Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 21 Nov 2025

SOX2 induces LPCAT1 expression to promote cholesterol metabolic reprogramming-mediated invasion and metastasis in osteosarcoma

in Molecular Diagnostics and Therapeutics

Linchao Zhu
Ying Sun

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1679244

681 views

Original Research

Published on 21 Nov 2025

Prognostic model for lung adenocarcinoma based on experimental drug-resistant cell lines and clinical patients

in Molecular Diagnostics and Therapeutics

Junnan Li
Jiasheng Zhang
Xinyang Zhang
Chengwu Cao
Tianjie Zhou
Fengxian Liu
Liqing Hu
Hang Fai Kwok
Hui Zou

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1654426

1,011 views

Original Research

Published on 20 Nov 2025

Multi-omics integration analysis based on plasma circulating proteins reveals potential therapeutic targets for ulcerative colitis

in Molecular Diagnostics and Therapeutics

Jihai Zhou
Wenwen Zhao
Yiping Lin
Bo Yang
Dongjie Sun
Zhu Liu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1686282

1,344 views

Original Research

Published on 19 Nov 2025

Progressively exploring and assessing the prognosis of bladder urothelial cancer based on the microenvironment through the integration of multiple databases

in Molecular Diagnostics and Therapeutics

Xiong Zou
Yanfeng Li
Xuefeng Peng
Changshi Gu
Qiang Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1702311

767 views

Editorial

Published on 17 Nov 2025

Editorial: In vitro transcription (IVT) reaction – the gateway to new therapeutic modalities

in Molecular Diagnostics and Therapeutics

Rok Sekirnik
Andreas N. Kuhn
Ana Margarida Azevedo
Zoltán Kis

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1730880

1,879 views

Original Research

Published on 17 Nov 2025

A prognostic nomogram for predicting overall survival in gastric signet ring cell carcinoma patients: a SEER database and Chinese registry analysis

in Molecular Diagnostics and Therapeutics

Jie Wu
Jichen Wang
Ning Chen
Junjie Nie
Ling Xia
Quanpeng Li
Xueting Deng
Guozhong Ji

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1704157

887 views

Original Research

Accepted on 14 Nov 2025

Exploring the risk stratification of carotid plaque hemodynamic based on four-dimensional blood flow technology

in Molecular Diagnostics and Therapeutics

Siyuan Zhang
Hong-liang Zhao
Xiaowei Song
Jian Wu
Rui Li

Frontiers in Molecular Biosciences

189 views

Original Research

Published on 14 Nov 2025

Investigating the molecular mechanisms of resveratrol in treating diabetic foot ulcers: a comprehensive analysis of network pharmacology and experiment validation

in Molecular Diagnostics and Therapeutics

Chao Sima
Zhe Wang
Sisi Wang
Haiyang Wang
Zhonghua Sun
Haoguo Wang
Daning Liang
Jianchi Li
Zhenning Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1708426

1,442 views

Review

Published on 13 Nov 2025

Advances in 3D bioprinting for modeling the blood-brain barrier in neurodegenerative diseases

in Molecular Diagnostics and Therapeutics

Shirleen Tan
Lifeng Qiu
Jolene Wei Ling Lee
Li Zeng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1703403

2,221 views

Original Research

Published on 11 Nov 2025

Identification and validation of potential shared diagnostic markers for sepsis-induced ARDS and cardiomyopathy via WGCNA and machine learning

in Molecular Diagnostics and Therapeutics

Jing Wei
Baoyue Huang
Kunlin Hu
Bin Xiong
Shulin Xiang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1665387

1,984 views

Editorial

Published on 10 Nov 2025

Editorial: Molecular underpinnings of genetic and rare diseases: from diagnostic tools to therapeutic approaches

in Molecular Diagnostics and Therapeutics

Abhilash Kumar Tripathi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1722468

927 views

Review

Published on 10 Nov 2025

SOX9: a novel janus-faced regulator in immunity and its promise as a therapeutic target

in Molecular Diagnostics and Therapeutics

Qian Shi
Shouyu He

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1700812

2,286 views

Original Research

Published on 07 Nov 2025

STAT3 as a critical target of Sijunzi Decoction in the treatment of gastric cancer: evidence from integrated network pharmacology and experimental validation

in Molecular Diagnostics and Therapeutics

XiaoYu Luo
GuiPing Xie
QianYing Tan
YaoHui Wang
HaiDan Wang
Jing Zhai

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1683806

1,027 views

Editorial

Published on 07 Nov 2025

Editorial: Estrogens and neurodegeneration: a link between menopause and Alzheimer’s disease in women

in Molecular Diagnostics and Therapeutics

Manuela Leri
Andrea Bertolini
Mario Diaz
Roberta Marongiu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1727385

957 views

Original Research

Accepted on 04 Nov 2025

A Data-Driven AI Framework for Personalized Diagnosis, Prognosis, and Therapeutic Optimization in Chronic Disease Management Using Multimodal Big Data Analytics

in Molecular Diagnostics and Therapeutics

Qi Cai

Frontiers in Molecular Biosciences

301 views

Original Research

Published on 03 Nov 2025

A diagnostic RNA sequencing assay for direct identification and interpretation of pathogenic variants in the FBN1 gene

in Molecular Diagnostics and Therapeutics

Manal Irshaid
Ghadeera Al Mansoori
Mohamed Sulaiman
Asjed Mohamed
Mohammed Abdoh
Youssef M. Shalaby
Bashar Al-Zohily
Aalia Batool
Sara Aleissaee
Lara Alzyoud

