Frontiers in Molecular Biosciences

Original Research

Published on 30 Jan 2026

Identification of CXCL12 as a key gene of trophoblast and endometrial stromal cell decidualization in pregnancy via scRNA-seq and experimental validation

in Molecular Diagnostics and Therapeutics

Xianli Sun
Haimei Yang
Zhe Leng
Wei Zhang
Zhou Jiang
Henglian Liu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1768015

508 views

Original Research

Published on 30 Jan 2026

Longitudinal profiling of serum ADAM17 across clinical stages in multiple myeloma: a dynamic biomarker and its association with T cell alterations

in Molecular Diagnostics and Therapeutics

Jiao Qu
Yancheng Li
Chenchen Li
Di Wu
Yulin Cao
Shumei Xiao
Xingshuo Bao
Qiubai Li
Zhichao Chen
Lei Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1768193

533 views

Original Research

Published on 29 Jan 2026

Pompe disease: a country-wide molecular screening in a cohort of 15,068 study participants

in Molecular Diagnostics and Therapeutics

Aleksander Pushkov
Daria Chudakova
Ilya Zhanin
Sergey Nikitin
Elena Basargina
Lydmila Kuzenkova
Daria Andreeva
Maria Vasil’eva
Sergey Vasichkin
Albina Gabitova

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1745925

1,103 views

Original Research

Published on 29 Jan 2026

Bioenergetic and immunological characterization of cryopreserved peripheral blood mononuclear cells (PBMCs) isolated from blood and buffy coat

in Mitochondria in Physiology and Disease

Fabian Dieter
Jendrik Grube
Alice Quentin
Gunter P. Eckert

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1716701

711 views

Original Research

Published on 29 Jan 2026

Biophysical insights into recombinant Zeocin binding protein: conformational stability and folding dynamics across pH and temperature

in Protein Biochemistry for Basic and Applied Sciences

Sara Alharbi
Ajamaluddin Malik
Abdulaziz Alamri
Javed Masood Khan
Mohd. Shahnawaz Khan
Abdullah Alhomida
Tauseef Ahmad

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1748036

519 views

Review

Published on 29 Jan 2026

Non-coding RNA transcripts and their exosomal counterparts in the pathogenesis, diagnosis, and treatment of skin cancers, with a focus on melanoma

in Molecular Diagnostics and Therapeutics

Linjing Zou
Xuemei Wen
Xiyan Dai
Yaguang Wu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1669297

644 views

Review

Accepted on 28 Jan 2026

Mitochondrial Metabolism in Cancer Stem Cells (CSCs): Molecular and Diagnostic Implications

in Molecular Diagnostics and Therapeutics

Charan PSVV
Sona Sunil
Nandana Thuyyath
Rekha Rani Kokkanti
Kousalya Lavudi

Frontiers in Molecular Biosciences

272 views

Original Research

Accepted on 28 Jan 2026

The Gut Microbiota Remodes Amino Acid and Lipid Metabolism in Incomplete Revascularization of CHD with Phlegm-Dampness Syndrome: An Integrated Multiomics and Network Pharmacology Study

in Metabolomics

Xinyu Zhang
Wei Jiang
Xiaoqing Li
Wenjing Xu
Tong Liu
Haiming Cao
Haining Zhao
Wenhua Shi
Taohua Lan
Weihui Lu

Frontiers in Molecular Biosciences

138 views

Original Research

Published on 28 Jan 2026

Plasmodium infection fully activates the immune system in peripheral blood and tumor microenvironment in a murine Lewis lung cancer model

in Molecular Diagnostics and Therapeutics

Qunfeng Huang
Dongheng Yang
Zhu Tao
Zhaoqing Yu
Wenting Ding
Na Tao
Xiulin Liao
Haoxin Lin
Zhipeng Cheng
Susu Gao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1724792

954 views

Original Research

Published on 28 Jan 2026

Antigen-specific T Cell precursor frequency influences the proliferation of stem-like T Cells in tumor-draining lymph nodes and anti-tumor immune responses

in Molecular Diagnostics and Therapeutics

Liangnian Wei
Rong Chen
Kaijing Zhang
Tianyang Guo
Pengfei Li
Chunbing Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1771474

