Frontiers in Molecular Biosciences

Original Research

Published on 13 Feb 2026

A data-driven AI framework for personalized diagnosis, prognosis, and therapeutic optimization in chronic disease management using multimodal big data analytics

Yu Zhang
Zhujin Song
Qi Cai

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1689168

530 views

Review

Published on 11 Feb 2026

Connecting the dots: deep learning-based automated model building methods in cryo-EM

Harsh Bansia
Amedee des Georges

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1613399

842 views

Original Research

Published on 29 Jan 2026

Pompe disease: a country-wide molecular screening in a cohort of 15,068 study participants

Aleksander Pushkov
Daria Chudakova
Ilya Zhanin
Sergey Nikitin
Elena Basargina
Lydmila Kuzenkova
Daria Andreeva
Maria Vasil’eva
Sergey Vasichkin
Albina Gabitova

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1745925

1,091 views

Original Research

Published on 29 Jan 2026

Bioenergetic and immunological characterization of cryopreserved peripheral blood mononuclear cells (PBMCs) isolated from blood and buffy coat

Fabian Dieter
Jendrik Grube
Alice Quentin
Gunter P. Eckert

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1716701

705 views

Original Research

Published on 28 Jan 2026

Plasmodium infection fully activates the immune system in peripheral blood and tumor microenvironment in a murine Lewis lung cancer model

Qunfeng Huang
Dongheng Yang
Zhu Tao
Zhaoqing Yu
Wenting Ding
Na Tao
Xiulin Liao
Haoxin Lin
Zhipeng Cheng
Susu Gao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1724792

911 views

Original Research

Published on 27 Jan 2026

Integrating causal human genetics and In vivo transcriptomics to uncover a shared lipid-centric architecture in metabolic and neurocognitive disease

Yi Li
Zhu Ni
Xiao-Yong Xia
Na Cheng
Yu Bo
Junwen He
Yang He
Xiang-Yu Meng
Xu Wang
Xuan Xu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1712198

798 views

Review

Published on 27 Jan 2026

RNA-based therapies for colorectal cancer: targeting the β-catenin pathway via microbiota -modulated miRNAs

Rajkumar Prabhakaran
Ramkumar Muthu
Rajkumar Manickam
Venkatesh Subramanian
Karthikeyan Mahendran

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1736094

1,702 views

Review

Published on 26 Jan 2026

Advances in cardiovascular supplementation: mechanisms, efficacy, and clinical perspectives

Xun Wu
Tanwei Fang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1699492

2,141 views

Original Research

Published on 23 Jan 2026

Investigating circulating expression profile for H19, MEG3, and MIAT long noncoding RNAs with miR-135a and miR-29a in chronic kidney disease and renal hemodialysis patients: interrelations with serum sclerostin

Marwa A. Dahpy
Marwa K. Khairallah
Rania Naguib
Mona A. Khalil
Salwa Seif Eldin
Marwa A. Sabet
Amira A. Kamel

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1703108

636 views

Original Research

Published on 20 Jan 2026

Gene expression profiling identifies ferroptosis-related genes and pathways in human colon cancers cell lines

M. Balik-Meisner
D. Phadke
D. Mav
R. Shah
K. R. Shockley
Carri Murphy
Erik J. Tokar
Birandra K. Sinha

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1680206

911 views

Original Research

Published on 16 Jan 2026

The predictive role of protease-activated receptor (PAR-1) polymorphisms and activated microplatelets on the severity of atherosclerosis – preliminary studies

Urszula Jakobsche-Policht
Agnieszka Bronowicka-Szydełko
Rajmund Adamiec
Dorota Bednarska-Chabowska
Łukasz Lewandowski
Rafał Małecki
Kinga Gostomska-Pampuch
Joanna Adamiec-Mroczek
Marta Myszka-Kozłowska
Dagmara Baczyńska

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1662954

860 views

Review

Published on 15 Jan 2026

Regulatory QTLs affecting miRNA-mRNA interactions in cancer: mechanisms, methods, and clinical implications

Vivek Kumar
Rohit Shukla
Amit Chaudhary
Mansi Gautam

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1749396

1,197 views

Original Research

Published on 15 Jan 2026

A novel tumor-progressing fibroblast signature derived from single-cell RNA sequencing enables prognostic stratification and reveals RNF11 as a functional regulator in bladder cancer

Miaoyu Zhang
Liangbin Lin
He Xu
Xu Su
Kui Zeng
Fangyang Zhong
Xianchao Su
Jie Chen
Min Cao
Hui Yu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1722809

934 views

Brief Research Report

Published on 15 Jan 2026

CSDE1 stabilizes AGO2 in embryonic stem cells

Yuguan Jiang
Mason Waye
Pavan Kumar Kakumani

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1745258

924 views

Original Research

Published on 15 Jan 2026

Exploring the risk stratification of carotid plaque hemodynamic using four-dimensional blood flow technology

Si-yuan Zhang
Hong-liang Zhao
Xiao-wei Song
Jian Wu
Rui Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1685377

787 views

Review

Published on 14 Jan 2026

Origin of the clock in Neurospora crassa

Ahmad Al-Omari
Cara Altimus
Jonathan Arnold
Sam Arsenault
Suchendra Bhandarkar
Shishir Bhusal
Christian Caranica
Jia Hwei Cheong
Zhaojie Deng
Arthur S. Edison

