Frontiers in Neuroscience | Neurodegeneration

Original Research

Published on 07 Oct 2025

Assessment of brain atrophy as a promising marker of radiological activity in patients with relapsing–remitting multiple sclerosis

in Neurodegeneration

Aleksandra Pogoda-Wesołowska
Ignacy Stachura
Piotr Szukało
Maria Wieczorek
Adam Stępień

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1661539

2,243 views

Review

Published on 06 Oct 2025

Emerging roles of primary cilia in the pathogenesis of amyotrophic lateral sclerosis

in Neurodegeneration

Hisashi Takahashi
Takashi Kasai
Aya Miyagawa-Hayashino
Tomoyuki Ohara

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1688839

3,614 views

Original Research

Published on 01 Oct 2025

Evaluating the efficacy of probiotics in treating Parkinson’s disease model rats using magnetic resonance enhanced gradient echo T2-weighted angiography sequence

in Neurodegeneration

Yanmin Su
Yanchao Dong
Jingtao Feng
Xiaoxia Zhang
Ying Yu
Hongzhi Lu

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1662530

2,480 views

Correction

Published on 29 Sep 2025

Correction: Src inhibition attenuates neuroinflammation and protects dopaminergic neurons in Parkinson's disease models

in Neurodegeneration

Hanyu Yang
Lu Wang
Caixia Zang
Yue Wang
Junmei Shang
Zihong Zhang
Hui Liu
Xiuqi Bao
Xiaoliang Wang
Dan Zhang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1640774

1,780 views

Brief Research Report

Published on 23 Sep 2025

Biomarkers of Alzheimer’s disease modification using adaptive cognitive assessments to improve responsiveness—a simulation study

in Neurodegeneration

Antonio Rodríguez-Romero
Shibeshih Belachew
Emmanuel Bartholomé
Claudia Mazzà
Óscar Reyes
Carlos Luque
Silvan Pless
Corrado Bernasconi

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1653261

3,619 views

Original Research

Published on 11 Sep 2025

The top 100 most cited publications on astrocytes in Alzheimer’s disease from 2000 to 2025: a bibliometric analysis

in Neurodegeneration

Qi He
Hong Yu
Xinyao Zhou
Kangyi Yang
Wenjie Xiao
Zirui Gao
Qian He

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1593188

3,669 views

Mini Review

Published on 11 Sep 2025

Akkermansia muciniphila in neurological disorders: mechanisms and therapeutic potential via the gut-brain axis

in Neurodegeneration

Jingzhi Feng
Xiaomin Hu
Jiancheng Liu
Wenchun Wang
Liuyi Chen
Rizhao Pang
Anren Zhang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1650807

6,158 views

Original Research

Published on 05 Sep 2025

Molecular pathogenesis of Alzheimer's disease onset in a mouse model: effects of cannabidiol treatment

in Neurodegeneration

Mary A. Bishara
Phoebe P. Chum
Fritz E. L. Miot
Ankita Hooda
Richard E. Hartman
Erik J. Behringer

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1667585

5,269 views

Review

Published on 02 Sep 2025

Role of the mitochondrial regulatory factor CHCHD2 in neurodegenerative diseases

in Neurodegeneration

Xinyu Guo
Peiyu Xu
Chen Liang
Yuntao Li

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1639651

2,167 views

Original Research

Published on 01 Sep 2025

NETSseq reveals inflammatory and aging mechanisms in distinct cell types, driving cerebellar decline in ataxia telangiectasia

in Neurodegeneration

Giuliano G. Stirparo
Xiao Xu
Toni Thompson
Keith Page
Jenna R. M. Harvey
David Cadwalladr
Jason Lawrence
Russell J. Burley
Joel Juvvanapudi
Megan Roberts

