Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 12 Dec 2025

Tirzepatide modulates gut microbiota homeostasis to protect against diabetic kidney disease

in Molecular Diagnostics and Therapeutics

Jun Ma
Mengyuan Tao
Wencheng Zhang
Li Zhou
Henglu Zhang
Fei Li
Hongman Zhang
Di Yao
Weiping Lu
Min Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1715024

2,065 views
1 citation

Editorial

Published on 11 Dec 2025

Editorial: Distinct phenotype but same genotype: hints for the diversity of phenotypes in ciliopathies

in Molecular Diagnostics and Therapeutics

John A. Sayer
Heymut Omran
Ewa Zietkiewicz

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1753098

711 views

Review

Published on 11 Dec 2025

Recent advances in applications of artificial intelligence-assisted Raman spectroscopy in diagnosis of cancers

in Molecular Diagnostics and Therapeutics

Xinran Zhu
Yanfu Zhao
Chunfang Zan
He Ma
Jingxin Liu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1690063

1,463 views
2 citations

Review

Published on 10 Dec 2025

Targeting microRNA-143 in colorectal cancer: advances in molecular biosciences for biomarker-based diagnostics, therapeutic strategies, and drug resistance prediction

in Molecular Diagnostics and Therapeutics

Xue Wang
Lei Wang
Long Ke

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1679533

1,173 views
1 citation

Original Research

Published on 10 Dec 2025

Glycoprotein M6B suppresses the maintenance of glioma stem cell stemness and proliferation via the integrin β1/β-catenin pathway

in Molecular Diagnostics and Therapeutics

Yanwen Chen
Yu Fan
Xingda Run
Maotang Liu
Shiwei Jiang
Zengli Miao
Wei Tian

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1731116

1,117 views

Original Research

Published on 10 Dec 2025

Evaluation of changes in plasma levels of MMP-8, MMP-13, and Thrombospondin 2 in patients with Osgood–Schlatter disease (OSD)

in Molecular Diagnostics and Therapeutics

Monika Kulesza
Tomasz Guszczyn
Aleksandra Kicman
Rafał Marecki
Michał Stanisław Kicman
Sławomir Ławicki

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1703728

701 views

Original Research

Published on 10 Dec 2025

Diagnostic utility of IBEX Bone Health for assessment of osteoporosis from knee radiographs

in Molecular Diagnostics and Therapeutics

Robert Meertens
Ben Lopez
Mike Gundry
Ben Crone
Wavell Vigers
Michelle Evans
Richard McWilliam
Sarah Jarvis

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1671053

797 views

Original Research

Published on 09 Dec 2025

Comparative analysis of lipid metabolism in trophoblast subpopulations in preeclampsia and in vitro hypoxia model

in Molecular Diagnostics and Therapeutics

Ivan Antipenko
Evgeny Knyazev
Timur Kulagin
Alexander Tonevitsky

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1731126

1,629 views

Correction

Published on 09 Dec 2025

Correction: Development of a prognostic model for early-stage gastric cancer-related DNA methylation-driven genes and analysis of immune landscape

in Molecular Diagnostics and Therapeutics

Chen Su
Zeyang Lin
Zhijian Ye
Jing Liang
Rong Yu
Zheng Wan
Jingjing Hou

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1658908

864 views

Original Research

Published on 08 Dec 2025

Sex-dependent alterations of salivary microbiome in Parkinson’s disease: associations with motor and non-motor clinical phenotypes

in Molecular Diagnostics and Therapeutics

Jie Zu
Wei Zhang
Li Du
Hui Zhao
Min Xu
Ruyi Chen
Yuting Zhang
Siyan Chen
Chuanying Xu
Liguo Dong

