Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Brief Research Report

Published on 22 Oct 2021

Severe and Regionally Widespread Increases in Tissue Urea in the Human Brain Represent a Novel Finding of Pathogenic Potential in Parkinson’s Disease Dementia

in Brain Disease Mechanisms

Melissa Scholefield
Stephanie J. Church
Jingshu Xu
Stefano Patassini
Federico Roncaroli
Nigel M. Hooper
Richard D. Unwin
Garth J. S. Cooper

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.711396

6,971 views
32 citations

Original Research

Published on 20 Oct 2021

Nanoparticles With Affinity for α-Synuclein Sequester α-Synuclein to Form Toxic Aggregates in Neurons With Endolysosomal Impairment

in Brain Disease Mechanisms

Peizhou Jiang
Ming Gan
Shu-Hui Yen
Dennis W. Dickson

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.738535

4,376 views
9 citations

Original Research

Published on 15 Oct 2021

Transcriptomic and Network Meta-Analysis of Frontotemporal Dementias

in Brain Disease Mechanisms

Virginie Bottero
Fahed Alrafati
Jose A. Santiago
Judith A. Potashkin

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.747798

8,291 views
21 citations

Original Research

Published on 14 Oct 2021

GRIN2A Variants Associated With Idiopathic Generalized Epilepsies

in Brain Disease Mechanisms

Xiao-Rong Liu
Xing-Xing Xu
Si-Mei Lin
Cui-Ying Fan
Ting-Ting Ye
Bin Tang
Yi-Wu Shi
Tao Su
Bing-Mei Li
Yong-Hong Yi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.720984

9,520 views
28 citations

Mini Review

Published on 13 Oct 2021

Sex Differences in Mitochondrial Function Following a Controlled Cortical Impact Traumatic Brain Injury in Rodents

in Brain Disease Mechanisms

Olivia J. Kalimon
Patrick G. Sullivan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.753946

6,036 views
18 citations

Review

Published on 11 Oct 2021

Dysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder

in Brain Disease Mechanisms

Ana Sofía Vallés
Francisco J. Barrantes

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.744597

9,963 views
25 citations

Review

Published on 11 Oct 2021

Epigenetic Regulations of Microglia/Macrophage Polarization in Ischemic Stroke

in Brain Disease Mechanisms

Meiqian Qiu
En Xu
Lixuan Zhan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.697416

9,565 views
36 citations

Review

Published on 07 Oct 2021

A Review of miRNAs as Biomarkers and Effect of Dietary Modulation in Obesity Associated Cognitive Decline and Neurodegenerative Disorders

in Brain Disease Mechanisms

Maddie Perdoncin
Alec Konrad
Joshua R. Wyner
Samir Lohana
Sneha S. Pillai
Duane G. Pereira
Hari Vishal Lakhani
Komal Sodhi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.756499

9,363 views
28 citations

Original Research

Published on 07 Oct 2021

Testing Fmr1KO Phenotypes in Response to GSK3 Inhibitors: SB216763 versus AFC03127

in Brain Disease Mechanisms

Pamela R. Westmark
Beatrice Garrone
Rosella Ombrato
Claudio Milanese
Francesco Paolo Di Giorgio
Cara J. Westmark

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.751307

5,223 views
9 citations

Review

Published on 06 Oct 2021

Current and Future Prospects for Gene Therapy for Rare Genetic Diseases Affecting the Brain and Spinal Cord

in Brain Disease Mechanisms

Thomas Leth Jensen
Casper René Gøtzsche
David P. D. Woldbye

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.695937

46,537 views
77 citations

Original Research

Published on 30 Sep 2021

Cofilin 2 Acts as an Inflammatory Linker Between Chronic Periodontitis and Alzheimer’s Disease in Amyloid Precursor Protein/Presenilin 1 Mice

in Brain Disease Mechanisms

Qing Zeng
Qin Fang
Xincai Zhou
Hongfa Yang
Yang Dou
Wenhao Zhang
Pu Gong
Xianfang Rong

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.728184

6,378 views
5 citations

Original Research

Published on 28 Sep 2021

Dysregulation of NF-κB-Associated LncRNAs in Autism Spectrum Disorder

in Brain Disease Mechanisms

Kasra Honarmand Tamizkar
Elham Badrlou
Termeh Aslani
Serge Brand
Shahram Arsang-Jang
Soudeh Ghafouri-Fard
Mohammad Taheri

