Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 06 Aug 2025

Shared molecular profiles of post-laser vision correction ectasia and keratoconus with key differences in CADPS, CPT1B, CIITA, and TBC1D4

in Molecular Diagnostics and Therapeutics

Katarzyna Jaskiewicz-Rajewicz
Alicja Wysocka
Magdalena Maleszka-Kurpiel
Eliza Matuszewska-Mach
Jakub Wozniak
Rafal Ploski
Jan Matysiak
Malgorzata Rydzanicz
Marzena Gajecka

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1616675

2,182 views

Original Research

Published on 06 Aug 2025

Using machine learning methods to investigate the role of volatile organic compounds in non-alcoholic fatty liver disease

in Molecular Diagnostics and Therapeutics

Chih-Hao Shen
Ruei-Hao Huang
Yaw-Kuen Li
Ta-Wei Chu
Dee Pei

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1631265

2,216 views
1 citation

Original Research

Published on 04 Aug 2025

Inflammation-nutrition biomarker model for survival prediction in lung cancer patients with concurrent tuberculosis

in Molecular Diagnostics and Therapeutics

Hongqi Zhou
Zihao Zhao
Jinhai Wang
Weiyun Jin
Bensong Xian
Lindi Li
XiangWen Nie
WeiWei Wu
Ran Chen
QiZhen Xie

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1624131

2,140 views

Technology and Code

Published on 01 Aug 2025

Enhancing head and neck cancer detection accuracy in digitized whole-slide histology with the HNSC-classifier: a deep learning approach

in Molecular Diagnostics and Therapeutics

Haiyang Yu
Wang Yu
Yuan Enwu
Jun Ma
Xin Zhao
Linlin Zhang
Fang Yang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1652144

2,054 views

Original Research

Published on 01 Aug 2025

A comprehensive analysis of the tryptophan metabolism-related gene signature to predict the prognosis of esophageal squamous cell carcinoma based on multi-omics

in Molecular Diagnostics and Therapeutics

Zhengjie Wu
Zhiping Liu
Yukun Wang
Geling Teng
Xiaodong Li
Tong Lu
Fangning Hu
Shuo Wu
Guanqiang Ma
Hua Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1613539

2,441 views
1 citation

Original Research

Published on 01 Aug 2025

Prognostic value of positive lymph node ratio, tumor deposit, and perineural invasion in advanced colorectal signet-ring cell carcinoma

in Molecular Diagnostics and Therapeutics

Liang Chu
Han Wang
Tao Ling
Shuhan Feng
Yucheng Ding
Yan Zhang
Ying Pan
Cenzhu Wang
Xiaohong Wang
Lei Liu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1617787

1,581 views

Original Research

Published on 30 Jul 2025

Inhibition of BRD4 prevents peribronchial fibrosis in mice with cutaneous lewisite exposure

in Molecular Diagnostics and Therapeutics

Huaxiu Zeng
Pooja Singh
Rajesh Sinha
Crystal T. Stephens
Aftab Ahmad
Mohammad Athar
Veena B. Antony

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1644792

2,019 views

Original Research

Published on 29 Jul 2025

Investigating potential targets of Wulingsan in diabetic nephropathy through network pharmacology and experimental validation

in Molecular Diagnostics and Therapeutics

Xicheng Hu
Zhen Wang
Liyan Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1647796

3,041 views

Original Research

Published on 28 Jul 2025

Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence

in Molecular Diagnostics and Therapeutics

Juan Chen
Lili Fu
Mengjin Li
Kun Xie
Xinming Li
Xu-jie Zhou
Li Yang
Liming Zhang
Cheng Xue
Zhiguo Mao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1627534

2,351 views
1 citation

Opinion

Published on 25 Jul 2025

Immune surveillance as a pharmacological target in the early stages of cancer

in Molecular Diagnostics and Therapeutics

Hongfei Jiang
Zhun Wei
Haibo Zhao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1643024

2,691 views
1 citation

Original Research

Published on 23 Jul 2025

Maternal plasma microRNA profiles in twin-twin transfusion syndrome and normal monochorionic twin pregnancies

in Molecular Diagnostics and Therapeutics

Steven T. Papastefan
Morgan M. Langereis
Catherine R. Redden
Daniel R. Liesman
Cassandra B. Huerta
Lucas E. Turner
Hee Kap Kang
Bethany T. Stetson
Katherine C. Ott
William S. Marriott

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1597215

1,681 views
1 citation

Original Research

Published on 22 Jul 2025

TOP2A as a prognostic biomarker in small cell carcinoma of the esophagus: an integrated bioinformatics and immunohistochemical study

in Molecular Diagnostics and Therapeutics

Xiaolei Yin
Xiaopeng Li
Lili Mi
Jiaojiao Hou
Fei Yin

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1640881

1,482 views

Original Research

Published on 18 Jul 2025

Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes

in Molecular Diagnostics and Therapeutics

Yue Cheng
Ran Ren
Yu Xu
Shaofeng Duan
Jilei Zhang
Zhongyuan Bao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1635296

1,975 views
1 citation

Review

Published on 17 Jul 2025

The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implications

in Molecular Diagnostics and Therapeutics

Jingru Huang
Jianfeng Qin
Yuguang Zhu
Ao Shen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1647300

