Frontiers in Molecular Biosciences

Original Research

Published on 13 Jan 2026

Reformulation of the protein databank for real-time search of geometrical attributes of protein structures

in Structural Biology

Musa Azeem
Christopher Lee
Aaron Hein
Christopher Ott
Homayoun Valafar

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1694750

1,149 views

Hypothesis and Theory

Accepted on 12 Jan 2026

Network-Driven Computational Framework Identifies FDA-Approved Drug Repurposing Across Heterogeneous Brain Cancers

in Biological Modeling and Simulation

Om Prakash

Frontiers in Molecular Biosciences

292 views

Original Research

Published on 12 Jan 2026

Identification of DNASE1L3 as a novel biomarker of clinical stage in liver hepatocellular carcinoma

in Molecular Diagnostics and Therapeutics

Weina Xue
Shuying Xie
Tong Wu
Ruixi Li
Dingyan Lu
Shuaishuai Chen
Yue Xu
Yonglin Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1681888

909 views

Original Research

Published on 12 Jan 2026

Construction and validation of a predictive model for hypothermia complication during endoscopic thyroidectomy for thyroid cancer

in Molecular Diagnostics and Therapeutics

Hui Ye
Lu Xia
Tian Zhan
Haiwei Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1758239

694 views

Review

Published on 12 Jan 2026

Liquid biopsy in cancer diagnosis and prognosis: a paradigm shift in precision oncology

in Molecular Diagnostics and Therapeutics

Rayane da Silva Abreu
Danielle Dias Pinto Ferreira
Natassia Silva de Araujo
Samuel Horita
Tatiana Martins Tilli
Wim Degrave
Aline dos Santos Moreira
Mariana Caldas Waghabi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1708518

1,999 views

Original Research

Published on 12 Jan 2026

JAK-centric explainable few-shot gene-expression diagnosis framework for alopecia via MultiPLIER priors and relation-style set-to-set comparison

in Molecular Diagnostics and Therapeutics

Nanlan Yu
Ling Ran
Xinrong Gong
Junfei Teng
Shulei Liu
Zhiqiang Song

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1753206

1,048 views

Review

Published on 12 Jan 2026

DNA methylation and prediction of biological age

in Genome Organization and Dynamics

Yanfang Chen
Xiangshu Cheng
Shaoping Ji

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1734464

1,263 views

Review

Published on 12 Jan 2026

Circular RNAs: roles in hepatocellular carcinoma immune regulation, implications in immunotherapy, and prospects for clinical translation

in RNA Networks and Biology

Yifan Chen
Jiayi Zhao
Rui Pu
Chao Fu
Zishuai Li
Jianhua Yin
Guangwen Cao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1750832

1,105 views

Original Research

Published on 12 Jan 2026

Bromo- and chloro-substituted flavones induce apoptosis and modulate cell death pathways in canine lymphoma and leukemia cells - a comparative in vitro study

in Molecular Recognition

Anita Dudek
Ewa Dejnaka
Joanna Sulecka-Zadka
Martyna Perz
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
Hanna Pruchnik
Aleksandra Pawlak

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1738255

1,000 views

Original Research

Accepted on 09 Jan 2026

Expanding the genetic code: phage-driven evolution of pyrrolysyl-synthetase for site-specific incorporation of synthetic phenylalanine and tyrosine derivatives

in Protein Biochemistry for Basic and Applied Sciences

Dakhnevich Anastasia
Sabina Miasoutova
Danila Iliushin
Aleksey Rozanov
Roman Ivanov

Frontiers in Molecular Biosciences

267 views

Mini Review

Published on 09 Jan 2026

Redox metabolism in cell senescence: focusing on contributions from the metabolomic field

in Metabolomics

Eliana Chacón
Guillermo Grünwaldt
Inés Marmisolle
Jennyfer Martínez
Celia Quijano

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1754469

1,212 views

Original Research

Published on 09 Jan 2026

Isolation, characterization, and biological evaluation of endophytic fungi from Phragmites australis: experimental and computational insights

in Protein Biochemistry for Basic and Applied Sciences

Dina Mahfouz Eskander
Mohamed E. El Awady
Mohamed Ali
Asmaa M. Fahim
Ahmed A. Hamed
Basel Sitohy

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1713876

1,045 views

Editorial

Published on 09 Jan 2026

Editorial: Tumor-host interactions: metabolic and signaling pathways altered in cancer, immune and stromal cells

in Cellular Biochemistry

Joanna Kopecka
Valentina Audrito

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1778371

688 views

Brief Research Report

Published on 08 Jan 2026

Differential roles for CLA-1L and UNC-10 in endosomal maturation and peptide release at C. elegans synapses impacting lifespan

in Cellular Biochemistry

Mia Krout
Elena Miciulis
Phong Q. Lai
Janet E. Richmond

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1675073

1,071 views

Original Research

Published on 08 Jan 2026

A novel prognostic model based on epithelial cell progression genes identifies OAS1 as a suppressor of bladder cancer aggressiveness

in Molecular Diagnostics and Therapeutics

Xu Su
Hui Yu
Miaoyu Zhang
Kui Zeng
Fangyang Zhong
Xuerui Chen
Yuanbiao Guo
Liangbin Lin