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1636787

2,913 views

Original Research

Published on 29 Aug 2025

Spatiotemporal differential regulation of extrasynaptic GluN2B receptor subunits and PSA-NCAM in brain aging and Alzheimer’s disease

in Neurodegeneration

Oghenetega E. Imiruaye
Isis G. Perez
Brian C. Carson
Christian Crouzet
Jerome Garcia
Derick Han
Subhrajit Bhattacharya

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1649625

2,926 views

Correction

Published on 29 Aug 2025

Correction: Protective effects of Hif2 inhibitor PT-2385 on a neurological disorder induced by deficiency of Irp2

in Neurodegeneration

Jiaqi Shen
Li Xu
Yuxuan Li
Weichen Dong
Jing Cai
Yutong Liu
Hongting Zhao
Tianze Xu
Esther Meyron Holtz
Yanzhong Chang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1667076

1,090 views

Original Research

Published on 29 Aug 2025

Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease

in Neurodegeneration

Demos Kynigopoulos
Eleni Fella
Lucy Shahabian
Christiana C. Christodoulou
Revekka Papacharalampous
Konstantinos Diskos
Lida Evmorfia Vagiaki
Kyriaki Sidiropoulou
Menelaos Pipis
Kleopas A. Kleopa

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1636624

3,077 views

Original Research

Published on 28 Aug 2025

A high triglyceride-glucose index correlates with cognitive impairment in Parkinson’s disease: a cross-sectional study

in Neurodegeneration

Yongqing Cheng
Shuangfei You
Xin Wang
Yingchao Ge
Lei Li
Taojie Ren
Songjie Chen
Guojun He
Shouru Xue

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1620118

2,089 views

Original Research

Published on 26 Aug 2025

Plasma FGF2 and YAP1 as novel biomarkers for MCI in the elderly: analysis via bioinformatics and clinical study

in Neurodegeneration

Yejing Zhao
Xiang Wang
Jie Zhang
Yanyan Zhao
Yi Li
Ji Shen
Ying Yuan
Jing Li

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1663276

1,985 views
1 citation

Systematic Review

Published on 25 Aug 2025

Emerging regenerative strategies for spinal cord injury: exosome-derived mechanisms and therapeutic insights

in Neurodegeneration

Haixia Fan
Jie Gao
Qian Chen
Shuangshuang Sun
Jinshen Guo
Xiaodong Liu
Jinhu Li

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1652196

4,770 views

Original Research

Published on 21 Aug 2025

A novel fluorescent probe, triphenylamine rhodamine-3-acetic acid (mRA) for the detection of Amyloid-β aggregates in Alzheimer's disease

in Neurodegeneration

Raja Chinnappan
Mateen A. Khan
Taj Mohammad
Sarah Mohammed Allwaibh
Shanmugam Easwaramoorthi
Ahmed Yaqinuddin
Sandhanasamy Devansan
Tanveer Ahmad Mir
Imtaiyaz Hassan

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1653063

2,481 views

Methods

Published on 19 Aug 2025

DNA: detecting early signs of neurodegenerative diseases through activity and sleep analysis

in Neurodegeneration

Hasina Attaullah
Sanaullah Sanaullah
Annika Peters
Qazi Arbab Ahmed
Justin Baudisch
Thorsten Jungeblut

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1617758

2,160 views

Review

Published on 19 Aug 2025

Impacts of mitochondrial dysfunction on axonal microtubule bundles as a potential mechanism of neurodegeneration

in Neurodegeneration

Scott Murray-Cors
Milli Owens
Yu-Ting Liew
Maureece Day
William Cairns
Andreas Prokop

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1631752

3,224 views

Case Report

Published on 15 Aug 2025

Unusual presentation of neurobrucellosis presenting with the features of parkinsonism: two case reports and a review of the literature

in Neurodegeneration

Moneera Aldraihem
Thamer S. Alhowaish
Yazeed Alotaibi
Mohammed AlShareet
Abdulrahman A. Alrasheed
Mazen AlAmr
Omar A. Alsinaidi
Abdulrahman S. Ali
Hisham AlDhukair

