Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 30 Apr 2025

Unraveling the role of histone acetylation in sepsis biomarker discovery

in Molecular Diagnostics and Therapeutics

Feng Cheng
Juxin Deng
Zhaoyang Du
Lei Li
Zhaolei Qiu
Min Zhu
Hongchang Zhao
Zhenjie Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1582181

3,362 views

Original Research

Published on 28 Apr 2025

MRI-based deep learning with clinical and imaging features to differentiate medulloblastoma and ependymoma in children

in Molecular Diagnostics and Therapeutics

Yasen Yimit
Parhat Yasin
Yue Hao
Abudouresuli Tuersun
Chencui Huang
Xiaoguang Zou
Ya Qiu
Yunling Wang
Mayidili Nijiati

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1570860

2,531 views
1 citation

Review

Published on 28 Apr 2025

APOBEC in breast cancer: a dual player in tumor evolution and therapeutic response

in Molecular Diagnostics and Therapeutics

Haiqi Lu
Zelin Lu
Yufei Wang
Miaoqin Chen
Guangliang Li
Xian Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1604313

4,414 views
3 citations

Original Research

Published on 25 Apr 2025

Mechanism study on the treatment of ulcerative colitis by Gegen Qinlian nano-preparation through promoting M2 macrophage polarization

in Molecular Diagnostics and Therapeutics

Jilei Li
Jiarui Cao
Zhenyu Zhang
Sizhe Wang
Meng Zhu
Lili Yang
Wenhui Ouyang
Chunzheng Ma

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1580874

4,312 views
2 citations

Original Research

Published on 25 Apr 2025

Risk factors of colorectal cancer in middle-aged and elder adults in China: findings from the China health and retirement longitudinal study

in Molecular Diagnostics and Therapeutics

Lin Zhang
Yuyan Zhang
Yujia Huo
Yang Zhao
Aimin Xu
Zhining Liu
Qiaojun Hong
Huiming Tu
Junjie Huang
Li Liu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1333834

5,160 views
1 citation

Original Research

Published on 24 Apr 2025

TNFAIP8L3 regulation of the TGF-β signaling pathway affects the proportion of macrophages during tumor antigen presentation and affects the prognosis of ovarian cancer

in Molecular Diagnostics and Therapeutics

Chaomin Yue
Xiao Zheng
Yuqing Ye
Danyang Li
Yanhong Zhou

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1566363

2,915 views
4 citations

Review

Published on 24 Apr 2025

The oxidative-stress-senescence axis in keratoconus: new insights into corneal degeneration

in Molecular Diagnostics and Therapeutics

Maria Laura Passaro
Michele Rinaldi
Valentina Morgera
Antonia Feola
Vito Romano
Mario Troisi
Diego Strianese
Raffaele Piscopo
Samantha Messina
Antonella Romano

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1539542

3,835 views
6 citations

Original Research

Published on 23 Apr 2025

Systematic use of protein free energy changes for classifying variants of uncertain significance: the case of IFT140 in Mainzer-Saldino Syndrome

in Molecular Diagnostics and Therapeutics

Macarena Gajardo
José Luis Guerrero
Bárbara Poblete
Esperanza Bayyad
Ignacio Castro
Jorge Maturana
Jaime Tobar
Víctor Faúndes
Paola Krall

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1561380

2,102 views

Original Research

Published on 16 Apr 2025

Regulation of SLC7A11 by LncRNA GPRC5D-AS1 mediates ferroptosis in skeletal muscle: Mechanistic exploration of sarcopenia

in Molecular Diagnostics and Therapeutics

Wei Gong
Yan Wang
Qun Li
Yating Gao
Jie Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1557218

2,782 views
1 citation

Correction

Published on 16 Apr 2025

Corrigendum: CircMIB1 inhibits glioma development and progression through a competing endogenous RNA interaction network

in Molecular Diagnostics and Therapeutics

Simin Chen
Longping Li
Wei Xu
Nanjiao Xie
Huiting Xu
Yongjun Zhou
Ying Zou
Kai Yi
Zuping Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1599157

