Frontiers in Oncology | Cancer Immunity and Immunotherapy

Review

Published on 19 Jan 2026

Advances in chimeric antigen receptor-natural killer cell therapy: from mechanisms and preclinical studies to clinical application

in Cancer Immunity and Immunotherapy

Tianyuan Ren
Fengjiang Wang
Xuan Liu
Jun Guo
Sitan Xie

Frontiers in Oncology

doi 10.3389/fonc.2025.1759796

1,322 views

Case Report

Published on 19 Jan 2026

Case Report: The double-edged sword: cytokine release syndrome and rapid tumor response in a patient treated with amivantamab and chemotherapy

in Cancer Immunity and Immunotherapy

Pengfei Cui
Guannan Sun
Gang Zhou
Xueguang Guo
Haili Huang
Jing Yang
Na Li
Jing Tan
Yi Hu
Dong Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1758359

1,007 views

Original Research

Published on 14 Jan 2026

The expression of mercaptopyruvate sulfurtransferase serves as a potential biomarker for prognostic stratification and immunotherapy in certain cancers

in Cancer Immunity and Immunotherapy

Boran Cui
Chenchen Xia
Li Yang
Xiaoyu Xi
Xinxin Gong
Yixi Liu
Cai Tian
Xiaoli Du
Jiexian Du
Zengfang Hao

Frontiers in Oncology

doi 10.3389/fonc.2025.1686443

995 views

Original Research

Published on 14 Jan 2026

In vivo detection of HER2-positive breast cancer and sentinel lymph node metastasis using activatable ICG-conjugated Trastuzumab

in Cancer Immunity and Immunotherapy

Yunpeng Liu
Mahendra Isa
Takahito Nakajima

Frontiers in Oncology

doi 10.3389/fonc.2025.1747065

636 views

Original Research

Published on 13 Jan 2026

A novel prognostic model for Hedgehog signaling pathway-related genes predicts the prognosis of hepatocellular carcinoma

in Cancer Immunity and Immunotherapy

Ting Liu
Yang Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1674924

686 views

Original Research

Published on 12 Jan 2026

Prognostic value and experimental validation of atherosclerosis-derived pathogenic genes in colorectal cancer

in Cancer Immunity and Immunotherapy

Yuqing Li
Jinhong Wei
Yuanyuan Xu
Zhenyu Wu
Saiqi He
Yuhang Zhu
Wen Ni
Di Zhang
Huiya Xu
Chuanjie Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1728087

681 views

Original Research

Published on 12 Jan 2026

PCDH1 facilitates migration, proliferation, and stemness of pancreatic cancer cells through PI3K-Akt signaling

in Cancer Immunity and Immunotherapy

Zhiqiang Yang
Zhipeng Zhang
Ye Song
Chuang Dai
Weihui Zhang
Dali Zhao

Frontiers in Oncology

doi 10.3389/fonc.2025.1696695

604 views

Review

Published on 09 Jan 2026

Engineering the next generation of CAR T- cells: precision modifications, logic gates and universal strategies to overcome exhaustion and tumor resistance

in Cancer Immunity and Immunotherapy

Juan Esteban Garcia-Robledo
Sergio Cabrera-Salcedo
Andreas Michael Brandauer
Francesco Romano
Joshua Rengifo-Martinez
Alejandro Toro-Pedroza
Juan Sebastián Victoria
Lady J. Rios-Serna
Alexandre Loukanov
Andrés Felipe Cardona

Frontiers in Oncology

doi 10.3389/fonc.2025.1698442

2,352 views

Review

Published on 09 Jan 2026

Frontiers of cytokine engineering in CAR cell therapy for cancer

in Cancer Immunity and Immunotherapy

Yinghan Wu
Yan-Ruide Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1642022

1,136 views

Systematic Review

Published on 09 Jan 2026

Comparative efficacy of antibody-drug conjugates and chemotherapy for malignant tumors: a systematic review and meta-analysis

in Cancer Immunity and Immunotherapy

Xin Gao
Linghui Tao
Wen Hao
Xiaqiu Wu
Feiye Zhu
Shengxia Lv
Yongsheng Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1697340

954 views

Original Research

Published on 09 Jan 2026

Effectiveness and mechanisms of lymphocytes at different time points in predicting consolidation immunotherapy following adaptive chemoradiotherapy in locally advanced non-small cell lung cancer

in Cancer Immunity and Immunotherapy

Zhen wei Sun
Jiayi Duan
Zhaohao Zhang
Meng Chen
Dandan Zhou
Liqiao Hou
Pingjun Gu
Jian Zhu
Haihua Yang
Suna Zhou

