Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Accepted on 04 Feb 2026

Optimized RTX Strategy Plus Structured Glucocorticoid Tapering for Primary Membranous Nephropathy: A Multicenter Propensity Score-Matched Cohort Study

in Molecular Diagnostics and Therapeutics

Yao Sun
Yuxia Zhang
Jing Liu
Yanting Yu
Min Wu
Qing Yin
Yujia Wang
Ziyu Liang
Huang Biao
Rining Tang

Frontiers in Molecular Biosciences

117 views

Correction

Accepted on 03 Feb 2026

Correction: Gasdermin B (GSDMB) in psoriatic patients–a preliminary comprehensive study

in Molecular Diagnostics and Therapeutics

Julia Nowowiejska-Purpurowicz

Frontiers in Molecular Biosciences

Editorial

Published on 02 Feb 2026

Editorial: Advancements in immune heterogeneity in inflammatory diseases and cancer: new targets, mechanisms, and strategies

in Molecular Diagnostics and Therapeutics

Yongqiang Zhang
Yuqin Tang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1794468

377 views

Review

Accepted on 30 Jan 2026

Artificial Intelligence-Based miRNA Analysis for Precision Oncology: Diagnostic and Prognostic Insights

in Molecular Diagnostics and Therapeutics

Tauqeer Zehra
Maryam Koopaie
Nishat Fatima
Gowhar Rashid
Iquebal Hasan
Zainab Siddiqui

Frontiers in Molecular Biosciences

210 views

Original Research

Accepted on 30 Jan 2026

Integrated Transcriptomic, Protein, and MicroRNA Profiling Reveals a Conserved Pyroptosis-Related Molecular Signature Across Breast Cancer Subtypes

in Molecular Diagnostics and Therapeutics

Agata Panfil
Tomasz Sirek
Agata Sirek
Nikola Zmarzły
Michalina Wróbel
Zbigniew Wróbel
Kacper Boroń
Dariusz Boron
Piotr Ossowski
Martyna Stefaniak

Frontiers in Molecular Biosciences

189 views

Original Research

Published on 30 Jan 2026

Arsenic trioxide-induced acute kidney injury: OPA1- and Drp1-mediated mitochondrial dynamics imbalance, PINK1/Parkin-dependent mitophagy, and Chuanhuang Fang III

in Molecular Diagnostics and Therapeutics

Peiji Wang
Zicong Wu
Zhiyong Song
Xingyu Deng
Yifan Zhang
Xuezhong Gong

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1778855

586 views

Original Research

Published on 30 Jan 2026

Identification of CXCL12 as a key gene of trophoblast and endometrial stromal cell decidualization in pregnancy via scRNA-seq and experimental validation

in Molecular Diagnostics and Therapeutics

Xianli Sun
Haimei Yang
Zhe Leng
Wei Zhang
Zhou Jiang
Henglian Liu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1768015

500 views

Original Research

Published on 30 Jan 2026

Longitudinal profiling of serum ADAM17 across clinical stages in multiple myeloma: a dynamic biomarker and its association with T cell alterations

in Molecular Diagnostics and Therapeutics

Jiao Qu
Yancheng Li
Chenchen Li
Di Wu
Yulin Cao
Shumei Xiao
Xingshuo Bao
Qiubai Li
Zhichao Chen
Lei Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1768193

530 views

Original Research

Published on 29 Jan 2026

Pompe disease: a country-wide molecular screening in a cohort of 15,068 study participants

in Molecular Diagnostics and Therapeutics

Aleksander Pushkov
Daria Chudakova
Ilya Zhanin
Sergey Nikitin
Elena Basargina
Lydmila Kuzenkova
Daria Andreeva
Maria Vasil’eva
Sergey Vasichkin
Albina Gabitova

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1745925

1,087 views

Review

Published on 29 Jan 2026

Non-coding RNA transcripts and their exosomal counterparts in the pathogenesis, diagnosis, and treatment of skin cancers, with a focus on melanoma

in Molecular Diagnostics and Therapeutics

Linjing Zou
Xuemei Wen
Xiyan Dai
Yaguang Wu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1669297

