Frontiers in Molecular Biosciences

Original Research

Published on 11 Feb 2026

Creatinine, leucine, and tetrahydrocorticosterone emerge as potential biomarkers for the diagnosis of sarcopenic osteoarthritis in middle-aged and elderly individuals: a cross-sectional exploratory study

in Metabolomics

Huihui Wu
Hui Gao
Liang Guo
Xinyu Feng
Zhishen Zhang
Yiding Zhao
Haihong Chen
Zhi Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1743095

322 views

Original Research

Published on 09 Feb 2026

Serum biomarker screening and metabolic profiling analysis of nonalcoholic fatty liver disease patients using untargeted metabolomics and machine learning techniques

in Metabolomics

Lijuan Dan
Huan Shi
Lina Cao
Xiuyan Li
Lirui Kong
Xiaojie You
Wenping Liu
Yanwei Hao
Dong Wang
Hongfei Song

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1730023

549 views

Original Research

Published on 09 Feb 2026

Single-cell RNA sequencing and integrated bioinformatics reveal new mitochondrial biomarkers in sarcopenia

in Metabolomics

Hongan Ying
Wenhan Wang
Lili Huang
Weiwen Hong
Lingchang Yang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1694362

385 views

Original Research

Published on 06 Feb 2026

Short-term continuous light exposure induces hippocampal rhythmic and functional alterations: a multi-timepoint metabolomics study

in Metabolomics

Xiuxuan Wu
Guanyu Zhang
Shuai Wu
Yuyu Hu
Yongqiang Zhang
Li Zhang
Xi Li
Jun Li
Danfeng Yang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1753977

512 views

Review

Published on 03 Feb 2026

Enhancing agrifood systems with metabolomics: from crop improvement to food quality

in Metabolomics

Marina Dantas Corradin
Joanna Lado
Santiago Luzardo
Daniel Vázquez
Facundo Ibáñez

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1766666

602 views

Original Research

Accepted on 28 Jan 2026

The Gut Microbiota Remodes Amino Acid and Lipid Metabolism in Incomplete Revascularization of CHD with Phlegm-Dampness Syndrome: An Integrated Multiomics and Network Pharmacology Study

in Metabolomics

Xinyu Zhang
Wei Jiang
Xiaoqing Li
Wenjing Xu
Tong Liu
Haiming Cao
Haining Zhao
Wenhua Shi
Taohua Lan
Weihui Lu

Frontiers in Molecular Biosciences

136 views

Original Research

Published on 27 Jan 2026

A validated LC-ESI-MS/MS assay for simultaneous plasma quantification of 11 antimicrobials to support personalized dosing in critically ill children

in Metabolomics

Yuan-Yuan Zhang
Jie Wang
Hong-Li Guo
Shi-Yu Wu
Hai-Feng Zhang
Peng-Fei Zheng
Hong-Jun Miao
Feng Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1745458

486 views

Original Research

Accepted on 22 Jan 2026

Untargeted Metabolomics Reveals Immune-Metabolic Signatures in Established Cases of Rheumatoid Arthritis

in Metabolomics

Afshan Masood
Reem Al Malki
Abeer Malkawi
Maha Al Mogren
Amal Jaafar
Hicham Benabdelkamel
Assim A Alfadda
Amina Fallata
Abdurhman S. Alarfaj
Mohamed Siaj

Frontiers in Molecular Biosciences

200 views

Original Research

Accepted on 16 Jan 2026

Comprehensive first–trimester targeted metabolomics for early prediction and understanding of GDM pathophysiology

in Metabolomics

Patrycja Mojsak
Adrian Godlewski
Krzysztof Sołowiej
Agnieszka Kulczynska-Przybik
Sandra Chmielewska
Barbara Mroczko
Barbara Szelachowska
Adam Krętowski
Michal Ciborowski

