Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Original Research

Published on 09 May 2025

Changes in glycinergic neurotransmission alter mammalian retinal information processing

in Brain Disease Mechanisms

Anneka Joachimsthaler
Katharina Hauf
Anja Armbruster
Shiri Zayit-Soudry
Efrat Naaman
Ido Perlman
Rina Leibu
Alina Kurolap
Hagit Baris Feldman
Jan Kremers

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1564870

2,072 views
1 citation

Editorial

Published on 08 May 2025

Editorial: SLC12A5-dependent neurological disorders

in Brain Disease Mechanisms

Igor Medina
Amy McTague
Coralie Di Scala
Claudio Rivera

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1611682

1,966 views

Review

Published on 01 May 2025

NFE2L1 as a central regulator of proteostasis in neurodegenerative diseases: interplay with autophagy, ferroptosis, and the proteasome

in Brain Disease Mechanisms

Hossein Khodadadi
Kamila Łuczyńska
Dawid Winiarczyk
Paweł Leszczyński
Hiroaki Taniguchi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1551571

3,962 views
6 citations

Editorial

Published on 30 Apr 2025

Editorial: Neuro-immune interplay: unraveling the complexities of neurological complications and immunology

in Brain Disease Mechanisms

Pankaj Gaur
Kumar Vaibhav
Meenakshi Ahluwalia
Seema Gupta

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1607675

2,033 views
1 citation

Original Research

Published on 28 Apr 2025

Traumatic brain injury and autophagy: a pilot study about the immunohistochemical expression of LC3B, Beclin 1, p62, and LAMP2A in human autoptic samples

in Brain Disease Mechanisms

Tommaso Livieri
Letizia Alfieri
Emiliana Giacomello
Djordje Alempijević
Tijana Petrovic
Yanko Georgiev Kolev
Davide Radaelli
Margherita Neri
Stefano D’Errico

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1562954

2,256 views

Brief Research Report

Published on 17 Apr 2025

Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusion

in Brain Disease Mechanisms

Iván Alquisiras-Burgos
Irlanda Peralta-Arrieta
Mónica Espinoza-Rojo
Alejandro Salazar-Salgado
Iván Antonino-Olguín
Alicia Sánchez-Mendoza
María Sánchez-Aguilar
Martha-Eugenia Ruiz-Tachiquín
Hilda-Alicia Valdez-Salazar
Alma Ortiz-Plata

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1536409

2,142 views

Original Research

Published on 15 Apr 2025

Brain microvascular endothelial cells differentiated from a Friedreich’s Ataxia patient iPSC are deficient in tight junction protein expression and paracellularly permeable

in Brain Disease Mechanisms

Frances M. Smith
Daniel J. Kosman

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1511388

2,626 views
1 citation

Original Research

Published on 09 Apr 2025

Profiling the expression and functional roles of mRNAs and lncRNAs associated with post-stroke aphasia

in Brain Disease Mechanisms

Yanling Xi
Hui Chang
Mei Qu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1513218

1,389 views

Mini Review

Published on 01 Apr 2025

Neurotrophic factor alpha 1 gene therapy in Alzheimer’s disease: scope and advancements

in Brain Disease Mechanisms

Ammara Shaikh
Fairus Ahmad
Seong Lin Teoh
Jaya Kumar
Mohamad Fairuz Yahaya

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1518868

5,123 views
5 citations

Original Research

Published on 24 Mar 2025

The serum proteomic profile in patients with migraine

in Brain Disease Mechanisms

Yating Han
Yuan Wang
Xiajuan Zou
Huailian Guo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1460403

2,451 views
2 citations

Original Research

Published on 21 Mar 2025

Soy-based purified ingredient diet affects mouse gut permeability and the microbiome in fragile X mice

in Brain Disease Mechanisms

Cara J. Westmark

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1520211

2,878 views
1 citation

Mini Review

Published on 19 Mar 2025

Elevated propionate and its association with neurological dysfunctions in propionic acidemia

in Brain Disease Mechanisms

Xiaoxin Chen
Qing Cheng
Guo-Fang Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1499376

4,533 views
4 citations

Original Research

Published on 04 Mar 2025

Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament

in Brain Disease Mechanisms

Elaine K. Hebda-Bauer
Megan H. Hagenauer
Daniel B. Munro
Peter Blandino
Fan Meng
Keiko Arakawa
John D. H. Stead
Apurva S. Chitre
A. Bilge Ozel
Pejman Mohammadi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1469467

3,185 views
1 citation

Original Research

Published on 20 Feb 2025

Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5

in Brain Disease Mechanisms

Menekse Oeztuerk
Diran Herebian
Kale Dipali
Andreas Hentschel
Nina Rademacher
Florian Kraft
Rita Horvath
Felix Distelmaier
Sven G. Meuth
Tobias Ruck

