Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Original Research

Published on 24 Jan 2022

Brain-Type Glycogen Phosphorylase Is Crucial for Astrocytic Glycogen Accumulation in Chronic Social Defeat Stress-Induced Depression in Mice

in Brain Disease Mechanisms

Yuanyuan Zhu
Ze Fan
Qiuying Zhao
Jiaqi Li
Guohong Cai
Rui Wang
Yi Liang
Naining Lu
Junjun Kang
Danlei Luo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.819440

8,645 views
13 citations

Mini Review

Published on 21 Jan 2022

MicroRNAs Play a Role in Parkinson’s Disease by Regulating Microglia Function: From Pathogenetic Involvement to Therapeutic Potential

in Brain Disease Mechanisms

Silu Li
Guorong Bi
Shunchang Han
Rui Huang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.744942

7,535 views
41 citations

Review

Published on 21 Jan 2022

Glycogen Synthase Kinase-3 Inhibitors: Preclinical and Clinical Focus on CNS-A Decade Onward

in Brain Disease Mechanisms

Sara Melisa Arciniegas Ruiz
Hagit Eldar-Finkelman

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.792364

34,796 views
112 citations

Original Research

Published on 17 Jan 2022

Aerobic Exercise Training-Induced Changes on DNA Methylation in Mild Cognitively Impaired Elderly African Americans: Gene, Exercise, and Memory Study - GEMS-I

in Brain Disease Mechanisms

Julius S. Ngwa
Evaristus Nwulia
Oyonumo Ntekim
Fikru B. Bedada
Bernard Kwabi-Addo
Sheeba Nadarajah
Steven Johnson
William M. Southerland
John Kwagyan
Thomas O. Obisesan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.752403

6,798 views
16 citations

Original Research

Published on 14 Jan 2022

Netrin-1 Ameliorates Postoperative Delirium-Like Behavior in Aged Mice by Suppressing Neuroinflammation and Restoring Impaired Blood-Brain Barrier Permeability

in Brain Disease Mechanisms

Ke Li
Jiayu Wang
Lei Chen
Meimei Guo
Ying Zhou
Xiaofeng Li
Mian Peng

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.751570

9,227 views
36 citations

Brief Research Report

Published on 12 Jan 2022

HDAC1 Regulates Neuronal Differentiation

in Brain Disease Mechanisms

Vanesa Nieto-Estevez
Gopakumar Changarathil
Adebayo Olukayode Adeyeye
Marissa Olga Coppin
Rawan Serena Kassim
Jingfei Zhu
Jenny Hsieh

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.815808

11,253 views
28 citations

Original Research

Published on 12 Jan 2022

Detection and Functional Evaluation of the P2X7 Receptor in hiPSC Derived Neurons and Microglia-Like Cells

in Brain Disease Mechanisms

Linda Francistiová
Kinga Vörös
Zsófia Lovász
András Dinnyés
Julianna Kobolák

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.793769

7,168 views
13 citations

Review

Published on 07 Jan 2022

Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

in Brain Disease Mechanisms

Shuang Chen
Da Xu
Liu Fan
Zhi Fang
Xiufeng Wang
Man Li

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.797253

16,120 views
65 citations

Review

Published on 06 Jan 2022

Hyperexcitability and Homeostasis in Fragile X Syndrome

in Brain Disease Mechanisms

Xiaopeng Liu
Vipendra Kumar
Nien-Pei Tsai
Benjamin D. Auerbach

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.805929

13,136 views
54 citations

Original Research

Published on 05 Jan 2022

Lipopolysaccharide From E. coli Increases Glutamate-Induced Disturbances of Calcium Homeostasis, the Functional State of Mitochondria, and the Death of Cultured Cortical Neurons

in Brain Disease Mechanisms

Zanda Bakaeva
Natalia Lizunova
Ivan Tarzhanov
Dmitrii Boyarkin
Svetlana Petrichuk
Vsevolod Pinelis
Andrey Fisenko
Alexander Tuzikov
Rinat Sharipov
Alexander Surin

