Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Original Research

Published on 13 Sep 2022

Identification of two novel variants of the BCL11B gene in two Chinese pedigrees associated with neurodevelopmental disorders

in Brain Disease Mechanisms

Fengyu Che
Xiaoling Tie
Hong Lei
Xi Zhang
Mingyue Duan
Liyu Zhang
Ying Yang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.927357

5,149 views
16 citations

Original Research

Published on 12 Sep 2022

Identification of the key immune-related genes in aneurysmal subarachnoid hemorrhage

in Brain Disease Mechanisms

Xing Wang
Dingke Wen
Chao You
Lu Ma

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.931753

5,229 views
10 citations

Mini Review

Published on 09 Sep 2022

Misfolding at the synapse: A role in amyotrophic lateral sclerosis pathogenesis?

in Brain Disease Mechanisms

Jeremy S. Lum
Justin J. Yerbury

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.997661

5,486 views
1 citation

Mini Review

Published on 09 Sep 2022

Innate immune activation: Parallels in alcohol use disorder and Alzheimer’s disease

in Brain Disease Mechanisms

Adriana Ramos
Radhika S. Joshi
Gyongyi Szabo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.910298

8,146 views
26 citations

Original Research

Published on 08 Sep 2022

Dexmedetomidine post-conditioning protects blood-brain barrier integrity by modulating microglia/macrophage polarization via inhibiting NF-κB signaling pathway in intracerebral hemorrhage

in Brain Disease Mechanisms

Hao Guo
Weiwei Zhang
Zhi Wang
Zhishan Li
Jing Zhou
Zhaoyu Yang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.977941

6,882 views
21 citations

Review

Published on 07 Sep 2022

A review of respirable fine particulate matter (PM2.5)-induced brain damage

in Brain Disease Mechanisms

Wei Li
Guohui Lin
Zaixing Xiao
Yichuan Zhang
Bin Li
Yu Zhou
Yong Ma
Erqing Chai

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.967174

27,366 views
83 citations

Original Research

Published on 05 Sep 2022

A polymorphic transcriptional regulatory domain in the amyotrophic lateral sclerosis risk gene CFAP410 correlates with differential isoform expression

in Brain Disease Mechanisms

Jack N. G. Marshall
Alexander Fröhlich
Li Li
Abigail L. Pfaff
Ben Middlehurst
Thomas P. Spargo
Alfredo Iacoangeli
Bing Lang
Ammar Al-Chalabi
Sulev Koks

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.954928

3,766 views
2 citations

Original Research

Published on 02 Sep 2022

Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer’s and Parkinson’s disease

in Brain Disease Mechanisms

Muslum Gok
Nimrod Madrer
Tamara Zorbaz
Estelle R. Bennett
David Greenberg
David A. Bennett
Hermona Soreq

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.941467

6,275 views
12 citations

Original Research

Published on 02 Sep 2022

Investigating changes in blood-cerebrospinal fluid barrier function in a rat model of chronic hypertension using non-invasive magnetic resonance imaging

in Brain Disease Mechanisms

Charith Perera
Daniele Tolomeo
Rebecca R. Baker
Yolanda Ohene
Alla Korsak
Mark F. Lythgoe
David L. Thomas
Jack A. Wells

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.964632

6,482 views
9 citations

Original Research

Published on 02 Sep 2022

Endoproteolysis of cellular prion protein by plasmin hinders propagation of prions

in Brain Disease Mechanisms

Charles E. Mays
Trang H. T. Trinh
Glenn Telling
Hae-Eun Kang
Chongsuk Ryou

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.990136

5,694 views
2 citations

General Commentary

Published on 02 Sep 2022

Commentary: SPTBN5, encoding the βV-spectrin protein, leads to a syndrome of intellectual disability, developmental delay, and seizures

in Brain Disease Mechanisms

Danique Beijer
Stephan L. Züchner

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.1011856

2,432 views
1 citation

Original Research

Published on 01 Sep 2022

Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca2+/calmodulin-dependent CaMKIIα activity in de novo mutations related to intellectual disability

in Brain Disease Mechanisms

Hajime Fujii
Hiroyuki Kidokoro
Yayoi Kondo
Masahiro Kawaguchi
Shin-ichiro Horigane
Jun Natsume
Sayaka Takemoto-Kimura
Haruhiko Bito

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.970031

6,364 views
7 citations

Review

Published on 31 Aug 2022

Based on molecular structures: Amyloid-β generation, clearance, toxicity and therapeutic strategies

in Brain Disease Mechanisms

Hai Yang
Jinping Li
Xiaoxiong Li
Linqiu Ma
Mingliang Hou
Huadong Zhou
Rui Zhou

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.927530

10,591 views
23 citations

Original Research

Published on 29 Aug 2022

Exercise modulates central and peripheral inflammatory responses and ameliorates methamphetamine-induced anxiety-like symptoms in mice

in Brain Disease Mechanisms

Guo-Fen Re
Hong Li
Ji-Qun Yang
Yue Li
Zunyue Zhang
Xiaocong Wu
Ruiyi Zhou
Deshenyue Kong
Huayou Luo
Yi-Qun Kuang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.955799

10,898 views
14 citations

Original Research

Published on 25 Aug 2022

Emerging evidence of genotype–phenotype associations of developmental and epileptic encephalopathy due to KCNC2 mutation: Identification of novel R405G

in Brain Disease Mechanisms

Sumei Wang
Yejing Yu
Xu Wang
Xiaolong Deng
Jiehui Ma
Zhisheng Liu
Weiyue Gu
Dan Sun