2,899 views
1 citation

Original Research

Published on 17 Jul 2025

Development of a human colorectal carcinoma cell-based platform for studying inducible nitric oxide synthase expression and nitric oxide signaling dynamics

in Molecular Diagnostics and Therapeutics

Xi Chen
Elizabeth A. Grimm
Yong Qin

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1637230

1,646 views

Original Research

Published on 16 Jul 2025

Identification and validation of integrated stress-response-related genes as biomarkers for age-related macular degeneration

in Molecular Diagnostics and Therapeutics

Jingyi Niu
Ling Jin
Yijun Hu
Yiting Wang
Xiaoning Hao
Wenwen Geng
Ruirui Ma

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1583237

1,949 views
1 citation

Brief Research Report

Published on 15 Jul 2025

An integrated approach for analyzing spatially resolved multi-omics datasets from the same tissue section

in Molecular Diagnostics and Therapeutics

Thao Tran
Felicia Wee
Craig Ryan Joseph
Wanqiu Zhang
Jeffrey Chun Tatt Lim
Zhen Wei Neo
Li Yen Chong
Francis Hong Xin Yap
Nathan Heath Patterson
Marc Claesen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1614288

6,392 views
1 citation

Original Research

Published on 15 Jul 2025

Expression and clinical significance of S100A8/9 in adults with secondary phagocytic lymphohistiocytosis

in Molecular Diagnostics and Therapeutics

Ziwei Fang
Xin Gao
Limin Duan
Jujuan Wang
Tian Tian
Ji Xu
Yongqian Shu
Guangli Yin
Hongxia Qiu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1607352

1,335 views
1 citation

Original Research

Published on 11 Jul 2025

Targeting USP42 induces DNA damage and inhibits cell growth in prostate cancer

in Molecular Diagnostics and Therapeutics

Yinghao Zhou
Chenchen Chen
Yibo Meng
Jianchao Ge
Shengkui Meng
Xillong Wang
Yaozong Xu
Guowei Shi
Wandong Yu
Xuetao Hu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1646331

1,865 views

Original Research

Published on 11 Jul 2025

Integrated network pharmacology and in vivo experiments to reveal the anti-inflammatory mechanism of Qinghuo Rougan Formula in uveitis

in Molecular Diagnostics and Therapeutics

Changying Jing
Yaqi Sun
Hongsheng Bi
Junguo Guo
Cong Ren
Jike Song
Beibei Wang
Qingmei Tian
Dadong Guo
Pengjuan He

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1632027

2,404 views

Original Research

Published on 11 Jul 2025

ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas

in Molecular Diagnostics and Therapeutics

Xiaodong Shao
Shaolei Guo
Jia Yang
Junjie Dai
Kaihua Cao
Xia Cai
Tianshi Song
Shun Yao
Umar Raza
Kun Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1640038

2,007 views

Review

Published on 11 Jul 2025

Review of research progress in sepsis-associated acute kidney injury

in Molecular Diagnostics and Therapeutics

Wanning Nian
Weichen Tao
Haiyi Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1603392

4,789 views
2 citations

Original Research

Published on 10 Jul 2025

An automatic laryngoscopic image segmentation system based on SAM prompt engineering: from glottis annotation to vocal fold segmentation

in Molecular Diagnostics and Therapeutics

Yucong Zhang
Yuchen Song
Juan Liu
Ming Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1616271

1,703 views
1 citation

Original Research

Published on 10 Jul 2025

Value of the 14-gene molecular assay in efficacy assessment of neoadjuvant chemoimmunotherapy for non-small cell lung cancer

in Molecular Diagnostics and Therapeutics

Xuyan Lan
Xiaoyu Sun
Ruiqi Chen
Lihuan Zhu
Xiaojie Pan
Tianxing Guo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1619139

1,750 views

2,097 articles

articles

Shared molecular profiles of post-laser vision correction ectasia and keratoconus with key differences in CADPS, CPT1B, CIITA, and TBC1D4

Using machine learning methods to investigate the role of volatile organic compounds in non-alcoholic fatty liver disease

Inflammation-nutrition biomarker model for survival prediction in lung cancer patients with concurrent tuberculosis

Enhancing head and neck cancer detection accuracy in digitized whole-slide histology with the HNSC-classifier: a deep learning approach

A comprehensive analysis of the tryptophan metabolism-related gene signature to predict the prognosis of esophageal squamous cell carcinoma based on multi-omics

Prognostic value of positive lymph node ratio, tumor deposit, and perineural invasion in advanced colorectal signet-ring cell carcinoma

Inhibition of BRD4 prevents peribronchial fibrosis in mice with cutaneous lewisite exposure

Investigating potential targets of Wulingsan in diabetic nephropathy through network pharmacology and experimental validation

Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence

Immune surveillance as a pharmacological target in the early stages of cancer

Maternal plasma microRNA profiles in twin-twin transfusion syndrome and normal monochorionic twin pregnancies

TOP2A as a prognostic biomarker in small cell carcinoma of the esophagus: an integrated bioinformatics and immunohistochemical study

Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes

The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implications

Development of a human colorectal carcinoma cell-based platform for studying inducible nitric oxide synthase expression and nitric oxide signaling dynamics

Identification and validation of integrated stress-response-related genes as biomarkers for age-related macular degeneration

An integrated approach for analyzing spatially resolved multi-omics datasets from the same tissue section

Expression and clinical significance of S100A8/9 in adults with secondary phagocytic lymphohistiocytosis

Targeting USP42 induces DNA damage and inhibits cell growth in prostate cancer

Integrated network pharmacology and in vivo experiments to reveal the anti-inflammatory mechanism of Qinghuo Rougan Formula in uveitis

ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas

Review of research progress in sepsis-associated acute kidney injury

An automatic laryngoscopic image segmentation system based on SAM prompt engineering: from glottis annotation to vocal fold segmentation

Value of the 14-gene molecular assay in efficacy assessment of neoadjuvant chemoimmunotherapy for non-small cell lung cancer