Frontiers in Neuroscience

Original Research

Published on 11 Dec 2025

DEG-BRIN-GCN: interpretable graph convolutional framework with differentially expressed genes brain region interaction network prior for AD diagnosis

in Neurogenomics

Zhihao Zhang
Hui Liu
Lianghui Xu
Mo Sha
Ayiguli Halike
Wenzhong Yang
Ke Lv
Jingjing Wei

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1697528

294 views

Case Report

Accepted on 02 Dec 2025

An Unexpected Discovery of a Novel Potentially Pathogenic APP Gene Variant: A Case Report of Slowly Progressive Alzheimer's Disease with Prominent Cerebral Amyloid Angiopathy

in Neurogenomics

Matyas Sykora
Marie Harmackova
Eva Parobková
Robert Rusina
Radoslav Matej

Frontiers in Neuroscience

129 views

Editorial

Accepted on 27 Nov 2025

Editorial: Advances in Systems Neurogenetics

in Neurogenomics

Paul Carney
Bing Zhang

Frontiers in Neuroscience

148 views

Mini Review

Accepted on 24 Nov 2025

Novel NPRL3 variant associated with Sleep-Related Hypermotor Epilepsy - a case report and educational review

in Neurogenomics

Serena Broggi
Kai-Nicolas Poppert
Matthias Mauritz
Gudrun Kalss
Markus Leitinger
Angela Abicht
Eugen Trinka
Fabio Rossini

Frontiers in Neuroscience

112 views

Technology and Code

Published on 04 Nov 2025

NMPhenogen: a comprehensive database for genotype–phenotype correlation in neuromuscular genetic disorders

in Neurogenomics

Usha Manjunath
Venkatesh R
Sacheta Sudhendra Kulkarni
Harshatha N. Reddy
Anupama Anil
Rakesh Kumar Mishra
Gayatri Rangarajan Iyer

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1696899

1,816 views

Original Research

Published on 31 Oct 2025

Transcriptomic analysis of identical twins with different onset ages of adrenoleukodystrophy

in Neurogenomics

Chuhua Fu
Qiuyu Su
Yinglian Chen
Yonghui Zhang
Yan Zhang
Ying Cao
Xinggang Wang
Zhiming Zhen
Chen Liu
Zhao Yang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1623285

1,021 views

Original Research

Published on 14 Oct 2025

Inflammation-related biomarkers and berberine therapy in post-stroke depression: evidence from bioinformatics, machine learning, and experimental validation

in Neurogenomics

Wei Liu
Ruheng Wei
Jingya Xu
Zhilong Liu
Yulai Li

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1684297

2,765 views

Original Research

Published on 14 Oct 2025

A novel KIDINS220 mutation associated with hereditary spastic paraplegia accompanied by severe peripheral neuropathy

in Neurogenomics

Xujun Chu
Jin Xu
Yilei Zheng
Xiaoyu Liu
Yun Yuan
Rui Wu

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1684980

1,433 views

Original Research

Published on 10 Oct 2025

In silico prediction of the impact of genomic variations in the small conductance calcium activated potassium channel SK3 structure and function

in Neurogenomics

Lucia Padilla
Coral Del Val
Daria B. Neidre
Agustín S. Kokenge
Juan E. Martinez
Antonio L. Teixeira
Igor Zwir
Gabriel A. de Erausquin

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1631536

1,988 views

Original Research

Published on 23 Sep 2025

Differential susceptibility to prenatal stress exposure in serotonin transporter-deficient female mice—an epigenetic exploration

in Neurogenomics

Magdalena T. Weidner
Johanna E. M. Zöller
Catharina S. Hamann
Karla G. Schraut
Muhammad Ali
Roy Lardenoije
Lars Eijssen
Konrad U. Foerstner
Nikita Gorbunov
Tatyana Strekalova

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1633386

4,272 views

Perspective

Published on 16 Sep 2025

Transposon activity and nucleotide triplet instability: new perspectives on their potential interplay in brain disorders

in Neurogenomics

Giuseppe Pepe
Marianna Storto
Alba Di Pardo
Vittorio Maglione

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1617315

2,864 views

Review

Published on 05 Sep 2025

Epigenetic remodeling: unveiling the potential endogenous mechanisms of exercise in alleviating neuropathic pain

in Neurogenomics

Hao Shan
Yuntao Xu
Jiabao Guo
Tong Li

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1622894

3,320 views

Original Research

Published on 14 Aug 2025

Transcriptomic features of immune inflammation and neural plasticity associated with early neurological improvement in acute ischemic stroke patients with large vessel occlusion

in Neurogenomics

Dong Zhang
Xinying Jing
Ruinan Ma
Zhizhang Li
Xiaoguang Zhang
Ying Ding
Yunhua Yue

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1581758

3,471 views
1 citation

Original Research

Published on 22 Jul 2025

Spectral divergence prioritizes key classes, genes, and pathways shared between substance use disorders and cardiovascular disease

in Neurogenomics

Everest Castaneda
Elissa Chesler
Erich Baker

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1572243

2,054 views

Original Research

Published on 16 Jul 2025

Association of rs440446 in the APOE intron region with multidimensional cognitive function, lipid/metabolic markers, and spontaneous neural activity in Chinese urban community-dwelling older adults

in Neurogenomics

Zhiyuan Wang
Hongyu Guo
Jianshuai Li
Xuejie Hu
Xin Li
Jinping Sun

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1629254

1,512 views

Case Report

Published on 09 Jul 2025

Case Report: Phenotypic heterogeneity within an NF1 family: assessment of the pathogenicity of a de novo c.6640dupA shift mutation and a splice variant with an epilepsy phenotype

in Neurogenomics

Sijing Ren
Yanling Wang
Xinhua Tong
Xiaoyu Wu
Huan Yan
Qing-Xia Kong

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1604771

1,768 views