Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Original Research

Published on 05 Jan 2021

Ndfip1 Prevents Rotenone-Induced Neurotoxicity and Upregulation of α-Synuclein in SH-SY5Y Cells

in Brain Disease Mechanisms

Xin Liu
Le Qu
Na Zhang
Xiaoqi Yu
Zhixin Xiao
Limei Song
Junxia Xie
Huamin Xu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.613404

7,981 views
14 citations

Review

Published on 23 Dec 2020

Target Molecules of STIM Proteins in the Central Nervous System

in Brain Disease Mechanisms

Karolina Serwach
Joanna Gruszczynska-Biegala

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.617422

13,399 views
38 citations

Review

Published on 11 Dec 2020

Modulation of the Mechanisms Driving Transthyretin Amyloidosis

in Brain Disease Mechanisms

Filipa Bezerra
Maria João Saraiva
Maria Rosário Almeida

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.592644

14,687 views
42 citations

Review

Published on 26 Nov 2020

Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection

in Brain Disease Mechanisms

Madeleine R. Brown
Sheena E. Radford
Eric W. Hewitt

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.609073

23,229 views
64 citations

Original Research

Published on 19 Nov 2020

AMI, an Indazole Derivative, Improves Parkinson’s Disease by Inhibiting Tau Phosphorylation

in Brain Disease Mechanisms

Zhang Mao
Zhu Wen-ting
Wang Hai-tao
Yu Hui
Lan Shi-yi
Xu Jiang-ping
Wang Wen-ya

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.00165

4,339 views
2 citations

Review

Published on 17 Nov 2020

How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD

in Brain Disease Mechanisms

YunHee Seol
Soomin Ki
Hannah L. Ryu
Sooyoung Chung
Junghee Lee
Hoon Ryu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.593724

6,420 views
10 citations

Brief Research Report

Published on 16 Nov 2020

Loss of DEK Expression Induces Alzheimer’s Disease Phenotypes in Differentiated SH-SY5Y Cells

in Brain Disease Mechanisms

Allie N. Greene
Lois G. Parks
Matia B. Solomon
Lisa M. Privette Vinnedge

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.594319

7,728 views
10 citations

Review

Published on 13 Nov 2020

Amyloid-β Peptide Impact on Synaptic Function and Neuroepigenetic Gene Control Reveal New Therapeutic Strategies for Alzheimer’s Disease

in Brain Disease Mechanisms

Bhanu Chandra Karisetty
Akanksha Bhatnagar
Ellen M. Armour
Mariah Beaver
Haolin Zhang
Felice Elefant

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.577622

19,118 views
66 citations

Original Research

Published on 11 Nov 2020

P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia

in Brain Disease Mechanisms

Stefano Calovi
Paula Mut-Arbona
Pál Tod
András Iring
Annette Nicke
Susana Mato
E. Sylvester Vizi
Jan Tønnesen
Beata Sperlagh

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.566251

9,006 views
18 citations

Original Research

Published on 02 Nov 2020

The Interplay Between Beta-Amyloid 1–42 (Aβ1–42)-Induced Hippocampal Inflammatory Response, p-tau, Vascular Pathology, and Their Synergistic Contributions to Neuronal Death and Behavioral Deficits

in Brain Disease Mechanisms

Beatriz Calvo-Flores Guzmán
Tessa Elizabeth Chaffey
Thulani Hansika Palpagama
Sarah Waters
Jordi Boix
Warren Perry Tate
Katie Peppercorn
Michael Dragunow
Henry John Waldvogel
Richard Lewis Maxwell Faull

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.552073

12,274 views
43 citations

Original Research

Published on 28 Oct 2020

Profiling Microglia From Alzheimer’s Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue

in Brain Disease Mechanisms

Astrid M. Alsema
Qiong Jiang
Laura Kracht
Emma Gerrits
Marissa L. Dubbelaar
Anneke Miedema
Nieske Brouwer
Elly M. Hol
Jinte Middeldorp
Roland van Dijk

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.00134

21,851 views
71 citations

Original Research

Published on 26 Oct 2020

Epinephrine May Contribute to the Persistence of Traumatic Memories in a Post-traumatic Stress Disorder Animal Model

in Brain Disease Mechanisms

Raquel Martinho
Ana Oliveira
Gabriela Correia
Márcia Marques
Rafaela Seixas
Paula Serrão
Mónica Moreira-Rodrigues

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.588802

10,045 views
22 citations

Brief Research Report

Published on 23 Oct 2020

Investigation of MLH1, MGMT, CDKN2A, and RASSF1A Gene Methylation in Thymomas From Patients With Myasthenia Gravis

in Brain Disease Mechanisms

Fabio Coppedè
Roberta Ricciardi
Angela Lopomo
Andrea Stoccoro
Anna De Rosa
Melania Guida
Loredana Petrucci
Michelangelo Maestri
Marco Lucchi
Lucia Migliore

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.567676

3,590 views
6 citations

Review

Published on 22 Oct 2020

High-Resolution Transcriptomic and Proteomic Profiling of Heterogeneity of Brain-Derived Microglia in Multiple Sclerosis

in Brain Disease Mechanisms

Anneke Miedema
Marion H. C. Wijering
Bart J. L. Eggen
Susanne M. Kooistra

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.583811

15,077 views
21 citations

Original Research

Published on 16 Oct 2020

Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells

in Brain Disease Mechanisms

Meiqi Li
Jianan Hu
Xiaoyu Yuan
Lihua Shen
Li Zhu
Qianqian Luo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.560891

