Frontiers in Molecular Biosciences

Original Research

Published on 17 Dec 2025

TNFα protein, DNA methylation, mRNA and miRNA expression evaluation in multiple sclerosis

in Structural Biology

E. Costantini
N. H. Greig
L. Aielli
P. C. Silva
M. Di Carlo
F. Konstantinidou
M. Reale

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1730177

1,041 views

Original Research

Published on 17 Dec 2025

Integrative proteomics reveals mitochondrial and immune signatures of MLH1 exon 13 deletion in Lynch syndrome–associated colorectal cancer

in Molecular Diagnostics and Therapeutics

Chen Chang
Yue Cao
Bin Zhang
Jingli Chen
Lin Chen
Wensheng Li
Guorong Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1722111

1,315 views

Systematic Review

Published on 17 Dec 2025

Mitochondrial dysfunction in Wilson disease: a systematic review and meta–analysis across human and animal models

in Mitochondria in Physiology and Disease

Raya Amin
Valentina Medici
Erik D. Fausak
Keren Sierra
Ieleen Li
Joshua Gong
Cecilia Giulivi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1712573

4,053 views

Original Research

Accepted on 16 Dec 2025

MiRNA-associated gene networks reveal potential candidate markers for Alzheimer's Disease

in RNA Networks and Biology

Shujuan Pan
Yanfang Zhou
Xiaoyu Wang
Jinghui Tong
Yanli Li
Junchao Huang
Song Chen
Yimin Cui
Zhiren Wang
Yunlong Tan

Frontiers in Molecular Biosciences

234 views

Review

Published on 16 Dec 2025

Molecular roles of microRNA-21 and exosomal miR-21 in gastrointestinal cancers: diagnostic, therapeutic, and drug resistance insights

in Molecular Diagnostics and Therapeutics

Chunguang Wang
Meiling Bai
Xingliang Liu
Zhijun Li
Haibin Wang
Shengbin Guo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1697875

1,803 views

Original Research

Published on 12 Dec 2025

Tirzepatide modulates gut microbiota homeostasis to protect against diabetic kidney disease

in Molecular Diagnostics and Therapeutics

Jun Ma
Mengyuan Tao
Wencheng Zhang
Li Zhou
Henglu Zhang
Fei Li
Hongman Zhang
Di Yao
Weiping Lu
Min Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1715024

2,099 views
1 citation

Opinion

Published on 12 Dec 2025

Modulation of transmembrane domain architecture by the intracellular C-terminal domain in yeast glucose transporter–receptor divergence

in Molecular Recognition

Jeong-Ho Kim

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1702400

742 views

Review

Published on 12 Dec 2025

The role of bHLH-PAS transcription factors in endoplasmic reticulum stress

in Cellular Biochemistry

Izabela Krauze
Małgorzata Krzystek-Korpacka
Kamila Maciejewska
Beata Greb-Markiewicz

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1730502

1,345 views

Editorial

Published on 11 Dec 2025

Editorial: Distinct phenotype but same genotype: hints for the diversity of phenotypes in ciliopathies

in Molecular Diagnostics and Therapeutics

John A. Sayer
Heymut Omran
Ewa Zietkiewicz

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1753098

712 views

Review

Published on 11 Dec 2025

Recent advances in applications of artificial intelligence-assisted Raman spectroscopy in diagnosis of cancers

in Molecular Diagnostics and Therapeutics

Xinran Zhu
Yanfu Zhao
Chunfang Zan
He Ma
Jingxin Liu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1690063

1,480 views
2 citations

Review

Published on 10 Dec 2025

Targeting microRNA-143 in colorectal cancer: advances in molecular biosciences for biomarker-based diagnostics, therapeutic strategies, and drug resistance prediction

in Molecular Diagnostics and Therapeutics

Xue Wang
Lei Wang
Long Ke

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1679533

1,183 views
1 citation

Methods

Published on 10 Dec 2025

FluoTag-EMSA: a fast and accessible quantitative method to assess RNA-binding specificity using 3′-tagged hybrid duplexes

in RNA Networks and Biology

Benjamin Rothé
Daniel B. Constam

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1727371

1,163 views

Original Research

Published on 10 Dec 2025

Glycoprotein M6B suppresses the maintenance of glioma stem cell stemness and proliferation via the integrin β1/β-catenin pathway

in Molecular Diagnostics and Therapeutics

Yanwen Chen
Yu Fan
Xingda Run
Maotang Liu
Shiwei Jiang
Zengli Miao
Wei Tian

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1731116

1,127 views

Original Research

Published on 10 Dec 2025

Diagnostic utility of IBEX Bone Health for assessment of osteoporosis from knee radiographs

in Molecular Diagnostics and Therapeutics

Robert Meertens
Ben Lopez
Mike Gundry
Ben Crone
Wavell Vigers
Michelle Evans
Richard McWilliam
Sarah Jarvis

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1671053

801 views

Original Research

Published on 10 Dec 2025

Evaluation of changes in plasma levels of MMP-8, MMP-13, and Thrombospondin 2 in patients with Osgood–Schlatter disease (OSD)

in Molecular Diagnostics and Therapeutics

Monika Kulesza
Tomasz Guszczyn
Aleksandra Kicman
Rafał Marecki
Michał Stanisław Kicman
Sławomir Ławicki