Frontiers in Oncology

doi 10.3389/fonc.2025.1683430

642 views

Case Report

Published on 08 Jan 2026

Polatuzumab vedotin-R-CHP used for high-risk EBV-negative DLBCL-type post-transplant lymphoproliferative disorder in a long-term kidney transplant recipient: a case report

in Cancer Immunity and Immunotherapy

Xiaoyu Jiang
Chunping Wu
Yuxun Oswald Zhang
Mingqing Luo
Yiwen Qiu
Miao Li
Lianshan Zhan
Daping Zhong

Frontiers in Oncology

doi 10.3389/fonc.2025.1673495

1,005 views

Case Report

Published on 08 Jan 2026

Case Report: Multimodal immunotherapeutic regimen (envafolimab + chemotherapy + radiotherapy) for four synchronous primary malignant neoplasms: a case report of 33-month survival and implications for tumor immunology

in Cancer Immunity and Immunotherapy

Yadong Liu
Yayu Zhang
Yu Zhang
Xuejuan Duan
Zhanjie Gao
Xianbo Zhang
Jing Zhao

Frontiers in Oncology

doi 10.3389/fonc.2025.1727323

607 views

Original Research

Published on 07 Jan 2026

Prognostic value of tumour-associated neutrophils in different polarization status releasing neutrophil extracellular traps in the immunotherapy of advanced non-small cell lung cancer

in Cancer Immunity and Immunotherapy

Weiwei Hong
Xin Ye
Lin Chen
Xiangzhi Chai
Yan Yin
Zhaoqing Li
Chen Fang
Xiaoying Qian
Biao Yu
Guizhen Qin

Frontiers in Oncology

doi 10.3389/fonc.2025.1705716

988 views

Case Report

Published on 07 Jan 2026

Case Report: Pembrolizumab associated lichen planus in early stage triple negative breast cancer

in Cancer Immunity and Immunotherapy

Ozge Buyukahisha
Abdullah Ozcelik
Deniz Baycelebi
Asena Cakir
Bulent Cetin

Frontiers in Oncology

doi 10.3389/fonc.2025.1726097

1,141 views

Mini Review

Published on 06 Jan 2026

Immunocytokines in cancer immunotherapy: opportunities and challenges

in Cancer Immunity and Immunotherapy

Shubo Wang
Lisha Yao
Jianying Cai
Huiquan Gao
Fuxin Zhou

Frontiers in Oncology

doi 10.3389/fonc.2025.1716612

1,258 views

Original Research

Published on 06 Jan 2026

Integrative multi-omics stratification and translational evaluation of Treg-targeted combination immunotherapy in breast cancer

in Cancer Immunity and Immunotherapy

Nari Kim
Seongwon Na
Hyo Jin Lee
Woojin Yi
Ga Won Son
Jin Park
Jisung Jang
Mihyun Kim
Seong-Yun Jeong
Kyung Won Kim

Frontiers in Oncology

doi 10.3389/fonc.2025.1731411

1,111 views

Brief Research Report

Published on 05 Jan 2026

The CDK inhibitor Roscovitine enhances the therapeutic efficacy of anti-PD-1 in non-small cell lung cancer

in Cancer Immunity and Immunotherapy

C. Marcela Diaz-Montero
Elise G. Holvey-Bates
Patricia A. Rayman
Yvonne Parker
Daniel J. Lindner
George R. Stark
Sarmishtha De

Frontiers in Oncology

doi 10.3389/fonc.2025.1745967

946 views

Original Research

Published on 05 Jan 2026

Tracking temporal shifts of peripheral blood NLR, PLR, and ALB: a prognostic tool for PD-1 inhibitor efficacy in advanced malignant melanoma

in Cancer Immunity and Immunotherapy

Yushu Deng
Yikai Han
Xiangrui Meng
Jiaxin Pei
Mengmeng Yang
Ziyi Xiao
Feng Wang
Taiying Lu

