Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 27 Feb 2025

Multitargeted biological actions of polydatin in preventing pseudogout acute attack

in Molecular Diagnostics and Therapeutics

Chiara Baggio
Paola Galozzi
Amelia Damasco
Vanni Lazzarin
Giampietro Ravagnan
Paolo Sfriso
Roberta Ramonda
Leonardo Punzi
Gianmaria Pennelli
Andrea Doria

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1553912

2,267 views

Review

Published on 26 Feb 2025

TRP channels and breast cancer: the role of TRPs in the pathophysiological development

in Molecular Diagnostics and Therapeutics

Yu Zhang
Yanfeng Yi
Yinghao Shu
Xiaochen Ru
Shuaibing He

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1528663

2,593 views
4 citations

Original Research

Published on 26 Feb 2025

Identifying potential biomarkers and molecular mechanisms related to arachidonic acid metabolism in vitiligo

in Molecular Diagnostics and Therapeutics

Xiaoqing Li
Li Yang
Longfei Zhu
Jingying Sun
Cuixiang Xu
Lijun Sun

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1536477

2,482 views
1 citation

Original Research

Published on 25 Feb 2025

Development of an enzyme-linked immunosorbent assay (ELISA) for determining neutrophil elastase (NE) – a potential useful marker of multi-organ damage observed in COVID-19 and post-Covid-19 (PCS)

in Molecular Diagnostics and Therapeutics

Joanna Adamiec-Mroczek
Joanna Kluz
Sandra Chwałek
Maciej Rabczyński
Kinga Gostomska-Pampuch
Łukasz Lewandowski
Marta Misiuk-Hojło
Beata Ponikowska
Goutam Chourasia
Ilias Dumas

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1542898

6,316 views

Original Research

Published on 25 Feb 2025

Q-Der: a next-generation CoQ10 analogue supercharging neuroprotection by combating oxidative stress and enhancing mitochondrial function

in Molecular Diagnostics and Therapeutics

Matteo Micucci
Federico Gianfanti
Sabrina Donati Zeppa
Giosuè Annibalini
Barbara Canonico
Fabiana Fanelli
Roberta Saltarelli
Riham Osman
Mariele Montanari
Daniele Lopez

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1525103

2,771 views
2 citations

Correction

Published on 25 Feb 2025

Corrigendum: Role of ARRB1 in prognosis and immunotherapy: a pan-cancer analysis

in Molecular Diagnostics and Therapeutics

Yingquan Ye
Haili Jiang
Yue Wu
Gaoxiang Wang
Yi Huang
Weijie Sun
Mei Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1577764

992 views

Hypothesis and Theory

Published on 25 Feb 2025

Jianpi Yangzheng Xiaozheng granule induced ferroptosis to suppress gastric cancer progression through reprogramming lipid metabolism via SCD1/Wnt/β-catenin axis

in Molecular Diagnostics and Therapeutics

Xiangyang Wang
Jingxiao Li
Rong Qin
Yi Yin
Jiepin Li
Sitian Lin
Xi Zou

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1523494

4,402 views
1 citation

Original Research

Published on 20 Feb 2025

Immunomagnetic enrichment coupled to PAX8/TP53 molecular pathology approach increases sensitivity in the detection of ovarian cancer cells in ascites

in Molecular Diagnostics and Therapeutics

Ivana Kurelac
Manuela Sollazzo
Monica De Luise
Francesca Nanetti
Laura Lanteri
Luigi D’Angelo
Beatrice Cavina
Simona Corrà
Stefano Miglietta
Sara Milioni

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1537407

2,278 views
3 citations

Editorial

Published on 19 Feb 2025

Editorial: Experimental and computational methods in the development of diagnostics and therapeutics for colon cancer

in Molecular Diagnostics and Therapeutics

Muhammad Suleman
Shahid Ali
Farooq Rashid
Faez Iqbal Khan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1568721

2,168 views

Original Research

Published on 17 Feb 2025

Genome-wide CRISPR/Cas9 screening identifies key profibrotic regulators of TGF-β1-induced epithelial-mesenchymal transformation and pulmonary fibrosis

in Molecular Diagnostics and Therapeutics

Chunjiang Tan
Juan Wang
Xiangrong Ye
Kaidirina Kasimu
Ye Li
Feng Luo
Hui Yi
Yifeng Luo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1507163

