Frontiers in Neurology | Dementia and Neurodegenerative Diseases

Original Research

Published on 19 Dec 2025

Canadian Creutzfeldt-Jakob disease incidence remained stable during the coronavirus disease (COVID-19) pandemic

in Dementia and Neurodegenerative Diseases

Jessy A. Slota
Dobrila Todoric
Vanessa Bergeron
Kristen Avery
Clark Phillipson
Dominic M. S. Kielich
Jennifer Myskiw
Lise Lamoureux
Kathy Frost
Sharon L. R. Simon

Frontiers in Neurology

doi 10.3389/fneur.2025.1729083

130 views

Original Research

Accepted on 18 Dec 2025

Thyroid Function Status and Heterogeneity of Efficacy of Maintenance Cognitive Stimulation in Late‑Life Dementia: A Stratified Observational Study of Subclinical Hypothyroidism/Hyperthyroidism

in Dementia and Neurodegenerative Diseases

Ruili Zhang
Yongling Zhou
Shan Wang
Feng Li
Xuan Zhao
Bowen Jia
Xiaxia Li
Junhui Yang
Ling Yang
Haiyuan Yu

Frontiers in Neurology

Original Research

Published on 18 Dec 2025

A gut microbiota-based predictive model for the treatment efficacy of Parkinson’s disease

in Dementia and Neurodegenerative Diseases

Chen Liu
Tianxia Yu

Frontiers in Neurology

doi 10.3389/fneur.2025.1686882

190 views

Systematic Review

Published on 17 Dec 2025

Effects of aerobic exercise interventions on cognitive function, sleep quality, and quality of life in older adults with mild cognitive impairment: a systematic review and meta-analysis

in Dementia and Neurodegenerative Diseases

Wanyu Shu
Liang Chen
Jiadong Qiu
Sung Min Kim

Frontiers in Neurology

doi 10.3389/fneur.2025.1693052

471 views

Original Research

Published on 17 Dec 2025

Trends in mortality from Alzheimer’s disease and related dementias with hyperlipidemia in the United States from 1999 to 2020—a CDC WONDER database study

in Dementia and Neurodegenerative Diseases

Junwen Wang
Kaide Xia
Dianmei Yang
Jing Wu
Longfei Liu
Ying Huang
Qing Shan
Haiwang Zhang
Yiming Wang

Frontiers in Neurology

doi 10.3389/fneur.2025.1705607

335 views

Review

Published on 16 Dec 2025

The metabolic-epigenetic interface: lysine succinylation orchestrates bidirectional crosstalk in neurodegenerative disorders

in Dementia and Neurodegenerative Diseases

Fanglei Chai
Chong Liu
Yandong Liu
Wei Zou

Frontiers in Neurology

doi 10.3389/fneur.2025.1678595

481 views

Original Research

Accepted on 11 Dec 2025

MALT1 in Cerebrospinal Fluid: A Prognostic Biomarker and Potential Therapeutic Target in Alzheimer's Disease

in Dementia and Neurodegenerative Diseases

Siyi Jiang
Ping Qi
Jia Tian
Huaizheng Liu
Chuanzheng Sun

Frontiers in Neurology

108 views

Original Research

Accepted on 05 Dec 2025

The diagnostic pathway of Alzheimer's disease in real-world clinical practice in Spain: results from the Adelphi Dementia Disease Specific Programme™

in Dementia and Neurodegenerative Diseases

Pascual Sánchez-Juan
Pablo Baz
Enrique Arrieta
Diego Novick
Silvia Díaz-Cerezo
Sarah Cotton
Chloe Walker
Ángel Trueba
Mercedes Núñez

Frontiers in Neurology

Systematic Review

Published on 05 Dec 2025

Comparison of the effects of choline alphoscerate and citicoline in patients with dementia disorders: a systematic review and meta-analysis

in Dementia and Neurodegenerative Diseases

Getu Gamo Sagaro
Francesco Amenta

Frontiers in Neurology

doi 10.3389/fneur.2025.1649661

1,013 views

Original Research

Published on 04 Dec 2025

Limited utility of imaging-based (N) markers in predicting cerebral spinal fluid Alzheimer’s disease biomarker positivity in lecanemab-eligible mild cognitive impairment

in Dementia and Neurodegenerative Diseases

Takeshi Kuroda
Yukiko Mori
Daiki Shoji
Satomi Kubota
Moeko Noguchi-Shinohara
Kenjiro Ono
Hidetomo Murakami

