Frontiers in Molecular Biosciences

Original Research

Accepted on 20 Jan 2025

An unfolded protein response (UPR)-signature regulated by NFKB-miR-29b/c axis fosters tumor aggressiveness and poor survival in bladder cancer

in Molecular Diagnostics and Therapeutics

Jian Zhang
Xiaosong Fan
Yu Chen
Yichao Han
Weixing Yu
Shaolin Zhang
Bicheng Yang
Junlong Zhang
Yanling Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1542650

Original Research

Accepted on 20 Jan 2025

Simulations of pH and Thermal Effects on SARS-CoV-2 Spike Glycoprotein

in Biological Modeling and Simulation

Ziyuan Niu
Georgios Kementzidis
Miriam Rafailovich
Marcia Simon
Evangelos Papadopoulos
Bertal Aktas
Yuefan Deng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1545041

Original Research

Published on 20 Jan 2025

Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study

in Metabolomics

Kaylie I. Kirkwood-Donelson
Alan K. Jarmusch
Carl D. Bortner
Bruce Alex Merrick
Birandra K. Sinha

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1520876

579 views

Original Research

Published on 20 Jan 2025

Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes

in Lipids, Membranes and Membranous Organelles

Yunus E. Dogan
Niharika Bala
Erika S. Galban
Russell L. Lewis
Nancy D. Denslow
Sihong Song
Abdel A. Alli

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1485506

433 views

Original Research

Accepted on 17 Jan 2025

Establishment and Validation of a Recurrent Prediction Model for Glioma: Extrinsic Apoptotic Molecules FADD and CASP8 Are Closely Associated With Glioma Recurrence

in Molecular Diagnostics and Therapeutics

Lei Yang
Li Lanying
YanFang Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1533370

Editorial

Published on 17 Jan 2025

Editorial: Metabolomics and transcriptomics in biomarker discovery: mass spectrometric techniques in volatilome research

in Metabolomics

Andras Szeitz
Jens Herbig
Konstantinos A. Kouremenos
Shane Fitzgerald
Steven J. Hallam

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1545016

595 views

Original Research

Published on 17 Jan 2025

Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliometric analysis

in Molecular Diagnostics and Therapeutics

Jianhao Bai
Zhongqi Wan
Wanru Zhou
Lijun Wang
Wei Lou
Yao Zhang
Haiying Jin

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1538743

345 views

Original Research

Published on 17 Jan 2025

Plasma proteome fingerprint in kidney diseases

in Molecular Diagnostics and Therapeutics

Kirill S. Nikolsky
Arthur T. Kopylov
Valeriya I. Nakhod
Natalia V. Potoldykova
Dmitry V. Enikeev
Tatiana V. Butkova
Liudmila I. Kulikova
Kristina A. Malsagova
Vladimir R. Rudnev
Denis V. Petrovskiy

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1494779

501 views

Original Research

Accepted on 16 Jan 2025

Long-term Iron Supplementation in Four Patients with X-linked Erythropoietic Protoporphyria: Associations with Serum Proteins and Erythrocyte Protoporphyrin Levels-A Single-Centre Retrospective Study

in Protein Biochemistry for Basic and Applied Sciences

Anna-Elisabeth Minder
Francesca Granata
Franziska van Breemen
Xiaoye Schneider-Yin
Elisabeth Irene Minder
Lanja Saleh
Jasmin Barman-Aksözen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1509803

Original Research

Published on 15 Jan 2025

Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines

in Molecular Diagnostics and Therapeutics

Alexandra Razumovskaya
Mariia Silkina
Andrey Poloznikov
Timur Kulagin
Maria Raigorodskaya
Nina Gorban
Anna Kudryavtseva
Maria Fedorova
Boris Alekseev
Alexander Tonevitsky

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1531175

659 views

Original Research

Published on 15 Jan 2025

First-trimester metabolic profiling of gestational diabetes mellitus: insights into early-onset and late-onset cases compared with healthy controls

in Metabolomics

Danuta Dudzik
Vangeliya Atanasova
Coral Barbas
Jose Luis Bartha

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1452312

526 views

Brief Research Report

Accepted on 13 Jan 2025

Uncovering a Novel Binding Trench in ERRα: Insights from Molecular Simulations

in Biological Modeling and Simulation

LAMEES HEGAZY

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1523932

102 views

Brief Research Report

Published on 13 Jan 2025

Metabolomics insights into doxorubicin and 5-fluorouracil combination therapy in triple-negative breast cancer: a xenograft mouse model study

in Metabolomics

Mai M. Hassanein
Yousra A. Hagyousif
Ruba A. Zenati
Hamza M. Al-Hroub
Farman Matloob Khan
Ahmad Y. Abuhelwa
Karem H. Alzoubi
Nelson C. Soares
Waseem El-Huneidi
Eman Abu-Gharbieh

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1517289

548 views

Original Research

Published on 13 Jan 2025

Enhanced intestinal epithelial co-culture model with orbital mechanical stimulation: a proof-of-concept application in food nanotoxicology

in Nanobiotechnology

Mattia Santoni
Giovanni Piccinini
Giovanni Liguori
Maria Roberta Randi
Massimo Baroncini
Liliana Milani
Francesca Danesi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1529027

354 views

Original Research

Accepted on 09 Jan 2025

Genome-wide CRISPR/Cas9 screening identifies key profibrotic regulators of TGF-β1-induced epithelial-mesenchymal transformation and pulmonary fibrosis

in Molecular Diagnostics and Therapeutics

Chunjiang Tan
Juan Wang
Xiangrong Ye
Kaidirina Kasimu
Ye Li
Feng Luo
Hui Yi
Yifeng Luo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1507163

172 views

Review

Published on 09 Jan 2025

Recent advances of lysine lactylation in prokaryotes and eukaryotes

in Cellular Biochemistry

Wenjuan Zhao
Jiayi Xin
Xin Yu
Zhifang Li
Nan Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1510975

787 views

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Articles

An unfolded protein response (UPR)-signature regulated by NFKB-miR-29b/c axis fosters tumor aggressiveness and poor survival in bladder cancer

Simulations of pH and Thermal Effects on SARS-CoV-2 Spike Glycoprotein

Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study

Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes

Establishment and Validation of a Recurrent Prediction Model for Glioma: Extrinsic Apoptotic Molecules FADD and CASP8 Are Closely Associated With Glioma Recurrence

Editorial: Metabolomics and transcriptomics in biomarker discovery: mass spectrometric techniques in volatilome research

Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliometric analysis

Plasma proteome fingerprint in kidney diseases

Long-term Iron Supplementation in Four Patients with X-linked Erythropoietic Protoporphyria: Associations with Serum Proteins and Erythrocyte Protoporphyrin Levels-A Single-Centre Retrospective Study

Predicting patient outcomes with gene-expression biomarkers from colorectal cancer organoids and cell lines

First-trimester metabolic profiling of gestational diabetes mellitus: insights into early-onset and late-onset cases compared with healthy controls

Uncovering a Novel Binding Trench in ERRα: Insights from Molecular Simulations

Metabolomics insights into doxorubicin and 5-fluorouracil combination therapy in triple-negative breast cancer: a xenograft mouse model study

Enhanced intestinal epithelial co-culture model with orbital mechanical stimulation: a proof-of-concept application in food nanotoxicology

Genome-wide CRISPR/Cas9 screening identifies key profibrotic regulators of TGF-β1-induced epithelial-mesenchymal transformation and pulmonary fibrosis

Recent advances of lysine lactylation in prokaryotes and eukaryotes