Frontiers in Molecular Biosciences

Original Research

Published on 19 Apr 2022

Variable and Conserved Regions of Secondary Structure in the β-Trefoil Fold: Structure Versus Function

in Structural Biology

Michael Blaber

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.889943

2,603 views
3 citations

Original Research

Published on 19 Apr 2022

Combining Coarse-Grained Simulations and Single Molecule Analysis Reveals a Three-State Folding Model of the Guanidine-II Riboswitch

in Structural Biology

Christin Fuks
Sebastian Falkner
Nadine Schwierz
Martin Hengesbach

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.826505

3,420 views
8 citations

Review

Published on 14 Apr 2022

High-Throughput Native Mass Spectrometry Screening in Drug Discovery

in Structural Biology

Agni F. M. Gavriilidou
Kleitos Sokratous
Hsin-Yung Yen
Luigi De Colibus

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.837901

20,507 views
52 citations

Original Research

Published on 14 Apr 2022

Computational Site Saturation Mutagenesis of Canonical and Non-Canonical Amino Acids to Probe Protein-Peptide Interactions

in Structural Biology

Jeffrey K. Holden
Ryan Pavlovicz
Alberto Gobbi
Yifan Song
Christian N. Cunningham

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.848689

7,828 views
10 citations

Review

Published on 12 Apr 2022

The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor

in Structural Biology

Beatriz Bueschbell
Prashiela Manga
Anke C. Schiedel

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.873777

9,963 views
19 citations

Original Research

Published on 11 Apr 2022

Building Biological Relevance Into Integrative Modelling of Macromolecular Assemblies

in Structural Biology

Anne-Elisabeth Molza
Yvonne Westermaier
Magali Moutte
Pierre Ducrot
Claudia Danilowicz
Veronica Godoy-Carter
Mara Prentiss
Charles H. Robert
Marc Baaden
Chantal Prévost

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.826136

4,502 views
6 citations

Original Research

Published on 11 Apr 2022

Ligand-Bound Forced Degradation as a Strategy to Generate Functionally Relevant Analytical Challenge Materials for Assessment of CQAs

in Structural Biology

John P. Giddens
John E. Schiel

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.789973

3,088 views
3 citations

Perspective

Published on 11 Apr 2022

Experiences From Developing Software for Large X-Ray Crystallography-Driven Protein-Ligand Studies

in Structural Biology

Nicholas M. Pearce
Rachael Skyner
Tobias Krojer

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.861491

3,966 views
3 citations

Original Research

Published on 11 Apr 2022

Structural Characterization of the Full-Length Anti-CD20 Antibody Rituximab

in Structural Biology

Benny Danilo Belviso
Giuseppe Felice Mangiatordi
Domenico Alberga
Vincenzo Mangini
Benedetta Carrozzini
Rocco Caliandro

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.823174

8,541 views
18 citations

Mini Review

Published on 08 Apr 2022

Contribution of Infrared Spectroscopy to the Understanding of Amyloid Protein Aggregation in Complex Systems

in Structural Biology

Diletta Ami
Paolo Mereghetti
Antonino Natalello

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.822852

6,694 views
21 citations

Original Research

Published on 07 Apr 2022

Structural Basis of Human Dimeric α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase Inhibition With TES-1025

in Structural Biology

Michele Cianci
Nicola Giacchè
Lucia Cialabrini
Andrea Carotti
Paride Liscio
Emiliano Rosatelli
Francesca De Franco
Massimiliano Gasparrini
Janet Robertson
Adolfo Amici

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.834700

5,150 views
7 citations

Mini Review

Published on 30 Mar 2022

Recent Approaches to the Identification of Novel Microtubule-Targeting Agents

in Structural Biology

Susanna Eli
Rossella Castagna
Marina Mapelli
Emilio Parisini

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.841777

9,735 views
30 citations

Review

Published on 30 Mar 2022

Using Structure-guided Fragment-Based Drug Discovery to Target Pseudomonas aeruginosa Infections in Cystic Fibrosis

in Structural Biology

Sheikh Mohammed Arif
R. Andres Floto
Tom L. Blundell

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.857000

9,674 views
8 citations

Original Research

Published on 29 Mar 2022

NMR Assignment of Methyl Groups in Immobilized Proteins Using Multiple-Bond 13C Homonuclear Transfers, Proton Detection, and Very Fast MAS

in Structural Biology

Piotr Paluch
Rafal Augustyniak
Mai-Liis Org
Kalju Vanatalu
Ats Kaldma
Ago Samoson
Jan Stanek

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.828785

5,363 views
10 citations

Opinion

Published on 25 Mar 2022

Hit and Indexing Rate in Serial Crystallography: Incomparable Statistics

in Structural Biology

Ki Hyun Nam

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.858815

3,249 views
7 citations

Opinion

Published on 18 Mar 2022

Kenneth Charles Holmes 1934–2021

in Structural Biology

Belinda Bullard

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.855014

3,070 views

Original Research

Published on 17 Mar 2022

Linking Alzheimer’s Disease and Type 2 Diabetes: Characterization and Inhibition of Cytotoxic Aβ and IAPP Hetero-Aggregates

in Structural Biology

Kenana Al Adem
Aya Shanti
Amit Srivastava
Dirar Homouz
Sneha Ann Thomas
Mostafa Khair
Cesare Stefanini
Vincent Chan
Tae-Yeon Kim
Sungmun Lee