Frontiers in Neurology

doi 10.3389/fneur.2025.1735548

395 views

Original Research

Published on 03 Dec 2025

Clinical phenotypes of motor neurone disease in a Kenyan hospital-based population

in Dementia and Neurodegenerative Diseases

Effie Nailah Kamadi
Jasmit Shah
Juzar Hooker
Thomas M. Jenkins
Dilraj Singh Sokhi

Frontiers in Neurology

doi 10.3389/fneur.2025.1662690

457 views

Original Research

Accepted on 30 Nov 2025

A Comparative Analysis of Health-Related and Individual Quality of Life in People with Parkinson's Disease

in Dementia and Neurodegenerative Diseases

Ketevan Toloraia
Siegward Elsas
Arzu Tasci
Peter Fuhr
Ute Gschwandtner

Frontiers in Neurology

126 views

Review

Published on 28 Nov 2025

New progress on the role and mechanism of tau protein in Alzheimer's disease and depression

in Dementia and Neurodegenerative Diseases

Yamei Wang
Jinglian Zhou
Qingqing Zhou
Hua Wang

Frontiers in Neurology

doi 10.3389/fneur.2025.1551273

1,105 views

Original Research

Published on 26 Nov 2025

Cross-species validation of a 6-miRNA blood signature for Parkinson’s disease: from MPTP mice to human PBMC and serum exosomes

in Dementia and Neurodegenerative Diseases

Nagyum Jung
Seung-Nam Kim

Frontiers in Neurology

doi 10.3389/fneur.2025.1704976

606 views

Systematic Review

Accepted on 21 Nov 2025

Ginkgo biloba extract EGb 761 in patients with dementia and a history of cerebral infarction – meta-analysis of pooled data from randomised clinical trials

in Dementia and Neurodegenerative Diseases

Jing-xuan Feng
Man-qi Zheng
Xue Tian
Andrea Zimmermann
An-xin Wang
Xia Meng

Frontiers in Neurology

280 views

Review

Published on 18 Nov 2025

Assessment of symptoms in myalgic encephalomyelitis/chronic fatigue syndrome: a comparative study of existing scales

in Dementia and Neurodegenerative Diseases

Jing Lu
Weibo Sun
Shulin Li
Yuanyuan Qu
Tingting Liu
Shuhao Guo
Chuwen Feng
Tiansong Yang

Frontiers in Neurology

doi 10.3389/fneur.2025.1618272

1,563 views

Original Research

Published on 13 Nov 2025

Metabolic-stem cell crosstalk in PD: NK1 cells as key mediators from a bioinformatics perspective

in Dementia and Neurodegenerative Diseases

Junxin Zhao
Yibiao Chen
Lundeng Hu
Shuna Huang
Qibin Zheng

Frontiers in Neurology

doi 10.3389/fneur.2025.1681261

833 views

Original Research

Published on 12 Nov 2025

Vaccine research in cognitive impairment and dementia: a bibliometric analysis and future outlook (2000–2025)

in Dementia and Neurodegenerative Diseases

Zhongli Wang
Xiaojia Xue
Hua Zhang
Jipeng Liu
Shoujie Dai
Haiping Duan
Shixue Li

Frontiers in Neurology

doi 10.3389/fneur.2025.1662314

1,154 views

Original Research

Published on 11 Nov 2025

Moderate tea consumption and dementia-related neuroimaging markers

in Dementia and Neurodegenerative Diseases

Ting Jin
Dongwei Lu
Jiyu Chen
Wenxuan Zhao
Yanfang Zhang
Qing Zhang
Xujun Ye
Juanjuan Qin

Frontiers in Neurology

doi 10.3389/fneur.2025.1634621

1,051 views

Review

Published on 07 Nov 2025

Dysfunctions of sleep and the circadian rhythm in Huntington’s disease

in Dementia and Neurodegenerative Diseases

Paulina Kaczmarska
Monika Rudzińska-Bar

Frontiers in Neurology

doi 10.3389/fneur.2025.1693307

1,242 views

Original Research

Accepted on 04 Nov 2025

Neuropsychological and Neuroimaging Characteristics of Patients with Mild Cognitive Impairment and Negative-Amyloid Deposition

in Dementia and Neurodegenerative Diseases

Xiangwei Dai
Junying Zhang
Xin Li
Yaojing Chen
Yanan Qiao
Shujuan Zhang
Kewei Chen
Lin Ai
Dantao Peng
Zhanjun Zhang

