Frontiers in Neuroscience | Neurodegeneration

Original Research

Published on 13 Feb 2026

Subcortical microstructural impairment in amyotrophic lateral sclerosis: clinical correlates of neurite orientation dispersion and density imaging (NODDI) changes

in Neurodegeneration

Minoo Sharbafshaaer
Maria Agnese Pirozzi
Giuseppina Caiazzo
Fabrizio Canale
Marcello Silvestro
Antonio Russo
Alessandro Tessitore
Fabrizio Esposito
Francesca Trojsi

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1757470

230 views

Original Research

Published on 10 Feb 2026

Carotid intraplaque neovascularization increases the risk of white matter hyperintensity progression: a prospective cohort study

in Neurodegeneration

Hao Zhang
Jun He
Jimei Xu
Rongfeng Wang
Yan Yan
Yuan Feng
Shugang Cao
Mingwu Xia

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1768896

325 views

Perspective

Published on 10 Feb 2026

Cerebrospinal fluid dynamics and brain function regulation: from homeostasis to neurological disorders

in Neurodegeneration

Yu Yang
Huixia Jia
He Liu

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1775240

471 views

Review

Accepted on 09 Feb 2026

Ferroptosis in Parkinson's Disease: A Review of Molecular Mechanisms and Emerging Therapeutic Strategies

in Neurodegeneration

Lingling Wang
Yue Zhang
Lei Guo

Frontiers in Neuroscience

Original Research

Accepted on 09 Feb 2026

Correlation Between Brain Symmetry Index and Motor Function in Parkinson's Disease: A Cross-Sectional Study

in Neurodegeneration

Xianling Xu
Jinfeng Xu
Yuqing Zhao
Jian Song
Haoping Gu
Wei Wei
Haoran Shi
Xiehua Xue

Frontiers in Neuroscience

Original Research

Accepted on 09 Feb 2026

Factors Associated with Longitudinal MDS-UPDRS III Score Trajectories in Early-Stage Parkinson's Disease

in Neurodegeneration

Wen Zhou
Duan Liu
Tian-fang Zeng
Qing-qing Xia

Frontiers in Neuroscience

Original Research

Accepted on 06 Feb 2026

Identifying Transcriptomic Signatures that Mediate the Causal Effect of Genotype on Alzheimer's Disease

in Neurodegeneration

Simran Kaur
Anna Tyler
Giovanna Durante
Gregory Cary
Gregory Carter
Matthew Mahoney

Frontiers in Neuroscience

253 views

Review

Published on 06 Feb 2026

Recent advances in postoperative delirium in elderly patients: pathophysiological mechanisms, risk prediction, and therapeutic strategies

in Neurodegeneration

Xuan-yin Ding
Ming-hui Zhang
Jun Liu
Dan Wu

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1759910

628 views

Brief Research Report

Accepted on 05 Feb 2026

Frontotemporal Lobar Degeneration Heterogeneity: Atypical Presentations and Heterogeneous Proteinopathies in Five Cases

in Neurodegeneration

Giulia Negro
Camilla Poloni
Valentina Medici
Chiara Calatozzolo
Alessandra Canazza
Riccardo Rocco Ferrari
Chiara Cutaia
Annalisa Davin
Tino Emanuele Poloni

Frontiers in Neuroscience

113 views

Original Research

Published on 05 Feb 2026

Differential pericyte pathology in the human retina and brain in diabetes mellitus and Alzheimer’s disease

in Neurodegeneration

Noëlle Bakker-van Bugnum
Aïcha A. Croes
Eva Prevaes
Cornelis J. F. van Noorden
Reinier O. Schlingemann
Ingeborg Klaassen

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1749112

657 views

Original Research

Published on 04 Feb 2026

Mapping the clinical correlates of brain hypoperfusion in behavioral variant frontotemporal dementia: insights from a SPECT imaging study

in Neurodegeneration

Electra Chatzidimitriou
Chrissa Sioka
Eleni Aretouli
Ioannis Iakovou
Panagiotis Ioannidis
Despina Moraitou

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1737054

936 views

Original Research

Published on 04 Feb 2026

Predicting longitudinal basal forebrain volume in the Alzheimer’s disease spectrum: the role of sex and ApoE epsilon 4 genotype

in Neurodegeneration

Alice Grazia
Fedor Levin
Frank Jessen
Michael Wagner
Oliver Peters
Josef Priller
Anja Schneider
Jens Wiltfang
Emrah Düzel
Katharina Buerger

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1730947

552 views

Original Research

Published on 04 Feb 2026

An induced pluripotent stem cell-based chemical genetic approach for studying spinal muscular atrophy

in Neurodegeneration

Richard M. Giadone
Kristina M. Holton
Xiaoyu Hu
Ted Natoli
Sabrina Ghosh
Stanley P. Gill
Nicholas Lyons
Aravind Subramanian
Lee L. Rubin

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1695359

800 views

Original Research

Accepted on 03 Feb 2026

Exploring the Pathogenic Mechanisms of Dementia Risk Factors: a task-fMRI study of mild cognitive impairment

in Neurodegeneration

Yuling Shen
Min Shi
Shanyu Liu
Yan Liu
Lijun Wang
Dongdong Yang

Frontiers in Neuroscience

104 views

Review

Published on 03 Feb 2026

Metabolic interactions in the brain: the crucial roles of neurons, astrocytes, and microglia in health and disease

in Neurodegeneration

Yonghui Pang
Jiachen Yang
Jingjing Liu
Zhengyi Xie
Jin Wang

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1731771

993 views

Original Research

Published on 02 Feb 2026

Alterations in functional connectivity of the anterior cingulate cortex associated with different levels of tau and amyloid-β deposition in patients with mild cognitive impairment

in Neurodegeneration

Wenzhang Qi
Yiming Ruan
Yue Tang
Darui Zheng
Qianqian Yuan
Chen Xue
Chaoyong Xiao