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1726620

1,001 views

Original Research

Published on 08 Dec 2025

Limitations of PICADAR as a diagnostic predictive tool for primary ciliary dyskinesia

in Molecular Diagnostics and Therapeutics

Andre Schramm
Johanna Raidt
Sarah Riepenhausen
Caroline Marie Torp Nygaard
Retno Tenardi-Wenge
Tavs Qvist
Pernille Witt
Michael Storck
Heike Olbrich
Kim Gjerum Nielsen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1691758

2,601 views

Original Research

Published on 05 Dec 2025

Development of a novel diagnostic model for Alzheimer’s disease based on glymphatic system and metabolism-related genes

in Molecular Diagnostics and Therapeutics

Ailing Jiang
Danli Shi
Xianting Que
Ziqun Lin
Yanlan Chen
Yanzhen Huang
Chao Liu
Yishuang Wen
Shuyi Zhang
Wen Huang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1585761

1,695 views

Review

Published on 04 Dec 2025

Non-invasive exposure biomarkers of tobacco smoke exposure in smokers of classic cigarettes and users of e-cigarettes and heated tobacco products

in Molecular Diagnostics and Therapeutics

Kamila Jończyk
Aleksandra Kicman
Anna Michalska-Falkowska
Justyna Śniadach
Napoleon Waszkiewicz

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1675523

1,234 views

Original Research

Published on 03 Dec 2025

Exploring the interaction mechanisms of CD46/TREM1 and LC3B/ATG5 in the inflammation-cancer transformation of oral squamous cell carcinoma based on bioinformatics

in Molecular Diagnostics and Therapeutics

Huixian Xie
Yingjie Xu
Beibei Cong
Meihua Gao
Wanchun Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1713632

1,050 views
1 citation

Editorial

Published on 02 Dec 2025

Editorial: Emerging trends in cancer research: diagnostic and therapeutic breakthroughs

in Molecular Diagnostics and Therapeutics

Valentyn Oksenych
Oleksandr Kamyshnyi
Rostyslav Bilyy

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1750771

1,156 views

Original Research

Published on 02 Dec 2025

TRAP1 induced cisplatin resistance in gastric cancer cells by regulating oxidative stress

in Molecular Diagnostics and Therapeutics

Zhenglei Ji
Lu Liu
Jingya Chen
Wanjing Zhu
Yunli Zhao
Huazhang Wu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1676811

1,019 views
1 citation

Retraction

Published on 28 Nov 2025

Retraction: Resveratrol improves mitochondrial biogenesis function and activates PGC-1α pathway in a preclinical model of early brain injury following subarachnoid hemorrhage

in Molecular Diagnostics and Therapeutics

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1751510

841 views

Editorial

Published on 27 Nov 2025

Editorial: New insights into oxidative medicine: unraveling the complexity of oxidative stress in health and disease

in Molecular Diagnostics and Therapeutics

Claudia Fiorillo
Amir M. Alsharabasy
Matteo Becatti

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1743079

943 views

Review

Published on 26 Nov 2025

Physiological and molecular mechanisms of tolerance to hypoxia and oxygen deficiency resistance markers

in Molecular Diagnostics and Therapeutics

Maria Silina
Dzhuliia Dzhalilova
Nikolai Fokichev
Olga Makarova

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1674608

1,582 views
1 citation

Original Research

Published on 24 Nov 2025

Decoding the peripheral transcriptomic and meta-genomic response to music in autism spectrum disorder via saliva-based RNA sequencing

in Molecular Diagnostics and Therapeutics

Andrea Cavenaghi
Nour El Zahraa Mallah
Laura Navarro
Federico Martinón-Torres
Alberto Gómez-Carballa
Antonio Salas

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1696704

2,137 views

Original Research

Published on 24 Nov 2025

Quantitative proteomic analysis reveals potential serum diagnostic markers for colorectal adenoma

in Molecular Diagnostics and Therapeutics

Chengli Yu
Xin Huang
Yating Cao
Qiuxia Yang
Ting Liu
Jingjie Zhou
Juping You
Ye Zhang
Ailing Yin
Haibing Hua

