Frontiers in Neurology | Neurological Biomarkers

Original Research

Published on 19 May 2025

Metabolomics insights into Charcot–Marie–Tooth disease: toward biomarker discovery

in Neurological Biomarkers

Signe Setlere
Theresa Schiemer
Annija Vaska
Linda Gailite
Dmitrijs Rots
Viktorija Kenina
Kristaps Klavins

Frontiers in Neurology

doi 10.3389/fneur.2025.1543547

2,852 views
2 citations

Original Research

Published on 19 May 2025

Butyrylcholinesterase and 24 h-urinary copper excretion as compliance assessment in long-term treated Wilson’s disease

in Neurological Biomarkers

Harald Hefter
Max Novak
Dietmar Rosenthal
Sven G. Meuth
Tom Luedde
Philipp Albrecht
Christian J. Hartmann
Sara Samadzadeh

Frontiers in Neurology

doi 10.3389/fneur.2025.1553573

1,861 views

Original Research

Published on 16 May 2025

The association between serum klotho protein and stroke: a cross-sectional study from NHANES 2007–2016

in Neurological Biomarkers

Hongjia Xu
Yiming Ding
Ye Zhang
Jianwen Li
Shiyue Zhou
Dewei Wang
Xinyue Xing
Xiaoyu Ma
Cunfu Wang
Shunliang Xu

Frontiers in Neurology

doi 10.3389/fneur.2025.1573027

3,334 views

Original Research

Published on 14 May 2025

Biomarker identification associated with M2 tumor-associated macrophage infiltration in glioblastoma

in Neurological Biomarkers

Xue-yuan Li
Zhi-yun Yu
Hong-jiang Li
Dong-ming Yan
Chao Yang
Xian-zhi Liu

Frontiers in Neurology

doi 10.3389/fneur.2025.1545608

2,395 views
1 citation

Original Research

Published on 13 May 2025

Development and internal verification of nomogram for forecasting delirium in the elderly admitted to intensive care units: an analysis of MIMIC-IV database

in Neurological Biomarkers

Li Jiang
Dongdong Yu
Ge Yang
Xiaoqian Wu
Dong Zhang

Frontiers in Neurology

doi 10.3389/fneur.2025.1580125

3,903 views

Original Research

Published on 08 May 2025

Values of lymphocyte-related ratios in predicting the clinical outcome of acute ischemic stroke patients receiving intravenous thrombolysis based on different etiologies

in Neurological Biomarkers

Yongyu Li
Keyang Chen
Lu Wang
Linhu Zhao
Chunyan Lei
Yu Gu
Xiaoyan Zhu
Qionghua Deng

Frontiers in Neurology

doi 10.3389/fneur.2025.1542889

1,755 views
3 citations

Methods

Published on 08 May 2025

Toward a unified gait freeze index: a standardized benchmark for clinical and regulatory evaluations

in Neurological Biomarkers

Alessandro Schaer
Henrik Maurenbrecher
Carlo Mangiante
Roman Sobkuliak
Kathrin Müsch
Paula Sanchez Lopez
Eduardo Martin Moraud
Olgac Ergeneman
George Chatzipirpiridis

Frontiers in Neurology

doi 10.3389/fneur.2025.1528963

2,082 views
1 citation

Mini Review

Published on 07 May 2025

Prognostic value of lymphocyte-to-monocyte ratio in acute ischemic stroke: a systematic review and meta-analysis

in Neurological Biomarkers

Chengli Tian
Yilin Yang
Jun Wan
Ran Wang
Ke Zhou
Yuanli Li
Wenlong Guo
Huijun Li
Yu Zhang

