Frontiers in Oncology | Hematologic Malignancies

Original Research

Published on 27 Oct 2025

Post-progression outcomes following BCMA-directed CAR T-cell therapy in myeloma: impact of extramedullary and paramedullary disease

in Hematologic Malignancies

Ziad Abuhelwa
Fnu Amisha
Wenyi Fan
Gabriel De Avila
Doris K. Hansen
Ariel F. Grajales-Cruz
Brandon Blue
Omar Castaneda
Hien Liu
Ciara L. Freeman

Frontiers in Oncology

doi 10.3389/fonc.2025.1663814

2,362 views

Case Report

Published on 24 Oct 2025

Case Report: Dual resistance to dasatinib/olverembatinib in accelerated-phase cml: identification of a novel SPECC1L-inserted e8a2 BCR::ABL1 transcript and ABL1 V379I mutation

in Hematologic Malignancies

Jingjing Fu
Yangming Tang
Xueqin Ruan
Runfa Wang
Tong Chen
Li Jiang
Yanli He
Zhihong Xu
Balian Wang
Haiqin Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1711888

1,484 views

Original Research

Published on 21 Oct 2025

Evaluating the effectiveness of integrated care in targeted therapy for patients with chronic lymphocytic leukemia

in Hematologic Malignancies

Xin Liu
Wumin Chen
Meiying Wang
Yan Gao
Xueqin Kou
Xianna Pan
Lijuan Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1685510

1,286 views

Original Research

Published on 20 Oct 2025

Unveiling hypoxic regulatory networks by bioinformatics: mechanisms of hypoxia-related hub genes driving rituximab resistance and poor prognosis in DLBCL

in Hematologic Malignancies

Jiayi Yao
Juan Huang
Yuanfei Mao
Zizhen Xu

Frontiers in Oncology

doi 10.3389/fonc.2025.1592441

1,985 views

Case Report

Published on 20 Oct 2025

Isolated central nervous system relapse in acute myeloid leukemia: a case report and review of therapeutic challenges

in Hematologic Malignancies

Colin Burns
Ian Muir
Jennifer Foster
Anthony Emanuel
Mark Kochenderfer

Frontiers in Oncology

doi 10.3389/fonc.2025.1667681

2,512 views

Case Report

Published on 17 Oct 2025

Hereditary spherocytosis concomitant with JAK2V617F-positive primary myelofibrosis: a case report

in Hematologic Malignancies

Chi-E Qiu
Lei Lei
Guosong Jiang
Xiuqun Huang
Yadan Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1665179

1,688 views

Case Report

Published on 17 Oct 2025

Acute obinutuzumab-induced thrombocytopenia in follicular lymphoma: case report and literature review

in Hematologic Malignancies

Jieyi Zhou
Miaomiao Chen
Yi Zhang
Ce Xu
Rong Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1643313

1,656 views
1 citation

Original Research

Published on 16 Oct 2025

Targeting the N-cadherin/β-catenin axis with MSAB reverses malignant phenotypes in blast crisis of CML

in Hematologic Malignancies

Yingying Zhou
Songqin Jian
Lijun Lu
Xiaofang Li
Ruyi Qiu

Frontiers in Oncology

doi 10.3389/fonc.2025.1657508

1,202 views

Original Research

Published on 16 Oct 2025

B7-H7 knockdown suppresses the proliferation, metastasis, and drug resistance of B-cell non-Hodgkin lymphoma cells by inhibiting the PI3K/Akt pathway

in Hematologic Malignancies

Aili Zhai
Qing Zou
Jiawei Yin
Shixin Ge
Xingfang Xiong
Tao Yan
Xiaoli Xie
Lijuan Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1665309

1,561 views

Systematic Review

Published on 15 Oct 2025

Comparing therapeutic effects of hematopoietic stem cell transplantation, tyrosine kinase inhibitors and chemotherapy in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: a systematic review and meta-analysis

in Hematologic Malignancies

Xiaohui Gao
Hui Zeng
Fei Sun
Xiaoyan Zhao
Haibing Wu
Minchao Yan
Yuan Li
Qinyan Fu
Gang Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1627825

1,803 views

Original Research

Published on 13 Oct 2025

Laboratory and imaging risk factors for mortality in children with primary hemophagocytic lymphohistiocytosis

in Hematologic Malignancies

Jia Huang
Sipei Xu
Rui Tang
Yan Huang
Wei Li
Chundan Gong
Sijie Gao
Hailun Peng
Li Xiao
Wei Ma

