Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 29 Jul 2025

Investigating potential targets of Wulingsan in diabetic nephropathy through network pharmacology and experimental validation

in Molecular Diagnostics and Therapeutics

Xicheng Hu
Zhen Wang
Liyan Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1647796

3,371 views
1 citation

Original Research

Published on 28 Jul 2025

Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence

in Molecular Diagnostics and Therapeutics

Juan Chen
Lili Fu
Mengjin Li
Kun Xie
Xinming Li
Xu-jie Zhou
Li Yang
Liming Zhang
Cheng Xue
Zhiguo Mao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1627534

2,699 views
2 citations

Opinion

Published on 25 Jul 2025

Immune surveillance as a pharmacological target in the early stages of cancer

in Molecular Diagnostics and Therapeutics

Hongfei Jiang
Zhun Wei
Haibo Zhao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1643024

3,845 views
1 citation

Original Research

Published on 23 Jul 2025

Maternal plasma microRNA profiles in twin-twin transfusion syndrome and normal monochorionic twin pregnancies

in Molecular Diagnostics and Therapeutics

Steven T. Papastefan
Morgan M. Langereis
Catherine R. Redden
Daniel R. Liesman
Cassandra B. Huerta
Lucas E. Turner
Hee Kap Kang
Bethany T. Stetson
Katherine C. Ott
William S. Marriott

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1597215

1,935 views
1 citation

Original Research

Published on 22 Jul 2025

TOP2A as a prognostic biomarker in small cell carcinoma of the esophagus: an integrated bioinformatics and immunohistochemical study

in Molecular Diagnostics and Therapeutics

Xiaolei Yin
Xiaopeng Li
Lili Mi
Jiaojiao Hou
Fei Yin

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1640881

1,698 views

Original Research

Published on 18 Jul 2025

Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes

in Molecular Diagnostics and Therapeutics

Yue Cheng
Ran Ren
Yu Xu
Shaofeng Duan
Jilei Zhang
Zhongyuan Bao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1635296

2,332 views
1 citation

Review

Published on 17 Jul 2025

The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implications

in Molecular Diagnostics and Therapeutics

Jingru Huang
Jianfeng Qin
Yuguang Zhu
Ao Shen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1647300

3,437 views
2 citations

Original Research

Published on 17 Jul 2025

Development of a human colorectal carcinoma cell-based platform for studying inducible nitric oxide synthase expression and nitric oxide signaling dynamics

in Molecular Diagnostics and Therapeutics

Xi Chen
Elizabeth A. Grimm
Yong Qin

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1637230

1,862 views

Original Research

Published on 16 Jul 2025

Identification and validation of integrated stress-response-related genes as biomarkers for age-related macular degeneration

in Molecular Diagnostics and Therapeutics

Jingyi Niu
Ling Jin
Yijun Hu
Yiting Wang
Xiaoning Hao
Wenwen Geng
Ruirui Ma

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1583237

2,320 views
1 citation

Brief Research Report

Published on 15 Jul 2025

An integrated approach for analyzing spatially resolved multi-omics datasets from the same tissue section

in Molecular Diagnostics and Therapeutics

Thao Tran
Felicia Wee
Craig Ryan Joseph
Wanqiu Zhang
Jeffrey Chun Tatt Lim
Zhen Wei Neo
Li Yen Chong
Francis Hong Xin Yap
Nathan Heath Patterson
Marc Claesen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1614288

7,702 views
1 citation

Original Research

Published on 15 Jul 2025

Expression and clinical significance of S100A8/9 in adults with secondary phagocytic lymphohistiocytosis

in Molecular Diagnostics and Therapeutics

Ziwei Fang
Xin Gao
Limin Duan
Jujuan Wang
Tian Tian
Ji Xu
Yongqian Shu
Guangli Yin
Hongxia Qiu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1607352

1,545 views
1 citation

Original Research

Published on 11 Jul 2025

Targeting USP42 induces DNA damage and inhibits cell growth in prostate cancer

in Molecular Diagnostics and Therapeutics

Yinghao Zhou
Chenchen Chen
Yibo Meng
Jianchao Ge
Shengkui Meng
Xillong Wang
Yaozong Xu
Guowei Shi
Wandong Yu
Xuetao Hu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1646331

2,226 views

Original Research

Published on 11 Jul 2025

Integrated network pharmacology and in vivo experiments to reveal the anti-inflammatory mechanism of Qinghuo Rougan Formula in uveitis

in Molecular Diagnostics and Therapeutics

Changying Jing
Yaqi Sun
Hongsheng Bi
Junguo Guo
Cong Ren
Jike Song
Beibei Wang
Qingmei Tian
Dadong Guo
Pengjuan He

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1632027

2,693 views

Original Research

Published on 11 Jul 2025

ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas

in Molecular Diagnostics and Therapeutics

Xiaodong Shao
Shaolei Guo
Jia Yang
Junjie Dai
Kaihua Cao
Xia Cai
Tianshi Song
Shun Yao
Umar Raza
Kun Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1640038

2,354 views

Review

Published on 11 Jul 2025

Review of research progress in sepsis-associated acute kidney injury

in Molecular Diagnostics and Therapeutics

Wanning Nian
Weichen Tao
Haiyi Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1603392

5,955 views
3 citations

Original Research

Published on 10 Jul 2025

An automatic laryngoscopic image segmentation system based on SAM prompt engineering: from glottis annotation to vocal fold segmentation

in Molecular Diagnostics and Therapeutics

Yucong Zhang
Yuchen Song
Juan Liu
Ming Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1616271