4,600 views
2 citations

Original Research

Published on 14 Feb 2025

An unfolded protein response (UPR)-signature regulated by the NFKB–miR-29b/c axis fosters tumor aggressiveness and poor survival in bladder cancer

in Molecular Diagnostics and Therapeutics

Jian Zhang
Xiaosong Fan
Yu Chen
Yichao Han
Weixing Yu
Shaolin Zhang
Bicheng Yang
Junlong Zhang
Yanling Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1542650

2,403 views
2 citations

Original Research

Published on 14 Feb 2025

A CRISPR-Cas-based recombinase polymerase amplification assay for ultra-sensitive detection of active Trypanosoma brucei evansi infections

in Molecular Diagnostics and Therapeutics

Andrés Álvarez-Rodríguez
Zeng Li
Bo-Kyung Jin
Benoit Stijlemans
Peter Geldhof
Stefan Magez

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1512970

3,196 views
4 citations

Original Research

Published on 13 Feb 2025

Calcium-dependent adhesion protein CDH18, a potential biomarker for prognosis in uterine corpus endometrial carcinoma

in Molecular Diagnostics and Therapeutics

Xiaoxuan Tang
Shanxing Dang
Jie Qiu
Ruilan Zhou
Jing Ling
Limei Zhang
Xiaopeng Peng
Qingyun Li
Jin Liu
Wei Liao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1530253

3,243 views
1 citation

Original Research

Published on 11 Feb 2025

IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury

in Molecular Diagnostics and Therapeutics

Hongshuang Su
Xiaoxi Lin
Ayinuer Paredong
Congcong Yao
Yan Zhang
Mengke Geng
Yuqian Guan
Lichao Gong
Feng Jiang
Qi Lv

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1538526

4,655 views
7 citations

Original Research

Published on 11 Feb 2025

Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer

in Molecular Diagnostics and Therapeutics

Angelica Nogueira Rodrigues
Andreza Karine de Barros Almeida Souto
Diocésio Alves Pinto de Andrade
Larissa Müller Gomes
Sandra Satie Koide
Renata de Godoy e Silva
Bruno Batista de Souza
Juliana Doblas Massaro
Andréia Cristina de Melo
Andrea Morais Borges

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1524594

3,567 views

Original Research

Published on 07 Feb 2025

Defining the high-risk category of patients with cutaneous melanoma: a practical tool based on prognostic modeling

in Molecular Diagnostics and Therapeutics

Oleksandr Dudin
Ozar Mintser
Vitalii Gurianov
Nazarii Kobyliak
Denys Kozakov
Sofiia Livshun
Oksana Sulaieva

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1543148

2,340 views

Original Research

Published on 07 Feb 2025

Serum glutathione peroxidase-3 concentration at diagnosis as a biomarker for assessing disease activity and damage of antineutrophil cytoplasmic antibody-associated vasculitis at diagnosis

in Molecular Diagnostics and Therapeutics

Jihye Chung
Jang Woo Ha
Yong-Beom Park
Sang-Won Lee

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1549454

2,002 views
2 citations

Original Research

Published on 06 Feb 2025

Deciphering the role of miRNA-mRNA interactions in cerebral vasospasm post intracranial hemorrhage

in Molecular Diagnostics and Therapeutics

Xiang Chu
Xiyan Zhu
Honghao Xu
Wenbing Zhao
Debin Guo
Xing Chen
Jinze Wu
Lei Li
Hao Wang
Jun Fei

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1492729

2,413 views

Review

Published on 06 Feb 2025

The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer

in Molecular Diagnostics and Therapeutics

Xiaosi Gu
Xin Hu
Sijia Zhang
Xiaoyu Zhang
Yong Wang
Lianlian Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1540048

2,038 views
1 citation

Review

Published on 04 Feb 2025

The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options

in Molecular Diagnostics and Therapeutics

Jiayong Yao
Xiaohong Dai
Xueping Yv
Lei Zheng
Jia Zheng
Binglin Kuang
Wei Teng
Weiwei Yu
Mingyue Li
Hongtao Cao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1541230