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.842582

8,582 views
17 citations

Original Research

Published on 16 Mar 2022

A Comprehensive 2D-LC/MS Online Platform for Screening of Acetylcholinesterase Inhibitors

in Structural Biology

Claudia Seidl
Juliana Maria de Lima
Gabriel Mazzi Leme
Ananda Ferreira Pires
Dwight R. Stoll
Carmen Lúcia Cardoso

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.868597

4,623 views
6 citations

Review

Published on 15 Mar 2022

Graphene Oxide and Biomolecules for the Production of Functional 3D Graphene-Based Materials

in Structural Biology

Paolo Passaretti

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.774097

6,836 views
24 citations

Original Research

Published on 11 Mar 2022

Structural Insights Into the Effects of Interactions With Iron and Copper Ions on Ferritin From the Blood Clam Tegillarca granosa

in Structural Biology

Tinghong Ming
Qinqin Jiang
Chunheng Huo
Hengshang Huan
Yan Wu
Chang Su
Xiaoting Qiu
Chenyang Lu
Jun Zhou
Ye Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.800008

4,069 views
5 citations

Original Research

Published on 09 Mar 2022

Human Mitochondrial DNA Polymerase Metal Dependent UV Lesion Bypassing Ability

in Structural Biology

Joon Park
Noe Baruch-Torres
Shigenori Iwai
Geoffrey K. Herrmann
Luis G. Brieba
Y. Whitney Yin

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.808036

4,283 views
6 citations

Review

Published on 01 Mar 2022

Two-Metal-Ion Catalysis: Inhibition of DNA Polymerase Activity by a Third Divalent Metal Ion

in Structural Biology

Jimin Wang
William H. Konigsberg

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.824794

6,792 views
23 citations

Review

Published on 25 Feb 2022

Conformational Dynamics of DNA Polymerases Revealed at the Single-Molecule Level

in Structural Biology

David P. Millar

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.826593

4,969 views
10 citations

Original Research

Published on 23 Feb 2022

Impact of a Single Nucleotide Polymorphism on the 3D Protein Structure and Ubiquitination Activity of E3 Ubiquitin Ligase Arkadia

in Structural Biology

Maria Birkou
Vasilios Raptis
Konstantinos D. Marousis
Athanasios Tsevis
Kyriakos Bourikas
Detlef Bentrop
Vasso Episkopou
Georgios A. Spyroulias

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.844129

2,852 views
3 citations

500 articles

articles

Variable and Conserved Regions of Secondary Structure in the β-Trefoil Fold: Structure Versus Function

Combining Coarse-Grained Simulations and Single Molecule Analysis Reveals a Three-State Folding Model of the Guanidine-II Riboswitch

High-Throughput Native Mass Spectrometry Screening in Drug Discovery

Computational Site Saturation Mutagenesis of Canonical and Non-Canonical Amino Acids to Probe Protein-Peptide Interactions

The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor

Building Biological Relevance Into Integrative Modelling of Macromolecular Assemblies

Ligand-Bound Forced Degradation as a Strategy to Generate Functionally Relevant Analytical Challenge Materials for Assessment of CQAs

Experiences From Developing Software for Large X-Ray Crystallography-Driven Protein-Ligand Studies

Structural Characterization of the Full-Length Anti-CD20 Antibody Rituximab

Contribution of Infrared Spectroscopy to the Understanding of Amyloid Protein Aggregation in Complex Systems

Structural Basis of Human Dimeric α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase Inhibition With TES-1025

Recent Approaches to the Identification of Novel Microtubule-Targeting Agents

Using Structure-guided Fragment-Based Drug Discovery to Target Pseudomonas aeruginosa Infections in Cystic Fibrosis

NMR Assignment of Methyl Groups in Immobilized Proteins Using Multiple-Bond 13C Homonuclear Transfers, Proton Detection, and Very Fast MAS

Hit and Indexing Rate in Serial Crystallography: Incomparable Statistics

Kenneth Charles Holmes 1934–2021

Linking Alzheimer’s Disease and Type 2 Diabetes: Characterization and Inhibition of Cytotoxic Aβ and IAPP Hetero-Aggregates

A Comprehensive 2D-LC/MS Online Platform for Screening of Acetylcholinesterase Inhibitors

Graphene Oxide and Biomolecules for the Production of Functional 3D Graphene-Based Materials

Structural Insights Into the Effects of Interactions With Iron and Copper Ions on Ferritin From the Blood Clam Tegillarca granosa

Human Mitochondrial DNA Polymerase Metal Dependent UV Lesion Bypassing Ability

Two-Metal-Ion Catalysis: Inhibition of DNA Polymerase Activity by a Third Divalent Metal Ion

Conformational Dynamics of DNA Polymerases Revealed at the Single-Molecule Level

Impact of a Single Nucleotide Polymorphism on the 3D Protein Structure and Ubiquitination Activity of E3 Ubiquitin Ligase Arkadia