1,273 views

Correction

Published on 15 Apr 2025

Corrigendum: The high-throughput solid-phase extraction of cis-cyclo(L-Leu-L-Pro) and cis-cyclo(L-Phe-L-Pro) from Lactobacillus plantarum demonstrates efficacy against multidrug-resistant bacteria and influenza A (H3N2) virus

in Molecular Diagnostics and Therapeutics

Jaeyoung Son
Yeonju Hong
Hyeri Seong
Yoon Sin Oh
Min-Kyu Kwak

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1605848

1,195 views
1 citation

Review

Published on 14 Apr 2025

Extracellular vesicles in triple-negative breast cancer: current updates, challenges and future prospects

in Molecular Diagnostics and Therapeutics

Prashant Kumar Tiwari
Anis Ahmad Chaudhary
Saurabh Gupta
Mandeep Chouhan
Himanshu Narayan Singh
Sarvesh Rustagi
Salah-Ud-Din Khan
Sanjay Kumar

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1561464

4,760 views
4 citations

Original Research

Published on 14 Apr 2025

Identification of mitochondrial function and programmed cell death associated key biomarkers and the circRNA-miRNA-mRNA regulatory network in systemic lupus erythematosus

in Molecular Diagnostics and Therapeutics

Junjie Cao
Aifang Li
Hui Zhou
Yujie Yan
Gaiying Luo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1586294

3,285 views
1 citation

Original Research

Published on 11 Apr 2025

HJURP modulates cell proliferation and chemoresistance via the MYC/TOP2A transcriptional axis in gastric cancer

in Molecular Diagnostics and Therapeutics

Xu Li
Xiwen Li
Yanlin Ren
Ling Wang
Zehao Mao
Shikun Gao
Peng Ma
Junjie Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1566293

3,144 views
3 citations

Retraction

Published on 10 Apr 2025

Retraction: Identification of novel candidate targets for suppressing ovarian cancer progression through IL-33/ST2 axis components using the system biology approach

in Molecular Diagnostics and Therapeutics

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1605599

1,797 views

Original Research

Published on 09 Apr 2025

Identification of metabolomics-based biomarker discovery in individuals with down syndrome utilizing kernel-tree model-enhanced explainable artificial intelligence methodology

in Molecular Diagnostics and Therapeutics

Cemil Colak
Fatma Hilal Yagin
Burak Yagin
Abedalrhman Alkhateeb
Mahmood Basil A. Al-Rawi
Moulay A. Akhloufi
Mohammadreza Aghaei

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1567199

3,013 views
6 citations

Editorial

Published on 08 Apr 2025

Editorial: Therapeutic mechanism of osteosarcoma

in Molecular Diagnostics and Therapeutics

Siyi Chen
Yang Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1597144

2,282 views

Original Research

Published on 07 Apr 2025

UPLC-Q-TOF-MS-based unbiased serum metabolomics investigation of cholangiocarcinoma

in Molecular Diagnostics and Therapeutics

Xiaowei Wang
Xuefeng Xu
Ran Jia
Yuanhong Xu
Ping Hu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1549223

2,782 views
2 citations

Review

Published on 07 Apr 2025

FOXOs and their roles in acute and chronic neurological disorders

in Molecular Diagnostics and Therapeutics

Yasin Asadi
Rozenn K. Moundounga
Anand Chakroborty
Augustina Pokokiri
Hongmin Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1538472

5,815 views
5 citations

Original Research

Published on 04 Apr 2025

Integrated multi-omics analysis reveals the functional and prognostic significance of lactylation-related gene PRDX1 in breast cancer

in Molecular Diagnostics and Therapeutics

Qinqing Wu
Heng Cao
Jiangdong Jin
Dongxu Ma
Yixiao Niu
Yanping Yu
Xiang Wang
Yiqin Xia

