Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Accepted on 11 Jul 2025

TOP2A as a Prognostic Biomarker in Small Cell Carcinoma of the Esophagus: An Integrated Bioinformatics and Immunohistochemical Study

in Molecular Diagnostics and Therapeutics

Xiaolei Yin
Xiaopeng Li
Lili Mi
Jiaojiao Hou
Fei Yin

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1640881

Original Research

Published on 11 Jul 2025

Targeting USP42 induces DNA damage and inhibits cell growth in prostate cancer

in Molecular Diagnostics and Therapeutics

Yinghao Zhou
Chenchen Chen
Yibo Meng
Jianchao Ge
Shengkui Meng
Xillong Wang
Yaozong Xu
Guowei Shi
Wandong Yu
Xuetao Hu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1646331

286 views

Original Research

Published on 11 Jul 2025

Integrated network pharmacology and in vivo experiments to reveal the anti-inflammatory mechanism of Qinghuo Rougan Formula in uveitis

in Molecular Diagnostics and Therapeutics

Changying Jing
Yaqi Sun
Hongsheng Bi
Junguo Guo
Cong Ren
Jike Song
Beibei Wang
Qingmei Tian
Dadong Guo
Pengjuan He

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1632027

532 views

Original Research

Published on 11 Jul 2025

ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas

in Molecular Diagnostics and Therapeutics

Xiaodong Shao
Shaolei Guo
Jia Yang
Junjie Dai
Kaihua Cao
Xia Cai
Tianshi Song
Shun Yao
Umar Raza
Kun Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1640038

276 views

Review

Published on 11 Jul 2025

Review of research progress in sepsis-associated acute kidney injury

in Molecular Diagnostics and Therapeutics

Wanning Nian
Weichen Tao
Haiyi Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1603392

345 views

Original Research

Published on 10 Jul 2025

An automatic laryngoscopic image segmentation system based on SAM prompt engineering: from glottis annotation to vocal fold segmentation

in Molecular Diagnostics and Therapeutics

Yucong Zhang
Yuchen Song
Juan Liu
Ming Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1616271

191 views

Original Research

Published on 10 Jul 2025

Value of the 14-gene molecular assay in efficacy assessment of neoadjuvant chemoimmunotherapy for non-small cell lung cancer

in Molecular Diagnostics and Therapeutics

Xuyan Lan
Xiaoyu Sun
Ruiqi Chen
Lihuan Zhu
Xiaojie Pan
Tianxing Guo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1619139

269 views

Original Research

Accepted on 08 Jul 2025

Comprehensive analysis of tryptophan metabolism-related gene signature to predict prognosis in Esophageal squamous cell carcinoma based on Multi-omics

in Molecular Diagnostics and Therapeutics

Zhengjie Wu
Zhiping Liu
Yukun Wang
Geling Teng
Xiaodong Li
Tong Lu
Fangning Hu
Shuo Wu
Guanqiang Ma
Hua Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1613539

Review

Accepted on 07 Jul 2025

The Role of Epigenetics in Pulmonary Fibrosis: Recent Advances in Mechanistic Insights and Therapeutic Implications

in Molecular Diagnostics and Therapeutics

Ao Shen
Jingru Huang
Jianfeng Qin
Yuguang Zhu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1647300

173 views

Original Research

Accepted on 07 Jul 2025

Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes

in Molecular Diagnostics and Therapeutics

Yue Cheng
Ran Ren
Yu Xu
Shaofeng Duan
Jilei Zhang
Zhongyuan Bao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1635296

184 views

Original Research

Published on 07 Jul 2025

Gene expression profiling of human umbilical vein endothelial cells overexpressing CELF2 as diagnostic targets in diabetes-induced erectile dysfunction

in Molecular Diagnostics and Therapeutics

Daniyaer Nuerdebieke
Lizhong Yao
Lange Guo
Jiuzhi Li
Hongliang Jia
Yukui Nan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1596534

318 views

Original Research

Published on 04 Jul 2025

Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues

in Molecular Diagnostics and Therapeutics

Yufan Sheng
Sen Niu
Da Li
Chunyuan Meng
Tong Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1605117

656 views

Original Research

Published on 03 Jul 2025

A nomogram model based on tumor necrosis factor-like ligand 1A(TL1A) and death receptor-3(DR3) promoter methylation for predicting 90-day prognosis in patients with HBV-associated acute-on-chronic liver failure

in Molecular Diagnostics and Therapeutics

Xue-Fei Wei
Feng Zhang
Han-Xu Zhu
Zhe-Zhe Tian
Miao-Miao Xu
Yu-Chen Fan
Kai Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1614311

359 views

Original Research

Accepted on 02 Jul 2025

Maternal plasma microRNA profiles in twin-twin transfusion syndrome and normal monochorionic twin pregnancies

in Molecular Diagnostics and Therapeutics

Steven Papastefan
Morgan M Langereis
Catherine Redden
Daniel R Liesman
Cassandra Huerta
Lucas E Turner
Hee Kap Kang
Bethany T Stetson
Katherine C. Ott
William S Marriott

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1597215

Original Research

Published on 01 Jul 2025

Clinicopathologic and proteomic characteristics of low-grade undifferentiated spindle cell sarcoma

in Molecular Diagnostics and Therapeutics

Yani Wei
Hongjun Li
Shujin He
Min Li
Yongyu Chen
Huijuan Shi
Anjia Han

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1591644

414 views

Review

Accepted on 30 Jun 2025

Structure, function, and pathology of PHF23

in Molecular Diagnostics and Therapeutics

Linlin Liu
Yu Liu
Rui Liu
Gangming Wu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1625962