564 views

Original Research

Published on 28 Jan 2026

Disulfidptosis-related genes signature predicts prognosis and immune microenvironment in colon cancer

in Molecular Diagnostics and Therapeutics

Wei Jiang
Huaxia Yang
Rui Li
Yanzhi Li
Shaoyou Xia

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1756041

604 views

Review

Published on 28 Jan 2026

Lipid remodeling and ferroptosis in phosphatidylcholine-mediated tumor–stroma crosstalk

in Lipids, Membranes and Membranous Organelles

Manikandan Vani Raju
Meenakshi Kaniyur Chandrasekaran
Lavanya Loganathan
Rathi Muthaiyan Ahalliya
Monica Mironescu
Ion Dan Mironescu
Chella Perumal Palanisamy
Gopalakrishnan Velliyur Kanniappan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1742305

1,114 views

Original Research

Accepted on 27 Jan 2026

Mitochondrial respiration in human peripheral blood mononuclear cells - methodology and influence of permeabilization and storage

in Mitochondria in Physiology and Disease

Shusuke Sekine
Imen Chamkha
Evelina Elmér
Eleonor Åsander Frostner
Emil Westerlund
Tianshi Liu
Johannes K Ehinger
Fredrik Sjövall
Hiroyuki Uchino
Eskil Elmér

Frontiers in Molecular Biosciences

181 views

Original Research

Published on 27 Jan 2026

Integrating causal human genetics and In vivo transcriptomics to uncover a shared lipid-centric architecture in metabolic and neurocognitive disease

in Molecular Diagnostics and Therapeutics

Yi Li
Zhu Ni
Xiao-Yong Xia
Na Cheng
Yu Bo
Junwen He
Yang He
Xiang-Yu Meng
Xu Wang
Xuan Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1712198

813 views

Review

Published on 27 Jan 2026

RNA-based therapies for colorectal cancer: targeting the β-catenin pathway via microbiota -modulated miRNAs

in RNA Networks and Biology

Rajkumar Prabhakaran
Ramkumar Muthu
Rajkumar Manickam
Venkatesh Subramanian
Karthikeyan Mahendran

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1736094

1,734 views

Original Research

Published on 27 Jan 2026

A validated LC-ESI-MS/MS assay for simultaneous plasma quantification of 11 antimicrobials to support personalized dosing in critically ill children

in Metabolomics

Yuan-Yuan Zhang
Jie Wang
Hong-Li Guo
Shi-Yu Wu
Hai-Feng Zhang
Peng-Fei Zheng
Hong-Jun Miao
Feng Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1745458

491 views

Original Research

Accepted on 26 Jan 2026

Integrative multi-omics analysis reveals cellular and molecular insights into gestational diabetes mellitus

in Molecular Diagnostics and Therapeutics

Niankun Chen
Lottie Hung
Shaole Shi
Shanshan Zhao
Chumei Zeng
Yihong Huang
Huilin Xu
Lixia Shen
Dongyu Wang
Zilian Wang

Frontiers in Molecular Biosciences

170 views

Review

Accepted on 26 Jan 2026

The Role of Exosomes in Ankylosing Spondylitis: From Biological Features and Functional Cargo to Clinical Applications

in Cellular Biochemistry

Hanying Yuan
Jia Xu
Youyu Zhang
Xuan Xi
Heng Pan
Shujing Zhao
Kaixu Li
De Li
Yan LU

Frontiers in Molecular Biosciences

151 views

Review

Published on 26 Jan 2026

Advances in cardiovascular supplementation: mechanisms, efficacy, and clinical perspectives

in Micronutrient Biology

Xun Wu
Tanwei Fang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1699492

2,168 views

Original Research

Accepted on 23 Jan 2026

Preclinical evaluation of waste-derived pomegranate extract (PWE) as a potential preventing and therapeutic agent for benign prostatic hyperplasia

in Cellular Biochemistry

Valeria Consoli
Agata Grazia D'Amico
Claudio Mario Russo
Emanuele Foderà
DANIELA PASSARELLA
Antonio Pecorino
Velia D'Agata
Luca Vanella
Valeria Sorrenti

Frontiers in Molecular Biosciences

228 views

Review

Published on 23 Jan 2026

S100A12 drives inflammatory and metabolic reprogramming in sepsis-associated acute kidney injury

in Molecular Diagnostics and Therapeutics

Huanqin Liu
Yanan Lv
Qingjie Xue
Jikui Shi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1741799