Frontiers in Neurology

218 views

Review

Published on 29 Oct 2025

Innovations in Alzheimer’s disease diagnostic technologies: clinical prospects of novel biomarkers, multimodal integration, and non-invasive detection

in Dementia and Neurodegenerative Diseases

Rui Wang
Siqin Peng
Jianrong Zhu
Ye Xu
Minghao Wang
Ling Zhang
Yilan Qiu
Defu Hou
Qinglin Wang
Rushi Liu

Frontiers in Neurology

doi 10.3389/fneur.2025.1651708

2,356 views

Original Research

Published on 24 Oct 2025

Iron chelation as a therapeutic target in vanadium neurotoxicity and Parkinson's disease: role of medicinal plants

in Dementia and Neurodegenerative Diseases

Francis Olaolorun
Melanie-Jayne R. Howes
Taiwo Elufioye
Oluwatoyin A. Odeku
James Olopade
Paul Chazot

Frontiers in Neurology

doi 10.3389/fneur.2025.1667943

961 views

Review

Published on 24 Oct 2025

Fatigue and neuropsychiatric symptoms in Parkinson’s disease: a narrative review

in Dementia and Neurodegenerative Diseases

Lidia Bojtos
Jon Rodríguez-Antigüedad
Javier Pagonabarraga
Saül Martínez-Horta
Jaime Kulisevsky

Frontiers in Neurology

doi 10.3389/fneur.2025.1670644

1,222 views

758 articles

articles

Canadian Creutzfeldt-Jakob disease incidence remained stable during the coronavirus disease (COVID-19) pandemic

Thyroid Function Status and Heterogeneity of Efficacy of Maintenance Cognitive Stimulation in Late‑Life Dementia: A Stratified Observational Study of Subclinical Hypothyroidism/Hyperthyroidism

A gut microbiota-based predictive model for the treatment efficacy of Parkinson’s disease

Effects of aerobic exercise interventions on cognitive function, sleep quality, and quality of life in older adults with mild cognitive impairment: a systematic review and meta-analysis

Trends in mortality from Alzheimer’s disease and related dementias with hyperlipidemia in the United States from 1999 to 2020—a CDC WONDER database study

The metabolic-epigenetic interface: lysine succinylation orchestrates bidirectional crosstalk in neurodegenerative disorders

MALT1 in Cerebrospinal Fluid: A Prognostic Biomarker and Potential Therapeutic Target in Alzheimer's Disease

The diagnostic pathway of Alzheimer's disease in real-world clinical practice in Spain: results from the Adelphi Dementia Disease Specific Programme™

Comparison of the effects of choline alphoscerate and citicoline in patients with dementia disorders: a systematic review and meta-analysis

Limited utility of imaging-based (N) markers in predicting cerebral spinal fluid Alzheimer’s disease biomarker positivity in lecanemab-eligible mild cognitive impairment

Clinical phenotypes of motor neurone disease in a Kenyan hospital-based population

A Comparative Analysis of Health-Related and Individual Quality of Life in People with Parkinson's Disease

New progress on the role and mechanism of tau protein in Alzheimer's disease and depression

Cross-species validation of a 6-miRNA blood signature for Parkinson’s disease: from MPTP mice to human PBMC and serum exosomes

Ginkgo biloba extract EGb 761 in patients with dementia and a history of cerebral infarction – meta-analysis of pooled data from randomised clinical trials

Assessment of symptoms in myalgic encephalomyelitis/chronic fatigue syndrome: a comparative study of existing scales

Metabolic-stem cell crosstalk in PD: NK1 cells as key mediators from a bioinformatics perspective

Vaccine research in cognitive impairment and dementia: a bibliometric analysis and future outlook (2000–2025)

Moderate tea consumption and dementia-related neuroimaging markers

Dysfunctions of sleep and the circadian rhythm in Huntington’s disease

Neuropsychological and Neuroimaging Characteristics of Patients with Mild Cognitive Impairment and Negative-Amyloid Deposition

Innovations in Alzheimer’s disease diagnostic technologies: clinical prospects of novel biomarkers, multimodal integration, and non-invasive detection

Iron chelation as a therapeutic target in vanadium neurotoxicity and Parkinson's disease: role of medicinal plants

Fatigue and neuropsychiatric symptoms in Parkinson’s disease: a narrative review