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1716130

1,050 views

Original Research

Published on 08 Jan 2026

Glycine attenuates sepsis-induced white matter injury by modulating gut microbiota

in Molecular Diagnostics and Therapeutics

Jingfei Liu
Li Zhang
Chunyang Feng
Ye Li
Huiling Wu
Xueer Wang
Dong Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1733207

1,369 views

Review

Published on 07 Jan 2026

Research progress on oral glucagon-like peptide-1 receptor agonists in the treatment of diabetes mellitus type 2

in Molecular Diagnostics and Therapeutics

Qian Shao
Juan Xiong
Jing Wu
Jingxin Mao
Qing Hu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1729904

1,450 views

Original Research

Published on 07 Jan 2026

Hypoxia-induced immunosuppression in uveal melanoma is mediated by CD63+ exosomes delivering lactate to reprogram immune cells

in Molecular Diagnostics and Therapeutics

Lei Dong
Suilian Zheng
Yixia Feng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1743009

1,060 views

Original Research

Published on 07 Jan 2026

Cellular insights into transposable elements in Alzheimer’s disease

in Genome Organization and Dynamics

Vikas Kumar
Samuel Beck

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1642599

1,407 views

Mini Review

Published on 07 Jan 2026

Pharmacophore modeling: advances and pitfalls

in Biological Modeling and Simulation

Mahmoud Y. Elsaka
M. Modather Taha
Amr Tayel
Haytham O. Tawfik
Mahmoud A. A. Ibrahim
Tamer Shoeib

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1760982

1,208 views

Original Research

Published on 07 Jan 2026

Effect of treatment duration on the associations between three modern antidiabetic drugs and survival outcomes of lung cancer in China

in Metabolomics

Zijia Chen
Xiaonan Wang
Zhongtao Zhang
Lu Yang
Chao Lei
Yupeng Di
Ye Huang
Yan Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1701515

872 views

Original Research

Published on 07 Jan 2026

Forsythiaside a facilitates autophagy to ameliorate chronic nonbacterial prostatitis in rats by blocking the PKCα/NF-κB pathway

in Cellular Biochemistry

Xingwei Yu
Hongao Tan
Yunqiu Gao
Dandan Qiu
Yan Zhu
Haixin Qi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1665650

599 views

Original Research

Published on 07 Jan 2026

A diverse satellite DNA repertoire in Limnoperna fortunei: insights into genome structure and chromosomal organization

in Genome Organization and Dynamics

Jonathan Pena Castro
Tiago Marafiga Degrandi
Allan Oliveira Leal
Augusto Luiz Ferreira Júnior
Mara Cristina de Almeida
Roberto Ferreira Artoni

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1733652

1,008 views

Original Research

Published on 07 Jan 2026

Herbal monomer–based therapeutic insights from traditional Chinese medicine in myocardial infarction

in Molecular Diagnostics and Therapeutics

Nan Bian
Libo Xia
Xianqiu Xiong
Yingyu Chen
Ying Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1721931

1,056 views

5,864 articles

articles

Reformulation of the protein databank for real-time search of geometrical attributes of protein structures

Network-Driven Computational Framework Identifies FDA-Approved Drug Repurposing Across Heterogeneous Brain Cancers

Identification of DNASE1L3 as a novel biomarker of clinical stage in liver hepatocellular carcinoma

Construction and validation of a predictive model for hypothermia complication during endoscopic thyroidectomy for thyroid cancer

Liquid biopsy in cancer diagnosis and prognosis: a paradigm shift in precision oncology

JAK-centric explainable few-shot gene-expression diagnosis framework for alopecia via MultiPLIER priors and relation-style set-to-set comparison

DNA methylation and prediction of biological age

Circular RNAs: roles in hepatocellular carcinoma immune regulation, implications in immunotherapy, and prospects for clinical translation

Bromo- and chloro-substituted flavones induce apoptosis and modulate cell death pathways in canine lymphoma and leukemia cells - a comparative in vitro study

Expanding the genetic code: phage-driven evolution of pyrrolysyl-synthetase for site-specific incorporation of synthetic phenylalanine and tyrosine derivatives

Redox metabolism in cell senescence: focusing on contributions from the metabolomic field

Isolation, characterization, and biological evaluation of endophytic fungi from Phragmites australis: experimental and computational insights

Editorial: Tumor-host interactions: metabolic and signaling pathways altered in cancer, immune and stromal cells

Differential roles for CLA-1L and UNC-10 in endosomal maturation and peptide release at C. elegans synapses impacting lifespan

A novel prognostic model based on epithelial cell progression genes identifies OAS1 as a suppressor of bladder cancer aggressiveness

Glycine attenuates sepsis-induced white matter injury by modulating gut microbiota

Research progress on oral glucagon-like peptide-1 receptor agonists in the treatment of diabetes mellitus type 2

Hypoxia-induced immunosuppression in uveal melanoma is mediated by CD63+ exosomes delivering lactate to reprogram immune cells

Cellular insights into transposable elements in Alzheimer’s disease

Pharmacophore modeling: advances and pitfalls

Effect of treatment duration on the associations between three modern antidiabetic drugs and survival outcomes of lung cancer in China

Forsythiaside a facilitates autophagy to ameliorate chronic nonbacterial prostatitis in rats by blocking the PKCα/NF-κB pathway

A diverse satellite DNA repertoire in Limnoperna fortunei: insights into genome structure and chromosomal organization

Herbal monomer–based therapeutic insights from traditional Chinese medicine in myocardial infarction