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.747785

5,192 views
15 citations

Original Research

Published on 24 Sep 2021

Conditional Deletion of EphA4 on Cx3cr1-Expressing Microglia Fails to Influence Histopathological Outcome and Blood Brain Barrier Disruption Following Brain Injury

in Brain Disease Mechanisms

Eman Soliman
Jatia Mills
Jing Ju
Alexandra M. Kaloss
Erwin Kristobal Gudenschwager Basso
Nathalie Groot
Colin Kelly
Elizabeth A. Kowalski
Mohamed Elhassanny
Michael Chen

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.747770

6,682 views
17 citations

Original Research

Published on 24 Sep 2021

Treatment With Nepicastat Decreases Contextual Traumatic Memories Persistence in Post-traumatic Stress Disorder

in Brain Disease Mechanisms

Raquel Martinho
Gabriela Correia
Rafaela Seixas
Ana Oliveira
Soraia Silva
Paula Serrão
Carlos Fernandes-Lopes
Cristina Costa
Mónica Moreira-Rodrigues

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.745219

7,638 views
15 citations

Mini Review

Published on 23 Sep 2021

Mitochondrial Protein PGAM5 Emerges as a New Regulator in Neurological Diseases

in Brain Disease Mechanisms

Min-Zong Liang
Ting-Ling Ke
Linyi Chen

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.730604

9,080 views
31 citations

Brief Research Report

Published on 09 Sep 2021

Novel Point-of-Care Diagnostic Method for Neonatal Encephalopathy Using Purine Nucleosides

in Brain Disease Mechanisms

Edward Beamer
Mary Isabel O’Dea
Aisling A. Garvey
Jonathon Smith
Aida Menéndez-Méndez
Lynne Kelly
Andreea Pavel
Sean Quinlan
Mariana Alves
Eva M. Jimenez-Mateos

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.732199

5,861 views
7 citations

Review

Published on 08 Sep 2021

Neurodevelopmental Disorders (NDD) Caused by Genomic Alterations of the Ubiquitin-Proteasome System (UPS): the Possible Contribution of Immune Dysregulation to Disease Pathogenesis

in Brain Disease Mechanisms

Frédéric Ebstein
Sébastien Küry
Jonas Johannes Papendorf
Elke Krüger

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.733012

16,402 views
48 citations

Mini Review

Published on 06 Sep 2021

L-Serine, an Endogenous Amino Acid, Is a Potential Neuroprotective Agent for Neurological Disease and Injury

in Brain Disease Mechanisms

Lisha Ye
Yechao Sun
Zhenglin Jiang
Guohua Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.726665

61,156 views
56 citations

Original Research

Published on 01 Sep 2021

Development of Tinnitus and Hyperacusis in a Mouse Model of Tobramycin Cochleotoxicity

in Brain Disease Mechanisms

Ryan J. Longenecker
Rende Gu
Jennifer Homan
Jonathan Kil

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.715952

8,279 views
5 citations

Original Research

Published on 01 Sep 2021

Sustained Baclofen-Induced Activation of GABAB Receptors After Cerebral Ischemia Restores Receptor Expression and Function and Limits Progressing Loss of Neurons

in Brain Disease Mechanisms

Mohammad Hleihil
Markus Vaas
Musadiq A. Bhat
Karthik Balakrishnan
Dietmar Benke

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.726133

6,630 views
17 citations

Brief Research Report

Published on 30 Aug 2021

Presenilin-1 Mutations Are a Cause of Primary Lateral Sclerosis-Like Syndrome

in Brain Disease Mechanisms

Juan Francisco Vázquez-Costa
María Payá-Montes
Marina Martínez-Molina
Teresa Jaijo
Jazek Szymanski
Miguel Mazón
Pablo Sopena-Novales
ENoD Consortium
Jordi Pérez-Tur
Teresa Sevilla

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.721047

4,745 views
10 citations

Review

Published on 26 Aug 2021

Novel Therapies for Parkinsonian Syndromes–Recent Progress and Future Perspectives

in Brain Disease Mechanisms

Dominika Przewodowska
Weronika Marzec
Natalia Madetko

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.720220

14,019 views
13 citations

Original Research

Published on 19 Aug 2021

Application of Trio-Whole Exome Sequencing in Genetic Diagnosis and Therapy in Chinese Children With Epilepsy

in Brain Disease Mechanisms

Tiejia Jiang
Jia Gao
Lihua Jiang
Lu Xu
Congying Zhao
Xiaojun Su
Yaping Shen
Weiyue Gu
Xiaohong Kong
Ying Yang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.699574

11,461 views
25 citations

Original Research

Published on 13 Aug 2021

Reelin Is Required for Maintenance of Granule Cell Lamination in the Healthy and Epileptic Hippocampus

in Brain Disease Mechanisms

Catarina Orcinha
Antje Kilias
Enya Paschen
Marie Follo
Carola A. Haas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2021.730811

6,454 views
13 citations