Frontiers in Oncology | Cancer Molecular Targets and Therapeutics

Case Report

Published on 09 May 2025

Case Report: Ensartinib as a first-line treatment for SMARCA4-deficient and EML4-ALK non-small cell lung cancer

in Cancer Molecular Targets and Therapeutics

Yanqing Pan
Lingxin Yan
Shaoxi Wang
Huiling Li
Quanfang Chen

Frontiers in Oncology

doi 10.3389/fonc.2025.1530142

1,131 views

Original Research

Published on 09 May 2025

Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma

in Cancer Molecular Targets and Therapeutics

Rong Su
Yong Du
Pan Tian
Weifang Ma
Yongfeng Hui
Shaoqi Yang

Frontiers in Oncology

doi 10.3389/fonc.2025.1553239

1,600 views

Original Research

Published on 09 May 2025

Uncovering key regulatory pathways and prognostic biomarkers in the tumor microenvironment of high-grade serous ovarian cancer through single-cell RNA sequencing and experimental validation

in Cancer Molecular Targets and Therapeutics

Yue Li
Long Zhao
Ying Tian
Qianqian Zhou
Xia Liu
Shucai Yang
Jinfeng Xu
Chang Zou
Jinling Zhang
Hui Luo

Frontiers in Oncology

doi 10.3389/fonc.2025.1591430

1,257 views

Original Research

Published on 08 May 2025

Integrated analysis identifies P4HA2 as a key regulator of STAT1-mediated colorectal cancer progression and a potential biomarker for precision therapy

in Cancer Molecular Targets and Therapeutics

Qianshi Zhang
Yinan Zhang
Zhiwei Sun
Huanle Wang
Guohang Dai
Yue Meng
Shasha Shi
Shuangyi Ren

Frontiers in Oncology

doi 10.3389/fonc.2025.1581860

917 views

Original Research

Published on 06 May 2025

Correlation of heat shock protein 1 expression with progression and prognosis of non-small cell lung cancer

in Cancer Molecular Targets and Therapeutics

Rui Wang
Rongqi Guo
Tianyi Huang
Yu Lu
Weisong Zhang
Yihao Wang
Qinggan Ni
Jianxiang Song
Xia Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1553248

1,057 views

Mini Review

Published on 05 May 2025

Downregulation of PAQR3 expression predicts poor prognosis of patients with pan-cancer: a meta-analysis

in Cancer Molecular Targets and Therapeutics

Kui Zhai
Xing-Peng Miao
Shi-Gui Ai
Qiang Guo
Ren-Zhong Zha

Frontiers in Oncology

doi 10.3389/fonc.2025.1574150

994 views

Case Report

Published on 02 May 2025

Case Report: Clinical response of ensartinib for inflammatory myofibroblastic tumor of the urinary bladder with multiple metastases and TPM4-ALK fusion

in Cancer Molecular Targets and Therapeutics

Hongtao Ren
Qi Cheng
Xi Chen
Dianjing Sui
Zhiyi Zhang
Fei Chen

Frontiers in Oncology

doi 10.3389/fonc.2025.1481602

837 views

Original Research

Published on 02 May 2025

The role of PSMC4 in non-small cell lung cancer: implications for prognosis, diagnosis, and immune microenvironment modulation

in Cancer Molecular Targets and Therapeutics

Lili Zhu
Yuanjun Li
Yunfei Xu
Jian Lei

Frontiers in Oncology

doi 10.3389/fonc.2025.1503466

1,099 views

Case Report

Published on 30 Apr 2025

Acquired ROS1 fusion and iruplinalkib response in advanced NSCLC after multiple lines of systematic therapy: a case report

in Cancer Molecular Targets and Therapeutics

Jiarui Liu
Zhichao Jiao
Jun Zhou
Yuan Yuan
Qiguang Li
Wei Zhou
Shuai Zhang
Shuping Yang

Frontiers in Oncology

doi 10.3389/fonc.2025.1571512

1,285 views

Review

Published on 30 Apr 2025

Mitochondrial ribosomal proteins: potential targets for cancer prognosis and therapy

in Cancer Molecular Targets and Therapeutics

Jianqing Zhu
Na Wen
Wen Chen
Haotian Yu

Frontiers in Oncology

doi 10.3389/fonc.2025.1586137

1,377 views

Original Research

Published on 30 Apr 2025

Safety and efficacy of apatinib in combination treatment versus apatinib as second-line treatment for advanced gastric cancer

in Cancer Molecular Targets and Therapeutics

Zhang Han
Zhu Yuanzeng
Wu Gang
Sun Peichun

Frontiers in Oncology

doi 10.3389/fonc.2025.1587069

986 views

Original Research

Published on 30 Apr 2025

Epigenetic disruption of adipogenic gene enhancers in dedifferentiated liposarcomas and its therapeutic value

in Cancer Molecular Targets and Therapeutics

Naoko Hattori
Hironori Takamatsu
Naoko Iida
Naofumi Asano
Satoshi Yamashita
Gina Miku Oba
Kozue Kimura
Akihiko Yoshida
Eisuke Kobayashi
Robert Nakayama

Frontiers in Oncology

doi 10.3389/fonc.2025.1419877

1,704 views

Original Research

Published on 29 Apr 2025

LSM2 drives glioma progression through alternative splicing dysregulation: a multi-omics approach to identify a potential therapeutic target

in Cancer Molecular Targets and Therapeutics

Cao Yang
Chang Ge
Wenjie Zhang
Jingxuan Xu

Frontiers in Oncology

doi 10.3389/fonc.2025.1521608

1,328 views

Case Report

Published on 29 Apr 2025

Copy number gain of MET gene with low level in a metastatic lung adenocarcinoma patient represents response to salvage treatment with savolitinib and osimertinib: a case report

in Cancer Molecular Targets and Therapeutics

Jian Wang
Xinying Dong
Yangxin Liu
Keying Lin
Jianxin Chen

Frontiers in Oncology

doi 10.3389/fonc.2025.1507677

1,051 views

Review

Published on 28 Apr 2025

Epigenetic insights into prostate cancer: exploring histone modifications and their therapeutic implications

in Cancer Molecular Targets and Therapeutics

Bunty Sharma
Himanshu Shekhar
Anidrisha Sahu
Damandeep Kaur
Shafiul Haque
Hardeep Singh Tuli
Himanshu Sharma
Ujjawal Sharma

Frontiers in Oncology

doi 10.3389/fonc.2025.1570193

1,461 views

Original Research

Published on 28 Apr 2025

Rational design of allosteric inhibitors targeting C797S mutant EGFR in NSCLC: an integrative in silico and in-vitro study

in Cancer Molecular Targets and Therapeutics

Jian Wang
Feiyang Yuan
Mahadevi Kendre
Zhijin He
Shaowei Dong
Abhinandan Patil
Kausing Padvi

Frontiers in Oncology

doi 10.3389/fonc.2025.1590779

1,463 views