638 views

Review

Accepted on 28 Jan 2026

Mitochondrial Metabolism in Cancer Stem Cells (CSCs): Molecular and Diagnostic Implications

in Molecular Diagnostics and Therapeutics

Charan PSVV
Sona Sunil
Nandana Thuyyath
Rekha Rani Kokkanti
Kousalya Lavudi

Frontiers in Molecular Biosciences

264 views

Original Research

Published on 28 Jan 2026

Plasmodium infection fully activates the immune system in peripheral blood and tumor microenvironment in a murine Lewis lung cancer model

in Molecular Diagnostics and Therapeutics

Qunfeng Huang
Dongheng Yang
Zhu Tao
Zhaoqing Yu
Wenting Ding
Na Tao
Xiulin Liao
Haoxin Lin
Zhipeng Cheng
Susu Gao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1724792

875 views

Original Research

Published on 28 Jan 2026

Antigen-specific T Cell precursor frequency influences the proliferation of stem-like T Cells in tumor-draining lymph nodes and anti-tumor immune responses

in Molecular Diagnostics and Therapeutics

Liangnian Wei
Rong Chen
Kaijing Zhang
Tianyang Guo
Pengfei Li
Chunbing Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1771474

494 views

Original Research

Published on 28 Jan 2026

Disulfidptosis-related genes signature predicts prognosis and immune microenvironment in colon cancer

in Molecular Diagnostics and Therapeutics

Wei Jiang
Huaxia Yang
Rui Li
Yanzhi Li
Shaoyou Xia

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1756041

525 views

Original Research

Published on 27 Jan 2026

Integrating causal human genetics and In vivo transcriptomics to uncover a shared lipid-centric architecture in metabolic and neurocognitive disease

in Molecular Diagnostics and Therapeutics

Yi Li
Zhu Ni
Xiao-Yong Xia
Na Cheng
Yu Bo
Junwen He
Yang He
Xiang-Yu Meng
Xu Wang
Xuan Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1712198

776 views

Original Research

Accepted on 26 Jan 2026

Integrative multi-omics analysis reveals cellular and molecular insights into gestational diabetes mellitus

in Molecular Diagnostics and Therapeutics

Niankun Chen
Lottie Hung
Shaole Shi
Shanshan Zhao
Chumei Zeng
Yihong Huang
Huilin Xu
Lixia Shen
Dongyu Wang
Zilian Wang

Frontiers in Molecular Biosciences

153 views

Review

Published on 23 Jan 2026

S100A12 drives inflammatory and metabolic reprogramming in sepsis-associated acute kidney injury

in Molecular Diagnostics and Therapeutics

Huanqin Liu
Yanan Lv
Qingjie Xue
Jikui Shi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1741799

757 views

Review

Accepted on 21 Jan 2026

Heterogeneous Regulation of Fibroblast Growth Factor 23 in Acute Kidney Injury, Chronic Kidney Disease, and Polycystic Kidney Disease: Mechanisms, Diagnostic Utility, and Clinical Implications

in Molecular Diagnostics and Therapeutics

Xiaohua Hu
Bo Yang
Nanmei Liu
Haimin Chen
Min Min
Cheng Xue

Frontiers in Molecular Biosciences

180 views

Original Research

Published on 20 Jan 2026

Gene expression profiling identifies ferroptosis-related genes and pathways in human colon cancers cell lines

in Molecular Diagnostics and Therapeutics

M. Balik-Meisner
D. Phadke
D. Mav
R. Shah
K. R. Shockley
Carri Murphy
Erik J. Tokar
Birandra K. Sinha

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1680206

894 views

Original Research

Published on 16 Jan 2026

The predictive role of protease-activated receptor (PAR-1) polymorphisms and activated microplatelets on the severity of atherosclerosis – preliminary studies

in Molecular Diagnostics and Therapeutics

Urszula Jakobsche-Policht
Agnieszka Bronowicka-Szydełko
Rajmund Adamiec
Dorota Bednarska-Chabowska
Łukasz Lewandowski
Rafał Małecki
Kinga Gostomska-Pampuch
Joanna Adamiec-Mroczek
Marta Myszka-Kozłowska
Dagmara Baczyńska

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1662954

843 views

Original Research

Published on 16 Jan 2026

Single-cell multi-omics sequencing reveals the immunological disturbance underlying Kawasaki disease

in Molecular Diagnostics and Therapeutics

Xue Fan
Shuang Deng
Yuehao Xu
Bin Wang
Xin Guo
Jinwen Liao
Mingguo Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1758948

