Frontiers in Molecular Biosciences

Review

Published on 23 Oct 2025

High-resolution protein modeling through Cryo-EM and AI: current trends and future perspectives – a review

in Structural Biology

Gnanaprakash Jeyaraj
Anith Kumar Rajendran
Kuppusamy Sathishkumar
Bader O. Almutairi
Aanand Vadivelu
Santosh Chokkakula
Yanyang Tu
Weimim Xie

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1688455

5,570 views
2 citations

Original Research

Published on 23 Oct 2025

Action mechanism and molecular design of indolepyrrodione inhibitors targeting IDO1

in Biological Modeling and Simulation

Xinmin Wang
Zhigang Zhang
Kaixuan Hu
Wentong Yu
Yan Cheng
Yuting Song
Xin Sun
Siyao Li
Tiantian Yang
Jianping Hu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1661700

2,155 views

Review

Published on 23 Oct 2025

Biophysical insights into the molecular mechanisms of beta amyloid aggregation and its toxic effects in Alzheimer’s disease

in Molecular Biophysics

Soghra Bagheri
Luciano Saso

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1704653

2,805 views

Review

Published on 23 Oct 2025

Antioxidant and oxidative enzymes, genetic variants, and cofactors as prognostic biomarkers of COVID-19 severity and mortality: a systematic review

in Cellular Biochemistry

Shukur Wasman Smail
Blnd Azad Ismail
Ivan Sdiq Maghdid
Abdullah Hayder Flaih
Christer Janson

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1700263

2,363 views
3 citations

Editorial

Published on 23 Oct 2025

Editorial: Epigenetic regulation in fibrosis

in Molecular Diagnostics and Therapeutics

Qingqing Wei
Xiaoru Hu
Yan Sanders

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1718307

1,142 views

Original Research

Published on 22 Oct 2025

Identification of mitochondrial related gene characteristics and potential molecular mechanism of acute otitis media

in Molecular Diagnostics and Therapeutics

Dingjing Zi
Xiaoyong Ren

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1642269

1,525 views

Original Research

Published on 22 Oct 2025

Screening and regulatory mechanisms of biomarkers related to neddylation in laryngeal squamous cell carcinoma

in Molecular Diagnostics and Therapeutics

Xin Wang
Haixiang Zhang
Jinping Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1654064

1,146 views

Review

Published on 21 Oct 2025

Phenolic acids in fermented foods: microbial biotransformation, antioxidant mechanisms, and functional health implications

in Cellular Biochemistry

Anand Kumar
S. Saranyadevi
Selva Kumar Thirumalaisamy
Tharindu Trishan Dapana Durage
Swapnil Ganesh Jaiswal
Digambar Kavitake
Shuai Wei

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1678673

4,350 views
6 citations

Original Research

Published on 21 Oct 2025

Unraveling metabolic reprogramming in ΔhnoxParacoccus denitrificans: a time-resolved metabolomics and AI-Powered proteome modeling approach

in Metabolomics

Md Shariful Islam
Aishat Alatishe
William Bahureksa
Erik Yukl

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1679650

2,059 views

Original Research

Published on 21 Oct 2025

Superoxide- and semiquinone-linked activation of molecular hydrogen in metal-catalyst-free solution

in Mitochondria in Physiology and Disease

Toru Ishibashi
Enjuro Harunari
Genki Ishihara
Tetsushi Niiyama
Mami Noda-Urata
Nobuaki Komori

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1680812

2,148 views

Original Research

Published on 21 Oct 2025

Untargeted metabolomics unveils metabolic biomarkers in HFpEF

in Metabolomics

Dongqin Duan
Muyashaer Abudurexiti
Refukaiti Abuduhalike
Salamaiti Aimaier
Ailiman Mahemuti

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1673430

2,505 views
1 citation

Review

Published on 21 Oct 2025

Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and emerging therapeutic strategies

in Molecular Diagnostics and Therapeutics

Yu Liu
Yu-Qiu Xu
Yu-Yin Long
Hui Xiao
Yu-Ying Ma
Yong-Wang Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1693456

6,229 views
4 citations

Original Research

Published on 20 Oct 2025

Specificity of mRNA binding to proteins within the NMD machinery is influenced in cancer

in RNA Networks and Biology

Umesh Kalathiya
Monikaben Padariya

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1606190

8,559 views

Review

Published on 17 Oct 2025

The janus-faced biology of GPNMB: from tissue homeostasis to cancer pathogenesis

in Molecular Diagnostics and Therapeutics

Cheng Long
Li Qin Yun
Ma Dai Yuan
Imad Ibrahim Ali Al-Sultan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1664764

2,869 views
1 citation

Review

Published on 17 Oct 2025

Recent research advances in RNA m5C methylation modification in liver diseases

in RNA Networks and Biology

Wenjuan Chen
Lifan Zhang
Xinyu Gu
Yafeng Liu
Shujun Zhang
Xinjun Hu
Penghui Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1657502

1,982 views

Original Research

Published on 16 Oct 2025

Impact of endurance training on mitochondrial H2O2 production and NRF2 levels in different rat organs

in Bioenergetics

Lukasz Galganski
Krzysztof Wojcicki
Wieslawa Jarmuszkiewicz
Jerzy A. Zoladz

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1653162

1,865 views
1 citation

Review

Published on 15 Oct 2025

Advances of nanopore direct sequencing technology and bioinformatics analysis for cell-free DNA detection and its clinical applications in cancer liquid biopsy

in Molecular Diagnostics and Therapeutics

Jiaxin Tan
Zetong Wu
Yunya Zhu
Biyuan Miao
Daofeng Xu
Jia Gu
Maohong Hu
Pingping Xu
Shaogui Wan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1662587