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1580622

8,364 views
4 citations

Editorial

Published on 03 Apr 2025

Editorial: Crosstalk between metabolism and immunity

in Molecular Diagnostics and Therapeutics

Jie Xiong

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1599219

1,511 views

Brief Research Report

Published on 03 Apr 2025

Determination of sample stability for a broad panel of coagulation parameters and factor assays on the Cobas t 711 analyzer starting from fresh-never-frozen plasma

in Molecular Diagnostics and Therapeutics

Michael Hoffmann
Norbert Gottschalk
Philipp Huber
Vanessa Scheling
Nicole von Allmen
J. Kolja Hegel

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1491239

2,217 views

Original Research

Published on 02 Apr 2025

LT-YOLO: long-term temporal enhanced YOLO for stenosis detection on invasive coronary angiography

in Molecular Diagnostics and Therapeutics

Jiaxin Li
Xiang Tang
Xuesong Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1558495

2,601 views
2 citations

Correction

Published on 01 Apr 2025

Corrigendum: Comprehensive landscape of junctional genes and their association with overall survival of patients with lung adenocarcinoma

in Molecular Diagnostics and Therapeutics

Bin Xie
Ting Wu
Duiguo Hong
Zhe Lu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1583736

906 views

2,139 articles

articles

Unraveling the role of histone acetylation in sepsis biomarker discovery

MRI-based deep learning with clinical and imaging features to differentiate medulloblastoma and ependymoma in children

APOBEC in breast cancer: a dual player in tumor evolution and therapeutic response

Mechanism study on the treatment of ulcerative colitis by Gegen Qinlian nano-preparation through promoting M2 macrophage polarization

Risk factors of colorectal cancer in middle-aged and elder adults in China: findings from the China health and retirement longitudinal study

TNFAIP8L3 regulation of the TGF-β signaling pathway affects the proportion of macrophages during tumor antigen presentation and affects the prognosis of ovarian cancer

The oxidative-stress-senescence axis in keratoconus: new insights into corneal degeneration

Systematic use of protein free energy changes for classifying variants of uncertain significance: the case of IFT140 in Mainzer-Saldino Syndrome

Regulation of SLC7A11 by LncRNA GPRC5D-AS1 mediates ferroptosis in skeletal muscle: Mechanistic exploration of sarcopenia

Corrigendum: CircMIB1 inhibits glioma development and progression through a competing endogenous RNA interaction network

Corrigendum: The high-throughput solid-phase extraction of cis-cyclo(L-Leu-L-Pro) and cis-cyclo(L-Phe-L-Pro) from Lactobacillus plantarum demonstrates efficacy against multidrug-resistant bacteria and influenza A (H3N2) virus

Extracellular vesicles in triple-negative breast cancer: current updates, challenges and future prospects

Identification of mitochondrial function and programmed cell death associated key biomarkers and the circRNA-miRNA-mRNA regulatory network in systemic lupus erythematosus

HJURP modulates cell proliferation and chemoresistance via the MYC/TOP2A transcriptional axis in gastric cancer

Retraction: Identification of novel candidate targets for suppressing ovarian cancer progression through IL-33/ST2 axis components using the system biology approach

Identification of metabolomics-based biomarker discovery in individuals with down syndrome utilizing kernel-tree model-enhanced explainable artificial intelligence methodology

Editorial: Therapeutic mechanism of osteosarcoma

UPLC-Q-TOF-MS-based unbiased serum metabolomics investigation of cholangiocarcinoma

FOXOs and their roles in acute and chronic neurological disorders

Integrated multi-omics analysis reveals the functional and prognostic significance of lactylation-related gene PRDX1 in breast cancer

Editorial: Crosstalk between metabolism and immunity

Determination of sample stability for a broad panel of coagulation parameters and factor assays on the Cobas t 711 analyzer starting from fresh-never-frozen plasma

LT-YOLO: long-term temporal enhanced YOLO for stenosis detection on invasive coronary angiography

Corrigendum: Comprehensive landscape of junctional genes and their association with overall survival of patients with lung adenocarcinoma