Frontiers in Molecular Biosciences

Review

Published on 06 Jan 2026

Strategies of AAV capsid engineering for targeted delivery to brain, muscle, and retina

in Molecular Diagnostics and Therapeutics

Xinyuan Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1750807

1,991 views

Original Research

Published on 06 Jan 2026

Advancing Trypanosoma cruzi N-myristoyltransferase as a drug target for Chagas disease through in silico discovery and biochemical evaluation

in Molecular Diagnostics and Therapeutics

Diana González García
Angel Torres
Alan Talevi
Lucas N. Alberca
Miguel A. Beltran
Frida Lara
Marina Da Silva Ferreira
Priscila S. G. Farani
Igor C. Almeida
Rosa A. Maldonado

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1666768

1,261 views

Opinion

Published on 06 Jan 2026

Some aspects of trypsin’s involvement in the regulation of physiological functions

in Protein Biochemistry for Basic and Applied Sciences

I. V. Kuzmina
S. M. Tolpygo
V. G. Vertiprakhov

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1750770

1,176 views

Original Research

Published on 06 Jan 2026

Pyrrolopyrimidine derivatives as dual COX-2/ACE2 inhibitors: design, synthesis, and anti-inflammatory evaluation

in Cellular Biochemistry

Hala Afifi
Samar S. Fatahala
Rania H. Abd El-Hameed
Shahenda Mahgoub
Radwan El-Haggar
Omnia Aly
Amal F. Gharib
Amira I. Sayed
Heba Taha

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1710650

1,169 views

Editorial

Published on 05 Jan 2026

Editorial: Cellular contributors and consequences of protein misfolding and aggregation

in Cellular Biochemistry

Anoop Arunagiri
Emily Sontag
Verena Kohler
Arunkumar Venkatesan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1759495

715 views

Editorial

Published on 05 Jan 2026

Editorial: Overcoming resistance in DDR inhibition: new targets and therapeutic strategies

in Molecular Diagnostics and Therapeutics

Chi-Lin Tsai
Ana Cristina Gonçalves
Zamal Ahmed

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1766744

932 views

Original Research

Published on 05 Jan 2026

Garlic oil-loaded nanodisks for the amelioration of acute lung injury via modulation of the NF-κB and Keap1–Nrf2 axis

in Nanobiotechnology

Ruilin Hou
Bowen Jiang
Kai Wang
Xiaoying Yang
Wenping Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1686436

955 views

Original Research

Published on 05 Jan 2026

Glutamate enhances the production of inflammatory cytokines IL-6 and IL-11, as well as chemokines CXCL2, CXCL3, and CXCL8 in keloid fibroblasts

in Metabolomics

Yan Chen
Yaohan Xu
Jiahe Zhang
Chenxi Feng
Jie Chen
Yinjing Song
Jing Pan
Jiang Zhu
Hao Cheng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1720876

1,042 views

Original Research

Published on 02 Jan 2026

Mechanistic study of glutamine metabolic reprogramming driving non-small cell lung cancer progression via the FGF17-FGFR4 axis mediating epithelial-mesenchymal transition

in Molecular Diagnostics and Therapeutics

Qinghua Kong
Xiaoyan Wang
Wei Ding

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1728698

1,100 views

Original Research

Accepted on 29 Dec 2025

An Interpretability Heart Disease Prediction Model Based on Stacking Ensemble with SHAP

in Molecular Diagnostics and Therapeutics

Yanjie Chen
Liqiang Chong
Zhenghao Bao
Shaoqiang Wang
Yuchen Wang
Yanan Feng

Frontiers in Molecular Biosciences

304 views

Correction

Published on 23 Dec 2025

Correction: Superoxide- and semiquinone-linked activation of molecular hydrogen in metal-catalyst-free solution

in Mitochondria in Physiology and Disease

Frontiers Editorial Office

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1760628

866 views

Opinion

Accepted on 22 Dec 2025

Homage to James Feeney, one of the pioneers of biological NMR-Part II

in Structural Biology

Gordon Roberts

Frontiers in Molecular Biosciences

304 views

Review

Published on 19 Dec 2025

Galectin-3 in acute myocardial infarction: from molecular mechanisms to clinical translation

in Molecular Diagnostics and Therapeutics

Tingting Liu
Fang Yang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1730173

1,989 views

Original Research

Published on 19 Dec 2025

Split-APEX implicates splicing factor SRSF1 and splicing helicases in ribosomal biogenesis

in RNA Networks and Biology

Vasileios Paschalis
Max F. K. Wills
Philippe De Gusmao Araujo
Christian Lucas
Sumera Tubasum
Shijie Cui
Hesna Kara
Carlos Bueno-Alejo
Marina Santana-Vega
Andrea Taladriz-Sender

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1714378

1,395 views

Review

Published on 18 Dec 2025

The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications

in Cellular Biochemistry

Emma Schröder
Tida V. Jalilvand
Janina Kahl
Charlotte S. Kaiser
Eva Liebau

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1724944

1,752 views

Review

Published on 18 Dec 2025

Methods for telomere length measurement: an update on current technologies and emerging approaches

in Molecular Diagnostics and Therapeutics

Julia A. Makarova
Uliana D. Belova
Maria I. Zvereva
Maxim Yu. Shkurnikov
Alexander G. Tonevitsky

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1725112

2,452 views

Original Research

Published on 18 Dec 2025

Single-cell dissection of PTM-related networks reveals an immunosuppressed osteosarcoma ecosystem

in Molecular Diagnostics and Therapeutics

Jingyu Chen
Wei Zhang
Hai Yan
Jinyu Chen
Hanrui Liu
Xingyu Zhou
Haiping Zhang
Dongdong Cheng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1718941

1,317 views

Original Research

Published on 18 Dec 2025

Machine learning-assisted network pharmacology reveals that the Chaihu-Longgu-Muli decoction modulates the inflammatory microenvironment to treat perimenopausal syndrome

in Molecular Diagnostics and Therapeutics

Puiian Wong
Ruoyu Li
Ding Li
Bin Fang
Yun Lan
Yuhang Qi
Jiaqian Zheng
Hui Mo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1719463

1,483 views

Original Research

Published on 18 Dec 2025

Decoding the exosomal nucleic acid delivery system axis of macrophage autophagy and immune reprogramming via multi-omics analysis

in RNA Networks and Biology

Zhoujun Zhu
Wei Xiang
Pengchao Zhang
Parhat Yasin
Xinghua Song

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1711082

1,372 views

Review

Published on 18 Dec 2025

Bridging ancient wisdom and modern technology: an AI and multi-omics framework for three causes tailored treatment in personalized medicine

in Molecular Diagnostics and Therapeutics

Xuewen Diao
Hao Zhang
Shiqi Wang
Qi Zhang
Zulong Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1732340

1,574 views

Original Research

Published on 17 Dec 2025

DeepKinome: quantitative prediction of kinase binding affinity by a compound using deep learning based regression model

in Biological Modeling and Simulation

Yeeun Lee
Jisu Eun
Jinhyuk Lee
Seungyoon Nam

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1698891

1,809 views

Original Research

Published on 17 Dec 2025

Integrative proteomics reveals mitochondrial and immune signatures of MLH1 exon 13 deletion in Lynch syndrome–associated colorectal cancer

in Molecular Diagnostics and Therapeutics

Chen Chang
Yue Cao
Bin Zhang
Jingli Chen
Lin Chen
Wensheng Li
Guorong Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1722111

1,313 views

Original Research

Published on 17 Dec 2025

Asparagine-related biomarkers and regulatory mechanisms in type 2 diabetes mellitus

in Molecular Diagnostics and Therapeutics

Jiayi Xia
Tao Cai
Peiyin Chen
Lu Gan
Bo Cao
Mingming Kong

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1733878

1,258 views

Original Research

Published on 17 Dec 2025

TNFα protein, DNA methylation, mRNA and miRNA expression evaluation in multiple sclerosis

in Structural Biology

E. Costantini
N. H. Greig
L. Aielli
P. C. Silva
M. Di Carlo
F. Konstantinidou
M. Reale

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1730177

1,039 views

5,864 articles

articles

Strategies of AAV capsid engineering for targeted delivery to brain, muscle, and retina

Advancing Trypanosoma cruzi N-myristoyltransferase as a drug target for Chagas disease through in silico discovery and biochemical evaluation

Some aspects of trypsin’s involvement in the regulation of physiological functions

Pyrrolopyrimidine derivatives as dual COX-2/ACE2 inhibitors: design, synthesis, and anti-inflammatory evaluation

Editorial: Cellular contributors and consequences of protein misfolding and aggregation

Editorial: Overcoming resistance in DDR inhibition: new targets and therapeutic strategies

Garlic oil-loaded nanodisks for the amelioration of acute lung injury via modulation of the NF-κB and Keap1–Nrf2 axis

Glutamate enhances the production of inflammatory cytokines IL-6 and IL-11, as well as chemokines CXCL2, CXCL3, and CXCL8 in keloid fibroblasts

Mechanistic study of glutamine metabolic reprogramming driving non-small cell lung cancer progression via the FGF17-FGFR4 axis mediating epithelial-mesenchymal transition

An Interpretability Heart Disease Prediction Model Based on Stacking Ensemble with SHAP

Correction: Superoxide- and semiquinone-linked activation of molecular hydrogen in metal-catalyst-free solution

Homage to James Feeney, one of the pioneers of biological NMR-Part II

Galectin-3 in acute myocardial infarction: from molecular mechanisms to clinical translation

Split-APEX implicates splicing factor SRSF1 and splicing helicases in ribosomal biogenesis

The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications

Methods for telomere length measurement: an update on current technologies and emerging approaches

Single-cell dissection of PTM-related networks reveals an immunosuppressed osteosarcoma ecosystem

Machine learning-assisted network pharmacology reveals that the Chaihu-Longgu-Muli decoction modulates the inflammatory microenvironment to treat perimenopausal syndrome

Decoding the exosomal nucleic acid delivery system axis of macrophage autophagy and immune reprogramming via multi-omics analysis

Bridging ancient wisdom and modern technology: an AI and multi-omics framework for three causes tailored treatment in personalized medicine

DeepKinome: quantitative prediction of kinase binding affinity by a compound using deep learning based regression model

Integrative proteomics reveals mitochondrial and immune signatures of MLH1 exon 13 deletion in Lynch syndrome–associated colorectal cancer

Asparagine-related biomarkers and regulatory mechanisms in type 2 diabetes mellitus

TNFα protein, DNA methylation, mRNA and miRNA expression evaluation in multiple sclerosis