypothesis and Theory

Published on 08 Dec 2025

The challenges of national health data ecosystems in feeding the European health data space: the Italian example

in Regulatory Science

Ylenia Murgia
Roberta Gazzarata
Mario Ciampi
Mario Sicuranza
Franco Cirillo
Christian Esposito
Norbert Maggi
Gabriella Balestra
Lucia Sacchi
Mauro Giacomini

Frontiers in Medicine

doi 10.3389/fmed.2025.1644719

480 views

Original Research

Published on 04 Dec 2025

Blockchain-enabled quality by design system for clinical trials

in Regulatory Science

Reza Vatankhah Barenji
Reza Ebrahimi Hariry

Frontiers in Medicine

doi 10.3389/fmed.2025.1546897

979 views

Policy and Practice Reviews

Accepted on 03 Dec 2025

Best Practices for the collection and analysis of patient experience data from social media for patient-focused drug development

in Regulatory Science

Philipp Cimiano
Nicole Brazda
Matthias Hartung
Cornelius Starke-Knäusel
Ana Lucia Schmidt
Maria Carmela De Vuono
Aditya Tyagi
Jürgen Gottowik
Raul Rodriguez-Esteban
Ben Collins

Frontiers in Medicine

102 views

Original Research

Published on 03 Dec 2025

The development of the neurosurgery workforce in Austria over the past quarter century: is more always better?

in Regulatory Science

Mario Mischkulnig
Roland Polacsek-Ernst
Lisa I. Körner
Josa Frischer
Cornelia M. Diendorfer
Christian Matula
Karl Roessler
Georg Widhalm
Christian Dorfer

Frontiers in Medicine

doi 10.3389/fmed.2025.1711856

644 views

Original Research

Published on 01 Dec 2025

Post-marketing surveillance of upadacitinib: multilevel analysis of venous thromboembolism reporting in global data and rheumatoid arthritis

in Regulatory Science

Renato Ferreira-da-Silva
Mariana Lobo
Ana Rafaela Abreu
Juliana Pereira-Macedo
Beatriz Mós
Carolina Ameijeiras Rodriguez
Inês Mariana Lourenço
Isabel Vieira
Jorge Junqueira Polónia
Luís Gouveia

Frontiers in Medicine

doi 10.3389/fmed.2025.1683751

859 views

Original Research

Accepted on 28 Nov 2025

Characteristics of adverse events and clinical risks of Intravenous immunoglobulin: a pharmacovigilance study based on FDA adverse event reporting system (FAERS)

in Regulatory Science

Zhen Lu
Xiaonan Lu
Yao Gao
Guangbin Shang
Yingjian Zeng

Frontiers in Medicine

496 views

Original Research

Accepted on 28 Nov 2025

Use of lorazepam for analgosedation during mechanical ventilation in paediatric intensive care

in Regulatory Science

Paul Healy
Marco Marano
Marcello Montibeller
Bianca Goffredo
Giuseppe Pontrelli
Oscar Della Pasqua

Frontiers in Medicine

122 views

Original Research

Published on 26 Nov 2025

Awareness and practices of community pharmacists toward dextromethorphan misuse in Jeddah, Saudi Arabia: implications for regulation and public health

in Regulatory Science

Aisha T. Alnami
Anfal S. Aljahdali
Haifa M. Alqahtani
Maha M. Khayat
Amal J. Aloshayni
Manal M. Aleesi
Mohammed M. Aldurdunji

Frontiers in Medicine

doi 10.3389/fmed.2025.1693207

939 views

Review

Published on 24 Nov 2025

Nonclinical regulatory considerations for investigational new drug applications for regulatory T cell therapies

in Regulatory Science

Phuong-Uyen Dinh
Lauren Mihalcik

Frontiers in Medicine

doi 10.3389/fmed.2025.1626067

1,091 views

Original Research

Published on 21 Nov 2025

Influence of a multidirectional overground body weight support system on walking-related tasks in typically developing children and adolescents