774 views

Review

Published on 23 Jan 2026

Advances in protein dot blot: principles, technical specifics, applications, and future perspectives

in Protein Biochemistry for Basic and Applied Sciences

Juan Lu
Feng-yi Mai
Xin-yu Li
Wen-tao Yang
Jing-rong Liang
Xing-long Li
Jie Guo
Chen-guang Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1768231

1,021 views

Original Research

Published on 23 Jan 2026

Investigating circulating expression profile for H19, MEG3, and MIAT long noncoding RNAs with miR-135a and miR-29a in chronic kidney disease and renal hemodialysis patients: interrelations with serum sclerostin

in RNA Networks and Biology

Marwa A. Dahpy
Marwa K. Khairallah
Rania Naguib
Mona A. Khalil
Salwa Seif Eldin
Marwa A. Sabet
Amira A. Kamel

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1703108

648 views

Original Research

Accepted on 22 Jan 2026

Genetic Constraints on Protein Loop Evolution: Out-of-Frame Stop Codons limit Bacillus subtilis Stationary-phase mutagenesis

in Genome Organization and Dynamics

Carmen Vallin
Mario Pedraza-Reyes
Eduardo A Robleto

Frontiers in Molecular Biosciences

189 views

5,864 articles

articles

Identification of CXCL12 as a key gene of trophoblast and endometrial stromal cell decidualization in pregnancy via scRNA-seq and experimental validation

Longitudinal profiling of serum ADAM17 across clinical stages in multiple myeloma: a dynamic biomarker and its association with T cell alterations

Pompe disease: a country-wide molecular screening in a cohort of 15,068 study participants

Bioenergetic and immunological characterization of cryopreserved peripheral blood mononuclear cells (PBMCs) isolated from blood and buffy coat

Biophysical insights into recombinant Zeocin binding protein: conformational stability and folding dynamics across pH and temperature

Non-coding RNA transcripts and their exosomal counterparts in the pathogenesis, diagnosis, and treatment of skin cancers, with a focus on melanoma

Mitochondrial Metabolism in Cancer Stem Cells (CSCs): Molecular and Diagnostic Implications

The Gut Microbiota Remodes Amino Acid and Lipid Metabolism in Incomplete Revascularization of CHD with Phlegm-Dampness Syndrome: An Integrated Multiomics and Network Pharmacology Study

Plasmodium infection fully activates the immune system in peripheral blood and tumor microenvironment in a murine Lewis lung cancer model

Antigen-specific T Cell precursor frequency influences the proliferation of stem-like T Cells in tumor-draining lymph nodes and anti-tumor immune responses

Disulfidptosis-related genes signature predicts prognosis and immune microenvironment in colon cancer

Lipid remodeling and ferroptosis in phosphatidylcholine-mediated tumor–stroma crosstalk

Mitochondrial respiration in human peripheral blood mononuclear cells - methodology and influence of permeabilization and storage

Integrating causal human genetics and In vivo transcriptomics to uncover a shared lipid-centric architecture in metabolic and neurocognitive disease

RNA-based therapies for colorectal cancer: targeting the β-catenin pathway via microbiota -modulated miRNAs

A validated LC-ESI-MS/MS assay for simultaneous plasma quantification of 11 antimicrobials to support personalized dosing in critically ill children

Integrative multi-omics analysis reveals cellular and molecular insights into gestational diabetes mellitus

The Role of Exosomes in Ankylosing Spondylitis: From Biological Features and Functional Cargo to Clinical Applications

Advances in cardiovascular supplementation: mechanisms, efficacy, and clinical perspectives

Preclinical evaluation of waste-derived pomegranate extract (PWE) as a potential preventing and therapeutic agent for benign prostatic hyperplasia

S100A12 drives inflammatory and metabolic reprogramming in sepsis-associated acute kidney injury

Advances in protein dot blot: principles, technical specifics, applications, and future perspectives

Investigating circulating expression profile for H19, MEG3, and MIAT long noncoding RNAs with miR-135a and miR-29a in chronic kidney disease and renal hemodialysis patients: interrelations with serum sclerostin

Genetic Constraints on Protein Loop Evolution: Out-of-Frame Stop Codons limit Bacillus subtilis Stationary-phase mutagenesis