Frontiers in Molecular Medicine

Hypothesis and Theory

Published on 04 Jan 2023

Whole patient knowledge modeling of COVID-19 symptomatology reveals common molecular mechanisms

Stephan Brock
David B. Jackson
Theodoros G. Soldatos
Klaus Hornischer
Anne Schäfer
Francesca Diella
Maximilian Y. Emmert
Simon P. Hoerstrup

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.1035290

7,126 views
3 citations

Technology and Code

Published on 22 Dec 2022

The COVID-19 explorer—An integrated, whole patient knowledge model of COVID-19 disease

Stephan Brock
Theodoros G. Soldatos
David B. Jackson
Francesca Diella
Klaus Hornischer
Anne Schäfer
Simon P. Hoerstrup
Maximilian Y. Emmert

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.1035215

3,761 views
4 citations

Original Research

Published on 16 Dec 2022

Three year results of Blessed: Expanded access for DeltaRex-G for an intermediate size population with advanced pancreatic cancer and sarcoma (NCT04091295) and individual patient use of DeltaRex-G for solid malignancies (IND# 19130)

Sant P. Chawla
Steven Wong
Doris Quon
Ania Moradkhani
Victoria S. Chua
Don A. Brigham
Rebecca A Reed
William Swaney
Frederick L. Hall
Erlinda M. Gordon

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.1092286

4,486 views
5 citations

Review

Published on 13 Dec 2022

Cancer cell targeting by CAR-T cells: A matter of stemness

Caterina D’Accardo
Gaetana Porcelli
Laura Rosa Mangiapane
Chiara Modica
Vincenzo Davide Pantina
Narges Roozafzay
Simone Di Franco
Miriam Gaggianesi
Veronica Veschi
Melania Lo Iacono

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.1055028

9,834 views
12 citations

Original Research

Published on 13 Dec 2022

Novel modular chimeric antigen receptor spacer for T cells derived from signal regulatory protein alpha Ig-like domains

Jan Koski
Farhana Jahan
Annu Luostarinen
Diana Schenkwein
Seppo Ylä-Herttuala
Helka Göös
Hector Monzo
Päivi M. Ojala
Pilvi Maliniemi
Matti Korhonen

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.1049580

5,260 views
6 citations

Specialty Grand Challenge

Published on 18 Nov 2022

Grand challenges in molecular cardiology

Leon J. De Windt

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.920039

2,378 views

Review

Published on 16 Nov 2022

Acetyl-CoA: An interplay between metabolism and epigenetics in cancer

Yang Hao
Qin Yi
Xu XiaoWu
Chen WeiBo
Zu GuangChen
Chen XueMin

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.1044585

14,827 views
15 citations

Hypothesis and Theory

Published on 01 Nov 2022

The vascular protective effect of matrix Gla protein during kidney injury

Yujiro Kida
Ikuyo Yamaguchi

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.970744

6,081 views
7 citations

Mini Review

Published on 01 Nov 2022

Strategies to improve safety profile of AAV vectors

Tuisku Suoranta
Nihay Laham-Karam
Seppo Ylä-Herttuala

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.1054069

14,070 views
14 citations

Original Research

Published on 25 Oct 2022

Calcineurin-NFAT dynamics correspond to cardiac remodeling during aortic banding and debanding, mimicking aortic valve replacement

Ida G. Lunde
Biljana Skrbic
Ivar Sjaastad
Geir Christensen
Cathrine R. Carlson
Theis Tønnessen

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.980717

3,751 views
1 citation

Review

Published on 17 Oct 2022

Insight into genomic organization of pathogenic coronaviruses, SARS-CoV-2: Implication for emergence of new variants, laboratory diagnosis and treatment options

Fikru B. Bedada
Gezahegn Gorfu
Shaolei Teng
Marguerite E. Neita

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.917201

4,186 views

Original Research

Published on 11 Oct 2022

Safety switch optimization enhances antibody-mediated elimination of CAR T cells

Tamer B. Shabaneh
Howell F. Moffett
Sylvia M. Stull
Thomas Derezes
Leah J. Tait
Spencer Park
Stan R. Riddell
Marc J. Lajoie

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.1026474

10,131 views
15 citations

Mini Review

Published on 10 Oct 2022

The role of calcium-calpain pathway in hyperthermia

Atsushi Enomoto
Takemichi Fukasawa

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.1005258

4,122 views
5 citations

Review

Published on 03 Oct 2022

Genetics in parkinson’s disease: From better disease understanding to machine learning based precision medicine

Mohamed Aborageh
Peter Krawitz
Holger Fröhlich

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.933383

4,842 views

Review

Published on 26 Sep 2022

The IRE1α pathway in glomerular diseases: The unfolded protein response and beyond

José R. Navarro-Betancourt
Andrey V. Cybulsky

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.971247

4,536 views
7 citations

Original Research

Published on 21 Sep 2022

Indole and p-cresol in feces of healthy subjects: Concentration, kinetics, and correlation with microbiome

Francesco Candeliere
Marta Simone
Alan Leonardi
Maddalena Rossi
Alberto Amaretti
Stefano Raimondi

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.959189

8,654 views
23 citations

Review

Published on 20 Sep 2022

Targeting epigenetic alterations in cancer stem cells

Francesco Verona
Vincenzo Davide Pantina
Chiara Modica
Melania Lo Iacono
Caterina D’Accardo
Gaetana Porcelli
Dario Cricchio
Alice Turdo
Miriam Gaggianesi
Simone Di Franco