1,937 views
1 citation

Original Research

Published on 10 Jul 2025

Value of the 14-gene molecular assay in efficacy assessment of neoadjuvant chemoimmunotherapy for non-small cell lung cancer

in Molecular Diagnostics and Therapeutics

Xuyan Lan
Xiaoyu Sun
Ruiqi Chen
Lihuan Zhu
Xiaojie Pan
Tianxing Guo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1619139

1,953 views

Original Research

Published on 07 Jul 2025

Gene expression profiling of human umbilical vein endothelial cells overexpressing CELF2 as diagnostic targets in diabetes-induced erectile dysfunction

in Molecular Diagnostics and Therapeutics

Daniyaer Nuerdebieke
Lizhong Yao
Lange Guo
Jiuzhi Li
Hongliang Jia
Yukui Nan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1596534

1,645 views

Original Research

Published on 04 Jul 2025

Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues

in Molecular Diagnostics and Therapeutics

Yufan Sheng
Sen Niu
Da Li
Chunyuan Meng
Tong Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1605117

2,308 views
1 citation

Original Research

Published on 03 Jul 2025

A nomogram model based on tumor necrosis factor-like ligand 1A(TL1A) and death receptor-3(DR3) promoter methylation for predicting 90-day prognosis in patients with HBV-associated acute-on-chronic liver failure

in Molecular Diagnostics and Therapeutics

Xue-Fei Wei
Feng Zhang
Han-Xu Zhu
Zhe-Zhe Tian
Miao-Miao Xu
Yu-Chen Fan
Kai Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1614311

2,270 views

Original Research

Published on 01 Jul 2025

Clinicopathologic and proteomic characteristics of low-grade undifferentiated spindle cell sarcoma

in Molecular Diagnostics and Therapeutics

Yani Wei
Hongjun Li
Shujin He
Min Li
Yongyu Chen
Huijuan Shi
Anjia Han

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1591644

2,359 views

Mini Review

Published on 30 Jun 2025

Estrogen, menopause, and Alzheimer’s disease: understanding the link to cognitive decline in women

in Molecular Diagnostics and Therapeutics

Nicholas Mervosh
Gayatri Devi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1634302

13,939 views
12 citations

Original Research

Published on 30 Jun 2025

Patient-derived gastric cancer organoids model heterogeneity and stroma-mediated chemoresistance in poorly cohesive carcinoma

in Molecular Diagnostics and Therapeutics

Yi Yin
Shuhong Zeng
Hui Zhang
Shuangshuang Wang
Fei Ke
Qiang Rui
Jinyong Zhou
Yuwen Zhuang
Weixing Shen
Jun Qian

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1631168

3,524 views
3 citations

Review

Published on 30 Jun 2025

Emerging biomarkers in amyotrophic lateral sclerosis: from pathogenesis to clinical applications

in Molecular Diagnostics and Therapeutics

Farah Anjum
Maha Bakhuraysah
Abdulaziz Alsharif
Taj Mohammad
Anas Shamsi
Md. Imtaiyaz Hassan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1608853

8,282 views
3 citations

2,138 articles

articles

Investigating potential targets of Wulingsan in diabetic nephropathy through network pharmacology and experimental validation

Decreased brain-derived neurotrophic factor expression in chronic kidney disease: integrated clinical and experimental evidence

Immune surveillance as a pharmacological target in the early stages of cancer

Maternal plasma microRNA profiles in twin-twin transfusion syndrome and normal monochorionic twin pregnancies

TOP2A as a prognostic biomarker in small cell carcinoma of the esophagus: an integrated bioinformatics and immunohistochemical study

Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes

The role of epigenetics in pulmonary fibrosis: recent advances in mechanistic insights and therapeutic implications

Development of a human colorectal carcinoma cell-based platform for studying inducible nitric oxide synthase expression and nitric oxide signaling dynamics

Identification and validation of integrated stress-response-related genes as biomarkers for age-related macular degeneration

An integrated approach for analyzing spatially resolved multi-omics datasets from the same tissue section

Expression and clinical significance of S100A8/9 in adults with secondary phagocytic lymphohistiocytosis

Targeting USP42 induces DNA damage and inhibits cell growth in prostate cancer

Integrated network pharmacology and in vivo experiments to reveal the anti-inflammatory mechanism of Qinghuo Rougan Formula in uveitis

ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas

Review of research progress in sepsis-associated acute kidney injury

An automatic laryngoscopic image segmentation system based on SAM prompt engineering: from glottis annotation to vocal fold segmentation

Value of the 14-gene molecular assay in efficacy assessment of neoadjuvant chemoimmunotherapy for non-small cell lung cancer

Gene expression profiling of human umbilical vein endothelial cells overexpressing CELF2 as diagnostic targets in diabetes-induced erectile dysfunction

Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues

A nomogram model based on tumor necrosis factor-like ligand 1A(TL1A) and death receptor-3(DR3) promoter methylation for predicting 90-day prognosis in patients with HBV-associated acute-on-chronic liver failure

Clinicopathologic and proteomic characteristics of low-grade undifferentiated spindle cell sarcoma

Estrogen, menopause, and Alzheimer’s disease: understanding the link to cognitive decline in women

Patient-derived gastric cancer organoids model heterogeneity and stroma-mediated chemoresistance in poorly cohesive carcinoma

Emerging biomarkers in amyotrophic lateral sclerosis: from pathogenesis to clinical applications