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.811171

5,726 views
16 citations

Original Research

Published on 04 Jan 2022

Abnormal Somatosensory Behaviors Associated With a Gain-of-Function Mutation in TRPV3 Channels

in Brain Disease Mechanisms

Mahar Fatima
Hannah Slade
Lorraine Horwitz
Angela Shi
Jingyi Liu
Delaney McKinstry
Troy Villani
Haoxing Xu
Bo Duan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.790435

4,378 views
10 citations

Original Research

Published on 04 Jan 2022

Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System

in Brain Disease Mechanisms

Benjamin Deckmyn
Dorothée Domenger
Chloé Blondel
Sarah Ducastel
Emilie Nicolas
Emilie Dorchies
Emilie Caron
Julie Charton
Emmanuelle Vallez
Benoit Deprez

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.808603

7,123 views
21 citations

Mini Review

Published on 04 Jan 2022

Modeling Somatic Mutations Associated With Neurodevelopmental Disorders in Human Brain Organoids

in Brain Disease Mechanisms

Bipan K. Deb
Helen S. Bateup

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.787243

8,123 views
7 citations

Systematic Review

Published on 24 Dec 2021

Effects of Mdivi-1 on Neural Mitochondrial Dysfunction and Mitochondria-Mediated Apoptosis in Ischemia-Reperfusion Injury After Stroke: A Systematic Review of Preclinical Studies

in Brain Disease Mechanisms

Nguyen Thanh Nhu
Qing Li
Yijie Liu
Jian Xu
Shu-Yun Xiao
Shin-Da Lee

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.778569

12,960 views
68 citations

Original Research

Published on 23 Dec 2021

Exendin-4 Preserves Blood-Brain Barrier Integrity via Glucagon-Like Peptide 1 Receptor/Activated Protein Kinase-Dependent Nuclear Factor-Kappa B/Matrix Metalloproteinase-9 Inhibition After Subarachnoid Hemorrhage in Rat

in Brain Disease Mechanisms

Zhiyi Xie
Budbazar Enkhjargal
Matei Nathanael
Lingyun Wu
Qiquan Zhu
Tongyu Zhang
Jiping Tang
John H. Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.750726

15,167 views
14 citations

Mini Review

Published on 23 Dec 2021

Cholinesterases in Tripartite Neuromuscular Synapse

in Brain Disease Mechanisms

Konstantin A. Petrov
Svetlana E. Proskurina
Eric Krejci

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.811220

6,954 views
11 citations

Original Research

Published on 23 Dec 2021

Histone Deacetylase Inhibitor Improves the Dysfunction of Hippocampal Gamma Oscillations and Fast Spiking Interneurons in Alzheimer’s Disease Model Mice

in Brain Disease Mechanisms

Keiko Takasu
Kazuki Niidome
Minoru Hasegawa
Koichi Ogawa

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.782206

5,667 views
14 citations

Brief Research Report

Published on 21 Dec 2021

RNA Quality in Post-mortem Human Brain Tissue Is Affected by Alzheimer’s Disease

in Brain Disease Mechanisms

Blake Highet
Remai Parker
Richard L. M. Faull
Maurice A. Curtis
Brigid Ryan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.780352

9,062 views
16 citations

Original Research

Published on 21 Dec 2021

Association of the Polygenic Risk Score With the Probability of Prodromal Parkinson’s Disease in Older Adults

in Brain Disease Mechanisms

Maria I. Maraki
Alexandros Hatzimanolis
Niki Mourtzi
Leonidas Stefanis
Mary Yannakoulia
Mary H. Kosmidis
Efthimios Dardiotis
Georgios M. Hadjigeorgiou
Paraskevi Sakka
Alfredo Ramirez

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.739571

5,126 views
15 citations

Review

Published on 20 Dec 2021

Lipid Metabolism Influence on Neurodegenerative Disease Progression: Is the Vehicle as Important as the Cargo?

in Brain Disease Mechanisms

Raja Elizabeth Estes
Bernice Lin
Arnav Khera
Marie Ynez Davis

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.788695

14,823 views
79 citations

Original Research

Published on 16 Dec 2021

Capping Protein Regulator and Myosin 1 Linker 3 (CARMIL3) as a Molecular Signature of Ischemic Neurons in the DWI-T2 Mismatch Areas After Stroke

in Brain Disease Mechanisms

Shin-Joe Yeh
Pang-Hung Hsu
Ti-Yen Yeh
Wei-Kang Yang
Ko-Ping Chang
Chien-Sung Chiang
Sung-Chun Tang
Li-Kai Tsai
Jiann-Shing Jeng
Sung-Tsang Hsieh