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.1011882

6,191 views
20 citations

Review

Published on 04 Aug 2022

The innate face of Giant Cell Arteritis: Insight into cellular and molecular innate immunity pathways to unravel new possible biomarkers of disease

Chiara Rizzo
Lidia La Barbera
Giuseppe Miceli
Antonino Tuttolomondo
Giuliana Guggino

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.933161

5,016 views
8 citations

Original Research

Published on 12 Jul 2022

Endothelial Function in Postmenopausal Women: The Possible Role of Heat Shock Protein 60 and Serum Androgens

Eleni Armeni
Anastasia Soureti
Areti Augoulea
Asimina Chondrou
Nikolaos Drakoulis
George Kaparos
Dimitrios Delialis
Spyros Stefos
Lasthenis Angelidakis
Alexandros Sianis

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.933188

2,274 views
3 citations

Review

Published on 08 Jul 2022

A Review on Biomarkers for the Evaluation of Autoimmune Cholestatic Liver Diseases and Their Overlap Syndromes

Henry H. Nguyen
Marvin J. Fritzler
Mark G. Swain

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.914505

4,767 views
5 citations

Brief Research Report

Published on 09 May 2022

Nicotinamide Riboside Improves Cardiac Function and Prolongs Survival After Disruption of the Cardiomyocyte Clock

Pieterjan Dierickx
Bryce J. Carpenter
Isaac Celwyn
Daniel P. Kelly
Joseph A. Baur
Mitchell A. Lazar

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.887733

7,048 views
13 citations

Original Research

Published on 27 Apr 2022

Gestational Dating by Urine Metabolic Profile at High Resolution Weekly Sampling Timepoints: Discovery and Validation

Karl G. Sylvester
Shiying Hao
Zhen Li
Zhi Han
Lu Tian
Subhashini Ladella
Ronald J. Wong
Gary M. Shaw
David K. Stevenson
Harvey J. Cohen

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.844280

3,116 views
2 citations

Methods

Published on 30 Mar 2022

Decoding Genetic Markers of Multiple Phenotypic Layers Through Biologically Constrained Genome-To-Phenome Bayesian Sparse Regression

Marie Deprez
Julien Moreira
Maxime Sermesant
Marco Lorenzi

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.830956

2,998 views
2 citations

Original Research

Published on 15 Mar 2022

Selective Inhibition of Bromodomain-Containing Protein 4 Reduces Myofibroblast Transdifferentiation and Pulmonary Fibrosis

Ksenija Bernau
Melissa Skibba
Jonathan P. Leet
Sierra Furey
Carson Gehl
Yi Li
Jia Zhou
Nathan Sandbo
Allan R. Brasier

Frontiers in Molecular Medicine

doi 10.3389/fmmed.2022.842558

4,868 views
13 citations

27 Publications

volumes

Whole patient knowledge modeling of COVID-19 symptomatology reveals common molecular mechanisms

The COVID-19 explorer—An integrated, whole patient knowledge model of COVID-19 disease

Three year results of Blessed: Expanded access for DeltaRex-G for an intermediate size population with advanced pancreatic cancer and sarcoma (NCT04091295) and individual patient use of DeltaRex-G for solid malignancies (IND# 19130)

Cancer cell targeting by CAR-T cells: A matter of stemness

Novel modular chimeric antigen receptor spacer for T cells derived from signal regulatory protein alpha Ig-like domains

Grand challenges in molecular cardiology

Acetyl-CoA: An interplay between metabolism and epigenetics in cancer

The vascular protective effect of matrix Gla protein during kidney injury

Strategies to improve safety profile of AAV vectors

Calcineurin-NFAT dynamics correspond to cardiac remodeling during aortic banding and debanding, mimicking aortic valve replacement

Insight into genomic organization of pathogenic coronaviruses, SARS-CoV-2: Implication for emergence of new variants, laboratory diagnosis and treatment options

Safety switch optimization enhances antibody-mediated elimination of CAR T cells

The role of calcium-calpain pathway in hyperthermia

Genetics in parkinson’s disease: From better disease understanding to machine learning based precision medicine

The IRE1α pathway in glomerular diseases: The unfolded protein response and beyond

Indole and p-cresol in feces of healthy subjects: Concentration, kinetics, and correlation with microbiome

Targeting epigenetic alterations in cancer stem cells

The innate face of Giant Cell Arteritis: Insight into cellular and molecular innate immunity pathways to unravel new possible biomarkers of disease

Endothelial Function in Postmenopausal Women: The Possible Role of Heat Shock Protein 60 and Serum Androgens

A Review on Biomarkers for the Evaluation of Autoimmune Cholestatic Liver Diseases and Their Overlap Syndromes

Nicotinamide Riboside Improves Cardiac Function and Prolongs Survival After Disruption of the Cardiomyocyte Clock

Gestational Dating by Urine Metabolic Profile at High Resolution Weekly Sampling Timepoints: Discovery and Validation

Decoding Genetic Markers of Multiple Phenotypic Layers Through Biologically Constrained Genome-To-Phenome Bayesian Sparse Regression

Selective Inhibition of Bromodomain-Containing Protein 4 Reduces Myofibroblast Transdifferentiation and Pulmonary Fibrosis