Frontiers in Oncology | Cancer Genetics

Review

Published on 04 Feb 2026

TRIM16: a context-dependent E3 ligase in autophagy, oxidative stress, and immune regulation – from cancer and systemic disease

in Cancer Genetics

Hanchen Dong
Jiayu Jiang
Ke Ni
Qinhong Ren
Xinran Yang
Liang Shang
Baoshan Cai
Leping Li

Frontiers in Oncology

doi 10.3389/fonc.2026.1743345

131 views

Mini Review

Accepted on 02 Feb 2026

Emerging Role of Low-Frequency Somatic Mutations in Cancer Relapse: From Early Detection to Precision Oncology

in Cancer Genetics

Eunsoo Kim
Gu Seob Roh
Seong Gyu Kwon

Frontiers in Oncology

Original Research

Accepted on 01 Feb 2026

UNITe: Exploiting Conserved links between Oncogenesis and Homeostasis to Identify Novel Cancer Drivers

in Cancer Genetics

Piyush Agrawal
Annan Timon
Vishaka Gopalan
Arashdeep Singh
Sridhar Hannenhalli

Frontiers in Oncology

174 views

Case Report

Published on 30 Jan 2026

Thyroid and breast carcinomas in a patient with Pendred syndrome: a case report and literature review

in Cancer Genetics

Hongji Wu
Jie Xu
Ruzhong Xu
Linlin Shi
Lin Xu
Jin Zhou
Haitao Zheng

Frontiers in Oncology

doi 10.3389/fonc.2026.1593186

305 views

Case Report

Published on 30 Jan 2026

Case Report: mTOR inhibitor treatment for epithelioid angiomyolipoma harboring biallelic TSC2 mutations

in Cancer Genetics

Shiori Ishikawa
Kota Ouchi
Shonosuke Wakayama
Yuki Kasahara
Keigo Komine
Hiroo Imai
Ken Saijo
Yuto Yamazaki
Masanobu Takahashi
Hidekazu Shirota

Frontiers in Oncology

doi 10.3389/fonc.2026.1735690

372 views

Original Research

Accepted on 28 Jan 2026

Next-Generation Sequencing for DLBCL Patients with early failure after Frontline R-CHOP Chemo-immunotherapy

in Cancer Genetics

Liu Shi
Xiaohua Liu
Jing Wang
Yong Su
Xiaochang Gong
Di Deng

Frontiers in Oncology

Original Research

Accepted on 27 Jan 2026

Distribution and Clinical Significance of Peripheral Blood Lymphocyte PD-1 and PD-L1 in non-Hodgkin Lymphoma: A Retrospective Study in Chinese Patients

in Cancer Genetics

Lu Liu
Lei Wang
Wei Wang
Yansu Wang
Yanrong Wang
Na Xu
Na Li
Haifeng Liu

Frontiers in Oncology

Case Report

Accepted on 27 Jan 2026

Case Report: Rare Pheochromocytoma in a Patient with Li-Fraumeni Syndrome; A 3 Event, 4 Hit Model of Pathogenesis

in Cancer Genetics

Yi Liu
Aaron Dinerman
Ina Lee
Liqiang Xi
Naris Nilubol
Ashley Grossman
Payal Khincha
Kenneth Aldape
Kathleen Anne Calzone
Karel Pacak

Frontiers in Oncology

Editorial

Published on 27 Jan 2026

Editorial: Exploring epigenetic mechanisms in cancer

in Cancer Genetics

Zaki A Sherif
Habtom W. Ressom
Olorunseun O Ogunwobi

Frontiers in Oncology

doi 10.3389/fonc.2026.1718426

362 views

Original Research

Published on 26 Jan 2026

Identification of unique biomarkers in colorectal cancer based on comprehensive analysis and machine learning

in Cancer Genetics

Liwei Wang
Aigang Ren
Xiaolong Cui
Yuan Shen
Qingxing Huang

Frontiers in Oncology

doi 10.3389/fonc.2025.1678750

629 views

Original Research

Accepted on 21 Jan 2026

Genetic Association of miR-146a, miR-196a2, and miR-499 Polymorphisms with Hepatocellular Carcinoma Risk in an Eastern Chinese Population

in Cancer Genetics

Lunjun Zhang
Qing Pang
Hongtao Wang
Tao Xu
Xiaolin Ding

Frontiers in Oncology

132 views

Case Report

Published on 21 Jan 2026

Malignant nodular fasciitis, a rare manifestation of a benign disease: case report

in Cancer Genetics

Albert J. Aboulafia
Nicole Liddy
Lauren Zeitlinger
Diana W. Molavi
Sudarsan Murali
David Aboulafia