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1628587

1,131 views

Original Research

Published on 21 Nov 2025

SOX2 induces LPCAT1 expression to promote cholesterol metabolic reprogramming-mediated invasion and metastasis in osteosarcoma

in Molecular Diagnostics and Therapeutics

Linchao Zhu
Ying Sun

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1679244

1,003 views

Original Research

Published on 21 Nov 2025

Prognostic model for lung adenocarcinoma based on experimental drug-resistant cell lines and clinical patients

in Molecular Diagnostics and Therapeutics

Junnan Li
Jiasheng Zhang
Xinyang Zhang
Chengwu Cao
Tianjie Zhou
Fengxian Liu
Liqing Hu
Hang Fai Kwok
Hui Zou

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1654426

1,552 views

Original Research

Published on 20 Nov 2025

Multi-omics integration analysis based on plasma circulating proteins reveals potential therapeutic targets for ulcerative colitis

in Molecular Diagnostics and Therapeutics

Jihai Zhou
Wenwen Zhao
Yiping Lin
Bo Yang
Dongjie Sun
Zhu Liu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1686282

3,086 views

2,138 articles

articles

Tirzepatide modulates gut microbiota homeostasis to protect against diabetic kidney disease

Editorial: Distinct phenotype but same genotype: hints for the diversity of phenotypes in ciliopathies

Recent advances in applications of artificial intelligence-assisted Raman spectroscopy in diagnosis of cancers

Targeting microRNA-143 in colorectal cancer: advances in molecular biosciences for biomarker-based diagnostics, therapeutic strategies, and drug resistance prediction

Glycoprotein M6B suppresses the maintenance of glioma stem cell stemness and proliferation via the integrin β1/β-catenin pathway

Evaluation of changes in plasma levels of MMP-8, MMP-13, and Thrombospondin 2 in patients with Osgood–Schlatter disease (OSD)

Diagnostic utility of IBEX Bone Health for assessment of osteoporosis from knee radiographs

Comparative analysis of lipid metabolism in trophoblast subpopulations in preeclampsia and in vitro hypoxia model

Correction: Development of a prognostic model for early-stage gastric cancer-related DNA methylation-driven genes and analysis of immune landscape

Sex-dependent alterations of salivary microbiome in Parkinson’s disease: associations with motor and non-motor clinical phenotypes

Limitations of PICADAR as a diagnostic predictive tool for primary ciliary dyskinesia

Development of a novel diagnostic model for Alzheimer’s disease based on glymphatic system and metabolism-related genes

Non-invasive exposure biomarkers of tobacco smoke exposure in smokers of classic cigarettes and users of e-cigarettes and heated tobacco products

Exploring the interaction mechanisms of CD46/TREM1 and LC3B/ATG5 in the inflammation-cancer transformation of oral squamous cell carcinoma based on bioinformatics

Editorial: Emerging trends in cancer research: diagnostic and therapeutic breakthroughs

TRAP1 induced cisplatin resistance in gastric cancer cells by regulating oxidative stress

Retraction: Resveratrol improves mitochondrial biogenesis function and activates PGC-1α pathway in a preclinical model of early brain injury following subarachnoid hemorrhage

Editorial: New insights into oxidative medicine: unraveling the complexity of oxidative stress in health and disease

Physiological and molecular mechanisms of tolerance to hypoxia and oxygen deficiency resistance markers

Decoding the peripheral transcriptomic and meta-genomic response to music in autism spectrum disorder via saliva-based RNA sequencing

Quantitative proteomic analysis reveals potential serum diagnostic markers for colorectal adenoma

SOX2 induces LPCAT1 expression to promote cholesterol metabolic reprogramming-mediated invasion and metastasis in osteosarcoma

Prognostic model for lung adenocarcinoma based on experimental drug-resistant cell lines and clinical patients

Multi-omics integration analysis based on plasma circulating proteins reveals potential therapeutic targets for ulcerative colitis