Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Review

Published on 10 Mar 2022

Modeling Epilepsy Using Human Induced Pluripotent Stem Cells-Derived Neuronal Cultures Carrying Mutations in Ion Channels and the Mechanistic Target of Rapamycin Pathway

in Brain Disease Mechanisms

Octavia Yifang Weng
Yun Li
Lu-Yang Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.810081

8,296 views
4 citations

Original Research

Published on 09 Mar 2022

Characterisation of the Function of a SINE-VNTR-Alu Retrotransposon to Modulate Isoform Expression at the MAPT Locus

in Brain Disease Mechanisms

Alexander Fröhlich
Abigail L. Pfaff
Vivien J. Bubb
Sulev Koks
John P. Quinn

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.815695

5,514 views
14 citations

Review

Published on 08 Mar 2022

Role of Semaphorins in Ischemic Stroke

in Brain Disease Mechanisms

Huaping Du
Yuan Xu
Li Zhu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.848506

6,670 views
16 citations

Original Research

Published on 03 Mar 2022

Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology

in Brain Disease Mechanisms

Andreia Gomes-Duarte
Morten T. Venø
Marina de Wit
Ketharini Senthilkumar
Mark H. Broekhoven
Joëlle van den Herik
Fleur R. Heeres
Daniëlle van Rossum
Mateja Rybiczka-Tesulov
Ivano Legnini

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.832133

7,359 views
21 citations

Original Research

Published on 02 Mar 2022

Blood SSR1: A Possible Biomarker for Early Prediction of Parkinson’s Disease

in Brain Disease Mechanisms

Wen Zhang
Jiabing Shen
Yuhui Wang
Kefu Cai
Qi Zhang
Maohong Cao

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.762544

6,792 views
11 citations

Original Research

Published on 25 Feb 2022

Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury

in Brain Disease Mechanisms

Lauren E. Fritsch
Jing Ju
Erwin Kristobal Gudenschwager Basso
Eman Soliman
Swagatika Paul
Jiang Chen
Alexandra M. Kaloss
Elizabeth A. Kowalski
Taylor C. Tuhy
Rachana Deven Somaiya

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.852243

11,972 views
45 citations

Original Research

Published on 24 Feb 2022

Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage

in Brain Disease Mechanisms

Elvira Ruslanovna Akhmetzyanova
Anna Viktorovna Timofeeva
Davran Khudaishukurovich Sabirov
Alexander Alexandrovich Kostennikov
Alexander Alexandrovich Rogozhin
Victoria James
S. S. Arkhipova
Albert Anatolevich Rizvanov
Yana Olegovna Mukhamedshina

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.802558

5,159 views
8 citations

Original Research

Published on 24 Feb 2022

Novel Intronic Mutations of TBK1 Promote Aberrant Splicing Modes in Amyotrophic Lateral Sclerosis

in Brain Disease Mechanisms

Ying-Qian Lu
Jian-Min Chen
Han Lin
Shu-Yan Feng
Chun-Hui Che
Chang-Yun Liu
Hua-Pin Huang
Zhang-Yu Zou

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.691534

4,939 views
7 citations

Editorial

Published on 18 Feb 2022

Editorial: Autism Spectrum Disorders and Metal Dyshomeostasis

in Brain Disease Mechanisms

Mukesh K. Pandey
Andreas M. Grabrucker
Sunil Q. Mehta
Robert J. Harvey

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.861483

2,858 views
1 citation

Original Research

Published on 16 Feb 2022

Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model

in Brain Disease Mechanisms

Hamza Benderradji
Sarra Kraiem
Emilie Courty
Sabiha Eddarkaoui
Cyril Bourouh
Emilie Faivre
Laure Rolland
Emilie Caron
Mélanie Besegher
Frederik Oger

