Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 15 Jan 2026

A novel tumor-progressing fibroblast signature derived from single-cell RNA sequencing enables prognostic stratification and reveals RNF11 as a functional regulator in bladder cancer

in Molecular Diagnostics and Therapeutics

Miaoyu Zhang
Liangbin Lin
He Xu
Xu Su
Kui Zeng
Fangyang Zhong
Xianchao Su
Jie Chen
Min Cao
Hui Yu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1722809

934 views

Original Research

Published on 15 Jan 2026

Exploring the risk stratification of carotid plaque hemodynamic using four-dimensional blood flow technology

in Molecular Diagnostics and Therapeutics

Si-yuan Zhang
Hong-liang Zhao
Xiao-wei Song
Jian Wu
Rui Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1685377

787 views

Original Research

Published on 12 Jan 2026

Construction and validation of a predictive model for hypothermia complication during endoscopic thyroidectomy for thyroid cancer

in Molecular Diagnostics and Therapeutics

Hui Ye
Lu Xia
Tian Zhan
Haiwei Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1758239

689 views

Original Research

Published on 12 Jan 2026

Identification of DNASE1L3 as a novel biomarker of clinical stage in liver hepatocellular carcinoma

in Molecular Diagnostics and Therapeutics

Weina Xue
Shuying Xie
Tong Wu
Ruixi Li
Dingyan Lu
Shuaishuai Chen
Yue Xu
Yonglin Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1681888

897 views

Review

Published on 12 Jan 2026

Liquid biopsy in cancer diagnosis and prognosis: a paradigm shift in precision oncology

in Molecular Diagnostics and Therapeutics

Rayane da Silva Abreu
Danielle Dias Pinto Ferreira
Natassia Silva de Araujo
Samuel Horita
Tatiana Martins Tilli
Wim Degrave
Aline dos Santos Moreira
Mariana Caldas Waghabi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1708518

1,986 views

Original Research

Published on 12 Jan 2026

JAK-centric explainable few-shot gene-expression diagnosis framework for alopecia via MultiPLIER priors and relation-style set-to-set comparison

in Molecular Diagnostics and Therapeutics

Nanlan Yu
Ling Ran
Xinrong Gong
Junfei Teng
Shulei Liu
Zhiqiang Song

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1753206

1,035 views

Original Research

Published on 08 Jan 2026

A novel prognostic model based on epithelial cell progression genes identifies OAS1 as a suppressor of bladder cancer aggressiveness

in Molecular Diagnostics and Therapeutics

Xu Su
Hui Yu
Miaoyu Zhang
Kui Zeng
Fangyang Zhong
Xuerui Chen
Yuanbiao Guo
Liangbin Lin

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1716130

1,049 views

Original Research

Published on 08 Jan 2026

Glycine attenuates sepsis-induced white matter injury by modulating gut microbiota

in Molecular Diagnostics and Therapeutics

Jingfei Liu
Li Zhang
Chunyang Feng
Ye Li
Huiling Wu
Xueer Wang
Dong Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1733207

1,351 views

Review

Published on 07 Jan 2026

Research progress on oral glucagon-like peptide-1 receptor agonists in the treatment of diabetes mellitus type 2

in Molecular Diagnostics and Therapeutics

Qian Shao
Juan Xiong
Jing Wu
Jingxin Mao
Qing Hu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1729904

1,436 views

Original Research

Published on 07 Jan 2026

Hypoxia-induced immunosuppression in uveal melanoma is mediated by CD63+ exosomes delivering lactate to reprogram immune cells

in Molecular Diagnostics and Therapeutics

Lei Dong
Suilian Zheng
Yixia Feng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1743009

1,053 views

Original Research

Published on 07 Jan 2026

Herbal monomer–based therapeutic insights from traditional Chinese medicine in myocardial infarction

in Molecular Diagnostics and Therapeutics

Nan Bian
Libo Xia
Xianqiu Xiong
Yingyu Chen
Ying Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1721931

1,044 views

Review

Published on 06 Jan 2026

Strategies of AAV capsid engineering for targeted delivery to brain, muscle, and retina

in Molecular Diagnostics and Therapeutics

Xinyuan Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1750807

1,969 views

Original Research

Published on 06 Jan 2026

Advancing Trypanosoma cruzi N-myristoyltransferase as a drug target for Chagas disease through in silico discovery and biochemical evaluation

in Molecular Diagnostics and Therapeutics

Diana González García
Angel Torres
Alan Talevi
Lucas N. Alberca
Miguel A. Beltran
Frida Lara
Marina Da Silva Ferreira
Priscila S. G. Farani
Igor C. Almeida
Rosa A. Maldonado

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1666768

1,252 views

Editorial

Published on 05 Jan 2026

Editorial: Overcoming resistance in DDR inhibition: new targets and therapeutic strategies

in Molecular Diagnostics and Therapeutics

Chi-Lin Tsai
Ana Cristina Gonçalves
Zamal Ahmed

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1766744

930 views

Original Research

Published on 02 Jan 2026

Mechanistic study of glutamine metabolic reprogramming driving non-small cell lung cancer progression via the FGF17-FGFR4 axis mediating epithelial-mesenchymal transition

in Molecular Diagnostics and Therapeutics

Qinghua Kong
Xiaoyan Wang
Wei Ding

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1728698

1,094 views

Original Research

Accepted on 29 Dec 2025

An Interpretability Heart Disease Prediction Model Based on Stacking Ensemble with SHAP

in Molecular Diagnostics and Therapeutics

Yanjie Chen
Liqiang Chong
Zhenghao Bao
Shaoqiang Wang
Yuchen Wang
Yanan Feng

Frontiers in Molecular Biosciences

297 views

Review

Published on 19 Dec 2025

Galectin-3 in acute myocardial infarction: from molecular mechanisms to clinical translation

in Molecular Diagnostics and Therapeutics

Tingting Liu
Fang Yang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1730173