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.754762

3,908 views
5 citations

Review

Published on 16 Dec 2021

DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication

in Brain Disease Mechanisms

Haibo Wang
Manohar Kodavati
Gavin W. Britz
Muralidhar L. Hegde

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.784361

11,696 views
50 citations

Review

Published on 15 Dec 2021

Structural and Functional Aspects of the Neurodevelopmental Gene NR2F1: From Animal Models to Human Pathology

in Brain Disease Mechanisms

Chiara Tocco
Michele Bertacchi
Michèle Studer

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.767965

13,095 views
49 citations

Review

Published on 14 Dec 2021

Neuroinflammation in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia and the Interest of Induced Pluripotent Stem Cells to Study Immune Cells Interactions With Neurons

in Brain Disease Mechanisms

Elise Liu
Léa Karpf
Delphine Bohl

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.767041

11,927 views
29 citations

1,115 articles

articles

Brain-Type Glycogen Phosphorylase Is Crucial for Astrocytic Glycogen Accumulation in Chronic Social Defeat Stress-Induced Depression in Mice

MicroRNAs Play a Role in Parkinson’s Disease by Regulating Microglia Function: From Pathogenetic Involvement to Therapeutic Potential

Glycogen Synthase Kinase-3 Inhibitors: Preclinical and Clinical Focus on CNS-A Decade Onward

Aerobic Exercise Training-Induced Changes on DNA Methylation in Mild Cognitively Impaired Elderly African Americans: Gene, Exercise, and Memory Study - GEMS-I

Netrin-1 Ameliorates Postoperative Delirium-Like Behavior in Aged Mice by Suppressing Neuroinflammation and Restoring Impaired Blood-Brain Barrier Permeability

HDAC1 Regulates Neuronal Differentiation

Detection and Functional Evaluation of the P2X7 Receptor in hiPSC Derived Neurons and Microglia-Like Cells

Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

Hyperexcitability and Homeostasis in Fragile X Syndrome

Lipopolysaccharide From E. coli Increases Glutamate-Induced Disturbances of Calcium Homeostasis, the Functional State of Mitochondria, and the Death of Cultured Cortical Neurons

Abnormal Somatosensory Behaviors Associated With a Gain-of-Function Mutation in TRPV3 Channels

Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System

Modeling Somatic Mutations Associated With Neurodevelopmental Disorders in Human Brain Organoids

Effects of Mdivi-1 on Neural Mitochondrial Dysfunction and Mitochondria-Mediated Apoptosis in Ischemia-Reperfusion Injury After Stroke: A Systematic Review of Preclinical Studies

Exendin-4 Preserves Blood-Brain Barrier Integrity via Glucagon-Like Peptide 1 Receptor/Activated Protein Kinase-Dependent Nuclear Factor-Kappa B/Matrix Metalloproteinase-9 Inhibition After Subarachnoid Hemorrhage in Rat

Cholinesterases in Tripartite Neuromuscular Synapse

Histone Deacetylase Inhibitor Improves the Dysfunction of Hippocampal Gamma Oscillations and Fast Spiking Interneurons in Alzheimer’s Disease Model Mice

RNA Quality in Post-mortem Human Brain Tissue Is Affected by Alzheimer’s Disease

Association of the Polygenic Risk Score With the Probability of Prodromal Parkinson’s Disease in Older Adults

Lipid Metabolism Influence on Neurodegenerative Disease Progression: Is the Vehicle as Important as the Cargo?

Capping Protein Regulator and Myosin 1 Linker 3 (CARMIL3) as a Molecular Signature of Ischemic Neurons in the DWI-T2 Mismatch Areas After Stroke

DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication

Structural and Functional Aspects of the Neurodevelopmental Gene NR2F1: From Animal Models to Human Pathology

Neuroinflammation in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia and the Interest of Induced Pluripotent Stem Cells to Study Immune Cells Interactions With Neurons