Frontiers in Pain Research | Pharmacological Treatment of Pain

Review

Published on 11 Dec 2025

The clinical application progress of multimodal analgesia strategy in enhanced recovery after surgery: a narrative review

in Pharmacological Treatment of Pain

Lin Yang
Wang Lou
Yang Jiang
Lina Yang
Dongna Wang
Jiapeng Wang

Frontiers in Pain Research

doi 10.3389/fpain.2025.1680157

876 views

Review

Published on 20 Oct 2025

At the Intersection of Pain and Sleep: a Roadmap for Preclinical Pain Research

in Pharmacological Treatment of Pain

Clare M. Diester
William Joo

Frontiers in Pain Research

doi 10.3389/fpain.2025.1609524

1,368 views

Original Research

Published on 22 Sep 2025

NOP agonist AT-403 promoted sleep in lactic acid-induced acute pain model

in Pharmacological Treatment of Pain

Bethany E. Pierce
Harlie A. McKelvey
Mary H. Hite
John M. Lyerly
Ivan M. Krizan
Kimberly M. Holter
Rong Chen
Nurulain T. Zaveri
Robert W. Gould

Frontiers in Pain Research

doi 10.3389/fpain.2025.1659121

1,358 views

Brief Research Report

Published on 13 Aug 2025

The effect of non-opioid multimodal analgesics and dexamethasone monotherapy on acute incisional pain behaviors in rats

in Pharmacological Treatment of Pain

Ratan K. Banik
Malcolm E. Johns
Twan Sia
Donald A. Simone

Frontiers in Pain Research

doi 10.3389/fpain.2025.1569246

1,309 views

Editorial

Published on 06 Aug 2025

Editorial: Insight in pharmacological treatment of pain – 2023

in Pharmacological Treatment of Pain

Robert Gyula Almasi

Frontiers in Pain Research

doi 10.3389/fpain.2025.1662611

884 views

Brief Research Report

Published on 11 Jun 2025

Sleep hygiene linked to patient-reported outcomes & objective sleep measures prior to upper extremity orthopaedic surgery

in Pharmacological Treatment of Pain

Nicholas A. Giordano
Tatiana Getz
Michael Gottschalk
Andrew H. Miller
Kim Dupree Jones
Jasmine Park
Yining Zhu
Annabelle Gong
Jack Hudson
Selma Selimovic

Frontiers in Pain Research

doi 10.3389/fpain.2025.1589748

2,417 views
1 citation

Editorial

Published on 10 Jun 2025

Editorial: Current treatment strategies and integrative medicine for management of pain in sickle cell disease

in Pharmacological Treatment of Pain

Kimberlei A. Richardson
Gabrielle Lynn McLemore
Keesha Powell-Roach
Kalpna Gupta

Frontiers in Pain Research

doi 10.3389/fpain.2025.1621147

1,629 views

Mini Review

Published on 04 Jun 2025

Widespread pain syndrome in long COVID-19: melatonin as an adjuvant treatment

in Pharmacological Treatment of Pain

Amine Souissi
Pablo Prieto-González
Helmi Ben Saad

Frontiers in Pain Research

doi 10.3389/fpain.2025.1609095

2,615 views
1 citation

Original Research

Published on 21 Feb 2025

Unpacking excessive polypharmacy patterns among individuals living with chronic pain in Quebec: a longitudinal study

in Pharmacological Treatment of Pain

Gwenaelle De Clifford-Faugère
Hermine Lore Nguena Nguefack
Nancy Ménard
Sylvie Beaudoin
M. Gabrielle Pagé
Line Guénette
Catherine Hudon
Oumar Mallé Samb
Anaïs Lacasse

Frontiers in Pain Research

doi 10.3389/fpain.2025.1512878

2,392 views
2 citations

Original Research

Published on 14 Feb 2025

Evaluation of long-term outcomes with intrathecal opioid treatment: a comparison utilizing data derived from pain clinic populations in Australia and New Zealand

in Pharmacological Treatment of Pain

Elouise Rose Comber
Jenny Strong
Orla Moore
Asaduzzaman Khan
James O’Callaghan
Benjamin Manion
Brendan Joseph Moore
Maree Therese Smith