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1703728

704 views

Review

Published on 10 Dec 2025

Bioactive chemical composition and pharmacological insights into Salvia species

in Metabolomics

Tayyiba Afzal
Jarosław Proćków
Jacek Łyczko

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1678109

1,748 views
1 citation

Original Research

Published on 10 Dec 2025

In-cell single-molecule FRET measurement of cytosolic RAF proteins to investigate the structural states and kinetics among them

in Molecular Biophysics

Kenji Okamoto
Yasushi Sako

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1718018

1,544 views

Original Research

Published on 09 Dec 2025

Comparative analysis of lipid metabolism in trophoblast subpopulations in preeclampsia and in vitro hypoxia model

in Molecular Diagnostics and Therapeutics

Ivan Antipenko
Evgeny Knyazev
Timur Kulagin
Alexander Tonevitsky

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1731126

1,642 views

Review

Published on 09 Dec 2025

Unfolding ARF and ARL GTPases: from biophysics to systems-level insights

in Molecular Recognition

Laura Quirion
Regina Strakhova
Matthew J. Smith
Jean-François Côté

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1712544

1,196 views

Correction

Published on 09 Dec 2025

Correction: Development of a prognostic model for early-stage gastric cancer-related DNA methylation-driven genes and analysis of immune landscape

in Molecular Diagnostics and Therapeutics

Chen Su
Zeyang Lin
Zhijian Ye
Jing Liang
Rong Yu
Zheng Wan
Jingjing Hou

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1658908

865 views

Original Research

Published on 08 Dec 2025

Sex-dependent alterations of salivary microbiome in Parkinson’s disease: associations with motor and non-motor clinical phenotypes

in Molecular Diagnostics and Therapeutics

Jie Zu
Wei Zhang
Li Du
Hui Zhao
Min Xu
Ruyi Chen
Yuting Zhang
Siyan Chen
Chuanying Xu
Liguo Dong

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1726620

1,011 views
1 citation

Review

Published on 08 Dec 2025

Exosomal non-coding RNAs: a new avenue for treating diabetic foot ulcers

in RNA Networks and Biology

Guohao Chen
Gang Chen
Jun Lu
Shaolong Hu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1701879

1,545 views

Original Research

Published on 08 Dec 2025

Limitations of PICADAR as a diagnostic predictive tool for primary ciliary dyskinesia

in Molecular Diagnostics and Therapeutics

Andre Schramm
Johanna Raidt
Sarah Riepenhausen
Caroline Marie Torp Nygaard
Retno Tenardi-Wenge
Tavs Qvist
Pernille Witt
Michael Storck
Heike Olbrich
Kim Gjerum Nielsen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1691758

2,608 views

Original Research

Published on 05 Dec 2025

Unraveling the molecular basis of sensory attributes in smoking spices: a nontargeted metabolite analysis using liquid chromatography high resolution mass spectrometry

in Metabolomics

Xiao Yang
Ling-Bo Ji
Xian-Kuan Huo
Ju-Fang Hao
Min Wang
Ren-Qi Wang
Bao-Jiang He

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1687831

1,042 views

5,866 articles

articles

TNFα protein, DNA methylation, mRNA and miRNA expression evaluation in multiple sclerosis

Integrative proteomics reveals mitochondrial and immune signatures of MLH1 exon 13 deletion in Lynch syndrome–associated colorectal cancer

Mitochondrial dysfunction in Wilson disease: a systematic review and meta–analysis across human and animal models

MiRNA-associated gene networks reveal potential candidate markers for Alzheimer's Disease

Molecular roles of microRNA-21 and exosomal miR-21 in gastrointestinal cancers: diagnostic, therapeutic, and drug resistance insights

Tirzepatide modulates gut microbiota homeostasis to protect against diabetic kidney disease

Modulation of transmembrane domain architecture by the intracellular C-terminal domain in yeast glucose transporter–receptor divergence

The role of bHLH-PAS transcription factors in endoplasmic reticulum stress

Editorial: Distinct phenotype but same genotype: hints for the diversity of phenotypes in ciliopathies

Recent advances in applications of artificial intelligence-assisted Raman spectroscopy in diagnosis of cancers

Targeting microRNA-143 in colorectal cancer: advances in molecular biosciences for biomarker-based diagnostics, therapeutic strategies, and drug resistance prediction

FluoTag-EMSA: a fast and accessible quantitative method to assess RNA-binding specificity using 3′-tagged hybrid duplexes

Glycoprotein M6B suppresses the maintenance of glioma stem cell stemness and proliferation via the integrin β1/β-catenin pathway

Diagnostic utility of IBEX Bone Health for assessment of osteoporosis from knee radiographs

Evaluation of changes in plasma levels of MMP-8, MMP-13, and Thrombospondin 2 in patients with Osgood–Schlatter disease (OSD)

Bioactive chemical composition and pharmacological insights into Salvia species

In-cell single-molecule FRET measurement of cytosolic RAF proteins to investigate the structural states and kinetics among them

Comparative analysis of lipid metabolism in trophoblast subpopulations in preeclampsia and in vitro hypoxia model

Unfolding ARF and ARL GTPases: from biophysics to systems-level insights

Correction: Development of a prognostic model for early-stage gastric cancer-related DNA methylation-driven genes and analysis of immune landscape

Sex-dependent alterations of salivary microbiome in Parkinson’s disease: associations with motor and non-motor clinical phenotypes

Exosomal non-coding RNAs: a new avenue for treating diabetic foot ulcers

Limitations of PICADAR as a diagnostic predictive tool for primary ciliary dyskinesia

Unraveling the molecular basis of sensory attributes in smoking spices: a nontargeted metabolite analysis using liquid chromatography high resolution mass spectrometry