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1748031

476 views

Brief Research Report

Published on 02 Feb 2026

Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer’s disease: expanding the genetic landscape in underrepresented populations

in Neurodegeneration

Claudio Villegas-Llerena
Solange R. Paredes-Moscosso
María Luisa Guevara-Fujita
Daisy Obispo
Nilton Custodio
Rosa Montesinos
José F. Parodi
Oscar Flores-Flores
John Hardy
Ricardo Fujita

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1724380

652 views

Review

Accepted on 31 Jan 2026

Spinal Motor Neuron Degeneration After Brachial Plexus Avulsion: Mechanisms and Therapeutic Targets

in Neurodegeneration

Jiantao Yang
Qin Bengang
yixi yang
jintao fang
wenting he

Frontiers in Neuroscience

137 views

Original Research

Accepted on 29 Jan 2026

Enhanced Diagnostic Interpretation of the MoCA Using Machine Learning

in Neurodegeneration

Christian Gourdeau
Charles L Gourdeau
Patrick J Bernier
Robert Laforce

Frontiers in Neuroscience

171 views

Original Research

Published on 29 Jan 2026

A critical perspective of prion disease surveillance in Brazil

in Neurodegeneration

Breno José Alencar Pires Barbosa
Maria Luiza Vasconcelos Montenegro
José Eriton Gomes da Cunha

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1762241

743 views

Systematic Review

Accepted on 28 Jan 2026

Association between Blood Neurofilament Light Chain Levels and Vascular Cognitive Impairment: A Systematic Review and Meta-Analysis

in Neurodegeneration

Fu-li Qin
Xia He
Xia-lian Huang
Yan-qiu Wang
Fengle Mao
Ke-fu Ding

Frontiers in Neuroscience

131 views

Original Research

Published on 28 Jan 2026

Altered static and dynamic functional network connectivity between subcortical nuclei and cortical regions of the default mode network in type 2 diabetes mellitus

in Neurodegeneration

Dongsheng Zhang
Xiaoling Zhang
Lei Wang
Xuejiao Yan
Xiaoyan Lei
Min Tang
Jie Gao
Yarong Wang

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1766192

961 views

Original Research

Accepted on 26 Jan 2026

Effect of curcumin and Garcinia kola on the cerebellum of the transected sciatic nerve of the diabetic rats: Glial and neuronal evidence

in Neurodegeneration

Abdullah Hilmi Marangoz
Hala Mahgoub Hamour
Arife Ahsen Kaplan
Işınsu Alkan
Gamze Altun
Suleyman Kaplan

Frontiers in Neuroscience

168 views

Original Research

Accepted on 26 Jan 2026

Dynamic functional connectivity alterations are linked cognitive deficits in subcortical ischemic vascular disease Running head: Dynamic functional connectivity

in Neurodegeneration

Yan Wei
Li Chen

Frontiers in Neuroscience

360 views

2,274 articles

articles

Subcortical microstructural impairment in amyotrophic lateral sclerosis: clinical correlates of neurite orientation dispersion and density imaging (NODDI) changes

Carotid intraplaque neovascularization increases the risk of white matter hyperintensity progression: a prospective cohort study

Cerebrospinal fluid dynamics and brain function regulation: from homeostasis to neurological disorders

Ferroptosis in Parkinson's Disease: A Review of Molecular Mechanisms and Emerging Therapeutic Strategies

Correlation Between Brain Symmetry Index and Motor Function in Parkinson's Disease: A Cross-Sectional Study

Factors Associated with Longitudinal MDS-UPDRS III Score Trajectories in Early-Stage Parkinson's Disease

Identifying Transcriptomic Signatures that Mediate the Causal Effect of Genotype on Alzheimer's Disease

Recent advances in postoperative delirium in elderly patients: pathophysiological mechanisms, risk prediction, and therapeutic strategies

Frontotemporal Lobar Degeneration Heterogeneity: Atypical Presentations and Heterogeneous Proteinopathies in Five Cases

Differential pericyte pathology in the human retina and brain in diabetes mellitus and Alzheimer’s disease

Mapping the clinical correlates of brain hypoperfusion in behavioral variant frontotemporal dementia: insights from a SPECT imaging study

Predicting longitudinal basal forebrain volume in the Alzheimer’s disease spectrum: the role of sex and ApoE epsilon 4 genotype

An induced pluripotent stem cell-based chemical genetic approach for studying spinal muscular atrophy

Exploring the Pathogenic Mechanisms of Dementia Risk Factors: a task-fMRI study of mild cognitive impairment

Metabolic interactions in the brain: the crucial roles of neurons, astrocytes, and microglia in health and disease

Alterations in functional connectivity of the anterior cingulate cortex associated with different levels of tau and amyloid-β deposition in patients with mild cognitive impairment

Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer’s disease: expanding the genetic landscape in underrepresented populations

Spinal Motor Neuron Degeneration After Brachial Plexus Avulsion: Mechanisms and Therapeutic Targets

Enhanced Diagnostic Interpretation of the MoCA Using Machine Learning

A critical perspective of prion disease surveillance in Brazil

Association between Blood Neurofilament Light Chain Levels and Vascular Cognitive Impairment: A Systematic Review and Meta-Analysis

Altered static and dynamic functional network connectivity between subcortical nuclei and cortical regions of the default mode network in type 2 diabetes mellitus

Effect of curcumin and Garcinia kola on the cerebellum of the transected sciatic nerve of the diabetic rats: Glial and neuronal evidence

Dynamic functional connectivity alterations are linked cognitive deficits in subcortical ischemic vascular disease Running head: Dynamic functional connectivity