Frontiers in Molecular Biosciences

277 views

Mini Review

Published on 09 Jan 2026

Redox metabolism in cell senescence: focusing on contributions from the metabolomic field

in Metabolomics

Eliana Chacón
Guillermo Grünwaldt
Inés Marmisolle
Jennyfer Martínez
Celia Quijano

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1754469

1,207 views

Original Research

Published on 07 Jan 2026

Effect of treatment duration on the associations between three modern antidiabetic drugs and survival outcomes of lung cancer in China

in Metabolomics

Zijia Chen
Xiaonan Wang
Zhongtao Zhang
Lu Yang
Chao Lei
Yupeng Di
Ye Huang
Yan Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1701515

865 views

Original Research

Published on 05 Jan 2026

Glutamate enhances the production of inflammatory cytokines IL-6 and IL-11, as well as chemokines CXCL2, CXCL3, and CXCL8 in keloid fibroblasts

in Metabolomics

Yan Chen
Yaohan Xu
Jiahe Zhang
Chenxi Feng
Jie Chen
Yinjing Song
Jing Pan
Jiang Zhu
Hao Cheng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1720876

1,037 views

Review

Published on 10 Dec 2025

Bioactive chemical composition and pharmacological insights into Salvia species

in Metabolomics

Tayyiba Afzal
Jarosław Proćków
Jacek Łyczko

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1678109

1,719 views

Original Research

Published on 05 Dec 2025

Unraveling the molecular basis of sensory attributes in smoking spices: a nontargeted metabolite analysis using liquid chromatography high resolution mass spectrometry

in Metabolomics

Xiao Yang
Ling-Bo Ji
Xian-Kuan Huo
Ju-Fang Hao
Min Wang
Ren-Qi Wang
Bao-Jiang He

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1687831

953 views

Original Research

Published on 03 Dec 2025

Comparative serum metabolomic profiling of hypertension in different traditional Chinese medicine syndromes

in Metabolomics

Sunan Yong
Le Shao
Zhi Liu
Chi Fang
Xiaobing Xie
Su Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1655493

1,196 views

Original Research

Published on 27 Nov 2025

Analysis of blood untargeted metabolomic characteristics of different subtypes of rosacea

in Metabolomics

Kejia Zhang
Yanyan Feng
Xiaoyu Zhang
Xingyan He
Sichun Qin
Xinxian Hu
Yuxi Liang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1652995

1,192 views

Original Research

Published on 24 Nov 2025

Enhanced bioproduction of phenolic compounds from Populus nigra L. using temporary immersion bioreactors and metabolomics

in Metabolomics

Malorie Laffon
Florent Magot
Caroline Birer Williams
Franck Michoux
Clément Lemoine
Arnaud Lanoue
Nathalie Giglioli-Guivarc’h

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1704160

1,473 views
1 citation

Review

Published on 18 Nov 2025

Lactate and lactylation in intervertebral disc degeneration

in Metabolomics

Yadong Liu
Jihao Yang
Zihui Wang
Jing Fu
Hongpeng Liu
Zekun Lu
Jinwei Dong
Zhong Li
Qiuyue Mao
Chunlan Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1685975

2,209 views

Original Research

Published on 13 Nov 2025

UHPLC-MS/MS-based plasma untargeted lipidomic analysis in patients with diabetes mellitus combined with hyperuricemia

in Metabolomics

Youqiong Xu
Yitao Zhu
Qihui Chen
Xinchao Zhang
Jinxi Fang
Wenchu Xu
Xiaoyang Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1656458

2,191 views

Original Research

Published on 30 Oct 2025

An exploratory study of urinary proteome in trigeminal neuralgia

in Metabolomics

Lilong Wei
Haitong Wang
Yun Zhou
Jianqiang Wu
Yongtong Cao
Yuliang Zhan
Youhe Gao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1618014

