Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 19 Nov 2025

Progressively exploring and assessing the prognosis of bladder urothelial cancer based on the microenvironment through the integration of multiple databases

in Molecular Diagnostics and Therapeutics

Xiong Zou
Yanfeng Li
Xuefeng Peng
Changshi Gu
Qiang Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1702311

1,084 views

Original Research

Published on 17 Nov 2025

A prognostic nomogram for predicting overall survival in gastric signet ring cell carcinoma patients: a SEER database and Chinese registry analysis

in Molecular Diagnostics and Therapeutics

Jie Wu
Jichen Wang
Ning Chen
Junjie Nie
Ling Xia
Quanpeng Li
Xueting Deng
Guozhong Ji

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1704157

1,251 views

Editorial

Published on 17 Nov 2025

Editorial: In vitro transcription (IVT) reaction – the gateway to new therapeutic modalities

in Molecular Diagnostics and Therapeutics

Rok Sekirnik
Andreas N. Kuhn
Ana Margarida Azevedo
Zoltán Kis

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1730880

2,688 views

Original Research

Published on 14 Nov 2025

Investigating the molecular mechanisms of resveratrol in treating diabetic foot ulcers: a comprehensive analysis of network pharmacology and experiment validation

in Molecular Diagnostics and Therapeutics

Chao Sima
Zhe Wang
Sisi Wang
Haiyang Wang
Zhonghua Sun
Haoguo Wang
Daning Liang
Jianchi Li
Zhenning Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1708426

2,191 views

Review

Published on 13 Nov 2025

Advances in 3D bioprinting for modeling the blood-brain barrier in neurodegenerative diseases

in Molecular Diagnostics and Therapeutics

Shirleen Tan
Lifeng Qiu
Jolene Wei Ling Lee
Li Zeng

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1703403

2,707 views

Original Research

Published on 11 Nov 2025

Identification and validation of potential shared diagnostic markers for sepsis-induced ARDS and cardiomyopathy via WGCNA and machine learning

in Molecular Diagnostics and Therapeutics

Jing Wei
Baoyue Huang
Kunlin Hu
Bin Xiong
Shulin Xiang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1665387

2,661 views

Editorial

Published on 10 Nov 2025

Editorial: Molecular underpinnings of genetic and rare diseases: from diagnostic tools to therapeutic approaches

in Molecular Diagnostics and Therapeutics

Abhilash Kumar Tripathi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1722468

1,105 views

Review

Published on 10 Nov 2025

SOX9: a novel janus-faced regulator in immunity and its promise as a therapeutic target

in Molecular Diagnostics and Therapeutics

Qian Shi
Shouyu He

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1700812

2,828 views

Original Research

Published on 07 Nov 2025

STAT3 as a critical target of Sijunzi Decoction in the treatment of gastric cancer: evidence from integrated network pharmacology and experimental validation

in Molecular Diagnostics and Therapeutics

XiaoYu Luo
GuiPing Xie
QianYing Tan
YaoHui Wang
HaiDan Wang
Jing Zhai

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1683806

1,363 views

Editorial

Published on 07 Nov 2025

Editorial: Estrogens and neurodegeneration: a link between menopause and Alzheimer’s disease in women

in Molecular Diagnostics and Therapeutics

Manuela Leri
Andrea Bertolini
Mario Diaz
Roberta Marongiu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1727385

1,261 views

Original Research

Published on 03 Nov 2025

A diagnostic RNA sequencing assay for direct identification and interpretation of pathogenic variants in the FBN1 gene

in Molecular Diagnostics and Therapeutics

Manal Irshaid
Ghadeera Al Mansoori
Mohamed Sulaiman
Asjed Mohamed
Mohammed Abdoh
Youssef M. Shalaby
Bashar Al-Zohily
Aalia Batool
Sara Aleissaee
Lara Alzyoud

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1693943

1,930 views

Original Research

Published on 03 Nov 2025

Immunomodulatory effect of betulin and its derivatives on IL-6 expression in colorectal cancer cell lines and molecular docking insights

in Molecular Diagnostics and Therapeutics

Marcel Madej
Adrianna Halama
Elwira Chrobak
Ewa Bębenek
Joanna Magdalena Gola

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1704804

1,587 views

Editorial

Published on 31 Oct 2025

Editorial: Bioinformatics and systems biology strategies in disease management with a special emphasis on cancer, Alzheimer’s disease and aging

in Molecular Diagnostics and Therapeutics

Tiratha Raj Singh
Brigitte Vannier
Ragini Raj Singh
Hari Om Yadav
Holger Fröhlich

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1725000

1,362 views

Mini Review

Published on 31 Oct 2025

RNA-based therapies for neurodevelopmental disorders: innovative tools for molecular correction

in Molecular Diagnostics and Therapeutics

Denise Drongitis
Lucia Verrillo
Alberto de Bellis
Maria Giuseppina Miano

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1681647

2,880 views

Review

Published on 30 Oct 2025

Immunological landscape of colorectal cancer: tumor microenvironment, cellular players and immunotherapeutic opportunities

in Molecular Diagnostics and Therapeutics

Adile Buse Andac-Aktas
Gizem Calibasi-Kocal

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1687556

3,586 views
2 citations

Original Research

Published on 29 Oct 2025

Identification and validation of mitochondrial-related genes in intestinal ischemia-reperfusion injury based on WGCNA and machine learning

in Molecular Diagnostics and Therapeutics

YiChen Hu
Jie Huang
XiaoLi Min
YuanPei Zhao
JiaHui Wang
HongYuan Liu
KaiWen Shi
WenLiang Li
WeiMing Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1691749