3,232 views
1 citation

Original Research

Published on 15 Oct 2025

Comprehensive analyses of single-cell and bulk RNA-seq reveal the biological and prognostic roles of BMP4 in pancreatic adenocarcinoma

in Molecular Diagnostics and Therapeutics

Ao Wang
Xinglong Shen
Shan Lu
Chao Bi
Yang Cao
Yunfeng Liu
Meng Li
Yun Zhao
Huaizhang Jin
Xiaopeng Shen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1686938

1,490 views

Original Research

Published on 15 Oct 2025

Mapping of chromatin architecture and enhancer-promoter interactions in the cochlea

in Genome Organization and Dynamics

Tuba Ege
Celia R. Bloom
Mi Zhou
Huizhan Liu
Litao Tao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1683964

2,818 views
1 citation

Review

Published on 15 Oct 2025

Animal models in tuberculosis metabolomics: a systematic review of current evidence and the road to translational relevance

in Metabolomics

Rochelle Caudron
Ilse Du Preez
Laneke Luies
Monique Opperman

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1688882

2,134 views

Review

Published on 15 Oct 2025

Mechanistic insights into cisplatin-induced ototoxicity: the central role of transient receptor potential channels

in Molecular Diagnostics and Therapeutics

Man Yu
Juanjuan Li
Xianhai Zeng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1694131

1,373 views

Original Research

Published on 14 Oct 2025

Construction of a diagnostic model and identification of effect genes for diabetic kidney disease with concurrent vascular calcification based on bioinformatics and multiple machine learning approaches

in Molecular Diagnostics and Therapeutics

Lili Huang
Wenjing Wu
Shenhui Lv
Danfang Deng
Xiaoqin Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1609307

2,742 views
2 citations

Original Research

Published on 14 Oct 2025

ITRAQ and PRM-based quantitative saliva proteomics in gastric cancer: biomarker discovery

in Molecular Diagnostics and Therapeutics

Zhanyan Liu
Jieren Liu
Zaid Chachar
Jimao Mo
Haoran Chi
Runtao Wen
Kaixin Luo
Lei Huang
Guanlin Li
Chenhao Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1640508

2,117 views
2 citations

Original Research

Published on 13 Oct 2025

Design and validation of a clinical whole genome sequencing-based assay for patient screening in a large healthcare system

in Molecular Diagnostics and Therapeutics

Josiah T. Wagner
John T. Welle
Isabelle A. Lucas Beckett
Kate R. Emery
Benjamin A. Cosgrove
Krzysztof Olszewski
Nick Wagner
Tucker C. Bower
Li Chi Yuan
Eric M. Shull

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1669085

2,434 views

5,870 articles

articles

High-resolution protein modeling through Cryo-EM and AI: current trends and future perspectives – a review

Action mechanism and molecular design of indolepyrrodione inhibitors targeting IDO1

Biophysical insights into the molecular mechanisms of beta amyloid aggregation and its toxic effects in Alzheimer’s disease

Antioxidant and oxidative enzymes, genetic variants, and cofactors as prognostic biomarkers of COVID-19 severity and mortality: a systematic review

Editorial: Epigenetic regulation in fibrosis

Identification of mitochondrial related gene characteristics and potential molecular mechanism of acute otitis media

Screening and regulatory mechanisms of biomarkers related to neddylation in laryngeal squamous cell carcinoma

Phenolic acids in fermented foods: microbial biotransformation, antioxidant mechanisms, and functional health implications

Unraveling metabolic reprogramming in ΔhnoxParacoccus denitrificans: a time-resolved metabolomics and AI-Powered proteome modeling approach

Superoxide- and semiquinone-linked activation of molecular hydrogen in metal-catalyst-free solution

Untargeted metabolomics unveils metabolic biomarkers in HFpEF

Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and emerging therapeutic strategies

Specificity of mRNA binding to proteins within the NMD machinery is influenced in cancer

The janus-faced biology of GPNMB: from tissue homeostasis to cancer pathogenesis

Recent research advances in RNA m5C methylation modification in liver diseases

Impact of endurance training on mitochondrial H2O2 production and NRF2 levels in different rat organs

Advances of nanopore direct sequencing technology and bioinformatics analysis for cell-free DNA detection and its clinical applications in cancer liquid biopsy

Comprehensive analyses of single-cell and bulk RNA-seq reveal the biological and prognostic roles of BMP4 in pancreatic adenocarcinoma

Mapping of chromatin architecture and enhancer-promoter interactions in the cochlea

Animal models in tuberculosis metabolomics: a systematic review of current evidence and the road to translational relevance

Mechanistic insights into cisplatin-induced ototoxicity: the central role of transient receptor potential channels

Construction of a diagnostic model and identification of effect genes for diabetic kidney disease with concurrent vascular calcification based on bioinformatics and multiple machine learning approaches

ITRAQ and PRM-based quantitative saliva proteomics in gastric cancer: biomarker discovery

Design and validation of a clinical whole genome sequencing-based assay for patient screening in a large healthcare system