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1697003

1,532 views

Original Research

Published on 13 Jan 2026

Reformulation of the protein databank for real-time search of geometrical attributes of protein structures

Musa Azeem
Christopher Lee
Aaron Hein
Christopher Ott
Homayoun Valafar

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1694750

1,133 views

Original Research

Published on 12 Jan 2026

Construction and validation of a predictive model for hypothermia complication during endoscopic thyroidectomy for thyroid cancer

Hui Ye
Lu Xia
Tian Zhan
Haiwei Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1758239

689 views

Original Research

Published on 12 Jan 2026

Identification of DNASE1L3 as a novel biomarker of clinical stage in liver hepatocellular carcinoma

Weina Xue
Shuying Xie
Tong Wu
Ruixi Li
Dingyan Lu
Shuaishuai Chen
Yue Xu
Yonglin Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1681888

897 views

Review

Published on 12 Jan 2026

Liquid biopsy in cancer diagnosis and prognosis: a paradigm shift in precision oncology

Rayane da Silva Abreu
Danielle Dias Pinto Ferreira
Natassia Silva de Araujo
Samuel Horita
Tatiana Martins Tilli
Wim Degrave
Aline dos Santos Moreira
Mariana Caldas Waghabi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1708518

1,986 views

Original Research

Published on 12 Jan 2026

JAK-centric explainable few-shot gene-expression diagnosis framework for alopecia via MultiPLIER priors and relation-style set-to-set comparison

Nanlan Yu
Ling Ran
Xinrong Gong
Junfei Teng
Shulei Liu
Zhiqiang Song

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1753206

1,035 views

Review

Published on 12 Jan 2026

Circular RNAs: roles in hepatocellular carcinoma immune regulation, implications in immunotherapy, and prospects for clinical translation

Yifan Chen
Jiayi Zhao
Rui Pu
Chao Fu
Zishuai Li
Jianhua Yin
Guangwen Cao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1750832

1,088 views

Review

Published on 12 Jan 2026

DNA methylation and prediction of biological age

Yanfang Chen
Xiangshu Cheng
Shaoping Ji

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1734464

1,207 views

Original Research

Published on 12 Jan 2026

Bromo- and chloro-substituted flavones induce apoptosis and modulate cell death pathways in canine lymphoma and leukemia cells - a comparative in vitro study

Anita Dudek
Ewa Dejnaka
Joanna Sulecka-Zadka
Martyna Perz
Agnieszka Krawczyk-Łebek
Edyta Kostrzewa-Susłow
Hanna Pruchnik
Aleksandra Pawlak

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1738255

987 views

545 Publications

volumes

A data-driven AI framework for personalized diagnosis, prognosis, and therapeutic optimization in chronic disease management using multimodal big data analytics

Connecting the dots: deep learning-based automated model building methods in cryo-EM

Pompe disease: a country-wide molecular screening in a cohort of 15,068 study participants

Bioenergetic and immunological characterization of cryopreserved peripheral blood mononuclear cells (PBMCs) isolated from blood and buffy coat

Plasmodium infection fully activates the immune system in peripheral blood and tumor microenvironment in a murine Lewis lung cancer model

Integrating causal human genetics and In vivo transcriptomics to uncover a shared lipid-centric architecture in metabolic and neurocognitive disease

RNA-based therapies for colorectal cancer: targeting the β-catenin pathway via microbiota -modulated miRNAs

Advances in cardiovascular supplementation: mechanisms, efficacy, and clinical perspectives

Investigating circulating expression profile for H19, MEG3, and MIAT long noncoding RNAs with miR-135a and miR-29a in chronic kidney disease and renal hemodialysis patients: interrelations with serum sclerostin

Gene expression profiling identifies ferroptosis-related genes and pathways in human colon cancers cell lines

The predictive role of protease-activated receptor (PAR-1) polymorphisms and activated microplatelets on the severity of atherosclerosis – preliminary studies

Regulatory QTLs affecting miRNA-mRNA interactions in cancer: mechanisms, methods, and clinical implications

A novel tumor-progressing fibroblast signature derived from single-cell RNA sequencing enables prognostic stratification and reveals RNF11 as a functional regulator in bladder cancer

CSDE1 stabilizes AGO2 in embryonic stem cells

Exploring the risk stratification of carotid plaque hemodynamic using four-dimensional blood flow technology

Origin of the clock in Neurospora crassa

Reformulation of the protein databank for real-time search of geometrical attributes of protein structures

Construction and validation of a predictive model for hypothermia complication during endoscopic thyroidectomy for thyroid cancer

Identification of DNASE1L3 as a novel biomarker of clinical stage in liver hepatocellular carcinoma

Liquid biopsy in cancer diagnosis and prognosis: a paradigm shift in precision oncology

JAK-centric explainable few-shot gene-expression diagnosis framework for alopecia via MultiPLIER priors and relation-style set-to-set comparison

Circular RNAs: roles in hepatocellular carcinoma immune regulation, implications in immunotherapy, and prospects for clinical translation

DNA methylation and prediction of biological age

Bromo- and chloro-substituted flavones induce apoptosis and modulate cell death pathways in canine lymphoma and leukemia cells - a comparative in vitro study