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1548255

2,784 views
1 citation

Original Research

Published on 19 Feb 2025

Impaired cerebrospinal fluid circulation and cerebral lymphatic drainage in a rat model of chronic hydrocephalus

in Brain Disease Mechanisms

Dong Bin Back
Bo-Ryoung Choi
Kyoung Ja Kwon
Dong-Hee Choi
Chan Young Shin
Jongmin Lee
Hahn Young Kim

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1516265

3,848 views

Opinion

Published on 18 Feb 2025

Histone monoaminylation is a novel epigenetic mechanism in psychiatric disorders

in Brain Disease Mechanisms

Jacob Peedicayil
Samuel Santhosh

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1534569

2,543 views
2 citations

Original Research

Published on 13 Feb 2025

Deciphering motor dysfunction and microglial activation in mThy1-α-synuclein mice: a comprehensive study of behavioral, gene expression, and methylation changes

in Brain Disease Mechanisms

Brett A. McGregor
Md. Obayed Raihan
Afrina Brishti
Junguk Hur
James E. Porter

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1544971

1,677 views
1 citation

Review

Published on 11 Feb 2025

The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders

in Brain Disease Mechanisms

Sean D. Fraser
Robert J. Harvey

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1550863

4,091 views

Original Research

Published on 05 Feb 2025

The effect of AKT inhibition in α-synuclein-dependent neurodegeneration

in Brain Disease Mechanisms

Bedri Ranxhi
Zoya R. Bangash
Zachary M. Chbihi
Sokol V. Todi
Peter A. LeWitt
Wei-Ling Tsou

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1524044

3,048 views
3 citations

Original Research

Published on 05 Feb 2025

Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation

in Brain Disease Mechanisms

L. Caccialupi Da Prato
A. Rezzag Lebza
A. Consumi
M. Tessier
A. Srinivasan
C. Rivera
J. Laurin
C. Pellegrino

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1522571

2,191 views
1 citation

Original Research

Published on 29 Jan 2025

Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects

in Brain Disease Mechanisms

Rodrigo Moraga-Amaro
Oscar Moreno
Jordi Llop
Marion Bankstahl
Jens P. Bankstahl

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1488261

2,824 views
2 citations

Review

Published on 27 Jan 2025

Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent

in Brain Disease Mechanisms

Mitsuharu Hattori

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1546083

4,341 views
6 citations

Original Research

Published on 15 Jan 2025

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

in Brain Disease Mechanisms

Pavel Uvarov
Satoshi Fudo
Cem Karakus
Andrey Golubtsov
Federico Rotondo
Tatiana Sukhanova
Shetal Soni
Coralie Di Scala
Tommi Kajander
Claudio Rivera

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1505722

3,994 views

Review

Published on 14 Jan 2025

Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases

in Brain Disease Mechanisms

Yinyin Xie
Wenlin Sun
Aoya Han
Xinru Zhou
Shijie Zhang
Changchang Shen
Yi Xie
Cui Wang
Nanchang Xie

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1527013

5,504 views
2 citations

1,099 articles

articles

Changes in glycinergic neurotransmission alter mammalian retinal information processing

Editorial: SLC12A5-dependent neurological disorders

NFE2L1 as a central regulator of proteostasis in neurodegenerative diseases: interplay with autophagy, ferroptosis, and the proteasome

Editorial: Neuro-immune interplay: unraveling the complexities of neurological complications and immunology

Traumatic brain injury and autophagy: a pilot study about the immunohistochemical expression of LC3B, Beclin 1, p62, and LAMP2A in human autoptic samples

Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusion

Brain microvascular endothelial cells differentiated from a Friedreich’s Ataxia patient iPSC are deficient in tight junction protein expression and paracellularly permeable

Profiling the expression and functional roles of mRNAs and lncRNAs associated with post-stroke aphasia

Neurotrophic factor alpha 1 gene therapy in Alzheimer’s disease: scope and advancements

The serum proteomic profile in patients with migraine

Soy-based purified ingredient diet affects mouse gut permeability and the microbiome in fragile X mice

Elevated propionate and its association with neurological dysfunctions in propionic acidemia

Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament

Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5

Impaired cerebrospinal fluid circulation and cerebral lymphatic drainage in a rat model of chronic hydrocephalus

Histone monoaminylation is a novel epigenetic mechanism in psychiatric disorders

Deciphering motor dysfunction and microglial activation in mThy1-α-synuclein mice: a comprehensive study of behavioral, gene expression, and methylation changes

The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders

The effect of AKT inhibition in α-synuclein-dependent neurodegeneration

Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation

Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects

Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases