Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 23 Sep 2025

Integrated analysis and experimental validation of E2F2 as a potential prognostic biomarker and its oncogenic roles in serous ovarian cancer

in Molecular Diagnostics and Therapeutics

Fengyin Jiang
He Fei
Lina Yang
Rujun Chen
Liwen Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1661558

2,000 views

Original Research

Published on 22 Sep 2025

Unleashing the immune modulatory potential of Leishmania amazonensis-derived extracellular vesicles in American cutaneous leishmaniasis

in Molecular Diagnostics and Therapeutics

Bruna Eugênia de Freitas
Armanda Rodrigues
Joana Palma-Marques
Juliana Inês Weber
Ana Valério-Bolas
Rodrigo Pedro Soares
Ana Claudia Torrecilhas
Micheli Ferla
Munira Muhammad Abdel Baqui
Raul Alexander Gonzales Cordova

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1593363

2,166 views

Correction

Published on 17 Sep 2025

Correction: The protection of sulforaphane on subarachnoid hemorrhage-induced intestinal mucosa injury in rats

in Molecular Diagnostics and Therapeutics

Zixiang Liu
Pengpeng Li
Yuanhai Zhang
Shidi Zhao
Wei Gao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1692389

1,294 views

Original Research

Accepted on 12 Sep 2025

Expression of Immune Related Genes and Possible Regulatory Mechanisms in Ulcerative Colitis

in Molecular Diagnostics and Therapeutics

Fanfan Qu
Baoqing Xu
Yi Zhou
Yang He
Yanda Wang
Jiaxin Li
Jiayin Li
Aihua Shen

Frontiers in Molecular Biosciences

807 views

Original Research

Published on 09 Sep 2025

Global research trends in metabolism-related intraocular malignancies: a multi-database bibliometric analysis and cross-validation study

in Molecular Diagnostics and Therapeutics

Jianhao Bai
Zhongqi Wan
Zhiyong Wu
Qing Peng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1683864

2,309 views

Original Research

Published on 03 Sep 2025

Establishment and application of a preset dilution factor strategy for human chorionic gonadotropin testing in clinical laboratory

in Molecular Diagnostics and Therapeutics

Shu Chen
Qin Li
Huaqiang Liao
Mingcai Zhao
Jie Chen
Hongyu Chen
Guangjun Xiao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1648421

1,806 views
1 citation

Original Research

Published on 03 Sep 2025

Increased serum anti-ceramide antibodies and decreased sphingosine-1-phosphate levels in patients with obstructive sleep apnea syndrome as potential markers of endothelial dysfunction

in Molecular Diagnostics and Therapeutics

Andrzej Wiśniewski
Elżbieta Wiśniewska
Łukasz Lewandowski
Izabela Nowak
Monika Kosacka

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1644828

2,097 views

Original Research

Published on 02 Sep 2025

The association between composite inflammatory indicators and the clinicopathological characteristics of differentiated thyroid carcinoma

in Molecular Diagnostics and Therapeutics

Li-Yuan Yang
Li-Peng Yang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1660379

1,733 views

Correction

Published on 01 Sep 2025

Correction: Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease

in Molecular Diagnostics and Therapeutics

Roberta Marongiu
Jimcy Platholi
Laibaik Park
Fangmin Yu
Garrett Sommer
Clara Woods
Teresa A. Milner
Michael J. Glass

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1684511

1,338 views

Original Research

Published on 01 Sep 2025

Gut microbiota-metabolome remodeling associated with low bone mass: an integrated multi-omics study in fracture patients

in Molecular Diagnostics and Therapeutics

Xian Zhao
Bin Wu
Pengli Han
Zhongyu Wang
Renwei Cao
Shuo Chen
Cheng Cheng
Hongkai Lian
Yejun Zha
Minjuan Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1646361

2,348 views
1 citation

Review

Published on 29 Aug 2025

The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers

in Molecular Diagnostics and Therapeutics

Lei Wang
Yujia Xu
Xiang Zhong
Guiping Wang
Zijun Shi
Can Mei
Linwanyue Chen
Jianbo Zhan
Jing Cheng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1653627

3,463 views
1 citation

Original Research

Published on 22 Aug 2025

The protection of sulforaphane on subarachnoid hemorrhage-induced intestinal mucosa injury in rats

in Molecular Diagnostics and Therapeutics

Zixiang Liu
Pengpeng Li
Yuanhai Zhang
Shidi Zhao
Wei Gao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1635795

1,881 views

Review

Published on 21 Aug 2025

Artificial intelligence in primary aldosteronism: current achievements and future challenges

in Molecular Diagnostics and Therapeutics

Yisi Xu
Benjin Liu
Xuqi Huang
Xudong Guo
Ning Suo
Shaobo Jiang
Hanbo Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1660588

6,536 views

Review

Published on 20 Aug 2025

Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury

in Molecular Diagnostics and Therapeutics

Yuming Ding
Linmei Gao
Yi Chen
Yanheng Qiao
Bo Yang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1643838

2,831 views
1 citation

Original Research

Published on 20 Aug 2025

Shared transcriptional regulators and network rewiring identify therapeutic targets linking type 2 diabetes mellitus and hypertension

in Molecular Diagnostics and Therapeutics

Claudia Desireé Norzagaray-Valenzuela
Marco Antonio Valdez-Flores
Josue Camberos-Barraza
Alberto Kousuke De la Herrán-Arita
Juan Fidel Osuna-Ramos
Javier Magaña-Gómez
Carla Angulo-Rojo
Alma Marlene Guadrón-Llanos
Katia Aviña-Padilla
Loranda Calderón-Zamora

