Frontiers in Molecular Biosciences

Original Research

Published on 18 Feb 2022

Fragment-Based Drug Discovery by NMR. Where Are the Successes and Where can It Be Improved?

in Structural Biology

Luca G. Mureddu
Geerten W. Vuister

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.834453

11,474 views
27 citations

Original Research

Published on 17 Feb 2022

iCn3D: From Web-Based 3D Viewer to Structural Analysis Tool in Batch Mode

in Structural Biology

Jiyao Wang
Philippe Youkharibache
Aron Marchler-Bauer
Christopher Lanczycki
Dachuan Zhang
Shennan Lu
Thomas Madej
Gabriele H. Marchler
Tiejun Cheng
Li Chuin Chong

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.831740

12,235 views
49 citations

Original Research

Published on 14 Feb 2022

Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase

in Structural Biology

Kathleen M. Frey
Nicole Bertoletti
Albert H. Chan
Joseph A. Ippolito
Mariela Bollini
Krasimir A. Spasov
William L. Jorgensen
Karen S. Anderson

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.805187

3,324 views
9 citations

Original Research

Published on 14 Feb 2022

Selection and Modelling of a New Single-Domain Intrabody Against TDP-43

in Structural Biology

Martina Gilodi
Simonetta Lisi
Erika F. Dudás
Marco Fantini
Rita Puglisi
Alexandra Louka
Paolo Marcatili
Antonino Cattaneo
Annalisa Pastore

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2021.773234

7,586 views
6 citations

Review

Published on 14 Feb 2022

Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms

in Structural Biology

Giulia Faravelli
Valentina Mondani
P. Patrizia Mangione
Sara Raimondi
Loredana Marchese
Francesca Lavatelli
Monica Stoppini
Alessandra Corazza
Diana Canetti
Guglielmo Verona

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.830006

3,828 views
14 citations

Review

Published on 11 Feb 2022

OB-fold Families of Genome Guardians: A Universal Theme Constructed From the Small β-barrel Building Block

in Structural Biology

Piero R. Bianco

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.784451

4,024 views
14 citations

Original Research

Published on 07 Feb 2022

Crystalline Sponge Method by Three-Dimensional Electron Diffraction

in Structural Biology

Pohua Chen
Yang Liu
Chaochao Zhang
Fei Huang
Leifeng Liu
Junliang Sun

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2021.821927

4,953 views
4 citations

Original Research

Published on 04 Feb 2022

Concurrent Identification and Characterization of Protein Structure and Continuous Internal Dynamics with REDCRAFT

in Structural Biology

Hanin Omar
Aaron Hein
Casey A. Cole
Homayoun Valafar

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.806584

2,044 views
2 citations

Original Research

Published on 27 Jan 2022

Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom

in Structural Biology

Barbara S. Soares
Surza Lucia G. Rocha
Viviane A. Bastos
Diogo B. Lima
Paulo C. Carvalho
Fabio C. Gozzo
Borries Demeler
Tayler L. Williams
Janelle Arnold
Amy Henrickson

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2021.787368

4,500 views
2 citations

Original Research

Published on 25 Jan 2022

Evidence for the Rapid and Divergent Evolution of Mycoplasmas: Structural and Phylogenetic Analysis of Enolases

in Structural Biology

Rong Chen
Lin Zhao
Rong Gan
Zhixin Feng
Chenxi Cui
Xing Xie
Fei Hao
Zhenzhen Zhang
Li Wang
Tingting Ran

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2021.811106

5,236 views
13 citations

Original Research

Published on 25 Jan 2022

In-Cell NMR of Intact Mammalian Cells Preserved with the Cryoprotectants DMSO and Glycerol Have Similar DNP Performance

in Structural Biology

Yiling Xiao
Rupam Ghosh
Kendra K. Frederick

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2021.789478

3,377 views
18 citations

Review

Published on 25 Jan 2022

Structural Insights Into Tautomeric Dynamics in Nucleic Acids and in Antiviral Nucleoside Analogs

in Structural Biology

Bogdan I. Fedeles
Deyu Li
Vipender Singh

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2021.823253

9,105 views
21 citations

Original Research

Published on 19 Jan 2022

Integrated Array Tomography for 3D Correlative Light and Electron Microscopy

in Structural Biology

Ryan Lane
Anouk H. G. Wolters
Ben N. G. Giepmans
Jacob P. Hoogenboom

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2021.822232

5,450 views
9 citations

Methods

Published on 17 Jan 2022

Merging NMR Data and Computation Facilitates Data-Centered Research

in Structural Biology

Kumaran Baskaran
D. Levi Craft
Hamid R. Eghbalnia
Michael R. Gryk
Jeffrey C. Hoch
Mark W. Maciejewski
Adam D. Schuyler
Jonathan R. Wedell
Colin W. Wilburn

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2021.817175

3,560 views
4 citations

Mini Review

Published on 14 Jan 2022

Structure Determination of Microtubules and Pili: Past, Present, and Future Directions

in Structural Biology

James A. Garnett
Joseph Atherton

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2021.830304

4,149 views
4 citations

Brief Research Report

Published on 12 Jan 2022

Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1–Nup98 Complex to Compete With mRNA Nuclear Export

in Structural Biology

Tinghan Li
Yibo Wen
Hangtian Guo
Tingting Yang
Haitao Yang
Xiaoyun Ji

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2021.813248

7,073 views
46 citations