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.950255

3,811 views
5 citations

Review

Published on 25 Aug 2022

Cholesterol as a key player in amyloid β-mediated toxicity in Alzheimer’s disease

in Brain Disease Mechanisms

Vladimir Rudajev
Jiri Novotny

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.937056

14,329 views
79 citations

Review

Published on 25 Aug 2022

Neuronal cell death mechanisms in Alzheimer’s disease: An insight

in Brain Disease Mechanisms

Parul Goel
Sasanka Chakrabarti
Kapil Goel
Karanpreet Bhutani
Tanya Chopra
Sharadendu Bali

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.937133

36,211 views
198 citations

Mini Review

Published on 15 Aug 2022

S100A10 and its binding partners in depression and antidepressant actions

in Brain Disease Mechanisms

Michelle X. Chen
Yong-Seok Oh
Yong Kim

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.953066

10,692 views
36 citations

Original Research

Published on 15 Aug 2022

Lysosomal-associated transmembrane protein 5 deficiency exacerbates cerebral ischemia/reperfusion injury

in Brain Disease Mechanisms

Zongyong Zhang
Lei Wang
Zhen Wang
Tingbao Zhang
Min Shi
Can Xin
Yichun Zou
Wei Wei
Xiang Li
Jincao Chen

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.971361

5,249 views
11 citations

Original Research

Published on 11 Aug 2022

Spatial-temporal changes of iron deposition and iron metabolism after traumatic brain injury in mice

in Brain Disease Mechanisms

Hao Cheng
Ning Wang
Xingyu Ma
Pengfei Wang
Wenwen Dong
Ziyuan Chen
Mingzhe Wu
Ziwei Wang
Linlin Wang
Dawei Guan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.949573

7,669 views
30 citations

Original Research

Published on 09 Aug 2022

Behavioral and Molecular Responses to Exogenous Cannabinoids During Pentylenetetrazol-Induced Convulsions in Male and Female Rats

in Brain Disease Mechanisms

Antonella Zirotti Rosenberg
Maxs Méndez-Ruette
Mario Gorziglia
Benjamín Alzerreca
Javiera Cabello
Sofía Kaufmann
Lukas Rambousek
Andrés Iturriaga Jofré
Ursula Wyneken
Carlos A. Lafourcade

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.868583

4,432 views
4 citations

Original Research

Published on 09 Aug 2022

Adult health and transition stage-specific rotenone-mediated Drosophila model of Parkinson’s disease: Impact on late-onset neurodegenerative disease models

in Brain Disease Mechanisms

Mohamad Ayajuddin
Limamanen Phom
Zevelou Koza
Priyanka Modi
Abhik Das
Rahul Chaurasia
Abuno Thepa
Nukshimenla Jamir
Kelevikho Neikha
Sarat Chandra Yenisetti

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.896183

5,553 views
19 citations

Mini Review

Published on 04 Aug 2022

A mini-review of the role of condensin in human nervous system diseases

in Brain Disease Mechanisms

Du Pang
Shengping Yu
Xuejun Yang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.889796

6,014 views
11 citations

Review

Published on 03 Aug 2022

Neuronopathic Gaucher disease: Beyond lysosomal dysfunction

in Brain Disease Mechanisms

Nohela B. Arévalo
Cristian M. Lamaizon
Viviana A. Cavieres
Patricia V. Burgos
Alejandra R. Álvarez
María J. Yañez
Silvana Zanlungo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.934820

17,104 views
21 citations

1,115 articles

articles

Identification of two novel variants of the BCL11B gene in two Chinese pedigrees associated with neurodevelopmental disorders

Identification of the key immune-related genes in aneurysmal subarachnoid hemorrhage

Misfolding at the synapse: A role in amyotrophic lateral sclerosis pathogenesis?

Innate immune activation: Parallels in alcohol use disorder and Alzheimer’s disease

Dexmedetomidine post-conditioning protects blood-brain barrier integrity by modulating microglia/macrophage polarization via inhibiting NF-κB signaling pathway in intracerebral hemorrhage

A review of respirable fine particulate matter (PM2.5)-induced brain damage

A polymorphic transcriptional regulatory domain in the amyotrophic lateral sclerosis risk gene CFAP410 correlates with differential isoform expression

Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer’s and Parkinson’s disease

Investigating changes in blood-cerebrospinal fluid barrier function in a rat model of chronic hypertension using non-invasive magnetic resonance imaging

Endoproteolysis of cellular prion protein by plasmin hinders propagation of prions

Commentary: SPTBN5, encoding the βV-spectrin protein, leads to a syndrome of intellectual disability, developmental delay, and seizures

Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca2+/calmodulin-dependent CaMKIIα activity in de novo mutations related to intellectual disability

Based on molecular structures: Amyloid-β generation, clearance, toxicity and therapeutic strategies

Exercise modulates central and peripheral inflammatory responses and ameliorates methamphetamine-induced anxiety-like symptoms in mice

Emerging evidence of genotype–phenotype associations of developmental and epileptic encephalopathy due to KCNC2 mutation: Identification of novel R405G

Cholesterol as a key player in amyloid β-mediated toxicity in Alzheimer’s disease

Neuronal cell death mechanisms in Alzheimer’s disease: An insight

S100A10 and its binding partners in depression and antidepressant actions

Lysosomal-associated transmembrane protein 5 deficiency exacerbates cerebral ischemia/reperfusion injury

Spatial-temporal changes of iron deposition and iron metabolism after traumatic brain injury in mice

Behavioral and Molecular Responses to Exogenous Cannabinoids During Pentylenetetrazol-Induced Convulsions in Male and Female Rats

Adult health and transition stage-specific rotenone-mediated Drosophila model of Parkinson’s disease: Impact on late-onset neurodegenerative disease models

A mini-review of the role of condensin in human nervous system diseases

Neuronopathic Gaucher disease: Beyond lysosomal dysfunction