in Regulatory Science

Hubertus J. A. van Hedel
Sophia Rhiel
Emanuel Frei-Zuercher
Urs Keller

Frontiers in Medicine

doi 10.3389/fmed.2025.1690286

659 views

Policy and Practice Reviews

Published on 20 Nov 2025

A comparison of the labeling of antineoplastic and supportive medicines in China, Japan, and the US based on the WHO essential medicines list

in Regulatory Science

Chenyu Du
Jiaxin Liu
Caiyi Wang
Pengcheng Liu

Frontiers in Medicine

doi 10.3389/fmed.2025.1600207

552 views

Review

Published on 19 Nov 2025

The status quo of the development of decentralized clinical trials

in Regulatory Science

Xiaoliang Chen
Mingxuan Zhao
Na Lei
Lichun Dong
Qiang Lv
Jiashi Sun
Jianchang He
Xianglin Zhang

Frontiers in Medicine

doi 10.3389/fmed.2025.1664648

1,374 views

Original Research

Accepted on 17 Nov 2025

Role of Cleaning Quality Traceability in Hospital Sterilization Centers

in Regulatory Science

Wenli Zhang

Frontiers in Medicine

126 views

Systematic Review

Published on 11 Nov 2025

The management of good manufacturing practice (GMP) inspections: a scoping review of the evidence

in Regulatory Science

Aisha Al Azawei
Kate Loughrey
Kim Surim
Mary Elizabeth Connolly
Bernard D. Naughton

Frontiers in Medicine

doi 10.3389/fmed.2025.1687864

2,049 views

Original Research

Published on 11 Nov 2025

Assessment of compliance with good review practices by medicine assessors within the Zambia medicines regulatory authority

in Regulatory Science

Constance Sakala Chisha
Stephanie Leigh
Makomani Siyanga
Neil McAuslane
Stuart Walker

Frontiers in Medicine

doi 10.3389/fmed.2025.1706139

627 views

505 articles

articles

Confronting Antimicrobial Resistance in Jordan: Regulatory, Economic, and Behavioural Determinants of Non-Prescription Antibiotic Dispensing in Community Pharmacies –A Mixed-Methods Study

Disruption of Normal Saline Supply Chain due to a Disaster: an analysis of the impact of normal saline shortage on anesthesia practice in a large hospital system and models towards resiliency

Clinical pharmacist-led interventions and their impact on outcomes in patients with bipolar I disorder: a systematic review and meta-analysis

Global trends in e-labeling: a comprehensive geographical perspective

Regulatory implementation of Optical Coherence Tomography as an analytical technique in pharmaceutical fillings

The evolution and application of the medical evidence chain

Deficiencies of the EU Medical Device Regulation when applying its own rules

Strengthening translational preclinical research through confirmatory multi-laboratory studies

An exploration and analysis of the role positioning, duty comparison, and career development path of clinical research nurses in developed and developing countries

The challenges of national health data ecosystems in feeding the European health data space: the Italian example

Blockchain-enabled quality by design system for clinical trials

Best Practices for the collection and analysis of patient experience data from social media for patient-focused drug development

The development of the neurosurgery workforce in Austria over the past quarter century: is more always better?

Post-marketing surveillance of upadacitinib: multilevel analysis of venous thromboembolism reporting in global data and rheumatoid arthritis

Characteristics of adverse events and clinical risks of Intravenous immunoglobulin: a pharmacovigilance study based on FDA adverse event reporting system (FAERS)

Use of lorazepam for analgosedation during mechanical ventilation in paediatric intensive care

Awareness and practices of community pharmacists toward dextromethorphan misuse in Jeddah, Saudi Arabia: implications for regulation and public health

Nonclinical regulatory considerations for investigational new drug applications for regulatory T cell therapies

Influence of a multidirectional overground body weight support system on walking-related tasks in typically developing children and adolescents

A comparison of the labeling of antineoplastic and supportive medicines in China, Japan, and the US based on the WHO essential medicines list

The status quo of the development of decentralized clinical trials

Role of Cleaning Quality Traceability in Hospital Sterilization Centers

The management of good manufacturing practice (GMP) inspections: a scoping review of the evidence

Assessment of compliance with good review practices by medicine assessors within the Zambia medicines regulatory authority