Frontiers in Pain Research

doi 10.3389/fpain.2025.1527371

1,619 views

Review

Published on 31 Jan 2025

Phytochemical-based therapeutics from traditional eastern medicine: analgesic effects and ion channel modulation

in Pharmacological Treatment of Pain

Sung Eun Kim
Geehoon Chung
Sun Kwang Kim

Frontiers in Pain Research

doi 10.3389/fpain.2025.1537154

3,513 views
5 citations

Original Research

Published on 24 Jan 2025

Systemic antihyperalgesic effect of a novel conotoxin from Californiconus californicus in an inflammatory pain model

in Pharmacological Treatment of Pain

Joaquín López-Carrillo
Johanna Bernáldez-Sarabia
Tushar J. Pawar
Samanta Jiménez
Salvador Dueñas
Andrea Figueroa-Montiel
José L. Olivares-Romero
Vinicio Granados-Soto
Alexei F. Licea-Navarro
Nadia L. Caram-Salas

Frontiers in Pain Research

doi 10.3389/fpain.2024.1500789

2,649 views

Editorial

Published on 07 Jan 2025

Editorial: Preclinical animal models and measures of pain: improving predictive validity for analgesic drug development - volume II

in Pharmacological Treatment of Pain

Anke Tappe-Theodor
Thomas J. Martin
S. Stevens Negus

Frontiers in Pain Research

doi 10.3389/fpain.2024.1523938

2,264 views

Systematic Review

Published on 07 Jan 2025

Pregabalin vs. gabapentin in the treatment of neuropathic pain: a comprehensive systematic review and meta-analysis of effectiveness and safety

in Pharmacological Treatment of Pain

Víctor Mayoral
Rafael Galvez
Marta Ferrándiz
Xoán Miguéns Vázquez
Carlos Cordero-García
Antonio Alcántara Montero
Concepción Pérez
María Pérez-Páramo

Frontiers in Pain Research

doi 10.3389/fpain.2024.1513597

73,169 views
13 citations

Original Research

Published on 07 Jan 2025

Real-world evaluation of select adverse drug reactions and healthcare utilization associated with parenteral Ibuprofen and ketorolac in adult and pediatric patients

in Pharmacological Treatment of Pain

Mosadoluwa Afolabi
Jensy Rodriguez-Silva
Ishveen Chopra
Ines Macias-Perez
Jason Makii
Emily Durr
Theresa Human

Frontiers in Pain Research

doi 10.3389/fpain.2024.1484948

4,701 views

Perspective

Published on 10 Dec 2024

A perspective: neuraxial therapeutics in pain management: now and future

in Pharmacological Treatment of Pain

Jose DeAndres
Anthony H. Dickenson
Salim Hayek
Andreas Linninger
Tony L. Yaksh

Frontiers in Pain Research

doi 10.3389/fpain.2024.1505019

1,522 views

Clinical Trial

Published on 25 Nov 2024

Cannabis combined with oxycodone for pain relief in fibromyalgia pain: a randomized clinical self-titration trial with focus on adverse events

in Pharmacological Treatment of Pain

Cornelis Jan van Dam
Cornelis Kramers
Arnt Schellekens
Marcel Bouvy
Eveline van Dorp
Mikael A. Kowal
Erik Olofsen
Albert Dahan
Marieke Niesters
Monique van Velzen

Frontiers in Pain Research

doi 10.3389/fpain.2024.1497111

41,341 views
4 citations

Brief Research Report

Published on 22 Nov 2024

Arginine supplementation improves lactate dehydrogenase levels in steady-state sickle cell patients: preliminary findings from Kinshasa, the Democratic Republic of Congo

in Pharmacological Treatment of Pain

Ange C. M. Ngonde
Philippe N. Lukanu
Ange Mubiala
Michel N. Aloni

Frontiers in Pain Research

doi 10.3389/fpain.2024.1391666

1,911 views

Clinical Trial

Published on 14 Oct 2024

Enhancing analgesia in acute renal colic pain: a randomized controlled trial of gabapentin adjunct to ketorolac-based regimen

in Pharmacological Treatment of Pain

Parisa Kianpour
Parmis Valavioun
Pooya Payandemehr
Arash Safaei
Yasaman Borhani
Hooshyar Honarmand
Mojtaba Mojtahedzadeh
Kamal Basiri
Elahe karimpour-Razkenari
Farhad Najmeddin

Frontiers in Pain Research

doi 10.3389/fpain.2024.1427711

2,987 views
2 citations

Systematic Review

Published on 10 Oct 2024

Non-opioid psychiatric medications for chronic pain: systematic review and meta-analysis

in Pharmacological Treatment of Pain

Shahana Ayub
Anil Krishna Bachu
Lakshit Jain
Shanli Parnia
Siddhi Bhivandkar
Rizwan Ahmed
Jasleen Kaur
Surya Karlapati
Sakshi Prasad
Hansini Kochhar