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1693943

1,507 views

Original Research

Published on 03 Nov 2025

Immunomodulatory effect of betulin and its derivatives on IL-6 expression in colorectal cancer cell lines and molecular docking insights

in Molecular Diagnostics and Therapeutics

Marcel Madej
Adrianna Halama
Elwira Chrobak
Ewa Bębenek
Joanna Magdalena Gola

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1704804

1,184 views

Original Research

Accepted on 31 Oct 2025

Advancing Trypanosoma cruzi N-Myristoyltransferase as a Drug Target for Chagas Disease through In Silico Discovery and Biochemical Evaluation

in Molecular Diagnostics and Therapeutics

Diana C. Gonzalez-Garcia
Angel Torres
Alan Talevi
Lucas N. Alberca
Miguel A. Beltran
Frida Lara
Marina da Silva Ferreira
Priscila Silva Grijó Farani
Igor C Almeida
Rosa Amelia Maldonado

Frontiers in Molecular Biosciences

322 views

Editorial

Published on 31 Oct 2025

Editorial: Bioinformatics and systems biology strategies in disease management with a special emphasis on cancer, Alzheimer’s disease and aging

in Molecular Diagnostics and Therapeutics

Tiratha Raj Singh
Brigitte Vannier
Ragini Raj Singh
Hari Om Yadav
Holger Fröhlich

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1725000

1,092 views

Mini Review

Published on 31 Oct 2025

RNA-based therapies for neurodevelopmental disorders: innovative tools for molecular correction

in Molecular Diagnostics and Therapeutics

Denise Drongitis
Lucia Verrillo
Alberto de Bellis
Maria Giuseppina Miano

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1681647

2,097 views

Review

Published on 30 Oct 2025

Immunological landscape of colorectal cancer: tumor microenvironment, cellular players and immunotherapeutic opportunities

in Molecular Diagnostics and Therapeutics

Adile Buse Andac-Aktas
Gizem Calibasi-Kocal

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1687556

2,509 views

Original Research

Published on 29 Oct 2025

Identification and validation of mitochondrial-related genes in intestinal ischemia-reperfusion injury based on WGCNA and machine learning

in Molecular Diagnostics and Therapeutics

YiChen Hu
Jie Huang
XiaoLi Min
YuanPei Zhao
JiaHui Wang
HongYuan Liu
KaiWen Shi
WenLiang Li
WeiMing Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1691749

1,394 views

Review

Published on 29 Oct 2025

Niche-specific epigenetic interventions in the spatially heterogeneous glioblastoma microenvironmental landscape: strategies for radiotherapy enhancement

in Molecular Diagnostics and Therapeutics

Junjie Wang
Kunjie Li
Yongzhe Wang
Junyi Zhang
Xin Peng
Ning Ji

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1704311

1,969 views

Review

Published on 28 Oct 2025

Dual-regulatory miRNAs: master regulators and therapeutic targets in bone-metastatic breast cancer

in Molecular Diagnostics and Therapeutics

Feifei Meng
Mengdi Zhang
Dongqing Pu
Guangxi Shi
Jingwei Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1680908

1,059 views

2,097 articles

articles

SOX2 induces LPCAT1 expression to promote cholesterol metabolic reprogramming-mediated invasion and metastasis in osteosarcoma

Prognostic model for lung adenocarcinoma based on experimental drug-resistant cell lines and clinical patients

Multi-omics integration analysis based on plasma circulating proteins reveals potential therapeutic targets for ulcerative colitis

Progressively exploring and assessing the prognosis of bladder urothelial cancer based on the microenvironment through the integration of multiple databases

Editorial: In vitro transcription (IVT) reaction – the gateway to new therapeutic modalities

A prognostic nomogram for predicting overall survival in gastric signet ring cell carcinoma patients: a SEER database and Chinese registry analysis

Exploring the risk stratification of carotid plaque hemodynamic based on four-dimensional blood flow technology

Investigating the molecular mechanisms of resveratrol in treating diabetic foot ulcers: a comprehensive analysis of network pharmacology and experiment validation

Advances in 3D bioprinting for modeling the blood-brain barrier in neurodegenerative diseases

Identification and validation of potential shared diagnostic markers for sepsis-induced ARDS and cardiomyopathy via WGCNA and machine learning

Editorial: Molecular underpinnings of genetic and rare diseases: from diagnostic tools to therapeutic approaches

SOX9: a novel janus-faced regulator in immunity and its promise as a therapeutic target

STAT3 as a critical target of Sijunzi Decoction in the treatment of gastric cancer: evidence from integrated network pharmacology and experimental validation

Editorial: Estrogens and neurodegeneration: a link between menopause and Alzheimer’s disease in women

A Data-Driven AI Framework for Personalized Diagnosis, Prognosis, and Therapeutic Optimization in Chronic Disease Management Using Multimodal Big Data Analytics

A diagnostic RNA sequencing assay for direct identification and interpretation of pathogenic variants in the FBN1 gene

Immunomodulatory effect of betulin and its derivatives on IL-6 expression in colorectal cancer cell lines and molecular docking insights

Advancing Trypanosoma cruzi N-Myristoyltransferase as a Drug Target for Chagas Disease through In Silico Discovery and Biochemical Evaluation

Editorial: Bioinformatics and systems biology strategies in disease management with a special emphasis on cancer, Alzheimer’s disease and aging

RNA-based therapies for neurodevelopmental disorders: innovative tools for molecular correction

Immunological landscape of colorectal cancer: tumor microenvironment, cellular players and immunotherapeutic opportunities

Identification and validation of mitochondrial-related genes in intestinal ischemia-reperfusion injury based on WGCNA and machine learning

Niche-specific epigenetic interventions in the spatially heterogeneous glioblastoma microenvironmental landscape: strategies for radiotherapy enhancement

Dual-regulatory miRNAs: master regulators and therapeutic targets in bone-metastatic breast cancer