888 views

Original Research

Accepted on 15 Jan 2026

A label-free microLC-SWATH-MS methodology with immunoaffinity depletion of high abundant serum proteins for quantitative proteomic comparison of fresh-frozen human normal breast tissue and tumor clinical specimens

in Molecular Diagnostics and Therapeutics

Katarzyna Macur
Aleksandra Ewa Bogucka
Anna Fel-Tukalska
Jarosław Skokowski
Stanisław Ołdziej
Paulina Czaplewska

Frontiers in Molecular Biosciences

372 views

Original Research

Accepted on 15 Jan 2026

Sex-based antibody subclass maturation drives direct enzymatic inhibition in Fabry disease patients receiving enzyme replacement therapy

in Molecular Diagnostics and Therapeutics

Tomas Baldwin
Hibba Kurdi
Ivan Doykov
Stefania Rosmini
Sabrina Nordin
Joao Bicho Augusto
Rebecca Kozor
Julien Colomban Baruteau
James Davison
David Moreno-Martinez

Frontiers in Molecular Biosciences

234 views

Review

Published on 15 Jan 2026

Target temperature management in acute ischemic stroke

in Molecular Diagnostics and Therapeutics

Lan Gao
Ting Yang
Hong Chong
Longfei Wu
Jinming Han

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1728769

957 views

2,138 articles

articles

Optimized RTX Strategy Plus Structured Glucocorticoid Tapering for Primary Membranous Nephropathy: A Multicenter Propensity Score-Matched Cohort Study

Correction: Gasdermin B (GSDMB) in psoriatic patients–a preliminary comprehensive study

Editorial: Advancements in immune heterogeneity in inflammatory diseases and cancer: new targets, mechanisms, and strategies

Artificial Intelligence-Based miRNA Analysis for Precision Oncology: Diagnostic and Prognostic Insights

Integrated Transcriptomic, Protein, and MicroRNA Profiling Reveals a Conserved Pyroptosis-Related Molecular Signature Across Breast Cancer Subtypes

Arsenic trioxide-induced acute kidney injury: OPA1- and Drp1-mediated mitochondrial dynamics imbalance, PINK1/Parkin-dependent mitophagy, and Chuanhuang Fang III

Identification of CXCL12 as a key gene of trophoblast and endometrial stromal cell decidualization in pregnancy via scRNA-seq and experimental validation

Longitudinal profiling of serum ADAM17 across clinical stages in multiple myeloma: a dynamic biomarker and its association with T cell alterations

Pompe disease: a country-wide molecular screening in a cohort of 15,068 study participants

Non-coding RNA transcripts and their exosomal counterparts in the pathogenesis, diagnosis, and treatment of skin cancers, with a focus on melanoma

Mitochondrial Metabolism in Cancer Stem Cells (CSCs): Molecular and Diagnostic Implications

Plasmodium infection fully activates the immune system in peripheral blood and tumor microenvironment in a murine Lewis lung cancer model

Antigen-specific T Cell precursor frequency influences the proliferation of stem-like T Cells in tumor-draining lymph nodes and anti-tumor immune responses

Disulfidptosis-related genes signature predicts prognosis and immune microenvironment in colon cancer

Integrating causal human genetics and In vivo transcriptomics to uncover a shared lipid-centric architecture in metabolic and neurocognitive disease

Integrative multi-omics analysis reveals cellular and molecular insights into gestational diabetes mellitus

S100A12 drives inflammatory and metabolic reprogramming in sepsis-associated acute kidney injury

Heterogeneous Regulation of Fibroblast Growth Factor 23 in Acute Kidney Injury, Chronic Kidney Disease, and Polycystic Kidney Disease: Mechanisms, Diagnostic Utility, and Clinical Implications

Gene expression profiling identifies ferroptosis-related genes and pathways in human colon cancers cell lines

The predictive role of protease-activated receptor (PAR-1) polymorphisms and activated microplatelets on the severity of atherosclerosis – preliminary studies

Single-cell multi-omics sequencing reveals the immunological disturbance underlying Kawasaki disease

A label-free microLC-SWATH-MS methodology with immunoaffinity depletion of high abundant serum proteins for quantitative proteomic comparison of fresh-frozen human normal breast tissue and tumor clinical specimens

Sex-based antibody subclass maturation drives direct enzymatic inhibition in Fabry disease patients receiving enzyme replacement therapy

Target temperature management in acute ischemic stroke