Frontiers in Pain Research

doi 10.3389/fpain.2024.1398442

9,377 views
6 citations

Review

Published on 09 Oct 2024

Pharmacology of spinal interventions: review of agents used in spine pain procedures

in Pharmacological Treatment of Pain

Ericson John V. Torralba
Robert F. Short
Jeffrey B. Travers
John M. Mathis

Frontiers in Pain Research

doi 10.3389/fpain.2024.1408905

2,903 views

Review

Published on 27 Sep 2024

The mechanism and potential therapeutic target of piezo channels in pain

in Pharmacological Treatment of Pain

Yi Xu
Yuheng Wang
Shuchong Mei
Jialing Hu
Lidong Wu
Luyang Xu
Lijie Bao
Xiaowei Fang

Frontiers in Pain Research

doi 10.3389/fpain.2024.1452389

5,631 views
5 citations

Original Research

Published on 25 Sep 2024

Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study

in Pharmacological Treatment of Pain

Yi-Ming Ren
Wei-Yu Hou
Bao-You Fan
Yuan-Hui Duan
Yun-Bo Sun
Tao Yang
Han-Ji Zhang
Tian-Wei Sun
Meng-Qiang Tian

Frontiers in Pain Research

doi 10.3389/fpain.2024.1370704

2,362 views

Clinical Trial

Published on 24 Sep 2024

A novel opioid/pramipexole combination treatment for the management of acute pain: a pilot study

in Pharmacological Treatment of Pain

Cara Girardi
Joseph Duronio
Ryan Patton
Kevin O’Brien
Stefan Clemens
Kori L. Brewer

Frontiers in Pain Research

doi 10.3389/fpain.2024.1422298

4,650 views
1 citation

81 articles

articles

The clinical application progress of multimodal analgesia strategy in enhanced recovery after surgery: a narrative review

At the Intersection of Pain and Sleep: a Roadmap for Preclinical Pain Research

NOP agonist AT-403 promoted sleep in lactic acid-induced acute pain model

The effect of non-opioid multimodal analgesics and dexamethasone monotherapy on acute incisional pain behaviors in rats

Editorial: Insight in pharmacological treatment of pain – 2023

Sleep hygiene linked to patient-reported outcomes & objective sleep measures prior to upper extremity orthopaedic surgery

Editorial: Current treatment strategies and integrative medicine for management of pain in sickle cell disease

Widespread pain syndrome in long COVID-19: melatonin as an adjuvant treatment

Unpacking excessive polypharmacy patterns among individuals living with chronic pain in Quebec: a longitudinal study

Evaluation of long-term outcomes with intrathecal opioid treatment: a comparison utilizing data derived from pain clinic populations in Australia and New Zealand

Phytochemical-based therapeutics from traditional eastern medicine: analgesic effects and ion channel modulation

Systemic antihyperalgesic effect of a novel conotoxin from Californiconus californicus in an inflammatory pain model

Editorial: Preclinical animal models and measures of pain: improving predictive validity for analgesic drug development - volume II

Pregabalin vs. gabapentin in the treatment of neuropathic pain: a comprehensive systematic review and meta-analysis of effectiveness and safety

Real-world evaluation of select adverse drug reactions and healthcare utilization associated with parenteral Ibuprofen and ketorolac in adult and pediatric patients

A perspective: neuraxial therapeutics in pain management: now and future

Cannabis combined with oxycodone for pain relief in fibromyalgia pain: a randomized clinical self-titration trial with focus on adverse events

Arginine supplementation improves lactate dehydrogenase levels in steady-state sickle cell patients: preliminary findings from Kinshasa, the Democratic Republic of Congo

Enhancing analgesia in acute renal colic pain: a randomized controlled trial of gabapentin adjunct to ketorolac-based regimen

Non-opioid psychiatric medications for chronic pain: systematic review and meta-analysis

Pharmacology of spinal interventions: review of agents used in spine pain procedures

The mechanism and potential therapeutic target of piezo channels in pain

Causality of genetically determined serum metabolites on lower back pain or/and sciatica: a comprehensive Mendelian randomized study

A novel opioid/pramipexole combination treatment for the management of acute pain: a pilot study