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.841892

6,399 views
10 citations

Mini Review

Published on 16 Feb 2022

Electrophysiological Properties of Human Cortical Organoids: Current State of the Art and Future Directions

in Brain Disease Mechanisms

Clara Zourray
Manju A. Kurian
Serena Barral
Gabriele Lignani

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.839366

13,896 views
18 citations

Review

Published on 15 Feb 2022

New Insights Into the Pivotal Role of CREB-Regulated Transcription Coactivator 1 in Depression and Comorbid Obesity

in Brain Disease Mechanisms

Clara Rossetti
Antoine Cherix
Laetitia F. Guiraud
Jean-René Cardinaux

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.810641

8,971 views
12 citations

Correction

Published on 14 Feb 2022

Corrigendum: Evaluation of Zn, Cu, and Se Levels in the North American Autism Spectrum Disorder Population

in Brain Disease Mechanisms

Sunil Q. Mehta
Supriya Behl
Patrick L. Day
Adriana M. Delgado
Nicholas B. Larson
Lindsay R. Stromback
Andrea R. Huebner
Timothy R. DeGrado
Jessica M. Davis
Paul J. Jannetto

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.831799

2,155 views
2 citations

Original Research

Published on 14 Feb 2022

14-3-3 Dysfunction in Dorsal Hippocampus CA1 (dCA1) Induces Psychomotor Behavior via a dCA1-Lateral Septum-Ventral Tegmental Area Pathway

in Brain Disease Mechanisms

Jiajing Zhang
Meaghan Navarrete
Yuying Wu
Yi Zhou

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.817227

5,786 views
10 citations

Original Research

Published on 11 Feb 2022

Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process

in Brain Disease Mechanisms

Keyoumu Nazere
Tetsuya Takahashi
Naoyuki Hara
Kazuki Muguruma
Masahiro Nakamori
Yu Yamazaki
Hiroyuki Morino
Hirofumi Maruyama

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.804702

8,180 views
20 citations

Original Research

Published on 10 Feb 2022

Circulating MicroRNAs From Plasma Small Extracellular Vesicles as Potential Diagnostic Biomarkers in Pediatric Epilepsy and Drug-Resistant Epilepsy

in Brain Disease Mechanisms

Yilong Wang
Yeping Wang
Yi Chen
Yi Hua
Lu Xu
Mengying Zhu
Congying Zhao
Weiran Zhang
Guoxia Sheng
Liu Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.823802

7,741 views
24 citations

Original Research

Published on 10 Feb 2022

The Impact of Electroacupuncture Early Intervention on the Brain Lipidome in a Mouse Model of Post-traumatic Stress Disorder

in Brain Disease Mechanisms

Cui-Hong Zhou
Fen Xue
Qing-Qing Shi
Shan-Shan Xue
Tian Zhang
Xin-Xu Ma
Li-Sheng Yu
Chuang Liu
Hua-Ning Wang
Zheng-Wu Peng

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.812479

5,276 views
9 citations

Original Research

Published on 09 Feb 2022

The Role of Non-canonical and Canonical Inflammasomes in Inflammaging

in Brain Disease Mechanisms

Brianna Cyr
Roey Hadad
Robert W. Keane
Juan Pablo de Rivero Vaccari

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.774014

7,541 views
29 citations

Original Research

Published on 03 Feb 2022

Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

in Brain Disease Mechanisms

Tanja Herrmann
Melanie Gerth
Ralf Dittmann
Daniel Pensold
Martin Ungelenk
Lutz Liebmann
Christian A. Hübner

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.807090

9,456 views
10 citations

Review

Published on 31 Jan 2022

MicroRNA-21 Is a Versatile Regulator and Potential Treatment Target in Central Nervous System Disorders

in Brain Disease Mechanisms

Xue Bai
Zhigang Bian

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.842288

10,898 views
63 citations

Methods

Published on 31 Jan 2022

Robust Transcriptional Profiling and Identification of Differentially Expressed Genes With Low Input RNA Sequencing of Adult Hippocampal Neural Stem and Progenitor Populations

in Brain Disease Mechanisms

Jiyeon K. Denninger
Logan A. Walker
Xi Chen
Altan Turkoglu
Alex Pan
Zoe Tapp
Sakthi Senthilvelan
Raina Rindani
Olga N. Kokiko-Cochran
Ralf Bundschuh

