Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Original Research

Published on 22 Aug 2025

Organelle stresses and energetic metabolisms promote endothelial–to–mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer’s disease

in Brain Disease Mechanisms

Fatma Saaoud
Mohammed Ben Issa
Lu Liu
Keman Xu
Yifan Lu
Ying Shao
Baosheng Han
Xiaohua Jiang
Xiaolei Liu
Avrum Gillespie

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1605012

4,608 views
1 citation

Editorial

Published on 14 Aug 2025

Editorial: Imaging brain network and brain energy metabolism impairments in brain disorders

in Brain Disease Mechanisms

Yuhei Takado
Mor Mishkovsky
Tomokazu Tsurugizawa

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1676946

1,637 views

Original Research

Published on 13 Aug 2025

ACTN2, regulated by PRDM9, affects the growth and inflammation of vascular smooth muscle cells by interacting with PDLIM1 in intracranial aneurysms

in Brain Disease Mechanisms

Guangxu Zhang
Jinbing Zhao
Zhiqiang Yu
Hongyi Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1606973

2,487 views

Original Research

Published on 08 Aug 2025

Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss

in Brain Disease Mechanisms

Joana Saavedra
Mariana Nascimento
António J. Figueira
Marina I. Oliveira da Silva
Tiago Gião
João Oliveira
Márcia A. Liz
Cláudio M. Gomes
Isabel Cardoso

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1636365

2,921 views
1 citation

Review

Published on 06 Aug 2025

Is postoperative cognitive dysfunction a disease of microglial inflammatory memory? A state-transition model from metabolic stress to epigenetic lock-in

in Brain Disease Mechanisms

Xiangyu Wu
Tingye He
Fei He
Li Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1648161

4,399 views
4 citations

Original Research

Published on 23 Jul 2025

Chronic reduction of synaptic proteins in the epileptogenic lesion of patients with hippocampal sclerosis

in Brain Disease Mechanisms

Akiko Oota-Ishigaki
Nami Suzuki
Keiya Iijima
Yutaro Takayama
Yuiko Kimura
Kotaro Hattori
Masaki Iwasaki
Takashi Hayashi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1635852

1,978 views
1 citation

Original Research

Published on 14 Jul 2025

Inhibition of BET proteins modulates amyloid-beta accumulation and cognitive performance in middle-aged mice prenatally exposed to maternal immune activation

in Brain Disease Mechanisms

Marta Matuszewska
Anna Wilkaniec
Magdalena Gąssowska-Dobrowolska
Magdalena Cieślik
Gabriela Olech-Kochańczyk
Ewelina Pałasz
Elżbieta Gawinek
Marcin Strawski
Grzegorz A. Czapski

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1619583

2,512 views
1 citation

Review

Published on 07 Jul 2025

Role of the chaperonin TCP-1 ring complex in protein aggregation and neurodegeneration

in Brain Disease Mechanisms

Vanlalrinchhani Varte
Diego E. Rincon-Limas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1617771

3,687 views
3 citations

Systematic Review

Published on 02 Jul 2025

Recognition of the microbial metabolite p-cresol in autism spectrum disorder: systematic review and meta-analysis

in Brain Disease Mechanisms

María Isabel Serrano-Tomás
Paulina Contreras-Romero
Mara Parellada
Javier Chaves-Cordero
Javier Zamora
Martha Hengst
Patricia Pozo
Rosa del Campo
Sheyla Guzmán-Salas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1576388

3,508 views
3 citations

Review

Published on 26 Jun 2025

Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia

in Brain Disease Mechanisms

Xin-yi Zou
Luo-yang Cai
Jin Zhang
Ying Yuan
Jie Song
Zhao-duan Hu
Xiao-feng Ruan
Rui Peng
Xiao-ming Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1585079

3,635 views
7 citations

Original Research

Published on 25 Jun 2025

Critical gene network and signaling pathway analysis of the extracellular signal-regulated kinase (ERK) pathway in ischemic stroke

in Brain Disease Mechanisms

Rui Mao
Lei Wang
Haitao Zhang
Jiaojiao Gong
Hua Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1604670

2,381 views

Review

Published on 25 Jun 2025

How endothelial cell metabolism shapes blood–brain barrier integrity in neurodegeneration

in Brain Disease Mechanisms

Jiaxin Wang
Yuchun Chen
Shiteng Chen
Zihan Mu
Jun Chen

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1623321

4,018 views
5 citations

Original Research

Published on 25 Jun 2025

Whole-genome sequencing shows modulation of neurodegenerative genes by Withania somnifera in human SK-N-SH cells

in Brain Disease Mechanisms

Eshita Sharma
Dilip Mehta
Nikita Jadhav
Gunjan Gujrati
S. Dhananya
Manju Moorthy
Gopalakrishna Ramaswamy
Yundong Zhou
Sujit Nair

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1512727

4,289 views
1 citation

Original Research

Published on 18 Jun 2025

Clusterin facilitates glioma progression via BCL2L1-dependent regulation of apoptotic resistance

in Brain Disease Mechanisms

Qingqing Xu
Xin Liu
Yibo Zhang
Shiyu Yuan
Wenli Huang
Mingshan Pi
Qi Xiong
Hongyan Zhou
Yuran Gui
Yifan Xiao

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1596021

2,242 views
1 citation

Original Research

Published on 27 May 2025

Exposure to a nanoplastic-enriched diet for fourteen days increases microglial immunoreactivity in the zebrafish telencephalon

in Brain Disease Mechanisms

Robert A. Mans
Hannah Kelehear
Sarah Rotschafer
Clare Ganas
Brendan Uche-Moon
Gabrielle Call
Callie C. Mauersberg
Justin Toller
Andrew Diamanduros

