Frontiers in Molecular Neuroscience

Original Research

Published on 08 Dec 2025

Effects of voluntary wheel running on appetite-regulating peptides and neuroinflammation in the hypothalamus of ovariectomized middle-aged mice

in Methods and Model Organisms

Mateusz Grabowski
Konstancja Grabowska
Magdalena Kostka
Natalia Pondel
Halina Jędrzejowska-Szypułka
Andrzej Małecki
Jarosław J. Barski
Marta Nowacka-Chmielewska

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1698306

1,501 views

Original Research

Published on 05 Dec 2025

Unraveling proteomic signatures and neuroinflammatory networks in a CCI rat model of early sciatica: insights for neuropathic pain mechanisms

in Pain Mechanisms and Modulators

Xingjuan Li
Xiaojie Wang
Jinhui Song
Bin Jiang
Yaqin Wen
Yang Wang
Bo Liu
Xiao Zheng

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1674151

1,545 views

Original Research

Published on 03 Dec 2025

Inhibition of pro-apoptotic UPR pathways PERK/CHOP and IRE1/JNK protects differentiated SH-SY5Y cells against rotenone-induced toxicity

in Molecular Signalling and Pathways

Natalia Siwecka
Wioletta Rozpȩdek-Kamińska
Michał Golberg
Wojciech Wiese
Grzegorz Galita
Ireneusz Majsterek

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1700897

1,515 views

Opinion

Published on 03 Dec 2025

Reelin signaling as a translational rheostat: linking synaptic homeostasis to neurodevelopment and neurodegeneration

in Neuroplasticity and Development

Murat S. Durakoglugil

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1731914

1,517 views

Original Research

Published on 02 Dec 2025

Regulation of granin neuropeptide gene expression in human brain during development

in Molecular Signalling and Pathways

Laura L. Demsey
Sonia Podvin
Vivian Hook

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1666795

1,647 views

Review

Published on 02 Dec 2025

Dynamic glycosylation remodeling in neurological disorders

in Brain Disease Mechanisms

Dan Xing
Yingxun Gong
Weiyi Xia
Huifang Tu
Limei Yuan
Yiqing Yin
Kaiyuan Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1674665

1,925 views

Review

Published on 01 Dec 2025

Interplay between lipid droplets and alpha-synuclein: implication in Parkinson’s disease pathogenesis

in Molecular Signalling and Pathways

Walid Idi
Razan Sheta
Abid Oueslati

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1681039

3,016 views
1 citation

Original Research

Published on 26 Nov 2025

A novel target for analgesic substances: physiological role of Na,K-ATPase as the signal transducer

in Pain Mechanisms and Modulators

Valentina A. Penniyaynen
Dmitriy M. Samosvat
Vera B. Plakhova
Svetlana A. Podzorova
Anna V. Berintseva
Irina P. Butkevich
Viktor A. Mikhailenko
Georgy G. Zegrya
Ke Ma
Ilya V. Dukhovlinov

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1717676

1,077 views

Original Research

Published on 25 Nov 2025

Construction of a diagnostic prediction model for ischemic stroke using lactylation-related genes

in Brain Disease Mechanisms

Jierong Mo
Deyuan Ning
Shuyi Chen
Tianen Zhou
Peiyi Liu
Zhiquan Li
Wenmin Tang
Lianshan Guo
Zhiyong Lin
Ran Zhan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1672374

2,171 views

Editorial

Published on 25 Nov 2025

Editorial: Nutrient signaling and neuroendocrine pathways in brain-organ communication

in Molecular Signalling and Pathways

Hiroyuki Aizawa
Hiroaki Masuzaki

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1711443

971 views

Review

Published on 21 Nov 2025

The cone visual cycle and its disorders: insights from zebrafish

in Methods and Model Organisms

Ioanna S. Koutroumpa
Stephan C. F. Neuhauss

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1730071

1,542 views

Original Research

Published on 19 Nov 2025

Predictive value of circulating SNHG1/miR-194-5p and carotid ultrasound for the onset of cerebral infarction in patients with transient cerebral ischemia

in Brain Disease Mechanisms

Wei Wang
Mingjia Lv
Xin Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1689127

1,085 views

Original Research

Published on 19 Nov 2025

Hypoxic preconditioning increases mitochondrial respiration and H2O2 production

in Brain Disease Mechanisms

Lisa Bergmeister
Carolina Doerrier
Barbara Fogli
Tímea Komlódi
Amrei Fischer
Kerstin Springer
Christoph Schwarzer
Erich Gnaiger

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1628567

2,399 views

Systematic Review

Published on 18 Nov 2025

C9orf72-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review

in Brain Disease Mechanisms

Seham Almalki
Mohamed Salama
Matthew J. Taylor
Zubair Ahmed
Richard I. Tuxworth

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1671906

3,769 views
1 citation

Review

Published on 17 Nov 2025

Alpha-neurexins in health and disease

in Molecular Signalling and Pathways

Nicolas Chofflet
Manni Wang
Mathilde Chofflet
Hideto Takahashi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1716782