Frontiers in Oncology

doi 10.3389/fonc.2025.1668762

1,452 views

Original Research

Published on 13 Oct 2025

Deep learning for scene understanding in mitochondrial dysregulation and blood cancer diagnosis

in Hematologic Malignancies

Feng Zhu
Zihan Liu
Jianming Chang
Yuanyuan Qin
Lulu Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1609851

1,367 views

Case Report

Published on 09 Oct 2025

Case Report: Immunophenotypically diverse immature patterns, including variable TdT expression, in aggressive B-cell lymphomas and leukemia with MYC rearrangement

in Hematologic Malignancies

Daishi Kato
Takahiro Fujino
Reiko Isa
Haruya Okamoto
Taku Tsukamoto
Shinsuke Mizutani
Yuji Shimura
Tsutomu Kobayashi
Hitoji Uchiyama
Masafumi Taniwaki

Frontiers in Oncology

doi 10.3389/fonc.2025.1684005

2,133 views

Mini Review

Published on 08 Oct 2025

Anti-angiogenesis in human lymphomas. New insights

in Hematologic Malignancies

Domenico Ribatti
Roberto Tamma
Giuseppe Ingravallo
Giorgina Specchia

Frontiers in Oncology

doi 10.3389/fonc.2025.1636332

1,524 views

Case Report

Published on 07 Oct 2025

Case Report: Uncommon co-occurrence of different renal histopathological entities in a patient with multiple myeloma and lymphoplasmacytic lymphoma

in Hematologic Malignancies

Marco Talarico
Gisella Vischini
Simona Barbato
Roberta Restuccia
Simone Masci
Ilaria Sacchetti
Enrica Manzato
Stefano Ghibellini
Michele Puppi
Miriam Iezza

Frontiers in Oncology

doi 10.3389/fonc.2025.1672690

1,852 views

Review

Published on 07 Oct 2025

Research advances in the adjunctive diagnosis of acute myeloid leukemia

in Hematologic Malignancies

Wentao Xie
Xinye Jiang
Jingying Huang
Mingwei Qin
Zhisheng Bi

Frontiers in Oncology

doi 10.3389/fonc.2025.1634935

2,697 views

Correction

Published on 06 Oct 2025

Correction: Targeting RAB7 in human B lymphoma by a small molecule inhibitor arrests tumor cell growth

in Hematologic Malignancies

Maria Fernandez
Rui Wang
Jingwei Wang
Shuai Wu
Kenneth Holder
Alia Nazarullah
Ricardo C. T. Aguiar
Zijun Y. Xu-Monette
Ken H. Young
Hui Yan

Frontiers in Oncology

doi 10.3389/fonc.2025.1711784

1,244 views

Original Research

Published on 03 Oct 2025

Improvement of revised international staging system risk stratification in patients with newly diagnosed multiple myeloma using a high bone marrow plasma cell percentage: a real-world study in China

in Hematologic Malignancies

Xiaoman Sun
Min Song
Pengyu Wang
Zhongmei Zhang
Rongqin Dai
Jie Shi

Frontiers in Oncology

doi 10.3389/fonc.2025.1627653

1,859 views

Original Research

Published on 02 Oct 2025

Ibrutinib combined with rituximab and high-dose methotrexate in newly diagnosed primary CNS diffuse large B-cell lymphoma: a pilot study with long-term follow-up

in Hematologic Malignancies

Yixian Guo
Yongzhi Shan
Yueshan Piao
Xiaoli Chang
Dongmei Zou
Qiang Ma
Yukui Wei
Geng Xu
Yaming Wang
Dandan Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1669385

3,275 views

Case Report

Published on 01 Oct 2025

Case Report: A rare RUNX1 rearrangement resulting from t(8;21)(p12;q22) in acute myeloid leukemia with plasmacytoid dendritic cell expansion

in Hematologic Malignancies

Jinying Gong
Jialong Liu
Lisha Lu
Jiru Wei
Xue Wu
Junyan Zou
Yuan Feng
Guoqing Zhu
Jing Han

Frontiers in Oncology

doi 10.3389/fonc.2025.1672416

1,847 views

Brief Research Report

Published on 01 Oct 2025

Current quality of life questionnaires are not relevant for assessing QOL issues in multiple myeloma patients in the era of modern therapies: results from a survey with myeloma patients and myeloma healthcare professionals

in Hematologic Malignancies

Catherine S. Y. Lecat
Sotirios Bristogiannis
Dipal Mehta
Yadanar Lwin
Joanne Land
Orla McCourt
Emma Dowling
Nuno Correia
Neil K. Rabin
Ke Xu

