Frontiers in Molecular Neuroscience | Pain Mechanisms and Modulators

Original Research

Published on 17 Dec 2025

Nrf2/HO-1-sulfiredoxin1 pathway involved in nanobubble hydrogen-dissolved water-mediated protective effects by ultrasound-guided early local injection in a rat model of chronic constriction injury-induced neuropathic pain

in Pain Mechanisms and Modulators

Junmin Yu
Zixiao Yin
Hongmin Ma
Bing Zhang
Chao Meng

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1666575

385 views

Original Research

Published on 05 Dec 2025

Unraveling proteomic signatures and neuroinflammatory networks in a CCI rat model of early sciatica: insights for neuropathic pain mechanisms

in Pain Mechanisms and Modulators

Xingjuan Li
Xiaojie Wang
Jinhui Song
Bin Jiang
Yaqin Wen
Yang Wang
Bo Liu
Xiao Zheng

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1674151

865 views

Original Research

Published on 26 Nov 2025

A novel target for analgesic substances: physiological role of Na,K-ATPase as the signal transducer

in Pain Mechanisms and Modulators

Valentina A. Penniyaynen
Dmitriy M. Samosvat
Vera B. Plakhova
Svetlana A. Podzorova
Anna V. Berintseva
Irina P. Butkevich
Viktor A. Mikhailenko
Georgy G. Zegrya
Ke Ma
Ilya V. Dukhovlinov

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1717676

728 views

Review

Published on 30 Oct 2025

The role and mechanisms of matrix metalloproteinase-9 in peripheral neuropathic pain

in Pain Mechanisms and Modulators

Shuai Ying Jia
Xiao-Jun Tang
Yao Su
Yu-Ning Liu
Zhi Ming
Jing-Yan Lin

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1647316

1,215 views

Systematic Review

Accepted on 07 Oct 2025

A Multi-Database Bibliometric and Translational Mapping of Microglial Mechanisms in Spinal Cord Pain Signaling

in Pain Mechanisms and Modulators

Lingji Zhou
Weiyu Pu
Shuxian Wang
Shihong Li
Song Cao

Frontiers in Molecular Neuroscience

481 views

Mini Review

Published on 03 Oct 2025

Neurochemical crossroads: exploring the neurotransmitter network in chronic pain and depression comorbidity

in Pain Mechanisms and Modulators

Min Ma
Yue Zhang
Kunming Tao
Zhijie Lu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1675814

3,560 views

Correction

Published on 29 Sep 2025

Correction: Endoglin alleviates neuropathic pain by protecting the blood–spinal cord barrier through the TGF-β/Smad2 signaling pathway

in Pain Mechanisms and Modulators

SiJing Liao
Fei-Ran Zhou
Qun Li
Tao Jin
Gui-Fang Xiang
Xin Wang
Yan Liu
Hq Zhu
Qing Liu
Yuexin Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1707410

1,498 views

Original Research

Published on 15 Sep 2025

Endoglin alleviates neuropathic pain by protecting the blood–spinal cord barrier through the TGF-β/Smad2 signaling pathway

in Pain Mechanisms and Modulators

SiJing Liao
Fei-Ran Zhou
Qun Li
Tao Jin
Gui-Fang Xiang
Xin Wang
Yan Liu
Hq Zhu
Qing Liu
Yuexin Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1603619

2,798 views

Editorial

Published on 29 Aug 2025

Editorial: Insights into molecular and cellular mechanisms of chronic pain and neuroinflammation

in Pain Mechanisms and Modulators

Silke Neumann
Amit Sharma
Jarek Maciaczyk

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1679721

2,054 views

Correction

Published on 21 Aug 2025

Correction: Exosome-mediated miRNA delivery: a molecular switch for reshaping neuropathic pain therapy

in Pain Mechanisms and Modulators

Ziqing Wei
Chunhui Guo
Hang Zhou
Yanling Wu
Xudong Zhou
Jibing Chen
Fujun Li

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1668038

1,305 views

Review

Published on 23 Jul 2025

Decoding chronic pain: the glutamate-GABA tug of war in the cerebral cortex

in Pain Mechanisms and Modulators

Dan Huang
Yu-Ting Dong
Liu-Xuan He
Rui-Zhu Zhou
Jian-Xiong Zhou
Sha Yang
Shu-Guang Yu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1572775

3,474 views

Review

Published on 04 Jul 2025

Exosome-mediated miRNA delivery: a molecular switch for reshaping neuropathic pain therapy

in Pain Mechanisms and Modulators

Ziqing Wei
Chunhui Guo
Hang Zhou
Yanling Wu
Xudong Zhou
Jibing Chen
Fujun Li

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1625943

4,784 views
2 citations

Review

Published on 26 Jun 2025

Decoding pain chronification: mechanisms of the acute-to-chronic transition

in Pain Mechanisms and Modulators

Shunwei Zhang
Youzhi Ning
Yiyi Yang
Guo Mu
Yongkui Yang
Changhe Ren
Changli Liao
Cehua Ou
Yue Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1596367

7,064 views
5 citations

Original Research

Published on 26 Jun 2025

Research hotspots and emerging trends in MicroRNA therapy for neuropathic pain: a bibliometric analysis (2009–2024)

in Pain Mechanisms and Modulators

Yiqiang Zhang
Shushu Chen
Jiangtao Chi
Qinghua Gao
Yujie Li
Huaizhao Wang
Yuanyuan Yu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1610844

1,882 views

Brief Research Report

Published on 16 Jun 2025

SARS-CoV-2 viral proteins trigger pain via TLR2/4-MyD88 pathway

in Pain Mechanisms and Modulators

Wenliang Su
Xinrui Wang
Minghui Gu
Qiwei Zheng
Jiawen Yu
Dongliang Mu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1163636

