Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Brief Research Report

Published on 16 May 2025

Clinical and molecular implications of cGAS/STING signaling in checkpoint inhibitor immunotherapy

in Molecular Diagnostics and Therapeutics

Hao Chen
Yang Zhong
Rongjie Feng
Xingyu Zhu
Kang Xu
Mingjie Kuang
Wei Chong

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1556736

1,358 views

Original Research

Published on 16 May 2025

Integrating network pharmacology and experimental validation to reveal the anti-growth mechanism of panaxadiol against glioblastoma via calcium signaling

in Molecular Diagnostics and Therapeutics

Guobin Qiu
Zhiyong Wu
Dunhui Yang
Luqiu Zhou

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1598413

939 views

Original Research

Published on 15 May 2025

Identification of potential diagnostic markers and molecular mechanisms of asthma and ulcerative colitis based on bioinformatics and machine learning

in Molecular Diagnostics and Therapeutics

Chenxuyu Zhang
Zheng Luo
Liang Ji

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1554304

1,461 views

Original Research

Published on 15 May 2025

A glutamine metabolism gene signature with prognostic and predictive value for colorectal cancer survival and immunotherapy response

in Molecular Diagnostics and Therapeutics

Yinmeng Zhang
He Zhu
Jiawei Fan
Jiahui Zhao
Yan Xia
Nan Zhang
Hong Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1599141

1,383 views

Editorial

Published on 15 May 2025

Editorial: Advancements and future challenges in molecular diagnostics and therapeutics

in Molecular Diagnostics and Therapeutics

Matteo Becatti
Masoud Mozafari
Roberta Risoluti

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1620909

728 views

Original Research

Published on 14 May 2025

Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease

in Molecular Diagnostics and Therapeutics

Roberta Marongiu
Jimcy Platholi
Laibak Park
Fangmin Yu
Garrett Sommer
Clara Woods
Teresa A. Milner
Michael J. Glass

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1597130

1,537 views

Original Research

Published on 14 May 2025

A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinoma

in Molecular Diagnostics and Therapeutics

Cenzhu Wang
Ying Fang
Yuhan Zhang
Shuhan Feng
Rui Hou
Hanfang Fan
Zeyu Wang
Lei Liu
Junli Ding
Junying Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1600626

890 views

Review

Published on 13 May 2025

Copper metabolism in hepatocellular carcinoma: from molecular mechanisms to therapeutic opportunities

in Molecular Diagnostics and Therapeutics

Ziling Pang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1578693

1,069 views

Original Research

Accepted on 12 May 2025

Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues

in Molecular Diagnostics and Therapeutics

Yufan Sheng
Sen Niu
Da Li
Chunyuan Meng
Tong Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1605117

262 views

Original Research

Published on 12 May 2025

Bioinformatics and experimental validation of ferroptosis-related genes in steroid-induced osteonecrosis of the femoral head

in Molecular Diagnostics and Therapeutics

Ming-gang Guo
Chen-fei Yang
Fa Yuan
Tao Yang
Ping-yuan Luo
Yu-bai He
Shuan Yang
Feng Chen
Wei Li
Zhi-wei Feng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1578755

1,223 views

Review

Published on 12 May 2025

The significance of calcium ions in cerebral ischemia-reperfusion injury: mechanisms and intervention strategies

in Molecular Diagnostics and Therapeutics

Yong-Wang Li
Yu Liu
Sheng-Zhen Luo
Xiao-Juan Huang
Yan Shen
Wei-Si Wang
Zhi-Chen Lang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1585758

837 views

Original Research

Published on 12 May 2025

New biomarkers of Kawasaki disease identified by gingival crevicular fluid proteomics

in Molecular Diagnostics and Therapeutics

Xue Fan
Ying Li
Yuehao Xu
Jianqing Lin
Xin Guo
Jinwen Liao
Mingguo Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1597412

1,020 views

Review

Published on 09 May 2025

Engineered exosomes: a promising drug delivery platform with therapeutic potential

in Molecular Diagnostics and Therapeutics

Genevieve Schwarz
Xuechen Ren
Wen Xie
Haitao Guo
Yong Jiang
Jinyu Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1583992

1,700 views
1 citation

Original Research

Published on 08 May 2025

Identification of biomarkers and immune microenvironment associated with heart failure through bioinformatics and machine learning

in Molecular Diagnostics and Therapeutics

Jingyun Jin
Shuyan Qin
Qiang Fu
Changzhi Yu
Hongjin Wu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1580880

1,946 views

Original Research

Published on 06 May 2025

Identification of key genes CCL5, PLG, LOX and C3 in clear cell renal cell carcinoma through integrated bioinformatics analysis

in Molecular Diagnostics and Therapeutics

Zhenwei Xie
Cheng Feng
Yude Hong
Libo Chen
Mingyong Li
Weiming Deng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1587196

1,345 views

Review

Published on 02 May 2025

Epigenetic modifications in cardiac fibrosis: recent evidence of new pharmacological targets

in Molecular Diagnostics and Therapeutics

Marian Pérez
Mónica Gómez
Jairo Castellar-López
Patricio Araos
Evelyn Mendoza-Torres
Samir Bolívar

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1583446

1,253 views