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.810722

9,600 views
15 citations

Review

Published on 28 Jan 2022

Mitochondrial Quality Control: A Pathophysiological Mechanism and Therapeutic Target for Stroke

in Brain Disease Mechanisms

Miaoxian Yang
Yu He
Shuixiang Deng
Lei Xiao
Mi Tian
Yuewen Xin
Chaocheng Lu
Feng Zhao
Ye Gong

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.786099

12,490 views
49 citations

Original Research

Published on 27 Jan 2022

An in vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-clinical Animal Models

in Brain Disease Mechanisms

Peter Deng
Julian A. N. M. Halmai
Ulrika Beitnere
David Cameron
Michele L. Martinez
Charles C. Lee
Jennifer J. Waldo
Krista Thongphanh
Anna Adhikari
Nycole Copping

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.789913

10,537 views
6 citations

Original Research

Published on 25 Jan 2022

Quantitative Proteomics Reveals the Dynamic Pathophysiology Across Different Stages in a Rat Model of Severe Traumatic Brain Injury

in Brain Disease Mechanisms

Weikang Luo
Zhaoyu Yang
Wei Zhang
Dan Zhou
Xiaohang Guo
Shunshun Wang
Feng He
Yang Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.785938

8,355 views
7 citations

1,115 articles

articles

Modeling Epilepsy Using Human Induced Pluripotent Stem Cells-Derived Neuronal Cultures Carrying Mutations in Ion Channels and the Mechanistic Target of Rapamycin Pathway

Characterisation of the Function of a SINE-VNTR-Alu Retrotransposon to Modulate Isoform Expression at the MAPT Locus

Role of Semaphorins in Ischemic Stroke

Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology

Blood SSR1: A Possible Biomarker for Early Prediction of Parkinson’s Disease

Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury

Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage

Novel Intronic Mutations of TBK1 Promote Aberrant Splicing Modes in Amyotrophic Lateral Sclerosis

Editorial: Autism Spectrum Disorders and Metal Dyshomeostasis

Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model

Electrophysiological Properties of Human Cortical Organoids: Current State of the Art and Future Directions

New Insights Into the Pivotal Role of CREB-Regulated Transcription Coactivator 1 in Depression and Comorbid Obesity

Corrigendum: Evaluation of Zn, Cu, and Se Levels in the North American Autism Spectrum Disorder Population

14-3-3 Dysfunction in Dorsal Hippocampus CA1 (dCA1) Induces Psychomotor Behavior via a dCA1-Lateral Septum-Ventral Tegmental Area Pathway

Amyloid Beta Is Internalized via Macropinocytosis, an HSPG- and Lipid Raft-Dependent and Rac1-Mediated Process

Circulating MicroRNAs From Plasma Small Extracellular Vesicles as Potential Diagnostic Biomarkers in Pediatric Epilepsy and Drug-Resistant Epilepsy

The Impact of Electroacupuncture Early Intervention on the Brain Lipidome in a Mouse Model of Post-traumatic Stress Disorder

The Role of Non-canonical and Canonical Inflammasomes in Inflammaging

Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

MicroRNA-21 Is a Versatile Regulator and Potential Treatment Target in Central Nervous System Disorders

Robust Transcriptional Profiling and Identification of Differentially Expressed Genes With Low Input RNA Sequencing of Adult Hippocampal Neural Stem and Progenitor Populations

Mitochondrial Quality Control: A Pathophysiological Mechanism and Therapeutic Target for Stroke

An in vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-clinical Animal Models

Quantitative Proteomics Reveals the Dynamic Pathophysiology Across Different Stages in a Rat Model of Severe Traumatic Brain Injury