Frontiers in Neurology

doi 10.3389/fneur.2025.1567112

2,961 views
3 citations

Review

Published on 01 May 2025

Roles of neuroimaging markers and biomarkers in cerebral small vessel disease and their associations with cognitive function

in Neurological Biomarkers

Xiaoqian Song
Chenyang Jin
Moxin Luan
Xueping Zheng

Frontiers in Neurology

doi 10.3389/fneur.2025.1483842

2,521 views
2 citations

Original Research

Published on 01 May 2025

Predictive value of the fibrinogen-to-albumin ratio for hemorrhagic transformation following intravenous thrombolysis in ischemic stroke: a retrospective propensity score-matched analysis

in Neurological Biomarkers

Xiao-Yu Liu
Hui-Yang Jia
Gang Wang

Frontiers in Neurology

doi 10.3389/fneur.2025.1465508

1,770 views
2 citations

Original Research

Published on 30 Apr 2025

Identification immune-related hub genes in diagnosing atherosclerosis with ischemic stroke through comprehensive bioinformatics analysis and machine learning

in Neurological Biomarkers

Ming Zhang
Li-Jun Tang
Shi-Yu Long

Frontiers in Neurology

doi 10.3389/fneur.2025.1507855

2,686 views

Original Research

Published on 30 Apr 2025

Association of alkaline-phosphatase/albumin ratio with all-cause mortality in critically ill patients with ischemic stroke: a retrospective study

in Neurological Biomarkers

Tao Zheng
Mengmeng Guo
Yating Han
Guanglu Li
Xianhua Wang
Shenjie Li
Yuting Gao
Wenxiong Tang
Zunjing Liu

Frontiers in Neurology

doi 10.3389/fneur.2025.1567767

3,102 views

Original Research

Published on 30 Apr 2025

CD9 expression rivals IDH mutation as a prognostic marker in glioma: a novel nomogram approach

in Neurological Biomarkers

Yue Peng
Qiang Ji
Xiangyu Guo
Weichunbai Zhang
Zixuan Yang
Wenbin Li

Frontiers in Neurology

doi 10.3389/fneur.2025.1507443

3,164 views

Brief Research Report

Published on 30 Apr 2025

Exploring Tau-C, Tau-A, and C1M as biomarkers for Parkinson’s disease

in Neurological Biomarkers

Meryem Benmarce
Kim Henriksen
Morten Karsdal
Signe Holm Nielsen

Frontiers in Neurology

doi 10.3389/fneur.2025.1566228

1,526 views

Original Research

Published on 30 Apr 2025

Association of plasma neurofilament light protein concentration with sleep disturbance after intracerebral hemorrhage

in Neurological Biomarkers

Peng Xu
Jinlei Yang
Xin Zhao
Fang Liu
Qiang Liu
Handong Wang

Frontiers in Neurology

doi 10.3389/fneur.2025.1482808

1,708 views

Original Research

Published on 28 Apr 2025

NINJ1 and MMP9: potential biomarkers for intracranial atherosclerosis plaque vulnerability

in Neurological Biomarkers

Xiao-lian Wei
Xin Da
Yu-ge Zhang
Zi-ang Li
Bing-jie Liu
Rui-fang Yan
Hua Zhong
Bin Yuan

Frontiers in Neurology

doi 10.3389/fneur.2025.1552948

3,651 views
5 citations

Original Research

Published on 28 Apr 2025

Muscle-specific kinase levels in blood are an early diagnostic biomarker for SOD1-93A mouse model of ALS

in Neurological Biomarkers

Shuuichi Mori
Heying Zhou
Takuya Omura
Hiroki Tsumoto
Yuri Miura
Kazuhiro Shigemoto

Frontiers in Neurology

doi 10.3389/fneur.2025.1556120

3,433 views

Original Research

Published on 24 Apr 2025

Association of serum A20 levels with stroke-associated pneumonia, early neurological deterioration, and poor neurological prognosis following acute supratentorial intracerebral hemorrhage: a prospective cohort study

in Neurological Biomarkers

Chao Tang
Wei Li
Suijun Zhu
Min Zhang
Gaofeng Xiong
Yijuan Lin

Frontiers in Neurology

doi 10.3389/fneur.2025.1546934

2,116 views

Original Research

Published on 24 Apr 2025

Predictive value of circulating inflammatory biomarkers for early-onset post-stroke cognitive impairment: a prospective cohort study

in Neurological Biomarkers

Weiquan Huang
Libin Liao
Qian Liu
Rongchao Ma
Wentong Hu
Yuan Dai
Luna Wang
Dujuan Sha

Frontiers in Neurology

doi 10.3389/fneur.2025.1565613

2,505 views
4 citations

Original Research

Published on 16 Apr 2025

Post-stroke mortality in ICU patients with serum glucose-potassium ratio: an analysis of MIMIC-IV database

in Neurological Biomarkers

Zhen Yuan
Aoli Chen
Yunqing Zeng
Jiwei Cheng

Frontiers in Neurology

doi 10.3389/fneur.2025.1578268

4,015 views
2 citations

Original Research

Published on 14 Apr 2025

Metabolomic analysis reveals trimethylamine N-oxide as a biomarker for poor outcome of severe spontaneous intracerebral hemorrhage patients receiving surgical treatment

in Neurological Biomarkers

Xinguo Sun
Kaige Zheng
Shanjun Wang
Yunzhao Chen
Hongen Liu
Xindong Gu
Zitong Wu
Hui Lu
Shuo Wang
Qingyuan Liu

Frontiers in Neurology

doi 10.3389/fneur.2025.1551239

2,283 views
1 citation

Original Research

Published on 11 Apr 2025

Brain-derived neurotrophic factor but not beta-secretase 1, vascular endothelial growth factor, glial fibrillary acidic protein and interleukin-1β correlate with cognitive impairment in adult persons with epilepsy: a cross-sectional single-center study from India

in Neurological Biomarkers

Kamini Bhavsar
Manjari Tripathi
Jyotirmoy Banerjee
Arpna Srivastava
Nidhi
Shivam Pandey
Divya Vohora

Frontiers in Neurology

doi 10.3389/fneur.2025.1540915

2,910 views
3 citations

Original Research

Published on 10 Apr 2025

Machine learning consensus clustering for inflammatory subtype analysis in stroke and its impact on mortality risk: a study based on NHANES (1999–2018)

in Neurological Biomarkers

Zhang Chunjuan
Wang Yulong
Zhou Xicheng
Ma Xiaodong

Frontiers in Neurology

doi 10.3389/fneur.2025.1562247

5,514 views
3 citations

Original Research

Published on 03 Apr 2025

Association between peripheral blood serum phenylalanine to tyrosine ratio and the risk of moyamoya disease: a case-control study

in Neurological Biomarkers

Shixiong Lei
Mengnan Wang
Jiali Pan
Daming Wang
Peicong Ge
Dong Zhang

Frontiers in Neurology

doi 10.3389/fneur.2025.1554697

1,941 views

459 articles

articles

Metabolomics insights into Charcot–Marie–Tooth disease: toward biomarker discovery

Butyrylcholinesterase and 24 h-urinary copper excretion as compliance assessment in long-term treated Wilson’s disease

The association between serum klotho protein and stroke: a cross-sectional study from NHANES 2007–2016

Biomarker identification associated with M2 tumor-associated macrophage infiltration in glioblastoma

Development and internal verification of nomogram for forecasting delirium in the elderly admitted to intensive care units: an analysis of MIMIC-IV database

Values of lymphocyte-related ratios in predicting the clinical outcome of acute ischemic stroke patients receiving intravenous thrombolysis based on different etiologies

Toward a unified gait freeze index: a standardized benchmark for clinical and regulatory evaluations

Prognostic value of lymphocyte-to-monocyte ratio in acute ischemic stroke: a systematic review and meta-analysis

Roles of neuroimaging markers and biomarkers in cerebral small vessel disease and their associations with cognitive function

Predictive value of the fibrinogen-to-albumin ratio for hemorrhagic transformation following intravenous thrombolysis in ischemic stroke: a retrospective propensity score-matched analysis

Identification immune-related hub genes in diagnosing atherosclerosis with ischemic stroke through comprehensive bioinformatics analysis and machine learning

Association of alkaline-phosphatase/albumin ratio with all-cause mortality in critically ill patients with ischemic stroke: a retrospective study

CD9 expression rivals IDH mutation as a prognostic marker in glioma: a novel nomogram approach

Exploring Tau-C, Tau-A, and C1M as biomarkers for Parkinson’s disease

Association of plasma neurofilament light protein concentration with sleep disturbance after intracerebral hemorrhage

NINJ1 and MMP9: potential biomarkers for intracranial atherosclerosis plaque vulnerability

Muscle-specific kinase levels in blood are an early diagnostic biomarker for SOD1-93A mouse model of ALS

Association of serum A20 levels with stroke-associated pneumonia, early neurological deterioration, and poor neurological prognosis following acute supratentorial intracerebral hemorrhage: a prospective cohort study

Predictive value of circulating inflammatory biomarkers for early-onset post-stroke cognitive impairment: a prospective cohort study

Post-stroke mortality in ICU patients with serum glucose-potassium ratio: an analysis of MIMIC-IV database

Metabolomic analysis reveals trimethylamine N-oxide as a biomarker for poor outcome of severe spontaneous intracerebral hemorrhage patients receiving surgical treatment

Brain-derived neurotrophic factor but not beta-secretase 1, vascular endothelial growth factor, glial fibrillary acidic protein and interleukin-1β correlate with cognitive impairment in adult persons with epilepsy: a cross-sectional single-center study from India

Machine learning consensus clustering for inflammatory subtype analysis in stroke and its impact on mortality risk: a study based on NHANES (1999–2018)

Association between peripheral blood serum phenylalanine to tyrosine ratio and the risk of moyamoya disease: a case-control study

articles

Metabolomics insights into Charcot–Marie–Tooth disease: toward biomarker discovery

Butyrylcholinesterase and 24 h-urinary copper excretion as compliance assessment in long-term treated Wilson’s disease

The association between serum klotho protein and stroke: a cross-sectional study from NHANES 2007–2016

Biomarker identification associated with M2 tumor-associated macrophage infiltration in glioblastoma

Development and internal verification of nomogram for forecasting delirium in the elderly admitted to intensive care units: an analysis of MIMIC-IV database

Values of lymphocyte-related ratios in predicting the clinical outcome of acute ischemic stroke patients receiving intravenous thrombolysis based on different etiologies

Toward a unified gait freeze index: a standardized benchmark for clinical and regulatory evaluations

Prognostic value of lymphocyte-to-monocyte ratio in acute ischemic stroke: a systematic review and meta-analysis

Roles of neuroimaging markers and biomarkers in cerebral small vessel disease and their associations with cognitive function

Predictive value of the fibrinogen-to-albumin ratio for hemorrhagic transformation following intravenous thrombolysis in ischemic stroke: a retrospective propensity score-matched analysis

Identification immune-related hub genes in diagnosing atherosclerosis with ischemic stroke through comprehensive bioinformatics analysis and machine learning

Association of alkaline-phosphatase/albumin ratio with all-cause mortality in critically ill patients with ischemic stroke: a retrospective study

CD9 expression rivals IDH mutation as a prognostic marker in glioma: a novel nomogram approach

Exploring Tau-C, Tau-A, and C1M as biomarkers for Parkinson’s disease

Association of plasma neurofilament light protein concentration with sleep disturbance after intracerebral hemorrhage

NINJ1 and MMP9: potential biomarkers for intracranial atherosclerosis plaque vulnerability

Muscle-specific kinase levels in blood are an early diagnostic biomarker for SOD1-93A mouse model of ALS

Association of serum A20 levels with stroke-associated pneumonia, early neurological deterioration, and poor neurological prognosis following acute supratentorial intracerebral hemorrhage: a prospective cohort study

Predictive value of circulating inflammatory biomarkers for early-onset post-stroke cognitive impairment: a prospective cohort study

Post-stroke mortality in ICU patients with serum glucose-potassium ratio: an analysis of MIMIC-IV database

Metabolomic analysis reveals trimethylamine N-oxide as a biomarker for poor outcome of severe spontaneous intracerebral hemorrhage patients receiving surgical treatment

Brain-derived neurotrophic factor but not beta-secretase 1, vascular endothelial growth factor, glial fibrillary acidic protein and interleukin-1β correlate with cognitive impairment in adult persons with epilepsy: a cross-sectional single-center study from India

Machine learning consensus clustering for inflammatory subtype analysis in stroke and its impact on mortality risk: a study based on NHANES (1999–2018)

Association between peripheral blood serum phenylalanine to tyrosine ratio and the risk of moyamoya disease: a case-control study

Butyrylcholinesterase and 24 h-urinary copper excretion as compliance assessment in long-term treated Wilson’s disease