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1563086

3,522 views
4 citations

Mini Review

Published on 16 May 2025

Regulatory mechanism of circular RNAs in brain and neurodegenerative diseases

in Brain Disease Mechanisms

Mandana Amelimojarad
Melika Amelimojarad

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1507575

2,993 views
3 citations

Original Research

Published on 09 May 2025

Changes in glycinergic neurotransmission alter mammalian retinal information processing

in Brain Disease Mechanisms

Anneka Joachimsthaler
Katharina Hauf
Anja Armbruster
Shiri Zayit-Soudry
Efrat Naaman
Ido Perlman
Rina Leibu
Alina Kurolap
Hagit Baris Feldman
Jan Kremers

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1564870

2,295 views
1 citation

Editorial

Published on 08 May 2025

Editorial: SLC12A5-dependent neurological disorders

in Brain Disease Mechanisms

Igor Medina
Amy McTague
Coralie Di Scala
Claudio Rivera

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1611682

2,191 views
1 citation

Review

Published on 01 May 2025

NFE2L1 as a central regulator of proteostasis in neurodegenerative diseases: interplay with autophagy, ferroptosis, and the proteasome

in Brain Disease Mechanisms

Hossein Khodadadi
Kamila Łuczyńska
Dawid Winiarczyk
Paweł Leszczyński
Hiroaki Taniguchi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1551571

4,776 views
7 citations

Editorial

Published on 30 Apr 2025

Editorial: Neuro-immune interplay: unraveling the complexities of neurological complications and immunology

in Brain Disease Mechanisms

Pankaj Gaur
Kumar Vaibhav
Meenakshi Ahluwalia
Seema Gupta

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1607675

2,214 views
1 citation

Original Research

Published on 28 Apr 2025

Traumatic brain injury and autophagy: a pilot study about the immunohistochemical expression of LC3B, Beclin 1, p62, and LAMP2A in human autoptic samples

in Brain Disease Mechanisms

Tommaso Livieri
Letizia Alfieri
Emiliana Giacomello
Djordje Alempijević
Tijana Petrovic
Yanko Georgiev Kolev
Davide Radaelli
Margherita Neri
Stefano D’Errico

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1562954

2,559 views

Brief Research Report

Published on 17 Apr 2025

Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusion

in Brain Disease Mechanisms

Iván Alquisiras-Burgos
Irlanda Peralta-Arrieta
Mónica Espinoza-Rojo
Alejandro Salazar-Salgado
Iván Antonino-Olguín
Alicia Sánchez-Mendoza
María Sánchez-Aguilar
Martha-Eugenia Ruiz-Tachiquín
Hilda-Alicia Valdez-Salazar
Alma Ortiz-Plata

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1536409

2,350 views

Original Research

Published on 15 Apr 2025

Brain microvascular endothelial cells differentiated from a Friedreich’s Ataxia patient iPSC are deficient in tight junction protein expression and paracellularly permeable

in Brain Disease Mechanisms

Frances M. Smith
Daniel J. Kosman

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1511388

2,864 views
1 citation

Original Research

Published on 09 Apr 2025

Profiling the expression and functional roles of mRNAs and lncRNAs associated with post-stroke aphasia

in Brain Disease Mechanisms

Yanling Xi
Hui Chang
Mei Qu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1513218

1,540 views

1,115 articles

articles

Organelle stresses and energetic metabolisms promote endothelial–to–mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer’s disease

Editorial: Imaging brain network and brain energy metabolism impairments in brain disorders

ACTN2, regulated by PRDM9, affects the growth and inflammation of vascular smooth muscle cells by interacting with PDLIM1 in intracranial aneurysms

Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss

Is postoperative cognitive dysfunction a disease of microglial inflammatory memory? A state-transition model from metabolic stress to epigenetic lock-in

Chronic reduction of synaptic proteins in the epileptogenic lesion of patients with hippocampal sclerosis

Inhibition of BET proteins modulates amyloid-beta accumulation and cognitive performance in middle-aged mice prenatally exposed to maternal immune activation

Role of the chaperonin TCP-1 ring complex in protein aggregation and neurodegeneration

Recognition of the microbial metabolite p-cresol in autism spectrum disorder: systematic review and meta-analysis

Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia

Critical gene network and signaling pathway analysis of the extracellular signal-regulated kinase (ERK) pathway in ischemic stroke

How endothelial cell metabolism shapes blood–brain barrier integrity in neurodegeneration

Whole-genome sequencing shows modulation of neurodegenerative genes by Withania somnifera in human SK-N-SH cells

Clusterin facilitates glioma progression via BCL2L1-dependent regulation of apoptotic resistance

Exposure to a nanoplastic-enriched diet for fourteen days increases microglial immunoreactivity in the zebrafish telencephalon

Regulatory mechanism of circular RNAs in brain and neurodegenerative diseases

Changes in glycinergic neurotransmission alter mammalian retinal information processing

Editorial: SLC12A5-dependent neurological disorders

NFE2L1 as a central regulator of proteostasis in neurodegenerative diseases: interplay with autophagy, ferroptosis, and the proteasome

Editorial: Neuro-immune interplay: unraveling the complexities of neurological complications and immunology

Traumatic brain injury and autophagy: a pilot study about the immunohistochemical expression of LC3B, Beclin 1, p62, and LAMP2A in human autoptic samples

Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusion

Brain microvascular endothelial cells differentiated from a Friedreich’s Ataxia patient iPSC are deficient in tight junction protein expression and paracellularly permeable

Profiling the expression and functional roles of mRNAs and lncRNAs associated with post-stroke aphasia