Frontiers in Molecular Biosciences

Original Research

Published on 04 Jul 2022

Impact of Formulation Choices on the Freeze-Drying of an Interleukin-6 Reference Material

in Structural Biology

Paul Matejtschuk
Christopher Bird
Ernest Ezeajughi
Kirsty MacLellan-Gibson
Meenu Wadhwa

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.868460

4,821 views
1 citation

Original Research

Published on 04 Jul 2022

Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design

in Structural Biology

Annarita Fiorillo
Gianni Colotti
Cécile Exertier
Anastasia Liuzzi
Francesca Seghetti
Alessandra Salerno
Jessica Caciolla
Andrea Ilari

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.900882

2,997 views
9 citations

Original Research

Published on 28 Jun 2022

Photoactivation of a Mechanosensitive Channel

in Structural Biology

Fucsia Crea
Antreas Vorkas
Aoife Redlich
Rubén Cruz
Chaowei Shi
Dirk Trauner
Adam Lange
Ramona Schlesinger
Joachim Heberle

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.905306

4,539 views
12 citations

Original Research

Published on 28 Jun 2022

Wild-Type α-Synuclein and Variants Occur in Different Disordered Dimers and Pre-Fibrillar Conformations in Early Stage of Aggregation

in Structural Biology

Adrien Guzzo
Patrice Delarue
Ana Rojas
Adrien Nicolaï
Gia G. Maisuradze
Patrick Senet

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.910104

3,731 views
10 citations

Original Research

Published on 28 Jun 2022

Deciphering the Molecular Interaction Between the Adhesion G Protein-Coupled Receptor ADGRV1 and its PDZ-Containing Regulator PDZD7

in Structural Biology

Baptiste Colcombet-Cazenave
Florence Cordier
Yanlei Zhu
Guillaume Bouvier
Eleni Litsardaki
Louise Laserre
Marie S. Prevost
Bertrand Raynal
Célia Caillet-Saguy
Nicolas Wolff

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.923740

3,771 views
4 citations

Brief Research Report

Published on 27 Jun 2022

Human Claudin-7 cis-Interactions Are Not Crucial for Membrane-Membrane (Trans-) Interactions

in Structural Biology

Lena Ahlswede
Carmen Siebenaller
Benedikt Junglas
Nadja Hellmann
Dirk Schneider

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.908383

1,868 views

Mini Review

Published on 27 Jun 2022

A Review of Methodologies for the Detection, Quantitation, and Localization of Free Cysteine in Recombinant Proteins: A Focus on Therapeutic Monoclonal Antibodies

in Structural Biology

Clive Metcalfe

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.886417

6,587 views
6 citations

Editorial

Published on 27 Jun 2022

Editorial: Integrative Structural Biology of Proteins and Macromolecular Assemblies: Bridging Experiments and Simulations

in Structural Biology

Paulo Ricardo Batista
Mario Oliveira Neto
David Perahia

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.947582

1,087 views
2 citations

Review

Published on 24 Jun 2022

Recent Technical Advances in Sample Preparation for Single-Particle Cryo-EM

in Structural Biology

Yixin Xu
Shangyu Dang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.892459

13,098 views
22 citations

Original Research

Published on 23 Jun 2022

Approaches to Using the Chameleon: Robust, Automated, Fast-Plunge cryoEM Specimen Preparation

in Structural Biology

Talya S. Levitz
Miriam Weckener
Ivan Fong
James H. Naismith
Catherine L. Drennan
Edward J. Brignole
Daniel K. Clare
Michele C. Darrow

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.903148

5,375 views
30 citations

Methods

Published on 23 Jun 2022

Biophysical Screening Pipeline for Cryo-EM Grid Preparation of Membrane Proteins

in Structural Biology

Stephan Niebling
Katharina Veith
Benjamin Vollmer
Javier Lizarrondo
Osvaldo Burastero
Janina Schiller
Angelica Struve García
Philipp Lewe
Carolin Seuring
Susanne Witt

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.882288

14,477 views
21 citations

Review

Published on 23 Jun 2022

OOP-ESEEM Spectroscopy: Accuracies of Distances of Spin-Correlated Radical Pairs in Biomolecules

in Structural Biology

Tarek Al Said
Stefan Weber
Erik Schleicher

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.890826

2,673 views
5 citations

Methods

Published on 17 Jun 2022

Thicker Ice Improves the Integrity and Angular Distribution of CDC48A Hexamers on Cryo-EM Grids

in Structural Biology

Brandon Huntington
Lingyun Zhao
Patrick Bron
Umar F. Shahul Hameed
Stefan T. Arold
Bilal M. Qureshi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.890390

4,971 views
6 citations

Original Research

Published on 15 Jun 2022

Williams-Beuren Syndrome Related Methyltransferase WBSCR27: From Structure to Possible Function

in Structural Biology

Sofia S. Mariasina
Chi-Fon Chang
Tsimafei L. Navalayeu
Anastasia A. Chugunova
Sergey V. Efimov
Viktor G. Zgoda
Vasily A. Ivlev
Olga A. Dontsova
Petr V. Sergiev
Vladimir I. Polshakov

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.865743

2,726 views
3 citations

Original Research

Published on 14 Jun 2022

Solution Structure of Tubuliform Spidroin N-Terminal Domain and Implications for pH Dependent Dimerization

in Structural Biology

Megija Šede
Jēkabs Fridmanis
Martins Otikovs
Jan Johansson
Anna Rising
Nina Kronqvist
Kristaps Jaudzems

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.936887

2,941 views
6 citations

Original Research

Published on 13 Jun 2022

Membrane Protein Activity Induces Specific Molecular Changes in Nanodiscs Monitored by FTIR Difference Spectroscopy

in Structural Biology

Federico Baserga
Antreas Vorkas
Fucsia Crea
Luiz Schubert
Jheng-Liang Chen
Aoife Redlich
Mariafrancesca La Greca
Julian Storm
Sabine Oldemeyer
Kirsten Hoffmann

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.915328

2,956 views
2 citations