2,769 views
3 citations

Original Research

Published on 03 Feb 2025

Potential biomarkers and immune infiltration linking endometriosis with recurrent pregnancy loss based on bioinformatics and machine learning

in Molecular Diagnostics and Therapeutics

Jianhui Chen
Qun Li
Xiaofang Liu
Fang Lin
Yaling Jing
Jiayan Yang
Lianfang Zhao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1529507

5,235 views
1 citation

Review

Published on 31 Jan 2025

Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies

in Molecular Diagnostics and Therapeutics

Rui Gao
Meilin Liu
Haoyi Yang
Yuhan Shen
Ni Xia

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1548355

3,129 views
2 citations

Original Research

Published on 30 Jan 2025

Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling

in Molecular Diagnostics and Therapeutics

Raquel Arantes Megid
Guilherme Gomes Ribeiro
Izabela Natalia Faria Gomes
Ana Carolina Laus
Letícia Ferro Leal
Luciane Sussuchi da Silva
Abu-Bakr Adetayo Ariwoola
Josiane Mourão Dias
Rui Manuel Reis
Renato Jose da Silva-Oliveira

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1537523

4,420 views
1 citation

Original Research

Published on 29 Jan 2025

Cellular and immune landscape of chronic liver diseases: insights from immunophenotyping

in Molecular Diagnostics and Therapeutics

Shaghayegh Soleimani
Ozgur Albayrak
Kayra Somay
Hong Yang
Buket Yigit
Burge Ulukan
Dila Atak
Murat Akyildiz
Metehan Gursoy
Elif Demirtas

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2024.1521811

2,889 views

2,096 articles

articles

Multitargeted biological actions of polydatin in preventing pseudogout acute attack

TRP channels and breast cancer: the role of TRPs in the pathophysiological development

Identifying potential biomarkers and molecular mechanisms related to arachidonic acid metabolism in vitiligo

Development of an enzyme-linked immunosorbent assay (ELISA) for determining neutrophil elastase (NE) – a potential useful marker of multi-organ damage observed in COVID-19 and post-Covid-19 (PCS)

Q-Der: a next-generation CoQ10 analogue supercharging neuroprotection by combating oxidative stress and enhancing mitochondrial function

Corrigendum: Role of ARRB1 in prognosis and immunotherapy: a pan-cancer analysis

Jianpi Yangzheng Xiaozheng granule induced ferroptosis to suppress gastric cancer progression through reprogramming lipid metabolism via SCD1/Wnt/β-catenin axis

Immunomagnetic enrichment coupled to PAX8/TP53 molecular pathology approach increases sensitivity in the detection of ovarian cancer cells in ascites

Editorial: Experimental and computational methods in the development of diagnostics and therapeutics for colon cancer

Genome-wide CRISPR/Cas9 screening identifies key profibrotic regulators of TGF-β1-induced epithelial-mesenchymal transformation and pulmonary fibrosis

An unfolded protein response (UPR)-signature regulated by the NFKB–miR-29b/c axis fosters tumor aggressiveness and poor survival in bladder cancer

A CRISPR-Cas-based recombinase polymerase amplification assay for ultra-sensitive detection of active Trypanosoma brucei evansi infections

Calcium-dependent adhesion protein CDH18, a potential biomarker for prognosis in uterine corpus endometrial carcinoma

IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury

Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer

Defining the high-risk category of patients with cutaneous melanoma: a practical tool based on prognostic modeling

Serum glutathione peroxidase-3 concentration at diagnosis as a biomarker for assessing disease activity and damage of antineutrophil cytoplasmic antibody-associated vasculitis at diagnosis

Deciphering the role of miRNA-mRNA interactions in cerebral vasospasm post intracranial hemorrhage

The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer

The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options

Potential biomarkers and immune infiltration linking endometriosis with recurrent pregnancy loss based on bioinformatics and machine learning

Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies

Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling

Cellular and immune landscape of chronic liver diseases: insights from immunophenotyping