7,651 views
18 citations

Original Research

Published on 06 Oct 2020

P2X7 Receptor Upregulation in Huntington’s Disease Brains

in Brain Disease Mechanisms

Ivana Ollà
María Santos-Galindo
Ainara Elorza
José J. Lucas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.567430

6,313 views
39 citations

Original Research

Published on 30 Sep 2020

L-Asparaginase Exerts Neuroprotective Effects in an SH-SY5Y-A53T Model of Parkinson’s Disease by Regulating Glutamine Metabolism

in Brain Disease Mechanisms

Qingxi Zhang
Yuyuan Gao
Jiahui Zhang
You Li
Jianing Chen
Rui Huang
Guixian Ma
Limin Wang
Yuhu Zhang
Kun Nie

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.563054

6,763 views
17 citations

Brief Research Report

Published on 17 Sep 2020

Revisiting the Idea That Amyloid-β Peptide Acts as an Agonist for P2X7

in Brain Disease Mechanisms

Lučka Bibič
Leanne Stokes

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.00166

4,702 views
8 citations

Review

Published on 10 Sep 2020

The Role of Copper in Tau-Related Pathology in Alzheimer’s Disease

in Brain Disease Mechanisms

Klara Zubčić
Patrick R. Hof
Goran Šimić
Maja Jazvinšćak Jembrek

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.572308

11,041 views
59 citations

Review

Published on 04 Sep 2020

Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism

in Brain Disease Mechanisms

Lu Chen
Lin Zhu
Di Lu
Zhe Wu
Yanbing Han
Puying Xu
Lvhua Chang
Qian Wu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.554547

8,486 views
12 citations

Review

Published on 21 Aug 2020

MicroRNAs in Alzheimer’s Disease: Function and Potential Applications as Diagnostic Biomarkers

in Brain Disease Mechanisms

Wei Wei
Zhi-Yong Wang
Li-Na Ma
Ting-Ting Zhang
Yu Cao
Hao Li

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.00160

20,252 views
97 citations

Review

Published on 14 Aug 2020

Pathomechanisms and Clinical Implications of Myasthenic Syndromes Exacerbated and Induced by Medical Treatments

in Brain Disease Mechanisms

Martin Krenn
Anna Grisold
Philipp Wohlfarth
Jakob Rath
Hakan Cetin
Inga Koneczny
Fritz Zimprich

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.00156

26,827 views
34 citations

Original Research

Published on 12 Aug 2020

P2X7 Receptor-Dependent microRNA Expression Profile in the Brain Following Status Epilepticus in Mice

in Brain Disease Mechanisms

Giorgia Conte
Ngoc T. Nguyen
Mariana Alves
Laura de Diego-Garcia
Aidan Kenny
Annette Nicke
David C. Henshall
Eva M. Jimenez-Mateos
Tobias Engel

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.00127

5,342 views
12 citations

Review

Published on 04 Aug 2020

Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease

in Brain Disease Mechanisms

Jing Zhao
Xinyue Liu
Weiming Xia
Yingkai Zhang
Chunyu Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2020.00137

30,988 views
151 citations

1,115 articles

articles

Ndfip1 Prevents Rotenone-Induced Neurotoxicity and Upregulation of α-Synuclein in SH-SY5Y Cells

Target Molecules of STIM Proteins in the Central Nervous System

Modulation of the Mechanisms Driving Transthyretin Amyloidosis

Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection

AMI, an Indazole Derivative, Improves Parkinson’s Disease by Inhibiting Tau Phosphorylation

How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD

Loss of DEK Expression Induces Alzheimer’s Disease Phenotypes in Differentiated SH-SY5Y Cells

Amyloid-β Peptide Impact on Synaptic Function and Neuroepigenetic Gene Control Reveal New Therapeutic Strategies for Alzheimer’s Disease

P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia

The Interplay Between Beta-Amyloid 1–42 (Aβ1–42)-Induced Hippocampal Inflammatory Response, p-tau, Vascular Pathology, and Their Synergistic Contributions to Neuronal Death and Behavioral Deficits

Profiling Microglia From Alzheimer’s Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue

Epinephrine May Contribute to the Persistence of Traumatic Memories in a Post-traumatic Stress Disorder Animal Model

Investigation of MLH1, MGMT, CDKN2A, and RASSF1A Gene Methylation in Thymomas From Patients With Myasthenia Gravis

High-Resolution Transcriptomic and Proteomic Profiling of Heterogeneity of Brain-Derived Microglia in Multiple Sclerosis

Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells

P2X7 Receptor Upregulation in Huntington’s Disease Brains

L-Asparaginase Exerts Neuroprotective Effects in an SH-SY5Y-A53T Model of Parkinson’s Disease by Regulating Glutamine Metabolism

Revisiting the Idea That Amyloid-β Peptide Acts as an Agonist for P2X7

The Role of Copper in Tau-Related Pathology in Alzheimer’s Disease

Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism

MicroRNAs in Alzheimer’s Disease: Function and Potential Applications as Diagnostic Biomarkers

Pathomechanisms and Clinical Implications of Myasthenic Syndromes Exacerbated and Induced by Medical Treatments

P2X7 Receptor-Dependent microRNA Expression Profile in the Brain Following Status Epilepticus in Mice

Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease