Frontiers in Neuroscience | Neurodegeneration

Original Research

Published on 01 Apr 2025

Intrastriatal injection of alpha-synuclein preformed fibrils to rats results in L-DOPA reversible sensorimotor impairments and alterations in non-motor function

in Neurodegeneration

Sheila M. Fleming
Sophia Scott
Edward J. Hamad
Danielle E. Herman
John G. Holden
Lily Yan
Katrina Linning-Duffy
Christopher J. Kemp
Joseph R. Patterson
Kathryn M. Miller

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1556447

261 views

Review

Published on 27 Mar 2025

α-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathies

in Neurodegeneration

Francisco J. Padilla-Godínez
Eunice Ruth Vázquez-García
María Isabel Trujillo-Villagrán
Luis O. Soto-Rojas
Marcela Palomero-Rivero
Omar Hernández-González
Francisco Pérez-Eugenio
Omar Collazo-Navarrete
Oscar Arias-Carrión
Magdalena Guerra-Crespo

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1570553

477 views

Original Research

Published on 25 Mar 2025

Association between serum sodium and sporadic Parkinson’s disease

in Neurodegeneration

Wen Zhou
Qingqing Xia
Duan Liu
Jun-ying Li
Liang Gong

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1555831

289 views

Editorial

Accepted on 24 Mar 2025

Translational Research in Hereditary Spastic Paraplegias: Filling the Diagnostic Gap and Therapeutic Perspectives

in Neurodegeneration

Andrea Martinuzzi
Craig Blackstone
Giovanni STEVANIN

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1595717

117 views

Editorial

Published on 18 Mar 2025

Editorial: Innovative approaches to catalyze preclinical and clinical research on amyotrophic lateral sclerosis (ALS) and related disorders

in Neurodegeneration

Thibaut Burg
Laura Tzeplaeff
Raphaelle Cassel
Paul Lingor

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1582539

761 views

Perspective

Published on 17 Mar 2025

High efficacy therapy to prevent the formation of meningeal tertiary lymphoid organs after CXCL13 index screening in early multiple sclerosis

in Neurodegeneration

Ana C. Londoño
Carlos A. Mora

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1558810

353 views

Review

Accepted on 14 Mar 2025

VPS13 and bridge-like lipid transporters, mechanisms and mysteries.

in Neurodegeneration

Laura Elizabeth Swan

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1534061

218 views

Review

Accepted on 14 Mar 2025

The Interplay Between α-Synuclein Aggregation and Necroptosis in Parkinson's Disease: A Spatiotemporal Perspective

in Neurodegeneration

Haoran Xiang
Yunhong Zha

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1567445

224 views

Original Research

Published on 13 Mar 2025

Differential cognitive functioning in the digital clock drawing test in AD-MCI and PD-MCI populations

in Neurodegeneration

Chen Wang
Kai Li
Shouqiang Huang
Jiakang Liu
Shuwu Li
Yuting Tu
Bo Wang
Pengpeng Zhang
Yuntian Luo
Tong Chen

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1558448

471 views

Review

Published on 12 Mar 2025

The role of intracellular and extracellular copper compartmentalization in Alzheimer’s disease pathology and its implications for diagnosis and therapy

in Neurodegeneration

Yu-Qi Li
Shuang-Shuang Tan
Di Wu
Qian Zhang
Tao Wang
Gang Zheng

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1553064

459 views

Original Research

Published on 12 Mar 2025

Phosphorylated neurofilament heavy chain (pNfH) concentration in cerebrospinal fluid predicts overall disease aggressiveness (D50) in amyotrophic lateral sclerosis

in Neurodegeneration

Julia Meyer
Nayana Gaur
Janina von der Gablentz
Bernd Friedrich
Annekathrin Roediger
Julian Grosskreutz
Robert Steinbach

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1536818

447 views

Original Research

Published on 12 Mar 2025

Distinct brain activity patterns associated with traditional Chinese medicine syndromes: a task-fMRI study of mild cognitive impairment

in Neurodegeneration

Zhaoying Li
Shanyu Liu
Yuling Shen
Huan Zhao
Zhenwei Chen
Rui Tan
Zhuoling Li
Ling Quan
Dongdong Yang
Min Shi

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1555365

403 views

Clinical Trial

Accepted on 05 Mar 2025

16 weeks of moderate intensity resistance exercise improves strength but is insufficient to alter brain structure in Gulf War Veterans with chronic musculoskeletal pain: A randomized controlled trial

in Neurodegeneration

Stephanie Van Riper
Jacon V Ninneman
Aaron J Stegner
Brady A Riedner
Laura D Ellingson
Ryan Dougherty
Patrick OConnor
Gunnar Roberge
Andrew Alexander
Douglas Dean

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1488397

109 views

Original Research

Accepted on 05 Mar 2025

TREM2 supports neuronal protection and microglial reactivity independently of affecting misfolded protein deposition in chronic neurodegenerative prion disease

in Neurodegeneration

Sarah Marie Carpanini
Barry Matthew Bradford
Alessio Alfieri
Pedro Piccardo
Jimena Monzón-Sandoval
Deborah Brown
Aileen Boyle
Neil A. Mabbott
Jean C. Manson
Barry W McColl

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1525017

158 views

Original Research

Published on 05 Mar 2025

The systemic inflammation markers as potential predictors of disease progression and survival time in amyotrophic lateral sclerosis

in Neurodegeneration

Ye Hong
Jian-Quan Shi
Shuai Feng
Shi-Qi Huang
Zhen-Hua Yuan
Shen Liu
Xiao-Hao Zhang
Jun-Shan Zhou
Teng Jiang
Hong-Dong Zhao

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1552949

593 views

Original Research

Published on 05 Mar 2025

Oxidative stress and inflammation combine to exacerbate cochlear damage and sensorineural hearing loss in C57BL/6 mice

in Neurodegeneration

Zhongwu Su
Yuyan Chen
Yu Liu
Jinyuan Cao
Jie Cui
Haitong Chen
Qi Li

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1563428

533 views