2,091 views

Original Research

Published on 03 Jun 2025

A NaV1.8FlpO mouse enabling selective intersectional targeting of low threshold C fiber mechanoreceptors and nociceptors

in Pain Mechanisms and Modulators

John C. Y. Chen
Lech Kaczmarczyk
Walker S. Jackson
Max Larsson

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1574219

1,890 views
1 citation

Original Research

Published on 16 May 2025

Bidirectional substance P signaling between periodontal ligament fibroblasts and sensory neurons under mechanical stress

in Pain Mechanisms and Modulators

Judit Symmank
Lara Löffler
Ulrike Schulze-Späte
Collin Jacobs

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1583908

2,779 views
1 citation

Mini Review

Published on 21 Mar 2025

Environmental enrichment for neuropathic pain via modulation of neuroinflammation

in Pain Mechanisms and Modulators

Jian-Dong Zhang
Zi-An Zhong
Wen-Yuan Xing

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1547647

2,738 views

Systematic Review

Published on 24 Dec 2024

Mapping the research landscape of microRNAs in pain: a comprehensive bibliometric analysis

in Pain Mechanisms and Modulators

Huaiming Wang
Qin Li
Jiang Zou
Jinjun Shu
Aimin Zhang
Hongwei Zhang
Qi Zhao
Shunxin Liu
Chan Chen
Guo Chen

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1493822

2,870 views
3 citations

Systematic Review

Published on 16 Oct 2024

Ziconotide and psychosis: from a case report to a scoping review

in Pain Mechanisms and Modulators

Marc Peraire
Rita Gimeno-Vergara
Jennifer Pick-Martin
Mireia Boscá
Iván Echeverria

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1412855

2,894 views
2 citations

Original Research

Published on 02 Oct 2024

Molecular determinants of resurgent sodium currents mediated by Navβ4 peptide and A-type FHFs

in Pain Mechanisms and Modulators

Yucheng Xiao
Yanling Pan
Jingyu Xiao
Theodore R. Cummins

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1433981

2,835 views
3 citations

Original Research

Published on 02 Oct 2024

Risk factors for poor prognosis in patients with zoster-associated neuralgia who underwent interventional pain management

in Pain Mechanisms and Modulators

Junpeng Yuan
Youjia Yu
Hong Liu
Huichan Xu
Yan Li
Xiaohong Jin

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1393219

2,120 views
2 citations

Editorial

Published on 16 Sep 2024

Editorial: Molecular neurobiology of chronic pain: pharmacological and non-pharmacological approaches in animal models

in Pain Mechanisms and Modulators

Mario A. Acuña
Kristina Valentinova
Pascal Darbon

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1487141

1,679 views

Editorial

Published on 12 Sep 2024

Editorial: Molecular mechanism of neuroimmune modulation and synaptic plasticity in acute and chronic pain, volume II

in Pain Mechanisms and Modulators

Shunmei Lu
Yuxin Zhang
Zilong Wang
Linlin Zhang
Xin Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1484826

1,615 views

340 articles

articles

Nrf2/HO-1-sulfiredoxin1 pathway involved in nanobubble hydrogen-dissolved water-mediated protective effects by ultrasound-guided early local injection in a rat model of chronic constriction injury-induced neuropathic pain

Unraveling proteomic signatures and neuroinflammatory networks in a CCI rat model of early sciatica: insights for neuropathic pain mechanisms

A novel target for analgesic substances: physiological role of Na,K-ATPase as the signal transducer

The role and mechanisms of matrix metalloproteinase-9 in peripheral neuropathic pain

A Multi-Database Bibliometric and Translational Mapping of Microglial Mechanisms in Spinal Cord Pain Signaling

Neurochemical crossroads: exploring the neurotransmitter network in chronic pain and depression comorbidity

Correction: Endoglin alleviates neuropathic pain by protecting the blood–spinal cord barrier through the TGF-β/Smad2 signaling pathway

Endoglin alleviates neuropathic pain by protecting the blood–spinal cord barrier through the TGF-β/Smad2 signaling pathway

Editorial: Insights into molecular and cellular mechanisms of chronic pain and neuroinflammation

Correction: Exosome-mediated miRNA delivery: a molecular switch for reshaping neuropathic pain therapy

Decoding chronic pain: the glutamate-GABA tug of war in the cerebral cortex

Exosome-mediated miRNA delivery: a molecular switch for reshaping neuropathic pain therapy

Decoding pain chronification: mechanisms of the acute-to-chronic transition

Research hotspots and emerging trends in MicroRNA therapy for neuropathic pain: a bibliometric analysis (2009–2024)

SARS-CoV-2 viral proteins trigger pain via TLR2/4-MyD88 pathway

A NaV1.8FlpO mouse enabling selective intersectional targeting of low threshold C fiber mechanoreceptors and nociceptors

Bidirectional substance P signaling between periodontal ligament fibroblasts and sensory neurons under mechanical stress

Environmental enrichment for neuropathic pain via modulation of neuroinflammation

Mapping the research landscape of microRNAs in pain: a comprehensive bibliometric analysis

Ziconotide and psychosis: from a case report to a scoping review

Molecular determinants of resurgent sodium currents mediated by Navβ4 peptide and A-type FHFs

Risk factors for poor prognosis in patients with zoster-associated neuralgia who underwent interventional pain management

Editorial: Molecular neurobiology of chronic pain: pharmacological and non-pharmacological approaches in animal models

Editorial: Molecular mechanism of neuroimmune modulation and synaptic plasticity in acute and chronic pain, volume II