1,096 views
1 citation

Original Research

Published on 24 Oct 2025

Global research trends and emerging themes in osteosarcoma metabolomics: a bibliometric and visualization analysis

in Metabolomics

Haoran Wu
Kunyun Xu
Centao Liu
Heng’an Ge
Jianfeng Yan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1608743

1,693 views
1 citation

Original Research

Published on 21 Oct 2025

Unraveling metabolic reprogramming in ΔhnoxParacoccus denitrificans: a time-resolved metabolomics and AI-Powered proteome modeling approach

in Metabolomics

Md Shariful Islam
Aishat Alatishe
William Bahureksa
Erik Yukl

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1679650

2,050 views

Original Research

Published on 21 Oct 2025

Untargeted metabolomics unveils metabolic biomarkers in HFpEF

in Metabolomics

Dongqin Duan
Muyashaer Abudurexiti
Refukaiti Abuduhalike
Salamaiti Aimaier
Ailiman Mahemuti

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1673430

2,486 views
1 citation

Review

Published on 15 Oct 2025

Animal models in tuberculosis metabolomics: a systematic review of current evidence and the road to translational relevance

in Metabolomics

Rochelle Caudron
Ilse Du Preez
Laneke Luies
Monique Opperman

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1688882

2,122 views

449 articles

articles

Creatinine, leucine, and tetrahydrocorticosterone emerge as potential biomarkers for the diagnosis of sarcopenic osteoarthritis in middle-aged and elderly individuals: a cross-sectional exploratory study

Serum biomarker screening and metabolic profiling analysis of nonalcoholic fatty liver disease patients using untargeted metabolomics and machine learning techniques

Single-cell RNA sequencing and integrated bioinformatics reveal new mitochondrial biomarkers in sarcopenia

Short-term continuous light exposure induces hippocampal rhythmic and functional alterations: a multi-timepoint metabolomics study

Enhancing agrifood systems with metabolomics: from crop improvement to food quality

The Gut Microbiota Remodes Amino Acid and Lipid Metabolism in Incomplete Revascularization of CHD with Phlegm-Dampness Syndrome: An Integrated Multiomics and Network Pharmacology Study

A validated LC-ESI-MS/MS assay for simultaneous plasma quantification of 11 antimicrobials to support personalized dosing in critically ill children

Untargeted Metabolomics Reveals Immune-Metabolic Signatures in Established Cases of Rheumatoid Arthritis

Comprehensive first–trimester targeted metabolomics for early prediction and understanding of GDM pathophysiology

Redox metabolism in cell senescence: focusing on contributions from the metabolomic field

Effect of treatment duration on the associations between three modern antidiabetic drugs and survival outcomes of lung cancer in China

Glutamate enhances the production of inflammatory cytokines IL-6 and IL-11, as well as chemokines CXCL2, CXCL3, and CXCL8 in keloid fibroblasts

Bioactive chemical composition and pharmacological insights into Salvia species

Unraveling the molecular basis of sensory attributes in smoking spices: a nontargeted metabolite analysis using liquid chromatography high resolution mass spectrometry

Comparative serum metabolomic profiling of hypertension in different traditional Chinese medicine syndromes

Analysis of blood untargeted metabolomic characteristics of different subtypes of rosacea

Enhanced bioproduction of phenolic compounds from Populus nigra L. using temporary immersion bioreactors and metabolomics

Lactate and lactylation in intervertebral disc degeneration

UHPLC-MS/MS-based plasma untargeted lipidomic analysis in patients with diabetes mellitus combined with hyperuricemia

An exploratory study of urinary proteome in trigeminal neuralgia

Global research trends and emerging themes in osteosarcoma metabolomics: a bibliometric and visualization analysis

Unraveling metabolic reprogramming in ΔhnoxParacoccus denitrificans: a time-resolved metabolomics and AI-Powered proteome modeling approach

Untargeted metabolomics unveils metabolic biomarkers in HFpEF

Animal models in tuberculosis metabolomics: a systematic review of current evidence and the road to translational relevance