Frontiers in Molecular Neuroscience | Pain Mechanisms and Modulators

Mini Review

Accepted on 19 Sep 2025

Neurochemical Crossroads: Exploring the Neurotransmitter Network in Chronic Pain and Depression Comorbidity

in Pain Mechanisms and Modulators

Min Ma
Yue Zhang
Kunming Tao
Zhijie Lu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1675814

Correction

Accepted on 18 Sep 2025

Correction: Endoglin alleviates neuropathic pain by protecting the blood–spinal cord barrier through the TGF-β/Smad2 signaling pathway

in Pain Mechanisms and Modulators

SiJing Liao
Fei-Ran Zhou
Qun Li
Tao Jin
Gui-Fang Xiang
Xin Wang
Yan Liu
Hq Zhu
Qing Liu
Yuexin Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1707410

106 views

Original Research

Published on 15 Sep 2025

Endoglin alleviates neuropathic pain by protecting the blood–spinal cord barrier through the TGF-β/Smad2 signaling pathway

in Pain Mechanisms and Modulators

SiJing Liao
Fei-Ran Zhou
Qun Li
Tao Jin
Gui-Fang Xiang
Xin Wang
Yan Liu
Hq Zhu
Qing Liu
Yuexin Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1603619

979 views

Editorial

Published on 29 Aug 2025

Editorial: Insights into molecular and cellular mechanisms of chronic pain and neuroinflammation

in Pain Mechanisms and Modulators

Silke Neumann
Amit Sharma
Jarek Maciaczyk

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1679721

973 views

Correction

Published on 21 Aug 2025

Correction: Exosome-mediated miRNA delivery: a molecular switch for reshaping neuropathic pain therapy

in Pain Mechanisms and Modulators

Ziqing Wei
Chunhui Guo
Hang Zhou
Yanling Wu
Xudong Zhou
Jibing Chen
Fujun Li

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1668038

860 views

Review

Published on 23 Jul 2025

Decoding chronic pain: the glutamate-GABA tug of war in the cerebral cortex

in Pain Mechanisms and Modulators

Dan Huang
Yu-Ting Dong
Liu-Xuan He
Rui-Zhu Zhou
Jian-Xiong Zhou
Sha Yang
Shu-Guang Yu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1572775

1,878 views

Review

Published on 04 Jul 2025

Exosome-mediated miRNA delivery: a molecular switch for reshaping neuropathic pain therapy

in Pain Mechanisms and Modulators

Ziqing Wei
Chunhui Guo
Hang Zhou
Yanling Wu
Xudong Zhou
Jibing Chen
Fujun Li

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1625943

2,427 views
1 citation

Original Research

Published on 26 Jun 2025

Research hotspots and emerging trends in MicroRNA therapy for neuropathic pain: a bibliometric analysis (2009–2024)

in Pain Mechanisms and Modulators

Yiqiang Zhang
Shushu Chen
Jiangtao Chi
Qinghua Gao
Yujie Li
Huaizhao Wang
Yuanyuan Yu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1610844

1,280 views

Review

Published on 26 Jun 2025

Decoding pain chronification: mechanisms of the acute-to-chronic transition

in Pain Mechanisms and Modulators

Shunwei Zhang
Youzhi Ning
Yiyi Yang
Guo Mu
Yongkui Yang
Changhe Ren
Changli Liao
Cehua Ou
Yue Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1596367

2,797 views
2 citations

Brief Research Report

Published on 16 Jun 2025

SARS-CoV-2 viral proteins trigger pain via TLR2/4-MyD88 pathway

in Pain Mechanisms and Modulators

Wenliang Su
Xinrui Wang
Minghui Gu
Qiwei Zheng
Jiawen Yu
Dongliang Mu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1163636

1,557 views

Original Research

Published on 03 Jun 2025

A NaV1.8FlpO mouse enabling selective intersectional targeting of low threshold C fiber mechanoreceptors and nociceptors

in Pain Mechanisms and Modulators

John C. Y. Chen
Lech Kaczmarczyk
Walker S. Jackson
Max Larsson

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1574219

1,331 views

Original Research

Published on 16 May 2025

Bidirectional substance P signaling between periodontal ligament fibroblasts and sensory neurons under mechanical stress

in Pain Mechanisms and Modulators

Judit Symmank
Lara Löffler
Ulrike Schulze-Späte
Collin Jacobs

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1583908

1,919 views

Mini Review

Published on 21 Mar 2025

Environmental enrichment for neuropathic pain via modulation of neuroinflammation

in Pain Mechanisms and Modulators

Jian-Dong Zhang
Zi-An Zhong
Wen-Yuan Xing

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1547647

2,030 views

Systematic Review

Published on 24 Dec 2024

Mapping the research landscape of microRNAs in pain: a comprehensive bibliometric analysis

in Pain Mechanisms and Modulators

Huaiming Wang
Qin Li
Jiang Zou
Jinjun Shu
Aimin Zhang
Hongwei Zhang
Qi Zhao
Shunxin Liu
Chan Chen
Guo Chen

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1493822

2,310 views
2 citations

Systematic Review

Published on 16 Oct 2024

Ziconotide and psychosis: from a case report to a scoping review

in Pain Mechanisms and Modulators

Marc Peraire
Rita Gimeno-Vergara
Jennifer Pick-Martin
Mireia Boscá
Iván Echeverria

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1412855

2,145 views
1 citation

Original Research

Published on 02 Oct 2024

Risk factors for poor prognosis in patients with zoster-associated neuralgia who underwent interventional pain management

in Pain Mechanisms and Modulators

Junpeng Yuan
Youjia Yu
Hong Liu
Huichan Xu
Yan Li
Xiaohong Jin

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1393219

1,612 views
1 citation