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1621413

2,558 views

Original Research

Published on 20 Aug 2025

Performance and clinical implications of non-invasive prenatal testing for rare chromosomal abnormalities: a retrospective study of 94,125 cases

in Molecular Diagnostics and Therapeutics

Haimei Qi
Haijun Chen
Zhuling Zhang
Jinhui Gan
Huifeng Liu
Xianping Yuan
Fuyu Luo
Junkun Chen
Shichun Shen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1645223

2,895 views
1 citation

Original Research

Published on 20 Aug 2025

Identification of kidney renal clear cell carcinoma prognosis based on gene expression and clinical information

in Molecular Diagnostics and Therapeutics

Xiong Zou
Xi Chen
Jianjun Yang
Yanfeng Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1630250

1,634 views

Original Research

Published on 15 Aug 2025

Preoperative serum inflammatory markers in the prognostic assessment of hepatocellular carcinoma resection in stages I/II

in Molecular Diagnostics and Therapeutics

Fan Liu
Yuan Xiang
Hao Xu
Xiaoxue Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1640390

1,556 views

Original Research

Published on 15 Aug 2025

Identification of anoikis-related genes classification patterns and immune infiltration characterization in chronic rhinosinusitis with nasal polyps based on machine learning

in Molecular Diagnostics and Therapeutics

Ziqi Chen
Lingmei Qu
Qing Hao
Shuang Teng
Shuo Liu
Qin Wu
Hongtian Yi
Xianji Shen
Liang Li
Zhaonan Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1624300

1,808 views

Original Research

Published on 14 Aug 2025

RetinalVasNet: a deep learning approach for robust retinal microvasculature detection

in Molecular Diagnostics and Therapeutics

Zhaomin Yao
Cengcong Xing
Gancheng Zhu
Weiming Xie
Zhiguo Wang
Guoxu Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1562608

1,875 views

Original Research

Published on 14 Aug 2025

Comprehensive proteomic characterization of pulmonary arterial hypertension in Chinese people

in Molecular Diagnostics and Therapeutics

Tianya Liu
Siqi Zhou
Rui Wang
Xiaomei Xu
Fang Gao
Jie Zu
Zhiping Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1652083

2,154 views

Original Research

Published on 08 Aug 2025

Identification and verification of biomarkers associated with neutrophils in acute myocardial infarction: integrated analysis of bulk RNA-seq, expression quantitative trait loci, and mendelian randomization

in Molecular Diagnostics and Therapeutics

Guoqing Liu
Xiangwen Lv
Jiahui Qin
Xingqing Long
Miaomiao Zhu
Chuwen Fu
Jian Xie
Peichun He

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1614350

2,302 views

Original Research

Published on 08 Aug 2025

CCDC138 overexpression predicts poor prognosis and highlights ciliopathy-linked mechanisms in uterine corpus endometrial carcinoma

in Molecular Diagnostics and Therapeutics

Aiping Wang
Fang Yang
Chunhua Zhang
Shi Li
Han Fu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1622496

1,863 views

Review

Published on 07 Aug 2025

The potential role of non-coding RNAs in acute kidney injury: a focus on natural medicine treatment

in Molecular Diagnostics and Therapeutics

Yuxin Guo
Yanru Zhao
Hanqing Zhang
Yunze Xing
Yaxuan Fang
Dingyuan Zheng
Hanqi Yang
Yanheng Qiao
Bo Yang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1648526

2,019 views
1 citation

2,097 articles

articles

Integrated analysis and experimental validation of E2F2 as a potential prognostic biomarker and its oncogenic roles in serous ovarian cancer

Unleashing the immune modulatory potential of Leishmania amazonensis-derived extracellular vesicles in American cutaneous leishmaniasis

Correction: The protection of sulforaphane on subarachnoid hemorrhage-induced intestinal mucosa injury in rats

Expression of Immune Related Genes and Possible Regulatory Mechanisms in Ulcerative Colitis

Global research trends in metabolism-related intraocular malignancies: a multi-database bibliometric analysis and cross-validation study

Establishment and application of a preset dilution factor strategy for human chorionic gonadotropin testing in clinical laboratory

Increased serum anti-ceramide antibodies and decreased sphingosine-1-phosphate levels in patients with obstructive sleep apnea syndrome as potential markers of endothelial dysfunction

The association between composite inflammatory indicators and the clinicopathological characteristics of differentiated thyroid carcinoma

Correction: Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease

Gut microbiota-metabolome remodeling associated with low bone mass: an integrated multi-omics study in fracture patients

The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers

The protection of sulforaphane on subarachnoid hemorrhage-induced intestinal mucosa injury in rats

Artificial intelligence in primary aldosteronism: current achievements and future challenges

Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury

Shared transcriptional regulators and network rewiring identify therapeutic targets linking type 2 diabetes mellitus and hypertension

Performance and clinical implications of non-invasive prenatal testing for rare chromosomal abnormalities: a retrospective study of 94,125 cases

Identification of kidney renal clear cell carcinoma prognosis based on gene expression and clinical information

Preoperative serum inflammatory markers in the prognostic assessment of hepatocellular carcinoma resection in stages I/II

Identification of anoikis-related genes classification patterns and immune infiltration characterization in chronic rhinosinusitis with nasal polyps based on machine learning

RetinalVasNet: a deep learning approach for robust retinal microvasculature detection

Comprehensive proteomic characterization of pulmonary arterial hypertension in Chinese people

Identification and verification of biomarkers associated with neutrophils in acute myocardial infarction: integrated analysis of bulk RNA-seq, expression quantitative trait loci, and mendelian randomization

CCDC138 overexpression predicts poor prognosis and highlights ciliopathy-linked mechanisms in uterine corpus endometrial carcinoma

The potential role of non-coding RNAs in acute kidney injury: a focus on natural medicine treatment