Frontiers in Oncology

doi 10.3389/fonc.2026.1685315

465 views

Case Report

Published on 21 Jan 2026

Challenging the extended phenotype: HRD-negative salivary gland carcinoma in a BRCA1 founder-variant carrier, case report and literature review

in Cancer Genetics

William Torres
Elizabeth Vargas
Diego-Felipe Ballen
Sandra M Tapiero-Rodriguez
Enrique Cadena
Rafael Parra-Medina
Julian C Riaño-Moreno

Frontiers in Oncology

doi 10.3389/fonc.2025.1692001

830 views

Case Report

Accepted on 15 Jan 2026

An Uncommon Germline Variant of Familial GIST Tumors: Broadening the Landscape of Inherited GIST Syndromes

in Cancer Genetics

Pallavi Roshini Ganesan
Max Vogel
Daniel Knight
Danielle Rosenzweig
Ross Michels

Frontiers in Oncology

181 views

Case Report

Published on 14 Jan 2026

Genetic investigation of a Tunisian family with Lynch syndrome: a case report

in Cancer Genetics

Rania Abdelmaksoud-Dammak
Nihel Ammous-Boukhris
Souhir Guidara
Slim Charfi
Ameni Feki
Manel Guirat
Rahma Daoud
Hassen Kamoun
Tahya Sellami-Boudawara
Afef Khanfir

Frontiers in Oncology

doi 10.3389/fonc.2025.1695240

696 views

Case Report

Published on 09 Jan 2026

Case Report: diffuse entire gastrointestinal tract involvement of ALK-positive anaplastic large cell lymphoma harboring JAK-STAT pathway mutations in an adolescent with leukemoid reaction

in Cancer Genetics

Sizhe Yang
Yang Dai
Qiyuan Li
Sha Zhao
Xueqin Deng
Feifan Chen
Yaping Zhang
Yufang Wang
Wenyan Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1709110

707 views

Original Research

Published on 07 Jan 2026

KEAP1 mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancer

in Cancer Genetics

Nicholas E. Bambach
Julio C. Ricarte-Filho
Erin R. Reichenberger
Christian Hernandez-Padilla
Kyle Hinkle
Amber Isaza
Andrew J. Bauer
Aime T. Franco

Frontiers in Oncology

doi 10.3389/fonc.2025.1685379

1,115 views

Original Research

Published on 06 Jan 2026

Identification of the HMGA2::CIBAR1-DT fusion transcript in two lipomas with chromosomal rearrangements involving chromosomes 8 and 12

in Cancer Genetics

Marta Brunetti
Kristin Andersen
Ingvild Lobmaier
Francesca Micci

Frontiers in Oncology

doi 10.3389/fonc.2025.1717031

528 views

Original Research

Published on 05 Jan 2026

Transcriptomics driven identification of hub gene miRNA interactions for biomarker and therapeutic target discovery in gynecological cancers

in Cancer Genetics

Yuanjun Zhu
Sisi Chen
Mei Cao
Wangbo Liu
Hanling Huang
Ke Huang
Lingling Shi

Frontiers in Oncology

doi 10.3389/fonc.2025.1719597

581 views

Original Research

Published on 05 Jan 2026

Metabolic reprogramming-driven stratification and therapeutic targeting in lung adenocarcinoma: implications for prognosis and personalized treatment

in Cancer Genetics

Jiabao Jia
Shiyun Feng
Rui Wang
Xiaoshuang Zhao
Youbin Cui

Frontiers in Oncology

doi 10.3389/fonc.2025.1696117

842 views

Original Research

Published on 02 Jan 2026

Integrating TBSRTC subcategorization and BRAF V600E testing for precision management of Bethesda III thyroid nodules: a WHO 5th edition-based study highlighting subtype-specific diagnostic disparities

in Cancer Genetics

Qing Yu
Zhirong Yang

Frontiers in Oncology

doi 10.3389/fonc.2025.1682593

829 views

Case Report

Published on 19 Dec 2025

Case Report: Expansion of the POLD1-related polymerase proofreading-associated polyposis spectrum: first report of duodenal adenocarcinomas and characterization of two likely pathogenic variants

in Cancer Genetics

Anais Folletet
Morgane Helyon
Maud Privat
Nancy Uhrhammer
Mathilde Gay-Bellile
Mathias Cavaille
Flora Ponelle-Chachuat
Yannick Bidet
Mathis Lepage