1,867 views

Review

Published on 29 Oct 2025

Niche-specific epigenetic interventions in the spatially heterogeneous glioblastoma microenvironmental landscape: strategies for radiotherapy enhancement

in Molecular Diagnostics and Therapeutics

Junjie Wang
Kunjie Li
Yongzhe Wang
Junyi Zhang
Xin Peng
Ning Ji

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1704311

2,627 views
2 citations

Review

Published on 28 Oct 2025

Dual-regulatory miRNAs: master regulators and therapeutic targets in bone-metastatic breast cancer

in Molecular Diagnostics and Therapeutics

Feifei Meng
Mengdi Zhang
Dongqing Pu
Guangxi Shi
Jingwei Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1680908

1,310 views
1 citation

Editorial

Published on 23 Oct 2025

Editorial: Epigenetic regulation in fibrosis

in Molecular Diagnostics and Therapeutics

Qingqing Wei
Xiaoru Hu
Yan Sanders

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1718307

1,135 views

Original Research

Published on 22 Oct 2025

Identification of mitochondrial related gene characteristics and potential molecular mechanism of acute otitis media

in Molecular Diagnostics and Therapeutics

Dingjing Zi
Xiaoyong Ren

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1642269

1,520 views

Original Research

Published on 22 Oct 2025

Screening and regulatory mechanisms of biomarkers related to neddylation in laryngeal squamous cell carcinoma

in Molecular Diagnostics and Therapeutics

Xin Wang
Haixiang Zhang
Jinping Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1654064

1,144 views

Review

Published on 21 Oct 2025

Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and emerging therapeutic strategies

in Molecular Diagnostics and Therapeutics

Yu Liu
Yu-Qiu Xu
Yu-Yin Long
Hui Xiao
Yu-Ying Ma
Yong-Wang Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1693456

6,166 views
4 citations

Review

Published on 17 Oct 2025

The janus-faced biology of GPNMB: from tissue homeostasis to cancer pathogenesis

in Molecular Diagnostics and Therapeutics

Cheng Long
Li Qin Yun
Ma Dai Yuan
Imad Ibrahim Ali Al-Sultan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1664764

2,846 views
1 citation

Original Research

Published on 15 Oct 2025

Comprehensive analyses of single-cell and bulk RNA-seq reveal the biological and prognostic roles of BMP4 in pancreatic adenocarcinoma

in Molecular Diagnostics and Therapeutics

Ao Wang
Xinglong Shen
Shan Lu
Chao Bi
Yang Cao
Yunfeng Liu
Meng Li
Yun Zhao
Huaizhang Jin
Xiaopeng Shen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1686938

1,484 views

2,138 articles

articles

Progressively exploring and assessing the prognosis of bladder urothelial cancer based on the microenvironment through the integration of multiple databases

A prognostic nomogram for predicting overall survival in gastric signet ring cell carcinoma patients: a SEER database and Chinese registry analysis

Editorial: In vitro transcription (IVT) reaction – the gateway to new therapeutic modalities

Investigating the molecular mechanisms of resveratrol in treating diabetic foot ulcers: a comprehensive analysis of network pharmacology and experiment validation

Advances in 3D bioprinting for modeling the blood-brain barrier in neurodegenerative diseases

Identification and validation of potential shared diagnostic markers for sepsis-induced ARDS and cardiomyopathy via WGCNA and machine learning

Editorial: Molecular underpinnings of genetic and rare diseases: from diagnostic tools to therapeutic approaches

SOX9: a novel janus-faced regulator in immunity and its promise as a therapeutic target

STAT3 as a critical target of Sijunzi Decoction in the treatment of gastric cancer: evidence from integrated network pharmacology and experimental validation

Editorial: Estrogens and neurodegeneration: a link between menopause and Alzheimer’s disease in women

A diagnostic RNA sequencing assay for direct identification and interpretation of pathogenic variants in the FBN1 gene

Immunomodulatory effect of betulin and its derivatives on IL-6 expression in colorectal cancer cell lines and molecular docking insights

Editorial: Bioinformatics and systems biology strategies in disease management with a special emphasis on cancer, Alzheimer’s disease and aging

RNA-based therapies for neurodevelopmental disorders: innovative tools for molecular correction

Immunological landscape of colorectal cancer: tumor microenvironment, cellular players and immunotherapeutic opportunities

Identification and validation of mitochondrial-related genes in intestinal ischemia-reperfusion injury based on WGCNA and machine learning

Niche-specific epigenetic interventions in the spatially heterogeneous glioblastoma microenvironmental landscape: strategies for radiotherapy enhancement

Dual-regulatory miRNAs: master regulators and therapeutic targets in bone-metastatic breast cancer

Editorial: Epigenetic regulation in fibrosis

Identification of mitochondrial related gene characteristics and potential molecular mechanism of acute otitis media

Screening and regulatory mechanisms of biomarkers related to neddylation in laryngeal squamous cell carcinoma

Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and emerging therapeutic strategies

The janus-faced biology of GPNMB: from tissue homeostasis to cancer pathogenesis

Comprehensive analyses of single-cell and bulk RNA-seq reveal the biological and prognostic roles of BMP4 in pancreatic adenocarcinoma