1,978 views

Review

Published on 18 Dec 2025

Methods for telomere length measurement: an update on current technologies and emerging approaches

in Molecular Diagnostics and Therapeutics

Julia A. Makarova
Uliana D. Belova
Maria I. Zvereva
Maxim Yu. Shkurnikov
Alexander G. Tonevitsky

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1725112

2,442 views

Original Research

Published on 18 Dec 2025

Single-cell dissection of PTM-related networks reveals an immunosuppressed osteosarcoma ecosystem

in Molecular Diagnostics and Therapeutics

Jingyu Chen
Wei Zhang
Hai Yan
Jinyu Chen
Hanrui Liu
Xingyu Zhou
Haiping Zhang
Dongdong Cheng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1718941

1,305 views

Original Research

Published on 18 Dec 2025

Machine learning-assisted network pharmacology reveals that the Chaihu-Longgu-Muli decoction modulates the inflammatory microenvironment to treat perimenopausal syndrome

in Molecular Diagnostics and Therapeutics

Puiian Wong
Ruoyu Li
Ding Li
Bin Fang
Yun Lan
Yuhang Qi
Jiaqian Zheng
Hui Mo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1719463

1,479 views

Review

Published on 18 Dec 2025

Bridging ancient wisdom and modern technology: an AI and multi-omics framework for three causes tailored treatment in personalized medicine

in Molecular Diagnostics and Therapeutics

Xuewen Diao
Hao Zhang
Shiqi Wang
Qi Zhang
Zulong Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1732340

1,566 views

Original Research

Published on 17 Dec 2025

Integrative proteomics reveals mitochondrial and immune signatures of MLH1 exon 13 deletion in Lynch syndrome–associated colorectal cancer

in Molecular Diagnostics and Therapeutics

Chen Chang
Yue Cao
Bin Zhang
Jingli Chen
Lin Chen
Wensheng Li
Guorong Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1722111

1,306 views

Original Research

Published on 17 Dec 2025

Asparagine-related biomarkers and regulatory mechanisms in type 2 diabetes mellitus

in Molecular Diagnostics and Therapeutics

Jiayi Xia
Tao Cai
Peiyin Chen
Lu Gan
Bo Cao
Mingming Kong

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1733878

1,254 views

Review

Published on 16 Dec 2025

Molecular roles of microRNA-21 and exosomal miR-21 in gastrointestinal cancers: diagnostic, therapeutic, and drug resistance insights

in Molecular Diagnostics and Therapeutics

Chunguang Wang
Meiling Bai
Xingliang Liu
Zhijun Li
Haibin Wang
Shengbin Guo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1697875

1,772 views

2,138 articles

articles

A novel tumor-progressing fibroblast signature derived from single-cell RNA sequencing enables prognostic stratification and reveals RNF11 as a functional regulator in bladder cancer

Exploring the risk stratification of carotid plaque hemodynamic using four-dimensional blood flow technology

Construction and validation of a predictive model for hypothermia complication during endoscopic thyroidectomy for thyroid cancer

Identification of DNASE1L3 as a novel biomarker of clinical stage in liver hepatocellular carcinoma

Liquid biopsy in cancer diagnosis and prognosis: a paradigm shift in precision oncology

JAK-centric explainable few-shot gene-expression diagnosis framework for alopecia via MultiPLIER priors and relation-style set-to-set comparison

A novel prognostic model based on epithelial cell progression genes identifies OAS1 as a suppressor of bladder cancer aggressiveness

Glycine attenuates sepsis-induced white matter injury by modulating gut microbiota

Research progress on oral glucagon-like peptide-1 receptor agonists in the treatment of diabetes mellitus type 2

Hypoxia-induced immunosuppression in uveal melanoma is mediated by CD63+ exosomes delivering lactate to reprogram immune cells

Herbal monomer–based therapeutic insights from traditional Chinese medicine in myocardial infarction

Strategies of AAV capsid engineering for targeted delivery to brain, muscle, and retina

Advancing Trypanosoma cruzi N-myristoyltransferase as a drug target for Chagas disease through in silico discovery and biochemical evaluation

Editorial: Overcoming resistance in DDR inhibition: new targets and therapeutic strategies

Mechanistic study of glutamine metabolic reprogramming driving non-small cell lung cancer progression via the FGF17-FGFR4 axis mediating epithelial-mesenchymal transition

An Interpretability Heart Disease Prediction Model Based on Stacking Ensemble with SHAP

Galectin-3 in acute myocardial infarction: from molecular mechanisms to clinical translation

Methods for telomere length measurement: an update on current technologies and emerging approaches

Single-cell dissection of PTM-related networks reveals an immunosuppressed osteosarcoma ecosystem

Machine learning-assisted network pharmacology reveals that the Chaihu-Longgu-Muli decoction modulates the inflammatory microenvironment to treat perimenopausal syndrome

Bridging ancient wisdom and modern technology: an AI and multi-omics framework for three causes tailored treatment in personalized medicine

Integrative proteomics reveals mitochondrial and immune signatures of MLH1 exon 13 deletion in Lynch syndrome–associated colorectal cancer

Asparagine-related biomarkers and regulatory mechanisms in type 2 diabetes mellitus

Molecular roles of microRNA-21 and exosomal miR-21 in gastrointestinal cancers: diagnostic, therapeutic, and drug resistance insights