Frontiers in Oncology

doi 10.3389/fonc.2025.1727289

943 views

Original Research

Published on 19 Dec 2025

The NSUN5 gene rs1880948 A>G polymorphism and neuroblastoma risk in Chinese children

in Cancer Genetics

Zijie Ye
Huijuan Zeng
Manna Zheng
Chao Hu
Jing Pan
Jiliang Yang
Tianbao Tan
Chunlei Zhou
Jing He
Yan Zou

Frontiers in Oncology

doi 10.3389/fonc.2025.1655312

976 views

Systematic Review

Published on 17 Dec 2025

Research status and hotspots of oncology genetic nursing: a bibliometric analysis

in Cancer Genetics

Ya Hu
Cangmei Fu

Frontiers in Oncology

doi 10.3389/fonc.2025.1523185

1,286 views

1,230 articles

articles

TRIM16: a context-dependent E3 ligase in autophagy, oxidative stress, and immune regulation – from cancer and systemic disease

Emerging Role of Low-Frequency Somatic Mutations in Cancer Relapse: From Early Detection to Precision Oncology

UNITe: Exploiting Conserved links between Oncogenesis and Homeostasis to Identify Novel Cancer Drivers

Thyroid and breast carcinomas in a patient with Pendred syndrome: a case report and literature review

Case Report: mTOR inhibitor treatment for epithelioid angiomyolipoma harboring biallelic TSC2 mutations

Next-Generation Sequencing for DLBCL Patients with early failure after Frontline R-CHOP Chemo-immunotherapy

Distribution and Clinical Significance of Peripheral Blood Lymphocyte PD-1 and PD-L1 in non-Hodgkin Lymphoma: A Retrospective Study in Chinese Patients

Case Report: Rare Pheochromocytoma in a Patient with Li-Fraumeni Syndrome; A 3 Event, 4 Hit Model of Pathogenesis

Editorial: Exploring epigenetic mechanisms in cancer

Identification of unique biomarkers in colorectal cancer based on comprehensive analysis and machine learning

Genetic Association of miR-146a, miR-196a2, and miR-499 Polymorphisms with Hepatocellular Carcinoma Risk in an Eastern Chinese Population

Malignant nodular fasciitis, a rare manifestation of a benign disease: case report

Challenging the extended phenotype: HRD-negative salivary gland carcinoma in a BRCA1 founder-variant carrier, case report and literature review

An Uncommon Germline Variant of Familial GIST Tumors: Broadening the Landscape of Inherited GIST Syndromes

Genetic investigation of a Tunisian family with Lynch syndrome: a case report

Case Report: diffuse entire gastrointestinal tract involvement of ALK-positive anaplastic large cell lymphoma harboring JAK-STAT pathway mutations in an adolescent with leukemoid reaction

KEAP1 mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancer

Identification of the HMGA2::CIBAR1-DT fusion transcript in two lipomas with chromosomal rearrangements involving chromosomes 8 and 12

Transcriptomics driven identification of hub gene miRNA interactions for biomarker and therapeutic target discovery in gynecological cancers

Metabolic reprogramming-driven stratification and therapeutic targeting in lung adenocarcinoma: implications for prognosis and personalized treatment

Integrating TBSRTC subcategorization and BRAF V600E testing for precision management of Bethesda III thyroid nodules: a WHO 5th edition-based study highlighting subtype-specific diagnostic disparities

Case Report: Expansion of the POLD1-related polymerase proofreading-associated polyposis spectrum: first report of duodenal adenocarcinomas and characterization of two likely pathogenic variants

The NSUN5 gene rs1880948 A>G polymorphism and neuroblastoma risk in Chinese children

Research status and hotspots of oncology genetic nursing: a bibliometric analysis