Frontiers in Oncology

doi 10.3389/fonc.2025.1656912

1,662 views

Original Research

Published on 30 Sep 2025

The significance of PET/CT combined with machine learning models for the classification of lymphoma involvement and metastases in enlarged lymph nodes

in Hematologic Malignancies

Jingyi Ren
Jinbo Lu
Xun Shi
Yuexin Cheng

Frontiers in Oncology

doi 10.3389/fonc.2025.1643924

1,418 views

Case Report

Published on 25 Sep 2025

Zanubrutinib as a salvage therapy for ibrutinib-resistant chronic lymphocytic leukemia: a case report

in Hematologic Malignancies

Zhenhui Lv
Ping Lu
Changhua Jing
Xuena Yi
Xueqiong Wu

Frontiers in Oncology

doi 10.3389/fonc.2025.1671124

3,512 views

Case Report

Published on 23 Sep 2025

Efficacy of brentuximab vedotin combined with sintilimab in relapsed/refractory DLBCL patient with secondary hemophagocytic syndrome: a case report and literature review

in Hematologic Malignancies

Siyu Cheng
Huihong Wu
Wenguang Bao
Zhigang Peng
Fengxiang Huang
Shengsheng Zhou
Qinli Mo
Ye Li
Yehong Bin
Dong Lan

Frontiers in Oncology

doi 10.3389/fonc.2025.1531713

2,014 views

2,059 articles

articles

Post-progression outcomes following BCMA-directed CAR T-cell therapy in myeloma: impact of extramedullary and paramedullary disease

Case Report: Dual resistance to dasatinib/olverembatinib in accelerated-phase cml: identification of a novel SPECC1L-inserted e8a2 BCR::ABL1 transcript and ABL1 V379I mutation

Evaluating the effectiveness of integrated care in targeted therapy for patients with chronic lymphocytic leukemia

Unveiling hypoxic regulatory networks by bioinformatics: mechanisms of hypoxia-related hub genes driving rituximab resistance and poor prognosis in DLBCL

Isolated central nervous system relapse in acute myeloid leukemia: a case report and review of therapeutic challenges

Hereditary spherocytosis concomitant with JAK2V617F-positive primary myelofibrosis: a case report

Acute obinutuzumab-induced thrombocytopenia in follicular lymphoma: case report and literature review

Targeting the N-cadherin/β-catenin axis with MSAB reverses malignant phenotypes in blast crisis of CML

B7-H7 knockdown suppresses the proliferation, metastasis, and drug resistance of B-cell non-Hodgkin lymphoma cells by inhibiting the PI3K/Akt pathway

Comparing therapeutic effects of hematopoietic stem cell transplantation, tyrosine kinase inhibitors and chemotherapy in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: a systematic review and meta-analysis

Laboratory and imaging risk factors for mortality in children with primary hemophagocytic lymphohistiocytosis

Deep learning for scene understanding in mitochondrial dysregulation and blood cancer diagnosis

Case Report: Immunophenotypically diverse immature patterns, including variable TdT expression, in aggressive B-cell lymphomas and leukemia with MYC rearrangement

Anti-angiogenesis in human lymphomas. New insights

Case Report: Uncommon co-occurrence of different renal histopathological entities in a patient with multiple myeloma and lymphoplasmacytic lymphoma

Research advances in the adjunctive diagnosis of acute myeloid leukemia

Correction: Targeting RAB7 in human B lymphoma by a small molecule inhibitor arrests tumor cell growth

Improvement of revised international staging system risk stratification in patients with newly diagnosed multiple myeloma using a high bone marrow plasma cell percentage: a real-world study in China

Ibrutinib combined with rituximab and high-dose methotrexate in newly diagnosed primary CNS diffuse large B-cell lymphoma: a pilot study with long-term follow-up

Case Report: A rare RUNX1 rearrangement resulting from t(8;21)(p12;q22) in acute myeloid leukemia with plasmacytoid dendritic cell expansion

Current quality of life questionnaires are not relevant for assessing QOL issues in multiple myeloma patients in the era of modern therapies: results from a survey with myeloma patients and myeloma healthcare professionals

The significance of PET/CT combined with machine learning models for the classification of lymphoma involvement and metastases in enlarged lymph nodes

Zanubrutinib as a salvage therapy for ibrutinib-resistant chronic lymphocytic leukemia: a case report

Efficacy of brentuximab vedotin combined with sintilimab in relapsed/refractory DLBCL patient with secondary hemophagocytic syndrome: a case report and literature review