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1647803

2,023 views

Review

Published on 13 Aug 2025

Gut dysbiosis as a potential driver of Parkinson’s and Alzheimer’s disease pathogenesis

in Neurodegeneration

Jacob M. Pfaffinger
Kallie E. Hays
Jason Seeley
Priyadharshine Ramesh Babu
Rebecca Ryznar

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1600148

4,691 views
5 citations

Original Research

Published on 11 Aug 2025

Brain functional network abnormalities in Parkinson’s disease patients at different disease stages

in Neurodegeneration

Wei Wei
Xinhui Wang
Chao Han
Yu Shen
Panlong Li
Yan Bai
Shuo Liu
Jingyao Xu
Yanhong Shi
Zhou Li

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1627838

1,843 views

Original Research

Published on 06 Aug 2025

Disrupted theta oscillation propagation in healthy elderly individuals with apolipoprotein E epsilon 4 allele

in Neurodegeneration

Duho Sihn
Min-Ki Kim
Sung-Phil Kim

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1579329

1,420 views

Review

Published on 01 Aug 2025

The emerging role of cellular senescence in amyotrophic lateral sclerosis

in Neurodegeneration

Xingli Tan
Naiyong Gao

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1599492

2,649 views

2,250 articles

articles

Assessment of brain atrophy as a promising marker of radiological activity in patients with relapsing–remitting multiple sclerosis

Emerging roles of primary cilia in the pathogenesis of amyotrophic lateral sclerosis

Evaluating the efficacy of probiotics in treating Parkinson’s disease model rats using magnetic resonance enhanced gradient echo T2-weighted angiography sequence

Correction: Src inhibition attenuates neuroinflammation and protects dopaminergic neurons in Parkinson's disease models

Biomarkers of Alzheimer’s disease modification using adaptive cognitive assessments to improve responsiveness—a simulation study

The top 100 most cited publications on astrocytes in Alzheimer’s disease from 2000 to 2025: a bibliometric analysis

Akkermansia muciniphila in neurological disorders: mechanisms and therapeutic potential via the gut-brain axis

Molecular pathogenesis of Alzheimer's disease onset in a mouse model: effects of cannabidiol treatment

Role of the mitochondrial regulatory factor CHCHD2 in neurodegenerative diseases

NETSseq reveals inflammatory and aging mechanisms in distinct cell types, driving cerebellar decline in ataxia telangiectasia

Spatiotemporal differential regulation of extrasynaptic GluN2B receptor subunits and PSA-NCAM in brain aging and Alzheimer’s disease

Correction: Protective effects of Hif2 inhibitor PT-2385 on a neurological disorder induced by deficiency of Irp2

Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease

A high triglyceride-glucose index correlates with cognitive impairment in Parkinson’s disease: a cross-sectional study

Plasma FGF2 and YAP1 as novel biomarkers for MCI in the elderly: analysis via bioinformatics and clinical study

Emerging regenerative strategies for spinal cord injury: exosome-derived mechanisms and therapeutic insights

A novel fluorescent probe, triphenylamine rhodamine-3-acetic acid (mRA) for the detection of Amyloid-β aggregates in Alzheimer's disease

DNA: detecting early signs of neurodegenerative diseases through activity and sleep analysis

Impacts of mitochondrial dysfunction on axonal microtubule bundles as a potential mechanism of neurodegeneration

Unusual presentation of neurobrucellosis presenting with the features of parkinsonism: two case reports and a review of the literature

Gut dysbiosis as a potential driver of Parkinson’s and Alzheimer’s disease pathogenesis

Brain functional network abnormalities in Parkinson’s disease patients at different disease stages

Disrupted theta oscillation propagation in healthy elderly individuals with apolipoprotein E epsilon 4 allele

The emerging role of cellular senescence in amyotrophic lateral sclerosis