1,965 views

Mini Review

Published on 14 Nov 2025

Habituation learning: insights from zebrafish larvae

in Methods and Model Organisms

Laura Köcher
Dominik Straumann

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1697688

2,017 views

Opinion

Published on 12 Nov 2025

One RNA-binding protein, many decisions: integrating the transcript life cycle into neuronal regulation

in Brain Disease Mechanisms

Epaminondas Doxakis
Yuan Chao Xue
Anca F. Savulescu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1716825

2,110 views

Original Research

Published on 10 Nov 2025

MicroRNAs and rs1803274 SNP-based BuChe downregulation are associated with metabolic syndrome through ghrelin hydrolysis and expression quantitative trait loci regulation in PD patients

in Brain Disease Mechanisms

Guenson Chevalier
Lucas Udovin
Matilde Otero-Losada
Sofia Bordet
Santiago Perez-Lloret
Francisco Capani

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1635201

1,514 views

Review

Published on 10 Nov 2025

The transcriptional and cellular landscape of cognitive resilience to Alzheimer’s disease

in Neuroplasticity and Development

Nina Khera
Ravikiran M. Raju
Stuart A. Lipton

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1665802

2,222 views
1 citation

Original Research

Published on 05 Nov 2025

Pex1 loss-of-function in zebrafish is viable and recapitulates hallmarks of Zellweger spectrum disorders

in Molecular Signalling and Pathways

Ursula Heins-Marroquin
Zlatan Hodzic
Beatriz Soares Carneiro da Silva
Agnes Hendriks
Floriane Gavotto
Marc O. Warmoes
Lisa Schlicker
Samy Omri
Christian Jäger
Enrico Glaab

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1634536

2,086 views

Brief Research Report

Published on 05 Nov 2025

Phosphoprofile reorganization of the actin binding protein Drebrin during long term depression

in Molecular Signalling and Pathways

Rafaela Pedro Silva
Till G. A. Mack
Marieluise Kirchner
Philipp Mertins
Britta J. Eickholt
Patricia Kreis

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1697642

1,696 views
1 citation

Original Research

Published on 03 Nov 2025

Focal postnatal deletion of Tsc2 causes epilepsy

in Brain Disease Mechanisms

Carlie McCoy
Mary Dusing
Lilian G. Jerow
Grace C. Winstel
Felix Zhan
Jason L. Rogers
Madison Wesley
J. Brian Otten
Steve C. Danzer
Candi L. LaSarge

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1686023

2,534 views

Systematic Review

Published on 31 Oct 2025

FUS-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review

in Brain Disease Mechanisms

Seham Almalki
Mohamed Salama
Matthew J. Taylor
Zubair Ahmed
Richard I. Tuxworth

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1671910

3,514 views
1 citation

Review

Published on 30 Oct 2025

The role and mechanisms of matrix metalloproteinase-9 in peripheral neuropathic pain

in Pain Mechanisms and Modulators

Shuai Ying Jia
Xiao-Jun Tang
Yao Su
Yu-Ning Liu
Zhi Ming
Jing-Yan Lin

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1647316

1,723 views

4,352 articles

articles

Effects of voluntary wheel running on appetite-regulating peptides and neuroinflammation in the hypothalamus of ovariectomized middle-aged mice

Unraveling proteomic signatures and neuroinflammatory networks in a CCI rat model of early sciatica: insights for neuropathic pain mechanisms

Inhibition of pro-apoptotic UPR pathways PERK/CHOP and IRE1/JNK protects differentiated SH-SY5Y cells against rotenone-induced toxicity

Reelin signaling as a translational rheostat: linking synaptic homeostasis to neurodevelopment and neurodegeneration

Regulation of granin neuropeptide gene expression in human brain during development

Dynamic glycosylation remodeling in neurological disorders

Interplay between lipid droplets and alpha-synuclein: implication in Parkinson’s disease pathogenesis

A novel target for analgesic substances: physiological role of Na,K-ATPase as the signal transducer

Construction of a diagnostic prediction model for ischemic stroke using lactylation-related genes

Editorial: Nutrient signaling and neuroendocrine pathways in brain-organ communication

The cone visual cycle and its disorders: insights from zebrafish

Predictive value of circulating SNHG1/miR-194-5p and carotid ultrasound for the onset of cerebral infarction in patients with transient cerebral ischemia

Hypoxic preconditioning increases mitochondrial respiration and H2O2 production

C9orf72-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review

Alpha-neurexins in health and disease

Habituation learning: insights from zebrafish larvae

One RNA-binding protein, many decisions: integrating the transcript life cycle into neuronal regulation

MicroRNAs and rs1803274 SNP-based BuChe downregulation are associated with metabolic syndrome through ghrelin hydrolysis and expression quantitative trait loci regulation in PD patients

The transcriptional and cellular landscape of cognitive resilience to Alzheimer’s disease

Pex1 loss-of-function in zebrafish is viable and recapitulates hallmarks of Zellweger spectrum disorders

Phosphoprofile reorganization of the actin binding protein Drebrin during long term depression

Focal postnatal deletion of Tsc2 causes epilepsy

FUS-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review

The role and mechanisms of matrix metalloproteinase-9 in peripheral neuropathic pain