Frontiers in Oncology

doi 10.3389/fonc.2025.1704359

811 views

Review

Published on 05 Jan 2026

OX40/OX40L: a new target for tumor immunotherapy and its clinical research progress

in Cancer Immunity and Immunotherapy

Zixuan Yuan
Yutong Pan
Haodong Yuan
Aihua Gong

Frontiers in Oncology

doi 10.3389/fonc.2025.1730620

1,342 views

Original Research

Accepted on 26 Dec 2025

Correlation between gut microbiota and their metabolites and the efficacy of chemotherapy combined with immunotherapy for extensive-stage small cell lung cancer

in Cancer Immunity and Immunotherapy

Wenjing Song
Shiwei Liu
Dan Zang
Wenjuan Meng
Chenguang Liu
Jun Chen

Frontiers in Oncology

207 views

Mini Review

Published on 18 Dec 2025

Myeloid-driven immunosuppression in head and neck cancer: single-cell ATAC/RNA and spatial transcriptomic perspectives

in Cancer Immunity and Immunotherapy

Rui Luo
Jianzheng Yang
Zimeng Cao
Bing Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1693152

2,060 views

Mini Review

Published on 17 Dec 2025

The challenge of cytotoxic T cell responses in carcinoma with a focus on lung carcinoma

in Cancer Immunity and Immunotherapy

Aditya Dash
Afsheen Banisadr
Donivian Al Dikka
Scott C. Johns
Mark M. Fuster

Frontiers in Oncology

doi 10.3389/fonc.2025.1669230

1,540 views
1 citation

Editorial

Published on 16 Dec 2025

Editorial: The insights of multi-omics into the microenvironment after tumor metastasis: a paradigm shift in molecular targeting modeling and immunotherapy for advanced cancer patients

in Cancer Immunity and Immunotherapy

Xuejian Liu
Qi Wang
Yang Ma
Xinhua Xiao
Xue Zhao
Hailin Tang
Divya Gopinath
Chao Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1749178

838 views

1,590 articles

articles

Advances in chimeric antigen receptor-natural killer cell therapy: from mechanisms and preclinical studies to clinical application

Case Report: The double-edged sword: cytokine release syndrome and rapid tumor response in a patient treated with amivantamab and chemotherapy

The expression of mercaptopyruvate sulfurtransferase serves as a potential biomarker for prognostic stratification and immunotherapy in certain cancers

In vivo detection of HER2-positive breast cancer and sentinel lymph node metastasis using activatable ICG-conjugated Trastuzumab

A novel prognostic model for Hedgehog signaling pathway-related genes predicts the prognosis of hepatocellular carcinoma

Prognostic value and experimental validation of atherosclerosis-derived pathogenic genes in colorectal cancer

PCDH1 facilitates migration, proliferation, and stemness of pancreatic cancer cells through PI3K-Akt signaling

Engineering the next generation of CAR T- cells: precision modifications, logic gates and universal strategies to overcome exhaustion and tumor resistance

Frontiers of cytokine engineering in CAR cell therapy for cancer

Comparative efficacy of antibody-drug conjugates and chemotherapy for malignant tumors: a systematic review and meta-analysis

Effectiveness and mechanisms of lymphocytes at different time points in predicting consolidation immunotherapy following adaptive chemoradiotherapy in locally advanced non-small cell lung cancer

Polatuzumab vedotin-R-CHP used for high-risk EBV-negative DLBCL-type post-transplant lymphoproliferative disorder in a long-term kidney transplant recipient: a case report

Case Report: Multimodal immunotherapeutic regimen (envafolimab + chemotherapy + radiotherapy) for four synchronous primary malignant neoplasms: a case report of 33-month survival and implications for tumor immunology

Prognostic value of tumour-associated neutrophils in different polarization status releasing neutrophil extracellular traps in the immunotherapy of advanced non-small cell lung cancer

Case Report: Pembrolizumab associated lichen planus in early stage triple negative breast cancer

Immunocytokines in cancer immunotherapy: opportunities and challenges

Integrative multi-omics stratification and translational evaluation of Treg-targeted combination immunotherapy in breast cancer

The CDK inhibitor Roscovitine enhances the therapeutic efficacy of anti-PD-1 in non-small cell lung cancer

Tracking temporal shifts of peripheral blood NLR, PLR, and ALB: a prognostic tool for PD-1 inhibitor efficacy in advanced malignant melanoma

OX40/OX40L: a new target for tumor immunotherapy and its clinical research progress

Correlation between gut microbiota and their metabolites and the efficacy of chemotherapy combined with immunotherapy for extensive-stage small cell lung cancer

Myeloid-driven immunosuppression in head and neck cancer: single-cell ATAC/RNA and spatial transcriptomic perspectives

The challenge of cytotoxic T cell responses in carcinoma with a focus on lung carcinoma

Editorial: The insights of multi-omics into the microenvironment after tumor metastasis: a paradigm shift in molecular targeting modeling and immunotherapy for advanced cancer patients